发布求助
文献互助 智能选刊 最新文献

Toxicological European research. Recherche europeenne en toxicologie最新文献

筛选
英文 中文
[Modification of hepatotoxic effect of halogenated hydrocarbons on partially hepatectomized rats (author's transl)]. [卤代烃对部分去肝大鼠肝毒性作用的修饰[作者译]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-07-01
H Ishikawa, M Fukuhara, K Suda, T Murai, K Hashimoto, C Boudene
{"title":"[Modification of hepatotoxic effect of halogenated hydrocarbons on partially hepatectomized rats (author's transl)].","authors":"H Ishikawa,&nbsp;M Fukuhara,&nbsp;K Suda,&nbsp;T Murai,&nbsp;K Hashimoto,&nbsp;C Boudene","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of hepatectomy on the hepatotoxic effect of halogenated hydrocarbons was studied. Male rats received oral administration of chloroform of carbon tetrachloride at a single dose of 500 mg/kg, 3 days prior to or after the partial hepatectomy. The hepatotoxic effect of the toxins was modified in a different manner according to the time of the hepatectomy. In the animals hepatectomized 3 days after the hepatotoxins administration, histological changes of the liver were similar to those of the non-hepatectomized rats, except with an increase in the activity of GOT and GPT. Contrary, in the animals hepatectomized 3 days prior to the hepatotoxins administration, the toxic effect of the chemicals was less enhanced than in the non-hepatectomized animals.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 4","pages":"197-200"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18314551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The problem of the use of mercurials cosmetics in Senegal (author's transl)]. [在塞内加尔使用含汞化妆品的问题(作者译)]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-07-01
G Gras, J Mondain
{"title":"[The problem of the use of mercurials cosmetics in Senegal (author's transl)].","authors":"G Gras,&nbsp;J Mondain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of skin-lightening preparations appears to be a problem for the coloured women in Africa as well as for the Black People in general. The mercurial creams occupy a place of choice into the most useful products for the skin depigmentation. An epidemiological study from twenty senegalese women using mercurials cosmetics has permitted to determine a mean value of 155,75 +/- 75,38 ppm Hg in scalp hair while the normal level is less than 10 ppm. An experimental study was realised with monkeys (Papio papio) treated with a soap containing mercuric biiodide. This study has shown, after only three months of experimentation, a significative augmentation of mercury levels in all the organs and specially in the kidneys and the hair.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 4","pages":"175-8"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18314548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Species differences in pharmaco-kinetics of chemicals. Correlations with toxicity (author's transl)]. 化学药物动力学的物种差异。与毒性的相关性[作者译]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-07-01
G Keck
{"title":"[Species differences in pharmaco-kinetics of chemicals. Correlations with toxicity (author's transl)].","authors":"G Keck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The species differences in kinetics of drugs or toxics were studied in laboratory and domestic animals at various stages of the fate in the body: - absorption, - distribution, blood transport, binding on plasmatic proteins, tissues; placenta passage, - elimination via the kidney, bile, and diverses secretions. Since they are very important in species differences bio-transformations of chemical substances were studied separately. The toxicological or pharmacological implications of these differences were shown from a theoretical point of view (phenomena of passage through the membranes), an experimental point of view (choice of species, extrapolation from animal to man) and from the veterinary point of view.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 4","pages":"207-15"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18314553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental studies on a new hair dyeing ingredient 2-(2', 4'-diaminophenoxy) ethanol : lack of genotoxic properties. 染发新原料2-(2′，4′-二氨基苯酚)乙醇的实验研究:无基因毒性。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-07-01
G Kalopissis
{"title":"Experimental studies on a new hair dyeing ingredient 2-(2', 4'-diaminophenoxy) ethanol : lack of genotoxic properties.","authors":"G Kalopissis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A benzene metadiamine derivative, 2-(2', 4' diaminophenoxy) ethanol proved to be interesting in hairdyeing. Its genotoxicity was investigated in various tests. The ingredient showed no mutagenicity in the different assays which indicates a correlation among the battery of tests. It also appears that within a chemical category, similarity of structure does not always imply similar genetic response.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 4","pages":"191-5"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18077821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interaction between benzene and toluene in long term inhalation exposure in rats (author's transl)]. [大鼠长期吸入接触苯和甲苯的相互作用[作者简介]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-07-01
D Gradiski, P Bonnet, P Duprat, D Zissu, J L Magadur, J P Guenier
{"title":"[Interaction between benzene and toluene in long term inhalation exposure in rats (author's transl)].","authors":"D Gradiski,&nbsp;P Bonnet,&nbsp;P Duprat,&nbsp;D Zissu,&nbsp;J L Magadur,&nbsp;J P Guenier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Industrial chemicals are seldom used as pure substances; hazards resulting from exposure to mixtures have, however not been solved. Our study deals with chronic inhalation toxicity of a mixture of benzene and toluene; few studies have been completed on this subject. Our results show: - leucopenia with benzene alone, at a concentration of 50 p.p.m., that is not detectable in the presence of toluene; - metabolic variations consisting in: a decrease in the phenol urinary rate versus time with benzene alone; a sharp decrease of this rate from the third month of exposure on, in presence of toluene.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 4","pages":"201-6"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18314552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic and cytostatic effect of T2-toxin on epithelial cell lines derived from rat liver. t2毒素对大鼠肝上皮细胞系的细胞毒和细胞抑制作用。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-05-01
E Morel-Chany, C Lafarge-Frayssinet, G Trincal
{"title":"Cytotoxic and cytostatic effect of T2-toxin on epithelial cell lines derived from rat liver.","authors":"E Morel-Chany,&nbsp;C Lafarge-Frayssinet,&nbsp;G Trincal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cytotoxic and cytostatic effects of T2-toxin (Fusarium mycotoxin) on cells in culture derived from rat hepatomas and rat livers were investigated. Results showed that these effects appeared to be dependent on both drug concentration and duration of drug exposure. Non-transformed, as well as spontaneous neoplastic transformed liver cells and hepatoma cells were sensitive to its effect. T2-toxin had no selective action on cancer cells; however, a progression appeared in sensitivity to the toxic effect as a function of the degree of tumorigenicity of the cell line. This progression dis not exist for the cytostatic effect, which remained only in relation to the degree of proliferation of the cells in culture.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 3","pages":"125-9"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18293534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity (author's transl)]. [尿n -乙酰- β -氨基葡萄糖酶作为肾毒性指标(作者译)]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-05-01
N Oudart, K Marcher, B Lacour, R G Boulu, C Guichard
{"title":"[Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity (author's transl)].","authors":"N Oudart,&nbsp;K Marcher,&nbsp;B Lacour,&nbsp;R G Boulu,&nbsp;C Guichard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) has been studied in rats submitted to potentially nephrotoxic drugs (acetylsalicylic acid, gentamicin). Both drugs induced increase in NAG excretion which was reversible and dose-dependent. The date presented in this paper suggest that urinary NAG determination may have value as screening device for the study of nephrotoxic effects in experimental toxicology.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 3","pages":"149-51"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18293535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic activation and toxicology - some models of chemical protection against drug toxicity. 代谢激活和毒理学——一些药物毒性化学保护模型。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-05-01
P Lesca
{"title":"Metabolic activation and toxicology - some models of chemical protection against drug toxicity.","authors":"P Lesca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article describes some examples concerning the mechanism involved in the drug toxicity mediated by the enzymes of metabolism. They concern the production of various reactive metabolites which strongly bind to biological macromolecules inducing different forms of toxicity (necrosis, mutations and cancers). Some recent data on the field of protection and prevention means against the hepatoxicity of carcinogenesis are described.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 3","pages":"161-6"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18072822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Polychlorocamphane (P.C.C.) effects on the microsomal enzyme activities and fat content of rat liver (author's transl)]. [多氯camphane (pcc)对大鼠肝脏微粒体酶活性和脂肪含量的影响]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-05-01
J M Poul, J Pays, M Dagorn
{"title":"[Polychlorocamphane (P.C.C.) effects on the microsomal enzyme activities and fat content of rat liver (author's transl)].","authors":"J M Poul,&nbsp;J Pays,&nbsp;M Dagorn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The rat liver mixed function oxydases are induced by polychlorocamphane incorporated in the food at a dose level of 250 ppm for 30 days. The fat content of liver is enhanced by the treatment, specially that of microsomal phospholipids and whole liver esterified cholesterol and triglycerides. Microsomal acylcoenzymeA-cholesterol-acytransferase activity, expressed in nM/g of liver weight, which catalyses the esterification of free cholesterol, is increased significantly by P.C.C. treatment. The accumulation of triglycerides is inconsistent with an enhanced lipolysis of adipose tissue since the plasma levels of free fatty acids are the same for control and treated rats. These results confirmed the eventual correlation between induction and hepatic steatosis suggested by some authors.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 3","pages":"153-9"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18293536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Contribution to the determination of four antimalarial molecules (chloroquine, quinine, pyrimethamine, sulfadoxime) mixed in biological fluids. I. Spectrophotometry UV (author's transl)]. [参与测定混合在生物液体中的四种抗疟疾分子(氯喹、奎宁、乙胺嘧啶、磺胺多肟)。1 .紫外分光光度法[作者简介]。
Toxicological European research. Recherche europeenne en toxicologie Pub Date : 1981-05-01
M Bonini, F Mokofio, S Argilas
{"title":"[Contribution to the determination of four antimalarial molecules (chloroquine, quinine, pyrimethamine, sulfadoxime) mixed in biological fluids. I. Spectrophotometry UV (author's transl)].","authors":"M Bonini,&nbsp;F Mokofio,&nbsp;S Argilas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antimalarial therapy is directed more and more towards the use of associated substances: Pyrimethamine, sulfadoxime, quinine et chloroquine. The authors propose a method of direct determination of these four molecules mixed in biological fluids. The recommended extraction process followed by a spectrophotometric UV determination is fast, reproductible and sufficiently sensitive to study the evolution of a therapy.</p>","PeriodicalId":23153,"journal":{"name":"Toxicological European research. Recherche europeenne en toxicologie","volume":"3 3","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18293533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信