Toxin Reviews最新文献_第6页

Epidemiologic and spatiotemporal study on access to snakebite care in Northern Nigeria 尼日利亚北部获得蛇咬伤护理的流行病学和时空研究

IF 3.1 4区医学

Toxin Reviews Pub Date : 2023-02-11 DOI: 10.1080/15569543.2023.2177873

Naziru Halliru, M. M. Badamasi, I. Y. Tudunwada, Titus B Dajel, S. Abubakar, Auwalu S. Hamza, Sandra B. Oluwashola, Nasiru K. Nalado, M. Dahiru, Ibrahim Na’abdu, Umar N. Saleh, A. M. Daiyab, S. Mohammed, G. Iliyasu, H. Muhammad, A. Habib

{"title":"Epidemiologic and spatiotemporal study on access to snakebite care in Northern Nigeria","authors":"Naziru Halliru, M. M. Badamasi, I. Y. Tudunwada, Titus B Dajel, S. Abubakar, Auwalu S. Hamza, Sandra B. Oluwashola, Nasiru K. Nalado, M. Dahiru, Ibrahim Na’abdu, Umar N. Saleh, A. M. Daiyab, S. Mohammed, G. Iliyasu, H. Muhammad, A. Habib","doi":"10.1080/15569543.2023.2177873","DOIUrl":"https://doi.org/10.1080/15569543.2023.2177873","url":null,"abstract":"Abstract The role of epidemiologic and spatiotemporal factors affecting access to care among snakebite patients in Nigeria are determined. In 2021 a total of 2,942 snakebite patients were prospectively studied at four designated Health Facilities for Managing Snakebites (HFMS). The patients came from 94 Local Government Areas (LGAs) in 12 states in northern Nigeria. It was found that 435 (14.8%) patients actually accessed care within ≤2 hours of bite although 38.0% could have reached the HFMS within the time by car. In certain areas 92% of patients would have been able to reach a secondary or tertiary facility within ≤2 hours. Similarly, 437 (14.9%) patients traveled distances of ≤20 Km to reach a designated HFMS although 86% of patients resided within 5 Km of a road network. There was longer median delay to access care (15 hours), more patients (365) and higher proportion not treated with antivenom (22%) in August the wettest month of the year. Furthermore the patients who died (47) took a median time of 48 hours compared to 11 hours among known survivors (2,649) to access care. Expanding antivenom access to other secondary and tertiary HF in high burden areas especially during peak seasons will potentially improve the outcome among patients.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"537 - 547"},"PeriodicalIF":3.1,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47719434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallic acid and sesame oil exert cardioprotection via mitochondrial protection and antioxidant properties on Ketamine-Induced cardiotoxicity model in rats 没食子酸和香油通过线粒体保护和抗氧化作用对氯胺酮致大鼠心脏毒性模型发挥心脏保护作用

IF 3.1 4区医学

Toxin Reviews Pub Date : 2023-01-13 DOI: 10.1080/15569543.2023.2165503

A. Salimi, M. Shabani, Deniz Bayrami, Armin Saray, Nastaran Farshbaf Moghimi

{"title":"Gallic acid and sesame oil exert cardioprotection via mitochondrial protection and antioxidant properties on Ketamine-Induced cardiotoxicity model in rats","authors":"A. Salimi, M. Shabani, Deniz Bayrami, Armin Saray, Nastaran Farshbaf Moghimi","doi":"10.1080/15569543.2023.2165503","DOIUrl":"https://doi.org/10.1080/15569543.2023.2165503","url":null,"abstract":"Abstract Ketamine is a cardiotoxic agent and can deplete ATP in cardiomyocytes through mitochondrial dysfunction. We investigated the effects of gallic acid and sesame oil in ketamine-induced cardiotoxicity in rats. Male Wistar rats were randomly divided into six groups including control; ketamine; ketamine + gallic acid; ketamine + sesame oil; gallic acid and sesame oil. Serum cardiac marker, cardiac tissue oxidative stress markers, histopathological analysis and mitochondrial toxicity parameters (succinate dehydrogenase activity, mitochondrial swelling, reactive oxygen species (ROS) production and collapse of mitochondria membrane potential) were measured on the fifteen days of the study. The results showed that ketamine administration increased serum cardiac markers, oxidative stress parameters, histopathological alterations and mitochondrial dysfunction in cardiac tissue. Gallic acid and sesame oil administration in presence of ketamine was observed to decrease serum cardiac markers, oxidative stress parameters, histopathological alterations and mitochondrial dysfunction in cardiac tissue. The results suggest that gallic acid and sesame oil exert cardioprotection via mitochondrial protection, antioxidant properties and ultimately improving mitochondrial function and cardiac function.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"515 - 526"},"PeriodicalIF":3.1,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43612991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification, characterization, and molecular phylogeny of scorpion enolase (Androctonus crassicauda and Hemiscorpius lepturus) 天蝎烯醇化酶的鉴定、表征及分子系统发育

IF 3.1 4区医学

Toxin Reviews Pub Date : 2023-01-02 DOI: 10.1080/15569543.2022.2080223

Elham Pondehnezhadan, Atefeh Chamani, F. Salabi, R. Soleimani

{"title":"Identification, characterization, and molecular phylogeny of scorpion enolase (Androctonus crassicauda and Hemiscorpius lepturus)","authors":"Elham Pondehnezhadan, Atefeh Chamani, F. Salabi, R. Soleimani","doi":"10.1080/15569543.2022.2080223","DOIUrl":"https://doi.org/10.1080/15569543.2022.2080223","url":null,"abstract":"Abstract Scorpions are the oldest terrestrial fauna with an ancient evolutionary history. To study the origins of scorpions, we conducted a molecular phylogenetic study of the arthropod using slowly evolving enolase sequences. In this study, we used deep RNA-seq technology to identify the enolase sequences of Androctonus crassicauda and Hemiscorpius lepturus scorpions. The scorpion’s enolase sequences were in silico analyzed to predict the protein structures, physicochemical characterization, and exon-intron organization. The enolase of the scorpion was found to be a protein of 433 amino acids with a molecular mass of ∼47 kDa and an acidic isoelectric point. Here, we reported the existence of 8 exons and an inner GC/AG intron for scorpion enolase. Using homology modeling, the enolase of the scorpions was found to be very conservative during the evolution process. Furthermore, our phylogenetic analysis indicated the independent evolution of the Buthidae family from other scorpions and also the sister group relationship of Hemiscorpionidae with the Caraboctonidae families. The scorpions’ enolase sequences demonstrated a close fit to those of spiders, followed by mite counterparts. This strongly supports our phylogeny analysis, which indicates a sister-group relationship between scorpions and spiders and their common ancestors with mites. This study provided support for the pairing of scorpions with spiders, mites, etc. using enolase as a nuclear gene. Our molecular clock analyzes of the arthropod show that the most recent common ancestor of arachnids and insects were diversified in the Cryogenian period of Neoproterozoic era, earlier than dates reported from fossil records.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"228 - 241"},"PeriodicalIF":3.1,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46925667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The content of ten elements in pig feed and manure and its relationship with element concentration in earthworms on swine farms 猪场饲料和粪肥中10种元素含量及其与蚯蚓体内元素浓度的关系

IF 3.1 4区医学

Toxin Reviews Pub Date : 2023-01-02 DOI: 10.1080/15569543.2022.2163662

B. Mitrović, S. Stefanović, D. Šefer, D. Jovanović, J. Ajtić

{"title":"The content of ten elements in pig feed and manure and its relationship with element concentration in earthworms on swine farms","authors":"B. Mitrović, S. Stefanović, D. Šefer, D. Jovanović, J. Ajtić","doi":"10.1080/15569543.2022.2163662","DOIUrl":"https://doi.org/10.1080/15569543.2022.2163662","url":null,"abstract":"Abstract The aim of this investigation is to determine the content of ten elements, Cr, Mn, Co, Ni, Fe, Zn, As, Cu, Se, and Cd, in pig feed, manure and earthworms (Lumbricus terrestris). Samples were collected during 2015 and 2017, on four pig farms in Serbia, and analyzed for elements by inductively coupled plasma mass spectrometry. According to the mean concentrations, the elements show the following trends: Fe > Mn > Zn > Cr > Ni > Cu > Cd > Se > As > Co in monocalcium phosphate, Zn > Mn > Fe > Cu > Co > Cr > Ni > Se > As > Cd in vitamin-mineral premixes, Fe > Zn > Mn > Cu > Ni > Cr > Se > Co > As > Cd in complete feed, and Fe > Zn > Mn > Cu > Ni > Cr > Co > Se > Cd > As in pig manure. The obtained results show that monocalcium phosphate and vitamin-mineral premixes are the main source of Mn, Zn, and Fe in complete feed mixtures. The Cd concentration in one sample of monocalcium phosphate exceeds the maximum permissible level. Only one out of six investigated complete feed mixtures was in accordance with the national and EU regulations. The presence of Fe, Zn, and Mn in earthworms reflects their concentration in pig manure, but this is not noticed for Cr, Cu, Se, As, Ni, Co, and Cd.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"332 - 341"},"PeriodicalIF":3.1,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60280861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DNA breaks evaluation of two water-based metalworking fluids by an occupational exposure design 职业暴露设计对两种水基金属加工液的DNA断裂评价

IF 3.1 4区医学

Toxin Reviews Pub Date : 2023-01-02 DOI: 10.1080/15569543.2022.2163663

Z. Moradpour, P. Abdolmaleki, Behnam Hajipour-Verdom, A. Khavanin, Z. Panjali, N. Maghsudi, Mansoureh Hamidi, R. Zendehdel

{"title":"DNA breaks evaluation of two water-based metalworking fluids by an occupational exposure design","authors":"Z. Moradpour, P. Abdolmaleki, Behnam Hajipour-Verdom, A. Khavanin, Z. Panjali, N. Maghsudi, Mansoureh Hamidi, R. Zendehdel","doi":"10.1080/15569543.2022.2163663","DOIUrl":"https://doi.org/10.1080/15569543.2022.2163663","url":null,"abstract":"Abstract Thermal degradation of water-based metalworking fluids (MWFs) produces carcinogen by-products. Since different additives have been used to eliminate hazardous material, the carcinogenic potential of two water-based MWFs was investigated in the lung epithelial cell line (A549). Two MWF types were studied in pure and on-used. The chemical content of all samples was assessed by gas chromatography–mass spectrometry (GC-MS). DNA damage of samples was evaluated in the doses range of 0.05–0.8 mg by comet assay. Comet images were analyzed with Open comet software. Amine borate and ethanolamine were found in B and C fluids respectively. Pyridazine compound by the potency of nitrosamine production was found in on-used C fluid. After using MWFs in the metal processing, a polycyclic component with bore central groups was produced in on-used B fluid. DNA damage of on-used fluid with boron component occurred at a level lower than ethyl amine-containing fluid. Moreover, the genotoxicity of air samples in B fluid was higher than C airborne samples significantly. More careful management have to be considered for the replacement of amine corrosion inhibitors with boron-containing chemical in MWFs. In conclusion design of a plan was required for the control of high-risk chemicals in the metal processing industry.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"342 - 348"},"PeriodicalIF":3.1,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43965886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Resveratrol: a panacea compound for diazinon-induced renal toxicity 白藜芦醇:一种治疗二嗪农引起的肾毒性的灵丹妙药

IF 3.1 4区医学

Toxin Reviews Pub Date : 2023-01-02 DOI: 10.1080/15569543.2021.2008452

Maryam Esfahani, A. Rahbar, S. Soleimani asl, Fereshteh Mehri

{"title":"Resveratrol: a panacea compound for diazinon-induced renal toxicity","authors":"Maryam Esfahani, A. Rahbar, S. Soleimani asl, Fereshteh Mehri","doi":"10.1080/15569543.2021.2008452","DOIUrl":"https://doi.org/10.1080/15569543.2021.2008452","url":null,"abstract":"Abstract Diazinon (DZN) is an organophosphate insecticide that has been globally used in agriculture and domestic areas for several years, leading to a variety of negative effects in different targets of humans. This study focused on evaluating the kidney protective role of resveratrol (Res) against sub-chronic DZN exposure by estimating oxidative, anti-oxidative, inflammatory, and apoptotic markers, along with renal function indexes. Overall, 30 Wistar rats were randomly divided into five groups. Groups 1 (control group), 2, 3, 4, and 5 received corn oil, DZN (70 mg/kg), DZN (70 mg/kg) plus Res 5 mg/kg, DZN (70 mg/kg) plus Res 10 mg/kg, and DZN (70 mg/kg) plus Res 20 mg/kg orally, respectively. DZN increased the serum and kidney level of malondialdehyde, total oxidant status, tumor necrosis factor-α (TNF-α), and the expression ratio of Fox-1 and Bax-2. On the other hand, DZN decreased the serum and kidney level of of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase activities (CAT), and the expression ratio of Forkhead box protein O1 (Foxo1); sirtuin 1(Sirt-1);. Based on the results, blood urea nitrogen (BUN) and creatinine (Cr) as the kidney function index were notably changed in all groups. Res treatment inversed DZN-induced kidney toxicity, Finally, Res improved DZN-induced kidney histopathological changes. Overall, these results first demonstrated that Res has protective effects on renal toxicities induced by DZN.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"40 - 50"},"PeriodicalIF":3.1,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44675275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Streptozotocin mechanisms and its role in rodent models for Alzheimer’s disease 链脲佐菌素机制及其在阿尔茨海默病啮齿类动物模型中的作用

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-12-05 DOI: 10.1080/15569543.2022.2150646

Mazzura Wan Chik, Nur Adiilah Ramli, Nurul Aqmar Mohamad Nor Hazalin, Gurmeet Kaur Surindar Singh

引用次数: 2

Toxic uranium contamination in groundwater of Thoothukudi district, India: Evaluation of health risks using the geochemical and statistical approach 印度Thoothukudi地区地下水中的有毒铀污染:利用地球化学和统计方法评价健康风险

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-11-30 DOI: 10.1080/15569543.2022.2150648

V. Raja, M. A. Neelakantan

{"title":"Toxic uranium contamination in groundwater of Thoothukudi district, India: Evaluation of health risks using the geochemical and statistical approach","authors":"V. Raja, M. A. Neelakantan","doi":"10.1080/15569543.2022.2150648","DOIUrl":"https://doi.org/10.1080/15569543.2022.2150648","url":null,"abstract":"Abstract The present investigation aims to determine the health risks of toxic uranium contamination in the drinking water of the Thoothukudi district. Two hundred and eighty-six samples were examined during the pre- and post-monsoon seasons and found the uranium concentration ranges from <0.2 to 167 ppb (mean 12, Standard deviation 21) (pre-monsoon) and <02 to 190 ppb (mean 13, Standard deviation 24) (post-monsoon). Geochemical modeling studies and the reducing nature of samples reveal that the uraninite mineral is under saturated conditions, and the least soluble U4O9 mineral species is predominantly distributed during both seasons. Statistical analysis provides that applying nitrogen and phosphate fertilizers may induce the dissolution of uranium minerals, which is responsible for elevated uranium in the collected samples. The calculated noncarcinogenic risk of uranium range from 0.005 to 8.09 (pre-monsoon) and 0.005 to 9.18 (post-monsoon). 15% (pre-monsoon) and 17% (post-monsoon) of the samples show a higher noncarcinogenic risk. The calculated cancer mortality and morbidity are within the permissible limit of 10−3, and the present health risk assessment of uranium is evident that the people from this district have the chemical toxicity of uranium than the carcinogenic risk due to drinking water.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"316 - 331"},"PeriodicalIF":3.1,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47288701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Human health risk and hydro-geochemical appraisal of groundwater in the southwest part of Bangladesh using GIS, water quality indices, and multivariate statistical approaches 利用GIS、水质指数和多元统计方法对孟加拉国西南部地下水的人类健康风险和水文地球化学评价

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-10-19 DOI: 10.1080/15569543.2022.2134572

T. K. Chakraborty, Md. Shahnul Islam, G. Ghosh, Prianka Ghosh, S. Zaman, Ahsan Habib, Md. Ripon Hossain, Himel Bosu, Md. Rashidul Islam, Mostafa Al Imran, A. S. Khan, Md. Shahariea Karim Josy

{"title":"Human health risk and hydro-geochemical appraisal of groundwater in the southwest part of Bangladesh using GIS, water quality indices, and multivariate statistical approaches","authors":"T. K. Chakraborty, Md. Shahnul Islam, G. Ghosh, Prianka Ghosh, S. Zaman, Ahsan Habib, Md. Ripon Hossain, Himel Bosu, Md. Rashidul Islam, Mostafa Al Imran, A. S. Khan, Md. Shahariea Karim Josy","doi":"10.1080/15569543.2022.2134572","DOIUrl":"https://doi.org/10.1080/15569543.2022.2134572","url":null,"abstract":"Abstract This study investigated the groundwater chemistry, suitability, and potential human health risk in the southwest part of Bangladesh. Groundwater samples were collected from the shallow aquifer throughout the study area. A set of different hydro-chemical analyses, water quality indices, multivariate statistics, and geo-statistical models were applied to achieve the study objectives. Study results show the concentration of NH3-N, HCO3 −, Ca2 +, As, Fe, and Mn exceeded Bangladesh drinking water standards in 94%, 100%, 100%, 73%, 97%, and 91% of samples, respectively. Groundwater quality indices indicate that about 94% of samples are suitable for irrigation, and about 82% are unsuitable for drinking. In the study area, groundwater is mainly Ca2+-Mg2-HCO3 − types, and rock-water interactions dominate the mineralization process. Ca2+ > Mg2+ > Na+ > K+, and HCO3 − > Cl− > SO4 2− are the sequential orders of major cation and major anion, respectively. Multivariate analyses show the geogenic origin is predominant over anthropogenic sources. Semivariogram models show moderate to weak spatial dependence. The non-carcinogenic and carcinogenic health risks via oral exposure pathways for adults and children are in the high (97%) and very high (100%) categories, respectively.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"285 - 299"},"PeriodicalIF":3.1,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42679857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Mitochondrial biogenesis alteration in arsenic-induced carcinogenesis and its therapeutic interventions 砷致癌过程中线粒体生物发生改变及其治疗干预

IF 3.1 4区医学

Toxin Reviews Pub Date : 2022-10-03 DOI: 10.1080/15569543.2022.2124420

K. Sathua, R. Singh

{"title":"Mitochondrial biogenesis alteration in arsenic-induced carcinogenesis and its therapeutic interventions","authors":"K. Sathua, R. Singh","doi":"10.1080/15569543.2022.2124420","DOIUrl":"https://doi.org/10.1080/15569543.2022.2124420","url":null,"abstract":"Abstract Arsenic poisoning is one of the major devastation and horrific concerns across the globe. Its concentration in the environment is continuously increasing over time, and hence it may play a role of exterminator for the future civilization. Cancer is the one of the main detrimental outcomes of arsenic poisoning. The International Agency for Research on Cancer suggested arsenic as a class-1 carcinogen. The underlying mechanism pertaining to arsenic-induced carcinogenesis is still enigmatic. Although plentiful evidences have vouched that the redox machinery is the main culprit for arsenic-induced carcinogenesis, however several reports have documented regarding participation of mitochondria as the root originators of the redox signaling in arsenic-induced carcinogenesis. Moreover, the redox machinery system plays a vital role in regulating mitochondrial biogenesis and homeostasis. However, there is still a knowledge gap regarding the influence of redox machinery systems on mitochondrial biogenesis and homeostasis in the development of arsenic-induced carcinogenesis. The objectives of this paper are to review and evaluate the role of mitochondrial biogenesis in the development of arsenic-induced carcinogenesis in addition to the possible therapeutic option for modulation of such signaling mechanisms.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":"42 1","pages":"447 - 459"},"PeriodicalIF":3.1,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43080997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0