Translational Stroke Research最新文献

{"title":"Circulating Microglia-derived Extracellular Vesicles Predict Recovery After Rehabilitation in Stroke Survivors.","authors":"Aurora Mangolini, Silvia Picciolini, Pietro Arcuri, Donata Bardi, Leandro Cosco, Francesca Cecchi, Lorenzo Romagnoli, Ester Marra, Pietro Parisse, Andrea Mannini, Jorge S Navarro, Marzia Bedoni, Alice Gualerzi","doi":"10.1007/s12975-026-01433-w","DOIUrl":"https://doi.org/10.1007/s12975-026-01433-w","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Glymphatic-Meningeal Lymphatic Function in Patients with Spontaneous Subarachnoid Hemorrhage.","authors":"Jianan Lu, Miao Lin, Heping Tian, Yibo Liu, Bingrui Zhu, Jin Mao, Jiahao Zhang, Haocheng Zhang, Sixuan Tian, Xu Li, Ding Xu, Chenhan Ling, Jianru Li, Hui Hong, Peiyu Huang, Jianmin Zhang, Chao Wang, Sheng Chen, Yuanjian Fang","doi":"10.1007/s12975-026-01438-5","DOIUrl":"https://doi.org/10.1007/s12975-026-01438-5","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Genetics and Molecular Biology of Brain Arteriovenous Malformations.","authors":"Takahiro Tsuchiya, Satoru Miyawaki, Hideaki Ono, Hiroki Hongo, Shotaro Ogawa, Yu Sakai, Yudai Hirano, Daisuke Sato, So Hirata, Satoshi Koizumi, Nobuhito Saito","doi":"10.1007/s12975-026-01436-7","DOIUrl":"10.1007/s12975-026-01436-7","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 3","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Edema and Intra-parenchymal Hemorrhage: A Mediated Pathway to Mortality and Functional Outcome in Cerebral Venous Sinus Thrombosis- A sub-analysis of the CLOT-VENUS Registry.","authors":"Nashwa Abdelhakim, Milagros Galecio-Castillo, Piyush Kalakoti, Leonardo Cruz-Criollo, Aaron Rodriguez-Calienes, Anderson Brito, Jorge Cespedes, Amir Shaban, Anish Venkatesan, Vanessa Cano Nigenda, Andres Alberto Mercado Pompa, Nicholas M Mohr, Adrian Pereda-Castillo, Kevin Enríquez Peregrino, Hector Valdez Ruvalcaba, Brian J Smith, James C Torner, Miguel A Barboza, Antonio Arauz, Santiago Ortega-Gutierrez","doi":"10.1007/s12975-026-01426-9","DOIUrl":"10.1007/s12975-026-01426-9","url":null,"abstract":"<p><p>Cytotoxic edema (CE) is a radiographic marker of early tissue injury in cerebral venous thrombosis (CVT) associated with poor outcomes, yet its mechanistic pathway remains unclear. We investigated whether intraparenchymal hemorrhage (IPH) mediates the association between CE and outcomes. We conducted a retrospective cohort study using the multicenter CLOT-VENUS registry, including acute CVT patients treated at two Comprehensive Stroke Centers in the USA and Mexico (2004-2024). CE was defined as hyperintensities around IPH or venous infarct with DWI restricted diffusion and corresponding low ADC, confirming true restricted diffusion. IPH was defined as hemorrhagic transformation of venous infarction or intracerebral hemorrhage on GRE MRI and/or NCCT. Mediation analyses assessed whether IPH mediated CE associations with in-hospital mortality and functional outcomes. Among 394 patients (mean age 42.7 years; 65.5% female), 128 (32.5%) demonstrated CE and 111(30.2%) IPH. CE was associated with in-hospital mortality (aOR 2.63, 95% CI 1.01-7.12) and poor 6-month mRS (aOR 1.71, 95% CI 1.06-2.74). CE was associated with IPH, which in turn was associated with mortality (aOR 8.73, 95% CI 2.93-30.45) and poor mRS (aOR 1.96, 95% CI 1.18-3.25). Adjustment for IPH rendered the CE-outcome associations non-significant. IPH accounted for 76.8% of CE's effect on mortality and 83.8% on 6-month mRS. Our findings suggest that IPH likely mediates the effect of CE on outcomes in CVT. Although the temporal sequence could not be confirmed, the results underscore the value of early CE detection for timely intervention.</p>","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Deep-Learning Model for Stroke Subtype Identification in Moyamoya Disease Based on Digital Subtraction Angiography.","authors":"Zhi-Wen Liu, Fei Shang, Ri-Miao Yang, Cong Han, Shuai Liu, Guo-Zheng Xu","doi":"10.1007/s12975-026-01432-x","DOIUrl":"10.1007/s12975-026-01432-x","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Linear Temporal Dynamics of Endothelial Progenitor Cells After Stroke: Associations with Perfusion Imaging, ASPECTs and Functional Outcome.","authors":"Juan Francisco García Granado, Francisco Javier Rodríguez Esparragón, Ernesto Santana Suárez, Jesús María González Martín, Sara Estefanía Cazorla Rivero, Almudena Raposo Usero, Ayoze Nauzet González Hernández","doi":"10.1007/s12975-026-01431-y","DOIUrl":"10.1007/s12975-026-01431-y","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cerebrovascular Reactivity Adjusted Fractional Amplitude of Low-Frequency Fluctuations Abnormalities in Middle Cerebral Artery Stenosis and Occlusive Disease.","authors":"Liqing Zhang, Luoyu Wang, Xue Tang, Yidi Zhu, Rong Wang, Zhongxiang Ding","doi":"10.1007/s12975-026-01430-z","DOIUrl":"10.1007/s12975-026-01430-z","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Segatella Copri-centered Gut Microbiota-mediated Metabolic Dysregulation Associated with Transition from Asymptomatic to Symptomatic Intracranial Atherosclerosis.","authors":"Manqi Zheng, Xiao Yang, Ruobing Tian, Xue Xia, Qin Xu, Ying Hui, Shuohua Chen, Yan Liu, Anxin Wang","doi":"10.1007/s12975-026-01428-7","DOIUrl":"10.1007/s12975-026-01428-7","url":null,"abstract":"<p><p>The mechanisms underlying the continuum from asymptomatic intracranial atherosclerotic stenosis (aICAS) to symptomatic intracranial large-artery atherosclerotic ischemic stroke (iLAA-IS) remain unclear. We investigated the gut microbiota-metabolite axis in this transition to identify predictive biomarkers and clarify key functional pathways. In a case-control study (63 iLAA-IS cases; 56 aICAS controls), fecal shotgun metagenomics and untargeted plasma metabolomics were profiled. Using machine learning with 10-fold nested cross-validation, we identified five robust biomarkers associated with the transition: Alistipes putredinis (risk-associated) and four protective features (Segatella copri, Gln-Gly, Methionine Sulfoxide, and N6-Acetyl-L-Lysine). Integrated models incorporating these markers significantly improved predictive performance relative to conventional risk factors (e.g., mean AUC of Gln-Gly: 0.9104 vs. 0.7188). Mechanistic analyses revealed a Segatella copri-centered metabolic dysregulation: its depletion coincided with a broad loss of anabolic pathways (BCAA biosynthesis, folate-SAM-methionine metabolism, and tRNA charging), which were positively linked to amino acid-related metabolites. In contrast, the pathways of Alistipes putredinis showed no such coupling. These findings suggest that the aICAS-to-iLAA-IS transition is characterized by chronic metabolic dysregulation, involving a Segatella copri-centered microbiota-metabolite axis. This multi-omic signature offers novel insights into stroke pathogenesis and potential targets for prevention.</p>","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Small Vessel Disease and Blood-Brain Barrier Disruption: Mechanisms and Therapeutic Strategies in Cognitive Impairment.","authors":"Yang Yang, Yuhang Qian, Jun Huang, Ying Luo","doi":"10.1007/s12975-026-01427-8","DOIUrl":"10.1007/s12975-026-01427-8","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotype-Aligned Metabolomics Identifies Plasma Arginine as a Candidate Predictor of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage.","authors":"Krzysztof Urbanowicz, Karol Wiśniewski, Mikołaj Opiełka, Michał Bieńkowski, Marta Popęda, Oliwier Krajewski, Ernest J Bobeff, Karol Zaczkowski, Bartosz Szmyd, Dariusz J Jaskólski, Ryszard T Smoleński","doi":"10.1007/s12975-026-01421-0","DOIUrl":"10.1007/s12975-026-01421-0","url":null,"abstract":"","PeriodicalId":23237,"journal":{"name":"Translational Stroke Research","volume":"17 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}