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Transactions of the American Clinical and Climatological Association最新文献

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INDEX. 索引。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
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引用次数: 0
MULTIFACETED ROLES OF PERICYTES IN LUNG INJURY AND REPAIR. 周细胞在肺损伤和修复中的多重作用。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Lynn M Schnapp
{"title":"MULTIFACETED ROLES OF PERICYTES IN LUNG INJURY AND REPAIR.","authors":"Lynn M Schnapp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pericytes are specialized, mural cells essential to vascular integrity and homeostasis, with emerging roles in lung injury, fibrosis, and viral pathology. Situated around capillaries, pericytes can transition into myofibroblast-like cells and contribute to extracellular matrix (ECM) deposition following lung injury. This review delves into pericyte biology in the lung, highlighting their contributions to fibrotic processes, immune response mediation, and potential as viral reservoirs. Experimental insights from murine models and human lung pericytes underscore their dual function in structural repair and immune signaling. Here, we explore the impact of pericyte plasticity on fibrosis and immune dynamics, evaluate their interactions with viruses, and discuss their potential as therapeutic targets in lung disease. A comprehensive understanding of pericyte plasticity and heterogeneity could pave the way for novel treatments targeting fibrosis and virus-induced lung pathology.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE THEODORE E. WOODWARD AWARD. 西奥多·伍德沃德奖。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"THE THEODORE E. WOODWARD AWARD.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"294-296"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PREVENTION OF HEALTH CARE-ASSOCIATED INFECTIONS IN U.S. HEALTH SYSTEMS: HARNESSING THE GUT MICROBIOME TO COMBAT INFECTION. 预防美国卫生系统的卫生保健相关感染：利用肠道微生物群对抗感染。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Nasia Safdar
{"title":"PREVENTION OF HEALTH CARE-ASSOCIATED INFECTIONS IN U.S. HEALTH SYSTEMS: HARNESSING THE GUT MICROBIOME TO COMBAT INFECTION.","authors":"Nasia Safdar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Health care-associated infections (HAIs) remain a major challenge in the U.S. health care system, with <i>Clostridioides difficile</i> (<i>C. difficile</i> or <i>C. diff</i>) being the most prevalent. The use of antibiotics disrupts the gut microbiota, predisposing individuals to infection. Recent research has highlighted the role of the gut microbiome in preventing and treating <i>C. difficile</i> infections (CDI). Strategies such as fecal microbiota transplantation (FMT) and live biotherapeutic products (LBPs) offer promising alternatives to conventional antibiotic treatments. This paper explores the mechanisms underlying CDI, the role of the gut microbiome in infection prevention, and innovative therapeutic approaches.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"260-268"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE GORDON WILSON MEMORIAL LECTURE. 戈登·威尔逊纪念演讲。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"THE GORDON WILSON MEMORIAL LECTURE.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"403-406"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPROVE YOUR SCIENTIFIC WRITING WITH PRINCIPLES OF LANDSCAPE ART COMPOSITION. 用景观艺术构图的原则来提高你的科学写作。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Virginia B Kraus
{"title":"IMPROVE YOUR SCIENTIFIC WRITING WITH PRINCIPLES OF LANDSCAPE ART COMPOSITION.","authors":"Virginia B Kraus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The scientific research article is a careful balance of factual information and social interaction in which academic writers need to make the results of their research public and persuasive. Although scientific communication through journal articles has a history spanning over 350 years, there remains significant potential for improvement. I hypothesize that compositional strategies employed by artists-particularly landscape artists-can enhance academic scientific writing by promoting interaction and improving persuasive communication. This article explores how principles fundamental to landscape art, such as notan, focal point, element hierarchy, the 80/20 rule, simplification, and repetition, can enhance scientific writing. Awareness and adoption of these artistic techniques can make the scientific writing process more engaging and enjoyable for lovers of science and art alike.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"130-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MACRO SOLUTIONS TO A MICRO PROBLEM: DRUG-RESISTANT PNEUMOCOCCAL PNEUMONIA. 宏观解决微观问题：耐药肺炎球菌肺炎。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Joshua P Metlay
{"title":"MACRO SOLUTIONS TO A MICRO PROBLEM: DRUG-RESISTANT PNEUMOCOCCAL PNEUMONIA.","authors":"Joshua P Metlay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Even before the COVID-19 pandemic, acute respiratory infections represented one of the most common reasons for patients to seek urgent medical care. <i>S. pneumoniae</i> is one of the most frequent bacterial causes of acute respiratory infections, especially community-acquired pneumonia. In the latter part of the twentieth century, the emergence of multidrug resistance among clinical isolates of <i>S. pneumoniae</i> threatened to render standard empiric antibiotic therapy ineffective. One of the biggest drivers of pneumococcal drug resistance is antibiotic overuse, among both adults and children. While the introduction of the pneumococcal conjugate vaccine in 2000 dramatically impacted the overall incidence of pneumococcal pneumonia in both children and adults, the levels of antibiotic resistance have remained significant. To reduce the overuse of antibiotics requires multidimensional interventions targeting patients, clinicians, and health systems. Studies have demonstrated improvement in this area, but the quality gap remains high. Future work will focus on organizational strategies and policies that optimize antibiotic use for patients with antibiotic responsive acute illnesses.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"393-402"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE MARY ALLEN ENGLE AWARD. 玛丽·艾伦·恩格尔奖。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
{"title":"THE MARY ALLEN ENGLE AWARD.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"32-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENABLING A HEALTHIER FUTURE FOR ALL THROUGH PRECISION MEDICINE. 通过精准医疗为所有人创造更健康的未来。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
Joshua C Denny
{"title":"ENABLING A HEALTHIER FUTURE FOR ALL THROUGH PRECISION MEDICINE.","authors":"Joshua C Denny","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The National Institutes of Health's <i>All of Us</i> Research Program is building one of the most comprehensive research cohorts in the United States. Launched in 2018, the program has enrolled more than 849,000 individuals to empower precision medicine relevant to all populations. Participants in <i>All of Us</i> share complete surveys, share electronic health records, donate biospecimens, and contribute other data, such as wearable device data. To date, <i>All of Us</i> has generated whole genome sequences for more than 414,000 participants and returned actionable genetic health information to more than 100,000. By examining the technological, engagement, and data integration challenges encountered, this paper highlights how <i>All of Us</i> builds on pioneering efforts in biomedical research and points to future directions, including expanded data sharing, international cooperation, and the potential to drive transformative discoveries in personalized health care. Current successes also highlight necessary future directions: even larger and more comprehensive cohorts, better data sharing, and more international cooperation.</p>","PeriodicalId":23186,"journal":{"name":"Transactions of the American Clinical and Climatological Association","volume":"135 ","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instructions to Authors: Transactions of the American Clinical and Climatological Association. 给作者的说明：美国临床与气候学会会刊。
Transactions of the American Clinical and Climatological Association Pub Date : 2025-01-01
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引用次数: 0
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