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Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis. 醋酸盐通过靶向氧化应激、炎症细胞因子和细胞凋亡，减轻铅诱导的睾丸类固醇生成和精子生成失调。
IF 1.6 4区 医学
Toxicological Research Pub Date : 2024-06-28 eCollection Date: 2024-10-01 DOI: 10.1007/s43188-024-00250-3
Elizabeth Enohnyket Besong, Tunmise Maryanne Akhigbe, Precious Adeoye Oyedokun, Moses Agbomhere Hamed, Roland Eghoghosoa Akhigbe
{"title":"Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis.","authors":"Elizabeth Enohnyket Besong, Tunmise Maryanne Akhigbe, Precious Adeoye Oyedokun, Moses Agbomhere Hamed, Roland Eghoghosoa Akhigbe","doi":"10.1007/s43188-024-00250-3","DOIUrl":"https://doi.org/10.1007/s43188-024-00250-3","url":null,"abstract":"<p><p>Lead exposure has been implicated in the aetiopathogenesis of male infertility via an oxidative stress-sensitive pathway. Conversely, acetate has been shown to confer cellular protection by improving the antioxidant defense mechanism. Yet, the effect of acetate on lead-induced testicular toxicity, viz., dysregulation of testicular steroidogenesis and spermatogenesis, has not been reported. The present study probed the influence of acetate on lead-induced dysregulation of testicular steroidogenesis and spermatogenesis. In our study, a reduction in body weight gain and testicular weight was identified in lead-exposed rats. While histopathological results established distortion of testicular histoarchitecture, reduced germ cell count, and suppressed spermatogenesis, biochemical studies confirmed that lead-deregulated testicular steroidogenesis was associated with reduced circulating gonadotropin-releasing hormone and gonadotropins, as well as down-regulated testicular 3β-HSD and 17β-HSD activities. These findings were accompanied by increased testicular malondialdehyde, TNF-α, IL-1β, and IL-6, and reduced glutathione, thiol and non-thiol protein levels, total antioxidant capacity, superoxide dismutase, and catalase activities. In addition, lead exposure increased NF<i>k</i>B and Bax levels, as well as caspase 3 activity, but reduced Bcl-2 levels. However, co-administration of acetate ameliorated lead-induced alterations. Collectively, acetate attenuated lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, NF<i>k</i>B-mediated inflammation, and caspase 3-driven apoptosis.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43188-024-00250-3.</p>","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Determination of ethanol in blood samples using partial least square regression applied to surface enhanced Raman spectroscopy. 更正：利用表面增强拉曼光谱的部分最小平方回归法测定血液样本中的乙醇含量。
IF 1.6 4区 医学
Toxicological Research Pub Date : 2024-06-26 eCollection Date: 2024-10-01 DOI: 10.1007/s43188-024-00245-0
Güneş Açikgöz, Berna Hamamci, Abdulkadir Yildiz
{"title":"Correction to: Determination of ethanol in blood samples using partial least square regression applied to surface enhanced Raman spectroscopy.","authors":"Güneş Açikgöz, Berna Hamamci, Abdulkadir Yildiz","doi":"10.1007/s43188-024-00245-0","DOIUrl":"https://doi.org/10.1007/s43188-024-00245-0","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.5487/TR.2018.34.2.127.].</p>","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs. 微小RNA上调YPEL3的表达并诱导人类乳腺癌细胞死亡。
IF 1.6 4区 医学
Toxicological Research Pub Date : 2024-06-21 eCollection Date: 2024-10-01 DOI: 10.1007/s43188-024-00251-2
Boyoung Lee, Yeo-Jung Kwon, Sangyun Shin, Tae-Uk Kwon, Hyemin Park, Hyein Lee, Ji-Heung Kwak, Young-Jin Chun
{"title":"Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs.","authors":"Boyoung Lee, Yeo-Jung Kwon, Sangyun Shin, Tae-Uk Kwon, Hyemin Park, Hyein Lee, Ji-Heung Kwak, Young-Jin Chun","doi":"10.1007/s43188-024-00251-2","DOIUrl":"https://doi.org/10.1007/s43188-024-00251-2","url":null,"abstract":"<p><p>MicroRNAs (miRNAs), molecules comprising 18-22 nucleotides, regulate expression of genes post-transcriptionally at the 3' untranslated region of target mRNAs. However, the biological roles and mechanisms of action of miRNAs in breast cancer remain unelucidated. Thus, in this study, we aimed to investigate the functions and possible mechanisms of action of miRNAs in breast cancer to suppress carcinogenesis. Using miRNA databases, we selected miR-34a and miR-605-5p to downregulate <i>MDM4</i> and <i>MDM2</i>, respectively, because these ubiquitin E3 ligases degrade p53 and promote carcinogenesis. Results showed that miR-34a and miR-605-5p suppressed MDM4 and MDM2 expression, respectively. Moreover, they reduced the expression of yes‑associated protein 1 (YAP1), a well-known oncogene involved in Hippo signaling, but upregulated the mRNA and protein expression of yippee-like 3 (YPEL3). To elucidate whether these miRNAs promote cellular senescence and death through YPEL3 upregulation, we examined their effects on cellular proliferation, SA-β-gal activity, and mitochondrial activity in human breast cancer MCF-7 cells. Given their upregulating effect on YPEL3 expression, miR-34a and miR-605-5p increased the number of β-galactosidase-positive cells and depolarized live cells (by 10%-12%). These data suggest that miR-34a and miR-605-5p promote cellular senescence and cell death. Thus, they may act as tumor suppressors by inducing Hippo signaling and may serve as novel therapeutic agents in breast cancer treatment.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43188-024-00251-2.</p>","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of cerebroprotein hydrolysate and its combination with antioxidants against oxidative stress-induced HT22 cell death. 脑蛋白水解物及其与抗氧化剂的结合对氧化应激诱导的 HT22 细胞死亡的神经保护作用
IF 1.6 4区 医学
Toxicological Research Pub Date : 2024-05-31 eCollection Date: 2024-10-01 DOI: 10.1007/s43188-024-00248-x
Eun-Ju Yang, Jae Cheon Kim, Dong Hee Na
{"title":"Neuroprotective effects of cerebroprotein hydrolysate and its combination with antioxidants against oxidative stress-induced HT22 cell death.","authors":"Eun-Ju Yang, Jae Cheon Kim, Dong Hee Na","doi":"10.1007/s43188-024-00248-x","DOIUrl":"https://doi.org/10.1007/s43188-024-00248-x","url":null,"abstract":"<p><p>This study aimed to investigate the neuroprotective effects of cerebroprotein hydrolysate (CPH) against oxidative stress-induced HT22 cell death. Additionally, the effect of antioxidants such as quercetin (QC) and <i>N</i>-acetyl-L-cysteine (NAC) on the neuroprotective activity of CPH was evaluated. The mouse-derived hippocampal neuronal cell line HT22 was pretreated with CPH or a mixture of CPH and QC or NAC. HT22 cell death was induced by either 10 mM glutamate, 2.5 μM amyloid-β (Aβ)<sub>25-35</sub>, and 300 μM cobalt chloride (CoCl<sub>2</sub>). As results, CPH effectively alleviated HT22 cell death induced by glutamate, Aβ<sub>25-35</sub>, and CoCl<sub>2</sub>. In addition, CPH combination with QC augmented cell viability in both glutamate- and Aβ<sub>25-35</sub>-stressed conditions but had no synergic effect on the CoCl<sub>2</sub>-stressed condition. The synergic effect of CPH and NAC combination was observed under all cell death conditions. The neuroprotective actions of CPH and its combinations with QC or NAC against various oxidative stress-induced HT22 cell deaths were demonstrated, providing a promising strategy for developing CPH preparations for the prevention and/or treatment of neurodegenerative diseases such as Alzheimer's disease.</p>","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroidogenic cytochrome P450 enzymes as drug target 作为药物靶点的类固醇细胞色素 P450 酶
IF 2.3 4区 医学
Toxicological Research Pub Date : 2024-04-22 DOI: 10.1007/s43188-024-00237-0
Changmin Kim, Eunseo Jeong, Yoo-Bin Lee, Donghak Kim
{"title":"Steroidogenic cytochrome P450 enzymes as drug target","authors":"Changmin Kim, Eunseo Jeong, Yoo-Bin Lee, Donghak Kim","doi":"10.1007/s43188-024-00237-0","DOIUrl":"https://doi.org/10.1007/s43188-024-00237-0","url":null,"abstract":"","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer 针对癌症生长因子信号转导和免疫细胞的单克隆抗体毒性机制的最新进展
IF 2.3 4区 医学
Toxicological Research Pub Date : 2024-04-22 DOI: 10.1007/s43188-024-00233-4
Miso Park, Ji Won Kim
{"title":"Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer","authors":"Miso Park, Ji Won Kim","doi":"10.1007/s43188-024-00233-4","DOIUrl":"https://doi.org/10.1007/s43188-024-00233-4","url":null,"abstract":"","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140677843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis 赖氨酸-63 链接的多泛素化：镉致癌的主要靶标
IF 2.3 4区 医学
Toxicological Research Pub Date : 2024-04-21 DOI: 10.1007/s43188-024-00236-1
Abderrahmen Chargui
{"title":"Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis","authors":"Abderrahmen Chargui","doi":"10.1007/s43188-024-00236-1","DOIUrl":"https://doi.org/10.1007/s43188-024-00236-1","url":null,"abstract":"","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140678888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics 六氟丙烯三聚体衍生物作为含氟电子冷却液的生物安全评估
IF 2.3 4区 医学
Toxicological Research Pub Date : 2024-04-17 DOI: 10.1007/s43188-024-00234-3
Yi-Tong Zhou, Pei-Jie Zhang, Shu-ping Wang, Chang-Hao Li, Jia-Qing Zhang, Wei-Xin Zhang, Yuanyang Zhao, Yuan-Cheng Cao, Jin-Xuan Fan
{"title":"Biosafety assessments of hexafluoropropylene trimer derivative as a fluorinated cooling fluid for electronics","authors":"Yi-Tong Zhou, Pei-Jie Zhang, Shu-ping Wang, Chang-Hao Li, Jia-Qing Zhang, Wei-Xin Zhang, Yuanyang Zhao, Yuan-Cheng Cao, Jin-Xuan Fan","doi":"10.1007/s43188-024-00234-3","DOIUrl":"https://doi.org/10.1007/s43188-024-00234-3","url":null,"abstract":"","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk assessment of cyclohexasiloxane D6 in cosmetic products 化妆品中环己基硅氧烷 D6 的风险评估
IF 2.3 4区 医学
Toxicological Research Pub Date : 2024-04-15 DOI: 10.1007/s43188-024-00235-2
Yeonju Ko, Donghyeon Lim, Hyunjoon Choi, Seongwon Choi, Shinai Choi, Jiyeon Hong, Young A. Yoon, Hyun Chung, Kyung-Min Lim, Kyu-Bong Kim, Joo Young Lee, S. Kwack, O. Bae
{"title":"Risk assessment of cyclohexasiloxane D6 in cosmetic products","authors":"Yeonju Ko, Donghyeon Lim, Hyunjoon Choi, Seongwon Choi, Shinai Choi, Jiyeon Hong, Young A. Yoon, Hyun Chung, Kyung-Min Lim, Kyu-Bong Kim, Joo Young Lee, S. Kwack, O. Bae","doi":"10.1007/s43188-024-00235-2","DOIUrl":"https://doi.org/10.1007/s43188-024-00235-2","url":null,"abstract":"","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory role of Echinochrome A in cancer-associated fibroblast-mediated lung cancer cell migration Echinochrome A 在癌症相关成纤维细胞介导的肺癌细胞迁移中的调控作用
IF 2.3 4区 医学
Toxicological Research Pub Date : 2024-04-11 DOI: 10.1007/s43188-024-00232-5
Da-Young Eum, Chaeyoung Lee, Cong So Tran, Jinyoung Lee, S. Park, Mi-So Jeong, Yunho Jin, J. Shim, Seoung Rak Lee, Minseob Koh, E. Vasileva, N. Mishchenko, Seong-Joon Park, Si Ho Choi, Yoo-Jin Choi, Hwayoung Yun, Kyu Heo
{"title":"Regulatory role of Echinochrome A in cancer-associated fibroblast-mediated lung cancer cell migration","authors":"Da-Young Eum, Chaeyoung Lee, Cong So Tran, Jinyoung Lee, S. Park, Mi-So Jeong, Yunho Jin, J. Shim, Seoung Rak Lee, Minseob Koh, E. Vasileva, N. Mishchenko, Seong-Joon Park, Si Ho Choi, Yoo-Jin Choi, Hwayoung Yun, Kyu Heo","doi":"10.1007/s43188-024-00232-5","DOIUrl":"https://doi.org/10.1007/s43188-024-00232-5","url":null,"abstract":"","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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