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Toxicological European research. Recherche europeenne en toxicologie最新文献

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Vinyl chloride and acrylonitrile: activation mechanism and mutagenicity. 氯乙烯和丙烯腈:活化机理和致突变性。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1982-01-01
M Duverger-Van Bogaert, M Lambotte-Vandepaer, C De Meester, M Mercier, F Poncelet
{"title":"Vinyl chloride and acrylonitrile: activation mechanism and mutagenicity.","authors":"M Duverger-Van Bogaert, M Lambotte-Vandepaer, C De Meester, M Mercier, F Poncelet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"4 1","pages":"35-7"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18098590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soluble glutathione S-transferases from rat testes: isoenzyme pattern and lack of inducibility by drug metabolizing enzyme inducers. 来自大鼠睾丸的可溶性谷胱甘肽s转移酶:同工酶模式和缺乏药物代谢酶诱导剂的诱导性。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1982-01-01
P J Dierickx
{"title":"Soluble glutathione S-transferases from rat testes: isoenzyme pattern and lack of inducibility by drug metabolizing enzyme inducers.","authors":"P J Dierickx","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The soluble glutathione S-transferase (GST) isoenzymes from rat testicular tissue were separated in one chromatographic run on carboxymethyl cellulose. GST was measured with 1-chloro-2,4-dinitrobenzene as the second substrate. The following percentages for the different isoenzymes were found: GST AA: 12.6%, GST A:8.1%, GST B:4.2%, GST C:18.1%, GST D and E: not detected, GST x:7.4%, and anionic GST:49.6%. These values were quite different from those found in liver tissue. Testicular GST could not be induced by the drug metabolizing enzyme inducers trans-stilbene oxide, DDT, and phenobarbital. The high GST content in rat testes may suggest that these enzymes function also in this tissue in the metabolism and detoxification of electrophilic xenobiotics.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"4 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18127268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Air pollution by cadmium in Marseille (author's transl)]. [马赛的镉污染空气(作者译)]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1982-01-01
A Viala, F Gouezo, B Mallet, J Fondarai, F Grimaldi, J P Cano
{"title":"[Air pollution by cadmium in Marseille (author's transl)].","authors":"A Viala,&nbsp;F Gouezo,&nbsp;B Mallet,&nbsp;J Fondarai,&nbsp;F Grimaldi,&nbsp;J P Cano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The control of the air pollution by cadmium in Marseille was realized between July 1st 1977 and June 30 1979 by determining the metal in the air dust by atomic absorption spectrophotometry without flame. The samples were taken on eight different stations located in the urban-center and in the suburbs. The atmospheric levels of cadmium in Marseille are low but a note-worthy increase was noticed from september 1978. A principal components analysis of the data compared with these obtained with other atmospheric pollutants, revealed the particular characteristic of cadmium in Marseille, which seems to be bound neither with the pollutants issued from motor vehicles, nor with zinc of which it is yet an impurity. However vigilance is indispensable against the environmental contamination by cadmium in consideration of its potential risks for the health.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"4 1","pages":"25-9"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18128706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Method of plasma acetate determination by gas chromatography after ethanol administration in man (author's transl)]. [人给药后血浆醋酸酯的气相色谱测定方法[作者译]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1982-01-01
R Bruno, Y Santoni, A Botta, J P Cano
{"title":"[Method of plasma acetate determination by gas chromatography after ethanol administration in man (author's transl)].","authors":"R Bruno,&nbsp;Y Santoni,&nbsp;A Botta,&nbsp;J P Cano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma acetate is extracted using ethanol in alkaline medium, in presence of internal standard. After concentration of the hydroalcoholic phase, the chromatographic analysis is performed utilizing 10% SP 1200 and 1% H3PO4 on chromosorb W. The linearity of the method has been tested from 0.05 to 10 mM/I, its reproducibility is +/- 3.5% for levels ranging from 0.1 to 10 mM/I and +/- 10% for those smaller than 0.1 mM/I. This method is sensitive enough to assess the physiological acetate levels and those obtained after ethanol biotransformation.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"4 1","pages":"31-4"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18127266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Allergenic residues of veterinary drugs in food (author's transl)]. [食品中兽药的致敏性残留(作者译)]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1982-01-01
V Burgat-Sacaze
{"title":"[Allergenic residues of veterinary drugs in food (author's transl)].","authors":"V Burgat-Sacaze","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Residues of veterinary drugs can be found in human food and be involved in allergic untoward reactions in consumers. The current french law on veterinary pharmacy allows to control this risk. Therefore, to evaluate this risk the following topics are considered: 1) origin of food contamination by allergenic compounds and characteristics of residues, 2) effects of these residues. Observations demonstrate that residues may elicit clinical reactions in sensitized individuals; on the contrary, an sensitizing effect is probably minor in pratice.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"4 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18128705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of fluoride on hepatic parenchyma of guinea pigs exposed to an atmosphere containing 150 micrograms of hydrofluoric acid per m3 for several months]. [氟化物对暴露于每立方米含有150微克氢氟酸的大气中数月的豚鼠肝实质的影响]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-11-01
C Rioufol, P Bourbon, P Lévy, J F David, J Alzieu
{"title":"[Effect of fluoride on hepatic parenchyma of guinea pigs exposed to an atmosphere containing 150 micrograms of hydrofluoric acid per m3 for several months].","authors":"C Rioufol,&nbsp;P Bourbon,&nbsp;P Lévy,&nbsp;J F David,&nbsp;J Alzieu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 6","pages":"299-304"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17187995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A study of the cytotoxicity of chloroform, 1-2-dichloroethane, 1,1,1-trichloroethane and hexachlorobutadiene to mouse L cells (author's transl)]. [氯仿、1-2-二氯乙烷、1,1,1-三氯乙烷和六氯丁二烯对小鼠L细胞的细胞毒性研究]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-11-01
Z Elias, P Hartemann, N Chau
{"title":"[A study of the cytotoxicity of chloroform, 1-2-dichloroethane, 1,1,1-trichloroethane and hexachlorobutadiene to mouse L cells (author's transl)].","authors":"Z Elias,&nbsp;P Hartemann,&nbsp;N Chau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A cytotoxicity test based on residual protein determination is described and the in vitro toxicity of certain chlorinated aliphatic hydrocarbons is evaluated with this test. The results obtained are sufficiently reproducible to yield an order of cytotoxicity: hexachlorobutadiene is about 100-fold more toxic than chloroform or 1,2-dichloroethane; whereas, 1,1,1-trichloroethane is 10-fold more toxic than these two compounds. The method is fast and lends itself to the toxic evaluation of large numbers of samples.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 6","pages":"293-8"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18344753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hepatic microsomal monoxygenase inhibition by nabam in the rat (author's transl)]. [纳巴姆对大鼠肝微粒体单加氧酶的抑制作用[作者译]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-11-01
A Périquet, R Derache
{"title":"[Hepatic microsomal monoxygenase inhibition by nabam in the rat (author's transl)].","authors":"A Périquet,&nbsp;R Derache","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nabam (fungicide dithiocarbamate) has been incorporated with the diet of rats during six months (the doses were: 0, 10, 50, 100, 500, 1000 and 2000 ppm). It decreases significantly the hepatic microsomal enzymes activity (aniline hydroxylase and aminopyrine N-demethylase and the liver P 450 content, but the cytochrome b 5 concentration doesn't seem to be modified. The microsomal lipidic and proteic content is only modified with the highest Nabam dose. Several hypotheses may be proposed to explain the Nabam effects: one is the inhibition of the monooxygenases and their biosynthesis repression.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 6","pages":"285-91"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18344752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long term toxicity and carcinogenicity of a new protein source in rats. 一种新的蛋白质来源对大鼠的长期毒性和致癌性。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-11-01
G C Perri, A Nunziata, A Argentino-Storino, R O Salerno, P Mercatelli
{"title":"Long term toxicity and carcinogenicity of a new protein source in rats.","authors":"G C Perri,&nbsp;A Nunziata,&nbsp;A Argentino-Storino,&nbsp;R O Salerno,&nbsp;P Mercatelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sprague Dawley rats were fed with yeast (Candida Maltosa) obtained by fermentation of n-Paraffins F.U. grade (C12-C19). The yeast was incorporated in the diet at 7.2, 18.4 and 34.5% by weight. Each diet was isocaloric and isoproteic with the others and with the standard diet. The yeast supplied 20, 50, 80% of the proteins of the diet respectively. 65 rats per sex per group were selected at random from over 1000 rats and assigned to each of the 4 diets for the carcinogenicity study; 57 rats per sex group were selected at random from the same 1000 rats and assigned to each of the 4 diets for the long term study. In long term study the rats were sacrificed at 3, 6, 15 and 24 months. In the carcinogenicity study the animals were kept till less than 10% of the starting number was surviving; the experiment lasted 30 months. Animals dead spontaneously or killed at the end of the trial were autopsied and the main organs fixed for histological examination. Lesions and tumours were classified. Biochemical, haematological and autopsy variations at the times of sacrifice were observed in the long term study. The experiment showed no pathological differences between controls and animals treated with 20 and 50% proteins from yeast. The group fed with 80% single cell protein showed a significant increase of malignant lymphomas incidence.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 6","pages":"305-10"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18344754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impairment of nervous system in workers exposed to inorganic mercury. 接触无机汞的工人神经系统受损。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-11-01
G Angotzi, N Battistini, F Carboncini, R Cioni, E Desideri, C Paradiso, D Nuti, E Sartorelli
{"title":"Impairment of nervous system in workers exposed to inorganic mercury.","authors":"G Angotzi,&nbsp;N Battistini,&nbsp;F Carboncini,&nbsp;R Cioni,&nbsp;E Desideri,&nbsp;C Paradiso,&nbsp;D Nuti,&nbsp;E Sartorelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Impairment of nervous functions has been investigated by clinical and neurophysiological methods in 55 workers exposed to inorganic mercury intoxication and 27 controls living in the same area. A polyneuropathy, mainly of sensory type, has been found in 6 exposed workers (10,9%) and 2 control (7,4%); a mono or multineuropathy of sensory or motor type was present in 15 exposed (27%) and 10 control (29,6%) subjects. Central N.S. involvement has been found in 7 out of 12 exposed workers examined and in 1 out of 7 controls by electronystagmography. Neurological examination demonstrated minor signs of cerebellar type in 3 instances.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 6","pages":"275-8"},"PeriodicalIF":0.0,"publicationDate":"1981-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18344751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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