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Transactions of the American Clinical and Climatological Association最新文献

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RECORDER'S REPORT: The 137th Meeting, The Williamsburg Lodge, Williamsburg, Virginia, October 16th through October 19th, 2025. 记录员报道：第137次会议，威廉斯堡别墅，威廉斯堡，弗吉尼亚州，2025年10月16日至10月19日。
Transactions of the American Clinical and Climatological Association Pub Date : 2026-01-01
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引用次数: 0
RETHINKING INTRAOPERATIVE OXYGEN: VARIABILITY, RISK, AND THE PATH TO EVIDENCE-BASED PRACTICE. 重新思考术中氧气：变异性、风险和循证实践之路。
Transactions of the American Clinical and Climatological Association Pub Date : 2026-01-01
Frederic T Billings Iv
{"title":"RETHINKING INTRAOPERATIVE OXYGEN: VARIABILITY, RISK, AND THE PATH TO EVIDENCE-BASED PRACTICE.","authors":"Frederic T Billings Iv","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oxygen administration is essential for safe anesthesia, but excess oxygen administration perturbs biochemistry and physiology. Understanding the impact of variable oxygen tension on mechanisms of perioperative organ injury and patient outcomes drives our research program. In a study of 367,000 surgical patients, the fraction of inspired oxygen varied widely from 100% to air (21%). The medical center and anesthesiologist who cared for the patient accounted for far more variability than patient or procedure factors. This non-patient-centered variation identifies an opportunity to determine the optimal approach to intraoperative oxygen administration. In preclinical studies, high oxygen increased kidney and brain injury and dysfunction; in clinical trials, surgical patients randomly assigned to hyperoxia had increased concentrations of markers of oxidative damage and impaired vascular reactivity compared to patients assigned to normoxia. We now have an opportunity to determine best practices for oxygen administration during surgery in a large multicenter clinical trial.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"136 ","pages":"149-157"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13695165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149273469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACTIVIN A PROMOTES PROGRESSION OF PANCREATITIS INTO PANCREATIC CANCER. 激活素a促进胰腺炎发展为胰腺癌。
Transactions of the American Clinical and Climatological Association Pub Date : 2026-01-01
Barbara Jung, Mark B Wiley, Jessica Bauer, Yuchen Wang, Stanley Intihar, Robert Fors, Agnieszka Bialkowska
{"title":"ACTIVIN A PROMOTES PROGRESSION OF PANCREATITIS INTO PANCREATIC CANCER.","authors":"Barbara Jung, Mark B Wiley, Jessica Bauer, Yuchen Wang, Stanley Intihar, Robert Fors, Agnieszka Bialkowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The five-year survival rate for pancreatic cancer patients remains at 13%. Acute pancreatitis and chronic pancreatitis are risk factors for developing pancreatic cancer, suggesting a strong inflammatory role for disease initiation. Recently, we found that activin a (activin), a TGFβ superfamily member, drives inflammation in acute pancreatitis via recruitment of macrophages and activation of neutrophils. Here, we expand our studies in pancreatic cancer in the setting of inflammation and activin signaling. We performed digital spatial profiling (DSP) on a tissue section of human chronic pancreatitis with suspicion of pancreatic cancer to quantify more than 50 proteins relative to activin expression <i>in situ</i>. We found that activin co-localization is associated with reduced T cell activation and increased MAPK and PI3K signaling. These data suggest a previously underappreciated immunomodulatory role for activin in the setting of pancreatic cancer.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"136 ","pages":"287-299"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13695175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149273471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THERAPIES FOR NEONATAL DISEASES OF THE SURFACTANT SYSTEM. 表面活性剂系统新生儿疾病的治疗。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Paul B McCray
{"title":"THERAPIES FOR NEONATAL DISEASES OF THE SURFACTANT SYSTEM.","authors":"Paul B McCray","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A critical adaptation required for successful extrauterine life is the onset of respiration. The production of pulmonary surfactant by alveolar type II (AT2) cells is required for functional ventilation. Pulmonary surfactant is produced in lamellar bodies in AT2 cells. Key components of pulmonary surfactant include phospholipids and surfactant proteins B (SP-B) and C (SP-C). Phospholipids are transported into lamellar bodies by ATP-binding cassette subfamily A member 3 (ABCA3) where they combine with SP-B and -C to form surfactant that is secreted into alveoli. Recessive loss of function mutations in surfactant protein B (<i>SFTPB</i>) and <i>ABCA3</i>, or monoallelic dominant mutations in surfactant protein C (<i>SFTPC</i>), can cause severe respiratory distress in term newborns, later-onset childhood interstitial lung disease (ChILD), or adult-onset ILD. Currently, no specific treatments for these diseases are available. Genetic therapies, including gene addition and gene editing strategies, offer the possibility to correct these defects in AT2 progenitor cells.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"119-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CLEAVAGE OF IGFBP-1 BY AN ENZYME IN URINE PREDICTS THE FUTURE NEED FOR KIDNEY REPLACEMENT THERAPY IN ACUTE KIDNEY INJURY. 尿中一种酶对igfbp-1的裂解预示着急性肾损伤患者未来需要肾脏替代治疗。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
John M Arthur, Joseph H Holthoff
{"title":"CLEAVAGE OF IGFBP-1 BY AN ENZYME IN URINE PREDICTS THE FUTURE NEED FOR KIDNEY REPLACEMENT THERAPY IN ACUTE KIDNEY INJURY.","authors":"John M Arthur, Joseph H Holthoff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The only Food and Drug Administration (FDA)-approved biomarker for prediction of acute kidney injury (AKI) in adults has a false positive rate (FPR) of 50%. We identified insulin-like growth factor-binding protein 1 (IGFBP-1) as a good but not great predictor of severe AKI. IGFBP-1 was cleaved by an enzyme in the urine. We tested the ability of IGFBP-1 cleavage to predict progression to dialysis. Urine from all 12 patients with stage 1 AKI that progressed to require dialysis cleaved the protein (100% sensitivity). FPR was 0% among healthy controls. FPRs among patients with stage 1 AKI at the time of collection were 11% for patients who did not progress beyond stage 1, 15% for patients who progressed to stage 2, and 50% for patients who progressed to stage 3 but did not require dialysis. The sensitivity of a test with these characteristics would be 100% in a typical intensive care unit (ICU) population, and the FPR would be 6%.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"345-355"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DECEASED MEMBERS 1884 THROUGH 2024. 1884年至2024年去世的成员。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"DECEASED MEMBERS 1884 THROUGH 2024.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"xvii-xxviii"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRESENT MEMBERS. 目前成员。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"PRESENT MEMBERS.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"xlii-xlix"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE GORDON WILSON LECTURE. 戈登·威尔逊的演讲。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"THE GORDON WILSON LECTURE.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"407"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACCA PRESIDENTS, PAST AND PRESENT (AND SPOUSES). Acca前任和现任总裁（及其配偶）。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"ACCA PRESIDENTS, PAST AND PRESENT (AND SPOUSES).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"xvi"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FINANCIAL COMPILATION. 金融编译。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"FINANCIAL COMPILATION.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"lxix-lxxxi"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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