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Transactions of the American Clinical and Climatological Association最新文献

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CONSTITUTION AND BY-LAWS: CONSTITUTION. 章程及细则:章程。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
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引用次数: 0
EUGENE A. "PAT" HILDRETH: 1924 - 2018. 尤金。“pat”hildreth: 1924 - 2018。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
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引用次数: 0
JEREMIAH METZGER LECTURES. Jeremiah metzger讲课。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
{"title":"JEREMIAH METZGER LECTURES.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33503689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMMUNOEDITING IN AUTOIMMUNE RHEUMATIC DISEASES. 自身免疫性风湿病的免疫编辑
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
Antony Rosen
{"title":"IMMUNOEDITING IN AUTOIMMUNE RHEUMATIC DISEASES.","authors":"Antony Rosen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The striking association of specific autoantibodies with distinct disease phenotypes and trajectories in human autoimmune rheumatic diseases provides a powerful opportunity to interrogate disease mechanism. In scleroderma, a subgroup of patients with autoantibodies to POLR3 have coincident onset of cancer and scleroderma. The majority of these patients have genetic changes (somatic mutations and loss of heterozygosity) in the POLR3A gene in their matched cancers, coupled with immune responses directed against the mutated and wild type autoantigen. In some individuals with scleroderma or dermatomyositis where specific immune responses mark a high risk of emergent cancer, cancer does not emerge. Such patients have a broader immune response that targets additional autoantigens, suggesting that the breadth and magnitude of the immune response regulates cancer, and that the rheumatic diseases provide a unique window into natural immunoediting of cancer in humans. This has implications for prediction and therapy in both autoimmunity and cancer.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROBERT W. SCHRIER, MD: 1936 - 2021. 罗伯特w.施里尔，医学博士:1936 - 2021。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
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引用次数: 0
INSIGHTS INTO THE REGULATION OF MAST CELL FUNCTION IN TYPE 2 INFLAMMATION. 深入了解 2 型炎症中肥大细胞功能的调控。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
Joshua A Boyce
{"title":"INSIGHTS INTO THE REGULATION OF MAST CELL FUNCTION IN TYPE 2 INFLAMMATION.","authors":"Joshua A Boyce","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Type 2 inflammation (T2I) underlies the pathogenesis of asthma, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis. Mast cells (MCs) are tissue resident hematopoietic effector cells thought to play major roles in T2I. Two subtypes of human MCs are recognized based on immunohistochemical differences. MCs expressing tryptase but not chymase (MC<sub>T</sub>) reside within mucosal epithelial surfaces, and MCs expressing tryptase, chymase, and cathepsin G (MC<sub>TC</sub>) reside in submucosal, perivascular and intraneural locations. During T2I, MCs (particularly MC<sub>T</sub>) increase markedly by unclear mechanisms. Single cell genomic studies reveal that traditional histochemical categorization vastly underestimates the extent of MC functional heterogeneity. MC<sub>T</sub> and MC<sub>TC</sub> likely reflect endpoints of a developmental continuum, emerging from a transitional stage of development in which MCs expand through <i>in situ</i> proliferation. This mechanism, likely driven by interleukin 4 and other cytokines, is unique among granulocytes and carries substantial implications for pathogenesis and therapy of T2I-associated diseases.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10382113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RECORDER'S REPORT: The 133rd Meeting, The Charleston Place, Charleston, South Carolina, March 24th through March 27th, 2022. 记录员报告:第133次会议于2022年3月24日至3月27日在南卡罗来纳州查尔斯顿查尔斯顿广场举行。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
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引用次数: 0
PRESENT MEMBERS. 目前的成员。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
{"title":"PRESENT MEMBERS.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33487387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE GORDON WILSON LECTURES. 戈登·威尔逊的讲座。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
{"title":"THE GORDON WILSON LECTURES.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33487730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GERALD MEDOFF, MD: 1936 - 2019. 杰拉尔德·梅多夫，医学博士:1936 - 2019。
Transactions of the American Clinical and Climatological Association Pub Date : 2022-01-01
{"title":"GERALD MEDOFF, MD: 1936 - 2019.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33487733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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