ASSESSMENT OF THE CONTENT OF MACROELEMENTS IN CATARACTAL AND NON-CATARACTAL CRYSTALLINE LENSES OF THE EYES

A. Chuprov, V. Treushnikov, S. Notova, S. M. Kim, Т. Kazakova, O. Marshinskaia
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Abstract

The elemental composition of cataract and non-cataract crystalline lenses was studied in this study. The study was carried out on Wistar rats (n = 30), two groups were formed: control and experimental. The animals of the experimental group were simulated age-related cataract using ultraviolet irradiation for 6 months. The sample collection of lenses was carried out after 2 (the early stages of cataract) and 6 months (the mature stages of cataract) of the experiment. The chemical composition of the samples was determined using by ICP-AES and ICP-MS. The generation of reactive oxygen species under the action of ultraviolet radiation leads to a change in the permeability of cell membranes and, as a consequence, to a disturbance of homeostasis of elements. There is an imbalance of macronutrients in the lenses with the progress of cataract accompanying by an increase in the level of calcium and sodium and decrease in potassium, magnesium and phosphorus.
白内障和非白内障晶状体中巨量元素含量的评估
本文研究了白内障和非白内障晶状体的元素组成。实验选用Wistar大鼠30只,分为对照组和试验组。实验组采用紫外线照射6个月模拟老年性白内障。实验2个月(白内障早期)和6个月(白内障成熟期)后进行晶状体样品采集。采用电感耦合等离子体发射光谱(ICP-AES)和电感耦合等离子体质谱(ICP-MS)测定样品的化学成分。在紫外线的作用下,活性氧的产生导致细胞膜通透性的改变,从而导致元素稳态的紊乱。随着白内障的发展,晶状体中钙、钠含量升高,钾、镁、磷含量降低,晶状体中常量营养素失衡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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