International Journal of Clinical and Diagnostic Pathology最新文献

{"title":"Adequacy of voided urine specimens evaluated using the Paris system for reporting urine cytology","authors":"Hasan Qasim Mohammed Ali al-Dayyeni, Dr. Hussam Hasson Ali","doi":"10.33545/pathol.2022.v5.i3a.479","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.479","url":null,"abstract":"Background: Adequacy (satisfactory) is a source of conflict and controversy in all cytopathology fields including the urinary tract specimens. Aim of the study: To examine the adequacy (satisfactory) factor of urine samples and their importance in the diagnosis of urothelial malignancy using the Paris system for reporting urinary cytology. Methods: This is a retrospective study including (314) cases of patients presented with hematuria or diagnosed as having urinary bladder mass. The slides were taken and centrifuged at 2000 RPM and stained according to the availability of the stains the year from which they obtained; Slides were taken from (2016, 2017 and 2020) were stained with (Hematoxylin and Eosin), while the slides taken from (2018-2019) were stained with (Papanicolaou) stain; In addition to some slides were stained with (Giemsa) stain in special cases, including the patients with age range of (8-98) years. All data were taken from archival files of these patients; we divide the urine volume parameter into more than and less than 30 ml. Results: the occurrence of high grade urothelial carcinoma was encountered in 8 of 103 cases (7.8%) at age below (50) years, and 13 of 74 cases (17.6%) at age from (51-60) years, and 43 of 137 cases (31.4%) at age more than (60) years. According to the association between the urine volume and the diagnosis of high grade urothelial carcinoma, there was 19 of 68 cases (27.9%) of patient’s urine volume obtained was ≥ 30 ml have high-grade urothelial carcinoma, while 45 of 246 (18.3%) of them urine volume was > 30 ml have high-grade urothelial carcinoma. According to the association between adequacy of urine sample with urine volume, there were 32 of 246 (13%) of patient’s urine volume obtained was > 30 ml having unsatisfactory urine sample for cytological analysis, while only 6 of 68 (8.8%) of patient’s urine volume obtained was ≥ 30 having unsatisfactory urine sample. Conclusion: A significant correlation between the detection of high-grade urothelial carcinoma and increase urine volume submitted for cytological evaluation, increased urine volume submitted for cytological examination decrease the frequency of unsatisfactory samples.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132445498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomorphological spectrum of various breast lumps using FNAC as diagnostic modality","authors":"Dr. Monika Pangotra, Dr. Rashmi Aithmia, Dr. Surinder K Atri","doi":"10.33545/pathol.2022.v5.i3a.471","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.471","url":null,"abstract":"Background: Breast carcinoma is the most common malignant tumour and the leading cause of death from cancer in women. FNAC of breast lumps is an important mode of investigation and forms a part of triple test. FNAC is cost effective and can prevent unnecessary surgery. This study intended to look the frequencies of different lesions in FNAC of palpable breast lump. Methods: It is a hospital based prospective study conducted from November 2016 to October 2017 conducted in Department of Pathology, GMC Jammu. FNAC was done in a total of 289 patients who presented with palpable breast lump along with suspected enlarged axillary lymph node, if any. We assessed the age of the patient, lesion size, site, type of lesion and axillary lymph node metastasis in case of malignancies. Results: Out of 289 patients studied, 250 (86.5%) were females and 39 (13.4%) were males. Age ranges from 7-88 years with a mean age of 36 years. Most of the patients were in 21-30 years age group (30.6%). cases (96.4%) presented with breast lump while the swelling was diffuse in 9 cases. Maximum number of cases in females were seen in the age group of 21-30 years i.e. 75 cases (30%). Upper outer quadrant was the most common quadrant involved in females with 70 cases (28%). On FNAC, there were 36 cases (12.4%) of Inflammatory lesions, 198 (68.5%) of benign cases and 29 cases (10.06%) of carcinoma breast. Among the benign lesions maximum number of cases i.e. 58 cases (20.06%) were reported as Fibroadenoma. On cytological categorisation of breast diseases on FNAC, maximum number of cases i.e. 221 (76.4%) were categorised as C2 (Benign) followed by 29 cases (10.06%) categorised as C5 (Malignant).","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132181397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case report: Giant hepatic cavernous hemangioma","authors":"D. Tm, D. R, Dr. Tharun Shyam","doi":"10.33545/pathol.2022.v5.i3a.477","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.477","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116878678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of significance of serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) as an early tumour marker in female patients with ovarian cancer","authors":"Geeta Bilonia, Dr. Rati Mathur, Dr. Suresh Singh","doi":"10.33545/pathol.2022.v5.i3a.472","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.472","url":null,"abstract":"Aim : To determine the usefulness of serum human epididymis protein4 (HE4) along with Carbohydrate Antigen 125 (CA125) as an early tumour marker in female patients with ovarian cancer. Method : The ovarian cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum HE4 and CA125. Total 262 subjects were included in this study.131 ovarian cancer Patients were divided according to different stages and 131 control subjects also included. Results : Serum HE4 and CA125 level raised significantly in ovarian cancer patients. Further increases with the advanced stage of the ovarian cancer. Conclusion : Both HE4 and CA125 can be useful diagnostic tumour marker in ovarian cancer.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132650516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To study the impotence of the correlation between fine needle aspiration cytology (FNAC) and histopathological diagnosis of thyroid lesion","authors":"Dr. Pruthvi Patel, Dhrumil Patel","doi":"10.33545/pathol.2022.v5.i3a.473","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.473","url":null,"abstract":"Introduction: Fine needle aspiration cytology (FNAC)is popular diagnostic as well as therapeutic test in thyroid pathology. FNAC has become the effective method in the Evaluation of thyroid lesion, being the safe, fast, reliable, and minimally invasive, cost Effective and reaching high sensitivity and Specificity. Aims and Objectives: The Aim of this study is to establish a cytohistological correlation in thyroid lesion and to find out can FNA obviate the need for histopathological diagnosis of thyroid lesion. Materials and Methods: The retrospective study was conducted in the department of Pathology of Geetanjali medical college and hospital, Udaipur, during the period between June 2020 to October 2021. Data for study is obtained from departmental records and tissue specimens received in the histopathology and cytology sections section in the specified period of study. Results: In the present study, 225 cases of Thyroidectomy were received at the Histopathology Section of Pathology Department, Geetanjali medical college and hospital, Udaipur, during the period Between June 2020 to October 2021. Out of These, 190 were non-neoplastic and 35 were Neoplastic. Among 35 neoplastic lesions, 28 Were benign and 7 were malignant,120 cases Were correlated with FNAC findings. In correlation study, FNAC had 100% Accuracy for malignant lesions.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130031116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare synchronous primary tumour of female genital tract","authors":"Meera M, D. Srivani, Dr. C Jayanthi, Dr. V Vigneswaramoorthi","doi":"10.33545/pathol.2022.v5.i3a.476","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.476","url":null,"abstract":"Introduction: Synchronous primary cancers are very rare in the general population. We present a rare case of synchronous primary endometrial and primary fallopian tube cancers. Case: The patient, a 61 year old female presented with postmenopausal bleeding, and diagnosed as Carcinoma Endometrium was taken up for Total Abdominal Hysterectomy with Bilateral Salpingo oophorectomy with Bilateral Pelvic Lymph Node Dissection. The histopathology revealed synchronous primary carcinomas of endometrium and left fallopian tube. Conclusion: The reason for better median overall survival of patients with synchronous primary endometrial and fallopian tube cancers is not intuitively obvious; perhaps because it is low grade and biologically less aggressive, detection of patients at earlier clinical stage is essential for appropriate management.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132845886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spectrum of thalassemia syndromes and abnormal haemoglobins in adult patients based on HPLC in a tertiary care centre of Punjab, India","authors":"Bharat Kumar Mahajan, V. Mehra, Sundar Mahajan, Gaganpreet Singh, Swati Setia","doi":"10.33545/pathol.2022.v5.i2a.470","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i2a.470","url":null,"abstract":"In the present study adult patients with anemia were analysed for thalassemia syndromes and other haemoglobino pathies by using high performance liquid chromatography. A total of 102 Patients’ blood samples were evaluated for complete blood count, RBC indices, reticulocyte count and peripheral blood film for morphology. For the confirmation and characterization of hemoglobinopathy, ‘BIORAD VARIANT II’ of HPLC instrument with CDM software was utilized. 60.8% of the patients were females while the remaining 39.2% were males. The results of this study showed that 79.4% of patients were having a normal hemoglobin while 17% patients showed the prevalence of thalassemia trait. Two cases of hereditary persistence of fetal hemoglobin (HPFH) were seen and one case each of sickle cell-beta thalassemia (HbSThal) and hemoglobin D-Iran (HD - Iran) were seen . It was observed that 65.4% of the patients without thalassemia trait had normocytic normochromic type of anemia. In contrast, all the patients with thalassemia trait and HbSThal had microcytic hypochromic anemia. This association was statistically significant with hemoglobinopathies mostly having microcytic hypochromic. The present findings show high performance liquid chromatography forms a rapid, accurate, and reproducible tool for the early detection and management of and variants.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128622398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient abnormal myelopoiesis at birth with Down syndrome: A rare case report","authors":"D. Tm, D. Karthik, Dr. Tharun Shyam","doi":"10.33545/pathol.2022.v5.i3a.475","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.475","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124307558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saddle chest: A special thoracic deformity","authors":"Dr. Wenlin Wang, Dr. Weiguang Long, Dr. Yang Liu, Dr. Bin Cai, Dr. Juan Luo","doi":"10.33545/pathol.2022.v5.i3a.483","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i3a.483","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130686066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 24 kgs giant mucinous cystadenoma in a post-menopausal woman: A rare case report","authors":"D. K. Rajendran, Dr. Veena Raja, Dr.M. Dhanalakshmi., Dr. Afrin T Fathima, Dr. S. Balamurugan","doi":"10.33545/pathol.2022.v5.i2a.469","DOIUrl":"https://doi.org/10.33545/pathol.2022.v5.i2a.469","url":null,"abstract":"Mucinous cystadenomas are among the most common benign ovarian neoplasms. Abdominal cystic tumours are highly prevalent. Due to the availability of superior imaging techniques, they are now diagnosed more commonly and considerably earlier. Over time, these adnexal masses can lead to fatal complications, such as ovarian torsion or haemorrhage. Incidental findings of these tumours are common as many of these patients are asymptomatic. 45-year-old female presented with abdominal distension for 1 year with polymenorrhagia. An exploratory laparotomy relieved a giant tumour weighing of 24.870 kgs drained 30 Litres of serous fluid. Histopathology revealed benign ovarian mucinous cystadenoma. A multidisciplinary approach in the preoperative, intraoperative and postoperative stages of management optimizes patient outcomes.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"5 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113977748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}