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Transactions of the American Clinical and Climatological Association最新文献

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IMPROVING DIVERSE PARTICIPATION IN CANCER CLINICAL TRIALS. 提高癌症临床试验的多样性。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
Ruben Mesa, Rebecca T Jones
{"title":"IMPROVING DIVERSE PARTICIPATION IN CANCER CLINICAL TRIALS.","authors":"Ruben Mesa,&nbsp;Rebecca T Jones","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite significant improvement in overall cancer mortality (>30% since 1991), these survival benefits have not been experienced by all groups uniformly especially in those of diverse heritage. Drivers of cancer health inequity are multi-factorial including more adverse social determinants of health, later stage cancer presentation, decreased health care access, decreased health literacy, and cultural barriers to prompt cancer care. Adding to these disparities is the historical inclusion of primarily well-insured Caucasian patients into cancer clinical trials leading to deep gaps in understanding both the efficacy and safety of new therapies in the actual populations for which these medications will be used. The need for trial accruals to reflect the U.S. population (i.e., diverse) is essential across diseases, but especially those in which certain minority populations are overrepresented (Latinos and hepatocellular carcinoma, African Americans and myeloma and prostate cancer). Strategies and new legislation to increase diversity in trial accruals are outlined and discussed.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493734/pdf/tacca1330000149.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41213851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NOTICE. 通知。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
{"title":"NOTICE.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10214817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CONSTITUTION AND BY-LAWS. 章程和细则。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
{"title":"CONSTITUTION AND BY-LAWS.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10230374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACCA Presidents, Past and Present (and Spouses). ACCA前任和现任主席(及其配偶)。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
{"title":"ACCA Presidents, Past and Present (and Spouses).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10230382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMERICAN CLINICAL AND CLIMATOLOGICAL ASSOCIATION MEETING LOCATIONS 1884-2022. 美国临床和气候协会会议地点1884-2022。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
{"title":"AMERICAN CLINICAL AND CLIMATOLOGICAL ASSOCIATION MEETING LOCATIONS 1884-2022.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493754/pdf/049-tacca1330000xlix.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41213837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ELIMINATING THE RACE COEFFICIENT IN KIDNEY FUNCTION ESTIMATING EQUATIONS: THE CENTER DID HOLD. 消除肾功能估计方程中的种族系数：中心确实成立。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
Chi-Yuan Hsu
{"title":"ELIMINATING THE RACE COEFFICIENT IN KIDNEY FUNCTION ESTIMATING EQUATIONS: THE CENTER DID HOLD.","authors":"Chi-Yuan Hsu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dr. Chi-yuan Hsu describes controversies surrounding the race coefficient (\"if African American\") in widely used kidney function estimating equations. He outlines recent research results on this topic by himself and others and comments on the relationship between activists and the academic medical community.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493757/pdf/tacca1330000247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41213845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SUPPRESION OF MITOCHONDRIAL RESPIRATION IS A FEATURE OF CELLULAR GLUCOSE TOXICITY. 线粒体呼吸抑制是细胞葡萄糖毒性的一个特征。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
Kumar Sharma, Guanshi Zhang, Rintaro Saito
{"title":"SUPPRESION OF MITOCHONDRIAL RESPIRATION IS A FEATURE OF CELLULAR GLUCOSE TOXICITY.","authors":"Kumar Sharma,&nbsp;Guanshi Zhang,&nbsp;Rintaro Saito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Glucose toxicity is central to the myriad complications of diabetes and is now believed to encompass neurodegenerative diseases and cancer as well as microvascular and macrovascular disease. Due to the widespread benefits of SGLT2 inhibitors, which affect glucose uptake in the kidney proximal tubular cell, a focus on cell metabolism in response to glucose has important implications for overall health. We previously found that a -Warburg-type effect underlies diabetic kidney disease and involves metabolic reprogramming. This is now supported by quantitative measurements of superoxide measurement in the diabetic kidney and systems biology analysis of urine metabolites in patients. Further exploration of mechanisms underlying mediators of mitochondrial suppression will be critical in understanding the chronology of glucose-induced toxicity and developing new therapeutics to arrest the systemic glucose toxicity of diabetes.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493723/pdf/tacca133000024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41213861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WINNERS OF THE MARY ALLEN ENGLE AWARD. 玛丽·艾伦·恩格尔奖获得者。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
{"title":"WINNERS OF THE MARY ALLEN ENGLE AWARD.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493731/pdf/tacca1330000158.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41213916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FINANCIAL COMPILATION. 金融编译。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
{"title":"FINANCIAL COMPILATION.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10230388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BIOLOGICAL ANTIARRHYTHMICS-SODIUM CHANNEL INTERACTING PROTEINS. 生物抗心律失常钠通道相互作用蛋白。
Transactions of the American Clinical and Climatological Association Pub Date : 2023-01-01
Gordon F Tomaselli
{"title":"BIOLOGICAL ANTIARRHYTHMICS-SODIUM CHANNEL INTERACTING PROTEINS.","authors":"Gordon F Tomaselli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Voltage gated Na channels (Na<sub>V</sub>) are essential for excitation of tissues. Mutations in Na<sub>V</sub>s cause a spectrum of human disease from autism and epilepsy to cardiac arrhythmias to skeletal myotonias. The carboxyl termini (CT) of Na<sub>V</sub> channels are hotspots for disease-causing mutations and are richly invested with protein interaction sites. We have focused on the regulation of Na<sub>V</sub> by two proteins that bind in this region: calmodulin (CaM) and non-secreted fibroblast growth factors (iFGF or FHF). CaM regulates Na<sub>V</sub> gating, mediating Ca<sup>2+</sup>-dependent inactivation (CDI) in a channel isoform-specific manner, while Ca<sup>2+</sup>-free CaM (apo-CaM) binding broadly regulates Na<sub>V</sub> opening and suppresses the arrhythmogenic late Na current (<i>I</i><sub>Na-L</sub>). FHFs inhibit CDI, in Na<sub>V</sub> isoforms that exhibit this property, and potently suppress I<sub>Na-L</sub>, the latter requiring the amino terminus of the FHF. A peptide comprised of the first 39 amino acids of FHF1<sub>A</sub> is sufficient to inhibit I<sub>Na-L</sub>, constituting a credible specific antiarrhythmic.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493736/pdf/tacca1330000136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41213839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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