Trakya University Journal of Natural Sciences最新文献_第7页

COMPARISON OF C AND N MINERALIZATION AND METAGENOME ANALYSIS OF RHIZOSPHERE SOILS BELONGING TO DIFFERENT COLCHICUM SPP. 不同秋水仙属根际土壤c、n矿化比较及宏基因组分析。

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Trakya University Journal of Natural Sciences Pub Date : 2021-10-01 DOI: 10.23902/trkjnat.971156

İpek Eki̇ci̇, C. Darıcı, Z. Sani, S. Dinçer

引用次数: 0

DETERMINATION OF FLOW AND VISCOELASTIC PROPERTIES OF THE KYRGYZ ETHNIC FOOD “SÜZMÖ” DEPENDING ON TEMPERATURE AND MOISTURE CONTENT 测定吉尔吉斯民族食品“sÜzmÖ”的流动和粘弹性随温度和水分含量的变化

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Trakya University Journal of Natural Sciences Pub Date : 2021-09-22 DOI: 10.23902/trkjnat.925710

Janyl Iskakova, Jamila Smanalieva

引用次数: 2

PHENOLOGICAL BEHAVIOURS of LOCAL ENDEMIC Paeonia mascula subsp. bodurii in ÇANAKKALE 地方性雄性芍药亚种物候行为研究。bodurii在ÇANAKKALE

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Trakya University Journal of Natural Sciences Pub Date : 2021-09-06 DOI: 10.23902/trkjnat.974130

Bahar Kokcu, E. Karabacak

引用次数: 0

A NEW SUAEDA RECORD FOR FLORA OF TURKEY: SUAEDA AEGYPTIACA (CHENOPODIACEAE-AMARANTHACEAE)

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Trakya University Journal of Natural Sciences Pub Date : 2021-08-19 DOI: 10.23902/trkjnat.903661

İ. Başköse, A. Yaprak

引用次数: 0

DETERMINATION OF CYTOTOXIC EFFECTS OF SOME DRUGS USED IN THE TREATMENT OF COVID-19 ON LUNG CANCER (A549) CELLS 一些用于治疗COVID-19的药物对肺癌(a549)细胞的细胞毒性作用的测定

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Trakya University Journal of Natural Sciences Pub Date : 2021-07-05 DOI: 10.23902/trkjnat.901480

A. Karakus, S. Ünal Karakuş, Fatma Usta, Ümit Herdem, Sude Aksu, F. Özdemir, Mehri Çukurcak, Ecem Çitakoğlu

引用次数: 0

A New Treatment Possibility for Skin Inflammatory Disease Psoriasis: In vitro Assessment of Salbutamol on Psoriatic Skin Spheroids 皮肤炎症性疾病银屑病的一种新的治疗可能性:沙丁胺醇对银屑病皮肤球体的体外评价

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Trakya University Journal of Natural Sciences Pub Date : 2021-06-24 DOI: 10.23902/trkjnat.878417

Ö. Somuncu, Berke Demi̇ri̇z, Irem Türkmen, S. Somuncu, B. Aksoy

引用次数: 0

THE FIRST REPORT OF GEOSMIN AND 2-METHYLISOBORNEOL PRODUCER CYANOBACTERIA FROM TURKISH FRESHWATERS 土耳其淡水中土臭素和2-甲基异龙脑蓝藻的首次报道

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Trakya University Journal of Natural Sciences Pub Date : 2021-06-16 DOI: 10.23902/trkjnat.884423

Zuhal Tunç, R. Akçaalan, Latife Köker, Meriç Albay

引用次数: 1

BIOMOLECULES AND NATURAL PRODUCTS REGULATE THE HUMAN ACE2 GENE EXPRESSION ON THE LUNG CANCER CELLS 生物分子和天然产物调控人ace2基因在肺癌细胞上的表达

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Trakya University Journal of Natural Sciences Pub Date : 2021-06-15 DOI: 10.23902/trkjnat.896013

Kaan Hürkan, Ş. Arslan, M. Atalar, A. Aydin, I. Demirtaş, Dogukan Mutlu, Bahattin Tabar, M. Alma

引用次数: 0

SYNTHESIS, CHARACTERIZATION AND BIOCOMPATIBILITY OF PLANT-OIL BASED HYDROGELS 植物油基水凝胶的合成、表征及生物相容性研究

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Trakya University Journal of Natural Sciences Pub Date : 2021-06-10 DOI: 10.23902/trkjnat.925742

Ozlem Yalcin Capan, Pinar Cakir Hatir

{"title":"SYNTHESIS, CHARACTERIZATION AND BIOCOMPATIBILITY OF PLANT-OIL BASED HYDROGELS","authors":"Ozlem Yalcin Capan, Pinar Cakir Hatir","doi":"10.23902/trkjnat.925742","DOIUrl":"https://doi.org/10.23902/trkjnat.925742","url":null,"abstract":"Biocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel and functional monomers to be used in hydrogel synthesis is increasing as the number of biomedical applications and need for biomaterials increase. The purpose of the study was to develop novel hydrogels from renewable materials. Acrylated methyl ricinoleate, a plant oil-based monomer, was used as the renewable material. The effects of acrylated methyl ricinoleate/N-isopropyl acrylamide molar ratio on hydrogel structural properties, thermal stability and in vitro cytotoxicity were studied. FTIR spectroscopy was used to characterize the structural properties of the hydrogels, while TGA was used to characterize the thermal properties. HEK293 and Cos-7 cell lines were used to test the cytotoxicity of the monomers and hydrogels. IC50 values for acrylated methyl ricinoleate and N-isopropyl acrylamide were found to be greater than 25 mg/mL. Cell viability of hydrogels containing 50% or more acrylated methyl ricinoleate was greater than 60%, while hydrogel biocompatibility decreased with decreasing molar ratio of acrylated methyl ricinoleate. Cells showed a minimum viability of 80% when incubated in hydrogel degradation products. An environmentally friendly synthesis method was developed and novel biocompatible hydrogels from renewable materials were produced for biomedical applications.","PeriodicalId":23163,"journal":{"name":"Trakya University Journal of Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75968653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY MTT法测定嗜盐阿魏提取物的抗HRSV活性

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Trakya University Journal of Natural Sciences Pub Date : 2021-03-22 DOI: 10.23902/TRKJNAT.805545

H. Doğan, Rüstem Duman

{"title":"THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY","authors":"H. Doğan, Rüstem Duman","doi":"10.23902/TRKJNAT.805545","DOIUrl":"https://doi.org/10.23902/TRKJNAT.805545","url":null,"abstract":"The trend towards natural products in the world is increasing due to the increased drug resistance of infectious diseases, the high prices for drugs and the difficulty of access. Also, bacterial or viral diseases that are difficult to treat and need a long time for proper treatment cause important infections in people. Since effective drugs could not be developed for most viral infections, it is very important to find natural products against viruses to introduce them to the world of science. The antiviral activities of the aqueous and methanol extract from Ferula halophila Pesmen, an endemic species to Turkey, has been investigated against human respiratory syncytial virus (HRSV, ATCC-VR-26). The cytotoxic and antiviral properties of plant extracts were investigated in HRSV / HEp-2 cell systems, respectively by the colorimetric MTT assay. In the study, the titer of RSV was used as 100 TCID50 (50% tissue culture infective dose). While MNTC (Maximum non-toxic concentration) of methanol extract was 195.313 µg/mL and CC50 (50% cytotoxic concentration) was 4366.22 µg/mL, it was determined as MNTC = 390.625 µg/mL and CC50 = 4366.22 for aqueous extract. According to the results, methanol extract showed more toxicity than the aqueous extract. The MNTC of Ribavirin used as a positive control was determined as 0.98 µg/mL and CC50 was 110.40 µg/mL. As a result of the study, it was determined that the methanol extract was not effective, whereas the aqueous extract had a significant anti-HRSV activity with the values of 50.69 µg/mL EC50 (50% Effective Concentration) and 97.54 Selectivity Index (SI). The EC50 and SI values of Ribavirin were 2.39 µg/mL and 46.19, respectively. According to the results, we can explain the presence of antiviral activity only in the aqueous extract and the absence in the methanol extract by the high toxicity of it and the insolubility of the antiviral compounds in the methanol extract.","PeriodicalId":23163,"journal":{"name":"Trakya University Journal of Natural Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90059917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2