Resveratrol: a panacea compound for diazinon-induced renal toxicity

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2023-01-02 DOI:10.1080/15569543.2021.2008452

Maryam Esfahani, A. Rahbar, S. Soleimani asl, Fereshteh Mehri

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引用次数: 4

Abstract

Abstract Diazinon (DZN) is an organophosphate insecticide that has been globally used in agriculture and domestic areas for several years, leading to a variety of negative effects in different targets of humans. This study focused on evaluating the kidney protective role of resveratrol (Res) against sub-chronic DZN exposure by estimating oxidative, anti-oxidative, inflammatory, and apoptotic markers, along with renal function indexes. Overall, 30 Wistar rats were randomly divided into five groups. Groups 1 (control group), 2, 3, 4, and 5 received corn oil, DZN (70 mg/kg), DZN (70 mg/kg) plus Res 5 mg/kg, DZN (70 mg/kg) plus Res 10 mg/kg, and DZN (70 mg/kg) plus Res 20 mg/kg orally, respectively. DZN increased the serum and kidney level of malondialdehyde, total oxidant status, tumor necrosis factor-α (TNF-α), and the expression ratio of Fox-1 and Bax-2. On the other hand, DZN decreased the serum and kidney level of of Total Antioxidant Capacity (TAC), Superoxide dismutase (SOD), Catalase activities (CAT), and the expression ratio of Forkhead box protein O1 (Foxo1); sirtuin 1(Sirt-1);. Based on the results, blood urea nitrogen (BUN) and creatinine (Cr) as the kidney function index were notably changed in all groups. Res treatment inversed DZN-induced kidney toxicity, Finally, Res improved DZN-induced kidney histopathological changes. Overall, these results first demonstrated that Res has protective effects on renal toxicities induced by DZN.

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白藜芦醇:一种治疗二嗪农引起的肾毒性的灵丹妙药

二嗪农(Diazinon, DZN)是一种有机磷杀虫剂，近年来在全球农业和家庭领域广泛使用，对人类不同目标产生了多种负面影响。本研究主要通过评估氧化、抗氧化、炎症和凋亡标志物以及肾功能指标来评估白藜芦醇(Res)对亚慢性DZN暴露的肾脏保护作用。30只Wistar大鼠随机分为5组。1组(对照组)、2组、3组、4组和5组分别给予玉米油、DZN (70 mg/kg)、DZN (70 mg/kg) + Res 5 mg/kg、DZN (70 mg/kg) + Res 10 mg/kg和DZN (70 mg/kg) + Res 20 mg/kg的口服。DZN升高了血清和肾脏丙二醛水平、总氧化水平、肿瘤坏死因子-α (TNF-α)以及Fox-1和Bax-2的表达率。另一方面，DZN降低了血清和肾脏总抗氧化能力(TAC)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平和叉头盒蛋白O1 (Foxo1)表达率;sirtuin蛋白1 (sirt - 1基因);。结果显示，各组大鼠肾功能指标血尿素氮(BUN)和肌酐(Cr)均有显著变化。Res治疗逆转了dzn诱导的肾毒性，最终改善了dzn诱导的肾脏组织病理改变。总之，这些结果首次证明了Res对DZN诱导的肾毒性具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.