Comparative study of significance of serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) as an early tumour marker in female patients with ovarian cancer

Abstract

Aim : To determine the usefulness of serum human epididymis protein4 (HE4) along with Carbohydrate Antigen 125 (CA125) as an early tumour marker in female patients with ovarian cancer. Method : The ovarian cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum HE4 and CA125. Total 262 subjects were included in this study.131 ovarian cancer Patients were divided according to different stages and 131 control subjects also included. Results : Serum HE4 and CA125 level raised significantly in ovarian cancer patients. Further increases with the advanced stage of the ovarian cancer. Conclusion : Both HE4 and CA125 can be useful diagnostic tumour marker in ovarian cancer.