STEM CELLS最新文献_第9页

Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury. 成年小鼠胰腺导管中罕见的、紧密结合的多细胞集群具有类似祖细胞的功能，并能在尖状细胞损伤后存活和增殖。

IF 4 2区医学

STEM CELLS Pub Date : 2024-04-15 DOI: 10.1093/stmcls/sxae005

Jacob R Tremblay, Jose A Ortiz, Janine C Quijano, Heather N Zook, Neslihan Erdem, Jeanne M LeBon, Wendong Li, Kevin Jou, Walter Tsark, Jeffrey R Mann, Mark T Kozlowski, David A Tirrell, Farzad Esni, Dannielle D Engle, Arthur D Riggs, Hsun Teresa Ku

{"title":"Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury.","authors":"Jacob R Tremblay, Jose A Ortiz, Janine C Quijano, Heather N Zook, Neslihan Erdem, Jeanne M LeBon, Wendong Li, Kevin Jou, Walter Tsark, Jeffrey R Mann, Mark T Kozlowski, David A Tirrell, Farzad Esni, Dannielle D Engle, Arthur D Riggs, Hsun Teresa Ku","doi":"10.1093/stmcls/sxae005","DOIUrl":"10.1093/stmcls/sxae005","url":null,"abstract":"Pancreatic ductal progenitor cells have been proposed to contribute to adult tissue maintenance and regeneration after injury, but the identity of such ductal cells remains elusive. Here, from adult mice, we identify a near homogenous population of ductal progenitor-like clusters, with an average of 8 cells per cluster. They are a rare subpopulation, about 0.1% of the total pancreatic cells, and can be sorted using a fluorescence-activated cell sorter with the CD133highCD71lowFSCmid-high phenotype. They exhibit properties in self-renewal and tri-lineage differentiation (including endocrine-like cells) in a unique 3-dimensional colony assay system. An in vitro lineage tracing experiment, using a novel HprtDsRed/+ mouse model, demonstrates that a single cell from a cluster clonally gives rise to a colony. Droplet RNAseq analysis demonstrates that these ductal clusters express embryonic multipotent progenitor cell markers Sox9, Pdx1, and Nkx6-1, and genes involved in actin cytoskeleton regulation, inflammation responses, organ development, and cancer. Surprisingly, these ductal clusters resist prolonged trypsin digestion in vitro, preferentially survive in vivo after a severe acinar cell injury and become proliferative within 14 days post-injury. Thus, the ductal clusters are the fundamental units of progenitor-like cells in the adult murine pancreas with implications in diabetes treatment and tumorigenicity.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"385-401"},"PeriodicalIF":4.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139415881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Reprogramming of Hepatocytes Into JAK/Stat-Dependent LGR5+ Liver Cells Able to Initiate Intrahepatic Cholangiocarcinoma. 直接将肝细胞重编程为 JAK/Stat 依赖性 LGR5+肝细胞，从而引发肝内胆管癌。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-04-15 DOI: 10.1093/stmcls/sxae006

Diana Chaker, Christophe Desterke, Nicolas Moniaux, Mohamed-Amine Bani, Noufissa Oudrhiri, Jamila Faivre, Ali G Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli

{"title":"Direct Reprogramming of Hepatocytes Into JAK/Stat-Dependent LGR5+ Liver Cells Able to Initiate Intrahepatic Cholangiocarcinoma.","authors":"Diana Chaker, Christophe Desterke, Nicolas Moniaux, Mohamed-Amine Bani, Noufissa Oudrhiri, Jamila Faivre, Ali G Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli","doi":"10.1093/stmcls/sxae006","DOIUrl":"10.1093/stmcls/sxae006","url":null,"abstract":"Somatic cells that have been partially reprogrammed by the factors Oct4, Sox2, Klf4, and cMyc (OSKM) have been demonstrated to be potentially tumorigenic in vitro and in vivo due to the acquisition of cancer-associated genomic alterations and the absence of OSKM clearance over time. In the present study, we obtained partially reprogrammed, SSEA1-negative cells by transducing murine hepatocytes with Δ1Δ3-deleted adenoviruses that expressed the 4 OSKM factors. We observed that, under long-term 2D and 3D culture conditions, hepatocytes could be converted into LGR5-positive cells with self-renewal capacity that was dependent on 3 cross-signaling pathways: IL6/Jak/Stat3, LGR5/R-spondin, and Wnt/β-catenin. Following engraftment in syngeneic mice, LGR5-positive cells that expressed the cancer markers CD51, CD166, and CD73 were capable of forming invasive and metastatic tumors reminiscent of intrahepatic cholangiocarcinoma (ICC): they were positive for CK19 and CK7, featured associations of cord-like structures, and contained cuboidal and atypical cells with dissimilar degrees of pleomorphism and mitosis. The LGR5+-derived tumors exhibited a highly vascularized stroma with substantial fibrosis. In addition, we identified pro-angiogenic factors and signaling pathways involved in neo-angiogenesis and vascular development, which represent potential new targets for anti-angiogenic strategies to overcome tumor resistance to current ICC treatments.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"301-316"},"PeriodicalIF":5.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation. 泛素E3连接酶FBXO9通过靶向DPPA5进行泛素化和降解来调节多能性。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-04-15 DOI: 10.1093/stmcls/sxae004

Samantha A Swenson, Kasidy K Dobish, Hendrik C Peters, C Bea Winship, R Willow Hynes-Smith, Mika Caplan, Karli J Wittorf, Gargi Ghosal, Shannon M Buckley

{"title":"Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation.","authors":"Samantha A Swenson, Kasidy K Dobish, Hendrik C Peters, C Bea Winship, R Willow Hynes-Smith, Mika Caplan, Karli J Wittorf, Gargi Ghosal, Shannon M Buckley","doi":"10.1093/stmcls/sxae004","DOIUrl":"10.1093/stmcls/sxae004","url":null,"abstract":"Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have unique characteristics where they can both contribute to all three germ layers in vivo and self-renewal indefinitely in vitro. Post-translational modifications of proteins, particularly by the ubiquitin proteasome system (UPS), control cell pluripotency, self-renewal, and differentiation. A significant number of UPS members (mainly ubiquitin ligases) regulate pluripotency and influence ESC differentiation with key elements of the ESC pluripotency network (including the \"master\" regulators NANOG and OCT4) being controlled by ubiquitination. To further understand the role of the UPS in pluripotency, we performed an RNAi screen during induction of cellular reprogramming and have identified FBXO9 as a novel regulator of pluripotency associated protein DPPA5. Our findings indicate that FBXO9 silencing facilitates the induction of pluripotency through decreased proteasomal degradation of DPPA5. These findings identify FBXO9 as a key regulator of pluripotency.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"317-328"},"PeriodicalIF":5.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placenta-Derived Decidua Stromal Cells: A New Frontier in the Therapy of Acute Graft-Versus-Host Disease. 胎盘衍生的蜕膜基质细胞--治疗急性移植物抗宿主病的新领域。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-04-15 DOI: 10.1093/stmcls/sxae003

Olle Ringdén, Behnam Sadeghi

{"title":"Placenta-Derived Decidua Stromal Cells: A New Frontier in the Therapy of Acute Graft-Versus-Host Disease.","authors":"Olle Ringdén, Behnam Sadeghi","doi":"10.1093/stmcls/sxae003","DOIUrl":"10.1093/stmcls/sxae003","url":null,"abstract":"Acute graft-versus-host disease (GVHD) is a frequent and potentially life-threatening complication following allogeneic hematopoietic cell transplantation (HCT). Mesenchymal stromal cells (MSCs), rare precursors found in all body tissues, possess immunosuppressive properties and can inhibit alloreactivity both in vitro and in vivo. Two decades ago, we introduced bone marrow-derived (BM) MSCs as a novel therapy for acute GVHD. While some patients responded to BM-MSCs, the response was not universal. Commercially available BM-MSCs are now used for acute GVHD treatment in Canada, Japan, and New Zealand. The fetus is protected from the mother's immune system by the placenta, and our research found that placenta-derived decidua stromal cells (DSCs) offer a stronger immunosuppressive effect than other sources of stromal cells. Safety studies in rabbits, rats, mice, and humans have shown negligible or no side effects from BM-MSCs or DSCs. In a phase I/II trial for severe acute GVHD, we treated 21 patients (median age, 49 years; range 1.6-72 years) with severe biopsy-proven gastrointestinal acute GVHD. The median cell dose of DSCs was 1.2 × 106 (range 0.9-2.9) cells/kg body weight, with a median of 2 (range 1-6) infusions given 1 week apart. The cell viability of DSCs was 93% (range, 69%-100%), and the median cell passage number was 4 (range, 2-4). All patients responded, with a complete response of acute GVHD in 11 patients and partial response in 10 and 1-year survival of 81%. Randomized trials are needed to prove the superiority of DSCs compared to ruxolitinib and/or other novel immunosuppressive therapies.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"291-300"},"PeriodicalIF":5.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139415880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy. 基于人类 iPSC 的慢性阻塞性肺病模型，用于研究疾病机制、预测 SARS-COV-2 的结果和测试预防性免疫疗法。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-03-14 DOI: 10.1093/stmcls/sxad094

Rania Dagher, Aigul Moldobaeva, Elise Gubbins, Sydney Clark, Mia Madel Alfajaro, Craig B Wilen, Finn Hawkins, Xiaotao Qu, Chia Chien Chiang, Yang Li, Lori Clarke, Yasuhiro Ikeda, Charles Brown, Roland Kolbeck, Qin Ma, Mauricio Rojas, Jonathan L Koff, Mahboobe Ghaedi

{"title":"Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy.","authors":"Rania Dagher, Aigul Moldobaeva, Elise Gubbins, Sydney Clark, Mia Madel Alfajaro, Craig B Wilen, Finn Hawkins, Xiaotao Qu, Chia Chien Chiang, Yang Li, Lori Clarke, Yasuhiro Ikeda, Charles Brown, Roland Kolbeck, Qin Ma, Mauricio Rojas, Jonathan L Koff, Mahboobe Ghaedi","doi":"10.1093/stmcls/sxad094","DOIUrl":"10.1093/stmcls/sxad094","url":null,"abstract":"Chronic inflammation and dysregulated repair mechanisms after epithelial damage have been implicated in chronic obstructive pulmonary disease (COPD). However, the lack of ex vivo-models that accurately reflect multicellular lung tissue hinders our understanding of epithelial-mesenchymal interactions in COPD. Through a combination of transcriptomic and proteomic approaches applied to a sophisticated in vitro iPSC-alveolosphere with fibroblasts model, epithelial-mesenchymal crosstalk was explored in COPD and following SARS-CoV-2 infection. These experiments profiled dynamic changes at single-cell level of the SARS-CoV-2-infected alveolar niche that unveiled the complexity of aberrant inflammatory responses, mitochondrial dysfunction, and cell death in COPD, which provides deeper insights into the accentuated tissue damage/inflammation/remodeling observed in patients with SARS-CoV-2 infection. Importantly, this 3D system allowed for the evaluation of ACE2-neutralizing antibodies and confirmed the potency of this therapy to prevent SARS-CoV-2 infection in the alveolar niche. Thus, iPSC-alveolosphere cultured with fibroblasts provides a promising model to investigate disease-specific mechanisms and to develop novel therapeutics.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"230-250"},"PeriodicalIF":5.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139105617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Stem Cells as a Therapeutic Target: Current Clinical Development and Future Prospective. 作为治疗靶点的癌症干细胞：当前的临床发展和未来展望。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-03-14 DOI: 10.1093/stmcls/sxad092

Alex Philchenkov, Anna Dubrovska

引用次数: 0

Aberrant Lipid Metabolic Signatures in Acute Myeloid Leukemia. 急性髓性白血病中异常的脂质代谢特征

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-03-14 DOI: 10.1093/stmcls/sxad095

Pooja Singh, Roopak Murali, Sri Gayathri Shanmugam, Steve Thomas, Julius Scott, Sudha Warrier, Frank Arfuso, Arun Dharmarajan, Rajesh Kumar Gandhirajan

{"title":"Aberrant Lipid Metabolic Signatures in Acute Myeloid Leukemia.","authors":"Pooja Singh, Roopak Murali, Sri Gayathri Shanmugam, Steve Thomas, Julius Scott, Sudha Warrier, Frank Arfuso, Arun Dharmarajan, Rajesh Kumar Gandhirajan","doi":"10.1093/stmcls/sxad095","DOIUrl":"10.1093/stmcls/sxad095","url":null,"abstract":"Leukemogenesis is a complex process that involves multiple stages of mutation in either hematopoietic stem or progenitor cells, leading to cancer development over time. Acute myeloid leukemia (AML) is an aggressive malignancy that affects myeloid cells. The major disease burden is caused by immature blast cells, which are eliminated using conventional chemotherapies. Unfortunately, relapse is a leading cause of death in AML patients, with 30%-80% experiencing it within 2 years of initial treatment. The dominant cause of relapse in leukemia is the presence of therapy-resistant leukemic stem cells (LSCs). These cells express genes related to stemness that are frequently difficult to eradicate and tend to survive standard treatments. Studies have demonstrated that by targeting the metabolic pathways of LSCs, it is possible to improve outcomes and extend the survival of those afflicted by leukemia. The overwhelming evidence suggests that lipid metabolism is reprogrammed in LSCs, leading to an increase in fatty acid uptake and de novo lipogenesis. Genes regulating this process also play a crucial role in therapy evasion. In this concise review, we summarize the lipid metabolism in normal hematopoietic cells, AML blast cells, and AML LSCs. We also compare the lipid metabolic signatures in de novo versus therapy-resistant AML blast and LSCs. We further discuss the metabolic switches, cellular crosstalk, potential targets, and inhibitors of lipid metabolism that could alleviate treatment resistance and relapse.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"200-215"},"PeriodicalIF":5.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effects of Hematopoietic Stem Cell Derived From Gene-Edited Mice on β654-Thalassemia. 基因编辑小鼠的造血干细胞对β654-地中海贫血症的治疗效果。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-03-14 DOI: 10.1093/stmcls/sxad096

Dan Lu, Xiuli Gong, Xinbing Guo, Yanwen Chen, Yiwen Zhu, Yudan Fang, Qin Cai, Miao Xu, Hua Yang, Dali Li, Yitao Zeng, Fanyi Zeng

{"title":"Therapeutic Effects of Hematopoietic Stem Cell Derived From Gene-Edited Mice on β654-Thalassemia.","authors":"Dan Lu, Xiuli Gong, Xinbing Guo, Yanwen Chen, Yiwen Zhu, Yudan Fang, Qin Cai, Miao Xu, Hua Yang, Dali Li, Yitao Zeng, Fanyi Zeng","doi":"10.1093/stmcls/sxad096","DOIUrl":"10.1093/stmcls/sxad096","url":null,"abstract":"β-thalassemia is an inherited blood disease caused by reduced or inadequate β-globin synthesis due to β-globin gene mutation. Our previous study developed a gene-edited mice model (β654-ER mice) by CRISPR/Cas9-mediated genome editing, targeting both the βIVS2-654 (C > T) mutation site and the 3' splicing acceptor site at 579 and corrected abnormal β-globin mRNA splicing in the β654-thalassemia mice. Herein, we further explored the therapeutic effect of the hematopoietic stem cells (HSCs) from β654-ER mice on β-thalassemia by consecutive HSC transplantation. The results indicated that HSC transplantation derived from gene-edited mice can significantly improve the survival rate of mice after lethal radiation doses and effectively achieve hematopoietic reconstruction and long-term hematopoiesis. Clinical symptoms, including hematologic parameters and tissue pathology of transplanted recipients, were significantly improved compared to the non-transplanted β654 mice. The therapeutic effect of gene-edited HSC transplantation demonstrated no significant difference in hematological parameters and tissue pathology compared with wild-type mouse-derived HSCs. Our data revealed that HSC transplantation from gene-edited mice completely recovered the β-thalassemia phenotype. Our study systematically investigated the therapeutic effect of HSCs derived from β654-ER mice on β-thalassemia and further confirmed the efficacy of our gene-editing approach. Altogether, it provided a reference and primary experimental data for the clinical usage of such gene-edited HSCs in the future.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"278-289"},"PeriodicalIF":5.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138883779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application Potential of Extracellular Vesicles Derived From Mesenchymal Stem Cells in Renal Diseases. 间充质干细胞细胞外囊泡在肾脏疾病中的应用潜力。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-03-14 DOI: 10.1093/stmcls/sxad089

Enhui Li, Jia Xu, Ning Liu, Qi Xiong, Weiwei Zhang, Yizi Gong, Linlin Zhang, Yikai He, Huipeng Ge, Xiangcheng Xiao

{"title":"Application Potential of Extracellular Vesicles Derived From Mesenchymal Stem Cells in Renal Diseases.","authors":"Enhui Li, Jia Xu, Ning Liu, Qi Xiong, Weiwei Zhang, Yizi Gong, Linlin Zhang, Yikai He, Huipeng Ge, Xiangcheng Xiao","doi":"10.1093/stmcls/sxad089","DOIUrl":"10.1093/stmcls/sxad089","url":null,"abstract":"The high prevalence and complex etiology of renal diseases already impose a heavy disease burden on patients and society. In certain kidney diseases such as acute kidney injury and chronic kidney disease, current treatments are limited to slowing rather than stabilizing or reversing disease progression. Therefore, it is crucial to study the pathological mechanisms of kidney disease and discover new therapeutic targets and effective therapeutic drugs. As cell-free therapeutic strategies are continually being developed, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have emerged as a hot topic for research in the field of renal diseases. Studies have demonstrated that MSC-EVs not only reproduce the therapeutic effects of MSCs but also localize to damaged kidney tissue. Compared to MSCs, MSC-EVs have several advantages, including ease of preservation, low immunogenicity, an inability to directly form tumors, and ease of artificial modification. Exploring the detailed mechanisms of MSC-EVs by developing standardized culture, isolation, purification, and drug delivery strategies will help facilitate their clinical application in kidney diseases. Here, we provide a comprehensive overview of studies about MSC-EVs in kidney diseases and discuss their limitations at the human nephrology level.","PeriodicalId":231,"journal":{"name":"STEM CELLS","volume":" ","pages":"216-229"},"PeriodicalIF":5.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138456744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Nicotinamide Riboside Modulates HIF-1 Signaling to Maintain and Enhance Odontoblastic Differentiation in Human Dental Pulp Stem Cells. 更正：烟酰胺核苷调节 HIF-1 信号以维持和增强人牙髓干细胞的牙髓分化。

IF 5.2 2区医学

STEM CELLS Pub Date : 2024-03-14 DOI: 10.1093/stmcls/sxad093

引用次数: 0