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Transactions of the American Clinical and Climatological Association最新文献

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THE GORDON WILSON MEMORIAL LECTURE. 戈登·威尔逊纪念演讲。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
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引用次数: 0
PREVENTION OF HEALTH CARE-ASSOCIATED INFECTIONS IN U.S. HEALTH SYSTEMS: HARNESSING THE GUT MICROBIOME TO COMBAT INFECTION. 预防美国卫生系统的卫生保健相关感染：利用肠道微生物群对抗感染。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Nasia Safdar
{"title":"PREVENTION OF HEALTH CARE-ASSOCIATED INFECTIONS IN U.S. HEALTH SYSTEMS: HARNESSING THE GUT MICROBIOME TO COMBAT INFECTION.","authors":"Nasia Safdar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Health care-associated infections (HAIs) remain a major challenge in the U.S. health care system, with <i>Clostridioides difficile</i> (<i>C. difficile</i> or <i>C. diff</i>) being the most prevalent. The use of antibiotics disrupts the gut microbiota, predisposing individuals to infection. Recent research has highlighted the role of the gut microbiome in preventing and treating <i>C. difficile</i> infections (CDI). Strategies such as fecal microbiota transplantation (FMT) and live biotherapeutic products (LBPs) offer promising alternatives to conventional antibiotic treatments. This paper explores the mechanisms underlying CDI, the role of the gut microbiome in infection prevention, and innovative therapeutic approaches.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"260-268"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPROVE YOUR SCIENTIFIC WRITING WITH PRINCIPLES OF LANDSCAPE ART COMPOSITION. 用景观艺术构图的原则来提高你的科学写作。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Virginia B Kraus
{"title":"IMPROVE YOUR SCIENTIFIC WRITING WITH PRINCIPLES OF LANDSCAPE ART COMPOSITION.","authors":"Virginia B Kraus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The scientific research article is a careful balance of factual information and social interaction in which academic writers need to make the results of their research public and persuasive. Although scientific communication through journal articles has a history spanning over 350 years, there remains significant potential for improvement. I hypothesize that compositional strategies employed by artists-particularly landscape artists-can enhance academic scientific writing by promoting interaction and improving persuasive communication. This article explores how principles fundamental to landscape art, such as notan, focal point, element hierarchy, the 80/20 rule, simplification, and repetition, can enhance scientific writing. Awareness and adoption of these artistic techniques can make the scientific writing process more engaging and enjoyable for lovers of science and art alike.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"130-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENABLING A HEALTHIER FUTURE FOR ALL THROUGH PRECISION MEDICINE. 通过精准医疗为所有人创造更健康的未来。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Joshua C Denny
{"title":"ENABLING A HEALTHIER FUTURE FOR ALL THROUGH PRECISION MEDICINE.","authors":"Joshua C Denny","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The National Institutes of Health's <i>All of Us</i> Research Program is building one of the most comprehensive research cohorts in the United States. Launched in 2018, the program has enrolled more than 849,000 individuals to empower precision medicine relevant to all populations. Participants in <i>All of Us</i> share complete surveys, share electronic health records, donate biospecimens, and contribute other data, such as wearable device data. To date, <i>All of Us</i> has generated whole genome sequences for more than 414,000 participants and returned actionable genetic health information to more than 100,000. By examining the technological, engagement, and data integration challenges encountered, this paper highlights how <i>All of Us</i> builds on pioneering efforts in biomedical research and points to future directions, including expanded data sharing, international cooperation, and the potential to drive transformative discoveries in personalized health care. Current successes also highlight necessary future directions: even larger and more comprehensive cohorts, better data sharing, and more international cooperation.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instructions to Authors: Transactions of the American Clinical and Climatological Association. 给作者的说明：美国临床与气候学会会刊。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
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引用次数: 0
RACIAL DISPARITIES IN STROKE AFFECTING BLACK AMERICANS. 影响美国黑人中风的种族差异。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Mary Cushman
{"title":"RACIAL DISPARITIES IN STROKE AFFECTING BLACK AMERICANS.","authors":"Mary Cushman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stroke is the fifth leading cause of death in the United States and disproportionately affects Black Americans. The Reasons for Geographic and Racial Disparities in Stroke (REGARDS) cohort study is investigating why this disparity exists by comparing Black and White adults age 45+. Seminal findings included that higher stroke incidence in Black than in White persons, but not higher case fatality, drives the disparity. Higher prevalence of stroke risk factors in Black participants, especially hypertension and diabetes, explained 50% of the racial disparity. Elevated lipoprotein(a) was three times more frequent in Black participants and was a race-specific stroke risk factor only among Black participants. Higher interleukin-6 was a strong stroke risk factor in both Black and White participants with a hazard ratio of 2.0 for concentrations in the top versus bottom quartile. In mediation analysis, higher interleukin-6 with presence of stroke risk factors party explained the race disparity in stroke. Findings highlight the potential that prevention of stroke risk factors, treatment of higher Lp(a), and inflammation reduction have in reducing the race disparity in stroke.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE BERT AND PEGGY DUPONT LECTURE: FROM EARTH TO MARS: THE LIFE OF MARS 2020'S PERSEVERANCE ROVER. 伯特和佩吉·杜邦讲座：从地球到火星：2020年火星毅力探测器的生活。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Bekah Sosland Siegfriedt
{"title":"THE BERT AND PEGGY DUPONT LECTURE: FROM EARTH TO MARS: THE LIFE OF MARS 2020'S PERSEVERANCE ROVER.","authors":"Bekah Sosland Siegfriedt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"309-319"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MACRO SOLUTIONS TO A MICRO PROBLEM: DRUG-RESISTANT PNEUMOCOCCAL PNEUMONIA. 宏观解决微观问题：耐药肺炎球菌肺炎。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Joshua P Metlay
{"title":"MACRO SOLUTIONS TO A MICRO PROBLEM: DRUG-RESISTANT PNEUMOCOCCAL PNEUMONIA.","authors":"Joshua P Metlay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Even before the COVID-19 pandemic, acute respiratory infections represented one of the most common reasons for patients to seek urgent medical care. <i>S. pneumoniae</i> is one of the most frequent bacterial causes of acute respiratory infections, especially community-acquired pneumonia. In the latter part of the twentieth century, the emergence of multidrug resistance among clinical isolates of <i>S. pneumoniae</i> threatened to render standard empiric antibiotic therapy ineffective. One of the biggest drivers of pneumococcal drug resistance is antibiotic overuse, among both adults and children. While the introduction of the pneumococcal conjugate vaccine in 2000 dramatically impacted the overall incidence of pneumococcal pneumonia in both children and adults, the levels of antibiotic resistance have remained significant. To reduce the overuse of antibiotics requires multidimensional interventions targeting patients, clinicians, and health systems. Studies have demonstrated improvement in this area, but the quality gap remains high. Future work will focus on organizational strategies and policies that optimize antibiotic use for patients with antibiotic responsive acute illnesses.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"393-402"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE MARY ALLEN ENGLE AWARD. 玛丽·艾伦·恩格尔奖。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"THE MARY ALLEN ENGLE AWARD.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"32-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRESIDENT'S ADDRESS: PASS HISTORY AND THE PASS PRESENT. 总统致辞：传递历史，传递现在。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Richard A Lange
{"title":"PRESIDENT'S ADDRESS: PASS HISTORY AND THE PASS PRESENT.","authors":"Richard A Lange","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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