Trace elements in medicine最新文献

{"title":"FEATURES OF ELEMENT COMPOSITION OF HAIR OF STUDENTS ARRIVING TO STUDY IN MOSCOW MEGAPOLIS FROM DIFFERENT REGIONS OF THE WORLD","authors":"A. Kirichuk","doi":"10.19112/2413-6174-2020-21-1-14-21","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-1-14-21","url":null,"abstract":"The purpose of this study was to study the elemental status of first-year students of the Russian University of Friendship of Peoples who arrived to study from various climatogeographic regions of the world. Studies have shown that first-year students who came to study from different climatogeographic regions of the world are characterized by significant differences in the elemental composition of hair. Students from Latin America are characterized by a relatively high level of toxic metals Al, As, Hg, Sn, and students from Africa stand out by the highest levels of Al, B, Cd, Fe, I, Mn, Ni, Pb, Si, Sn, V. students from Iran and Azerbaijan revealed the minimum value of Co, Cu, Fe, I, Mg, Mn, Sn, V among all the studied groups. It was established that there are significant differences in the content of Ca, K, Mg, Na, P in the hair of male students from different regions of the world. Male students from Africa were characterized by the lowest Ca and P content in their hair, and the highest Mg content. The lowest content of K and Na was found in students from the countries of the Near and Middle East.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"27 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74548792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE BIOLOGICAL SIGNIFICANCE OF SELENIUM AND ITS PLACE IN RNA VIRAL DISEASES","authors":"T. M. Guseynov, R. T. Guliyeva, F. R. Yakhyayeva","doi":"10.19112/2413-6174-2020-21-4-21-31","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-4-21-31","url":null,"abstract":"ABSTRACT. Selenium as an essential trace element takes part in the regulation of many vital processes. This is realized with the help of over 25 selenoproteins that affect oxidative stress, immune response, hormonal metabolism, cognitive function, etc. Recently (in the next 30 - 40 years), there have been reports of the effect on viral infections, which have now become widespread. It turned out that almost all RNA viruses are selenium-dependent objects, that is, their genome contains the codes of the most important selenium containing proteins, including such as glutathione peroxidase, thioredoxinreductase, selenium-P protein, etc. Their synthesis during the development of a viral infection at the expense of the host leads to a weakening of the synthesis of the body's own intracellular selenium proteins, which contributes to the development of oxidative stress and a failure of the immune response. And this leads to the devastation of the selenium depot of the body, intended for the synthesis of its selenium proteins, which participate in vital regulatory processes. This circumstance determines, to replenish the body's resources with selenium, the expediency of using selenium-containing pharmacopoeia preparations as adjuvant in the treatment of RNA viral infections.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"47 1","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75817354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF ELEMENTAL COMPOSITION OF CHAMERION ANGUSTIFOLIUM AND THEIR NUTRITIONAL VALUE FOR HUMANS","authors":"S. Nekhoroshev, E. Botirov, N. Gornikov, A. V. Nekhorosheva, V. V. Kubar","doi":"10.19112/2413-6174-2020-21-1-37-44","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-1-37-44","url":null,"abstract":"Chamerion angustifolium (L.) Holub., the family Onagraceae (kipreyny), is an herbaceous plant that grows abundant in the wild of Eurasia and North America, since the 16th century widely used in fresh and dried form as a medicinal plant in folk medicine, and in fermented form for the preparation of infusions (tea drinks). It is known from scientific publications that 61 elements have been found in the mineral component of this plant, the content of which depends on the area of its growth. At the same time, most works provide results of determination of gross content of elements, on the basis of which many researchers refer to Ch. angustifolium to a possible source of vital human elements. It does not take into account that many of these elements cannot be fully absorbed by the body during digestion. During this work by means of a mass spectrometry method with the inductive and connected plasma (ISP-MS) the maintenance of 25 the elements, most important for the person was studied (Al, B, V, Fe, I, K, Cd, Ca, Co, Si, Li, Mg, Mn, Cu, As, Na, Ni, Sn, Hg, Pb, Se, Sr, P, Cr, Zn). These elements are converted into a water-soluble form in the conventional method of preparing a tea beverage from dry veg-etable raw materials - Ch leaves. angustifolium collected in 2018 in the wild in the territory of the Nizhnevartovsky district of Khanty-Mansi Autonomous District - Ugra, as well as comparison of the obtained results with reference values of standards of adequate daily consumption of human elements. As a result, Ch was found to be in the leaves. angustifolium the most important elements for human nutrition are manganese and magnesium, contained in the amount of 3.3%/g and 1.1%/g (respectively) of daily consumption of these elements by adults. This plant raw material is not toxic to humans since the known daily level of human toxicity in Ch leaves. angustifolium as defined will primarily be achieved by manganese (0.33%/g) and potassium (0.22%/g). The remaining elements reach less than 0.1% of the known daily toxicity level, or have no toxic effect on humans at all when ingested with food.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"73 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84813843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF THE CONTENT OF MACROELEMENTS IN CATARACTAL AND NON-CATARACTAL CRYSTALLINE LENSES OF THE EYES","authors":"A. Chuprov, V. Treushnikov, S. Notova, S. M. Kim, Т. Kazakova, O. Marshinskaia","doi":"10.19112/2413-6174-2020-21-4-53-59","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-4-53-59","url":null,"abstract":"The elemental composition of cataract and non-cataract crystalline lenses was studied in this study. The study was carried out on Wistar rats (n = 30), two groups were formed: control and experimental. The animals of the experimental group were simulated age-related cataract using ultraviolet irradiation for 6 months. The sample collection of lenses was carried out after 2 (the early stages of cataract) and 6 months (the mature stages of cataract) of the experiment. The chemical composition of the samples was determined using by ICP-AES and ICP-MS. The generation of reactive oxygen species under the action of ultraviolet radiation leads to a change in the permeability of cell membranes and, as a consequence, to a disturbance of homeostasis of elements. There is an imbalance of macronutrients in the lenses with the progress of cataract accompanying by an increase in the level of calcium and sodium and decrease in potassium, magnesium and phosphorus.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"58 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75850758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MÖSSBAUER SPECTROSCOPY OF FERROUS FUMARATE IN PHARMACEUTICAL PRODUCT USED TO TREAT ANEMIA","authors":"F. Vagizov, Kfu","doi":"10.19112/2413-6174-2020-21-3-43-49","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-3-43-49","url":null,"abstract":"The World Health Organization (WHO) considers iron deficiency anemia a serious public health problem in developing countries and recommends the use of iron tablets containing iron II for prevention and treatment. The results of Mössbauer measurements of the drug “Ferretab”, which is widely used in medicine for the treatment and prevention of iron deficiency anemia, are presented. This drug contains fumarate iron, C4H2FeO4, and has a small amount of folic acid. In this paper, the temperature dependence of isomer shift and quadrupole splitting values of 57Fe nuclei in iron fumarate were studied. The measurements show that when the temperature increases, the isomer shift and quadrupole splitting of 57Fe nuclei in iron fumarate decreases, the decrease in the isomer shift value is associated with the second-order Doppler effect. Based on Mössbauer measurements, the Debye temperature of this drug was determined. The Debye temperature gives us information about the strong bonding of 57Fe atoms with the environment. A high temperature value means a strong bond and vice versa, a small temperature value means a bond with low rigidity. The coupling constant (Debye temperature) defined for “Ferretab” iron nuclei has been compared with different Debye temperatures found in previous studies on some iron deficiency anemia drugs. Additionally, the values were compared with various clinical studies conducted in in-vivo and in-vitro for comparison of the efficacy of some of the most commonly used drugs to treat and prevent iron deficiency anemia. According to these comparisons, it was established a possible relationship between the Debye temperature of the iron atoms of the drugs under study and their effectiveness. It was noted that the lower the Debye temperature of iron atoms of the drug, the more iron absorbs the human body.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"39 1","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73237613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ELEMENTAL CONTENT OF HAIR AS AN INDICATOR FOR NATURAL AND TECHNOGENIC CONDITION OF TASHKENT REGION","authors":"E. Danilova, N. Osinskaya, S. Khusniddinova, Y. Ahmedov","doi":"10.19112/2413-6174-2020-21-3-24-32","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-3-24-32","url":null,"abstract":"The samples of soils, drinking water and hair of habitants of 15 districts in Tashkent region studied using the method of neutron activation analysis. The results obtained from soil and drinking water analyses indicated that contents of Zn, Co, Cu and other elements in a number of districts are higher in comparison with average values throughout the region. This is related to developed industry in these regions. The analysis of the habitants' hair also indicated increased values, which are caused by environmental contamination and working conditions. For generalized assessment of environmental condition it was suggested to use the logarithm of multiplication of the lithophylic elements (Ba, Ca, K, La, Na, Rb, Sc, Sr) content, characterizing the geochemical condition. And similarly, the logarithm of multiplication of potential pollutants, typical for this area, such as Br, Co, Cr, Sb, U, Zn content in soil, water and hair was used as conditional index of overall pollution. It was demonstrated, that fluctuations of lithophylic elements content logarithm value throughout the districts of the region are insignificant and fall within range of 3941, while logarithm values for the potential pollutants vary from 3.1 to 9.3. The distribution of a hypothetical integral pollutant is presented in the cartogram. The correlation analysis conducted has established a relationship between the content of elements in environmental objects and some diseases, indicating that increased or decreased content of elements in the hair is highly likely one of the signs of a particular disease, especially in environmentally disadvantaged districts of the region.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"57 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84798121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEPENDENCE OF CHEMICAL ELEMENTS URINE EXCRETION FROM ALIMENTARY IN TAKE OF MACRO- AND MICRONUTRIENTS OF THE FIRST COURSE STUDENTS-FEMALES FROM RUDN UNIVERSITY","authors":"А.А. Skalny, A. Galchenko, M. Yakovlev, A. Barinov, N. V. Titov, B. D. Tkachenko, A. I. Chernyavka, O. Orlova, Yulia N. Lobanova, Itmo Universit","doi":"10.19112/2413-6174-2020-21-2-49-53","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-2-49-53","url":null,"abstract":"One of the most significant ways of removing chemical elements from the body is the urinary route. Thus, knowing the concentration of chemical elements in the urine, as well as the chemical composition of the diet, an attempt can be made to assess the dependence of the degree of excretion of macro- and micronutrients on the consumption of nutrients. The aim of the study was to identify the dependence of the excretion of chemical elements in urine on the nutritional intake of macro- and micronutrients using the example of first-year students of RUDN University. 75 first-year students of RUDN University, aged 20 to 50, took part in the study. The morning urine samples were taken from the subjects for analysis on chemical elements by the method of mass spectrometry with inductively coupled plasma, and their nutritional status was evaluated by frequency analysis. A positive correlation was revealed between the urinary concentration of Cr and Fe with the nutritional intake of all macronutrients, the total energy value of the diet, the consumption of cholesterol, K, Na, Mg, S, I, Se, Cu, Zn, Fe, vitamins B2, B5, B12, D. Concentration Cr in urine, in addition, was higher in women with a high consumption of Mn, and the concentration of iron was higher with a high intake of Si. Al concentrations were inversely correlated with all the same indicators, except for Mn, I, Se, Si, K, S. With an increase in total fat intake, Al concentrations in urine increased. The most universal dependences of the degree of excretion of chemical elements on nutrients were found for aluminum, chromium, and iron.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"21 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81961195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHYSICAL ACTIVITY AND TRACE ELEMENT METABOLISM","authors":"A. Skalny","doi":"10.19112/2413-6174-2020-21-2-3-12","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-2-3-12","url":null,"abstract":"Currently, there is no doubt about the prevailing influence of the level of physical activity of an individual on the functional state of the body. However, the available literature data on the impact of physical stress on the body's supply of trace elements and their distribution in tissues are largely contradictory. This review of available literature data provides an insight into the relationship between physical activity and microelement homeostasis. The influence of human physical activity on the exchange of toxic (lead, cadmium, Nickel, etc.) and essential trace elements, such as iron, selenium, copper, cobalt, chromium, and zinc is reviewed. Based on the analyzed works, it is concluded that in order to correct the metabolic and microelement status of a person during physical activity, the most reasonable and necessary is the modulation of homeostasis of zinc and selenium.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"47 1","pages":"3-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74925211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF CHEMICAL HAIR CONTENT WITH NUTRITIONAL CHARACTERISTICS IN FIRST GRADE PFUR STUDENTS","authors":"A. Galchenko, M. Yakovlev, А.А. Skalny, A. Kirichuk, O. Orlova, R. Almasry, A. Barinov, N. V. Titov, T. V. Korobeynikova","doi":"10.19112/2413-6174-2020-21-2-41-48","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-2-41-48","url":null,"abstract":"The aim of the study was to determine the relationship of the content of chemical elements in the hair with the nature of nutrition. We examined 107 people (75 women and 32 men), first-year students of the Peoples` Friendship University of Russia from 33 countries. The average age of the subjects was 22 years. The hair was taken from the occipital part of the head. Hair was analyzed for qualitative and quantitative elemental composition by induced coupled plasma mass spectrometry. The average dietary intake of students was assessed by the method of frequency analysis using the Nutrilogic software. The results of the study showed that more than half of the students had a deficiency in consumption of P (61.68%), I (57.01%), Mo (75.70%), Cr (78.50%), choline (71.96%). The strongest correlations of the content of the chemical elements in the hair with the intake of nutrients in men were found for (chemical element in the hair - nutrient, dependence, direct or inverse, p value) W - Mo, ↓, 0.007; Co - vitamin B12, ↑, 0.003, Hg - β-carotene, ↓, 0.002; Mg - folate, ↑, 0.001; Mg - pantothenic acid, ↓, 0.0001; P - vitamin B12, ↑, 0.0001; P - pantothenic acid, ↑, 0.001. No such relationships were found among women, with the exception of beryllium concentrations: its content in the hair decreased with an increase in the intake of protein, fats, vitamins B1 and B12, as well as Na and Fe (in all cases, p≤0.001). Thus, the data obtained indicate that insufficient intake of various nutrients can significantly affect the status of a number of chemical elements. Moreover, the list of chemical elements is different for different nutrients.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"31 1","pages":"41-48"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88243587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONTENTS OF BIOELEMENTS IN MEDICINAL PLANTS IN THE DEPLETED OPENCAST AFFECTED AREA (ON THE EXAMPLE OF TUBINSKY VILLAGE, REPUBLIC OF BASHKORTOSTAN)","authors":"I. Semenova, Y. Rafikova, G. Biktimerova, Y. Suyundukov","doi":"10.19112/2413-6174-2017-18-1-43-51","DOIUrl":"https://doi.org/10.19112/2413-6174-2017-18-1-43-51","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"43 1","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73974143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}