Toxicologic Pathology最新文献_第2页

A Developmental Atlas as a Reflection of Our Professional Lifecycle. 反映我们职业生命周期的发展图集。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2024-06-01 Epub Date: 2024-08-16 DOI: 10.1177/01926233241269099

Renee Hukkanen

引用次数: 0

Retraction Notice: "Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats". 撤稿通知："槲皮素在预防硫代乙酰胺诱发的大鼠肝损伤中的作用》。

IF 1.5 4区医学

Toxicologic Pathology Pub Date : 2024-05-20 DOI: 10.1177/01926233241256964

引用次数: 0

Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays. 用于 18 个月膳食致癌性试验的 C57BL/6J 小鼠自发病理结果的历史对照数据。

IF 1.5 4区医学

Toxicologic Pathology Pub Date : 2024-05-17 DOI: 10.1177/01926233241248658

L. Elies, Elise Guillaume, Mathilde Gorieu, Patricia Neves, F. Schorsch

{"title":"Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays.","authors":"L. Elies, Elise Guillaume, Mathilde Gorieu, Patricia Neves, F. Schorsch","doi":"10.1177/01926233241248658","DOIUrl":"https://doi.org/10.1177/01926233241248658","url":null,"abstract":"A retrospective analysis in C57BL6/J mice used in dietary carcinogenicity studies was performed to determine the survival rate, causes of death and incidences of spontaneous non-tumoral and tumoral findings. Data were collected from 1600 mice from control dose groups of sixteen 18-month carcinogenicity assays performed between 2003 and 2021 at the same test facility with similar environmental conditions and experimental procedures. The survival rate was high in both sexes (81%-85%) and the causes of humane euthanasia or death were mainly non-tumoral (chronic ulcerative dermatitis, atrial thrombosis). Benign tumors were more frequent than malignant tumors and females were more affected than males. Pituitary gland adenoma in females, lymphoma, bronchioloalveolar adenoma, and harderian gland adenoma in both sexes were the most common tumors. Systemic amyloidosis, the most frequent non-tumoral lesion, was observed variably across studies without sex predilection. The analysis by cohort (3 time periods of 6 years) showed a tendency toward higher incidences of lymphoma and pituitary gland adenoma and lower incidences of amyloidosis over time. The results presented here provide for the first time a robust set of control historical data in untreated C57BL/6J mice kept for 18 months contributing to build in depth knowledge of this animal model.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays. 用于 18 个月膳食致癌性试验的 C57BL/6J 小鼠自发病理结果的历史对照数据。

IF 1.5 4区医学

Toxicologic Pathology Pub Date : 2024-05-17 DOI: 10.1177/01926233241248658

Laëtitia Elies, Elise Guillaume, Mathilde Gorieu, Patricia Neves, Frédéric Schorsch

{"title":"Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays.","authors":"Laëtitia Elies, Elise Guillaume, Mathilde Gorieu, Patricia Neves, Frédéric Schorsch","doi":"10.1177/01926233241248658","DOIUrl":"https://doi.org/10.1177/01926233241248658","url":null,"abstract":"A retrospective analysis in C57BL6/J mice used in dietary carcinogenicity studies was performed to determine the survival rate, causes of death and incidences of spontaneous non-tumoral and tumoral findings. Data were collected from 1600 mice from control dose groups of sixteen 18-month carcinogenicity assays performed between 2003 and 2021 at the same test facility with similar environmental conditions and experimental procedures. The survival rate was high in both sexes (81%-85%) and the causes of humane euthanasia or death were mainly non-tumoral (chronic ulcerative dermatitis, atrial thrombosis). Benign tumors were more frequent than malignant tumors and females were more affected than males. Pituitary gland adenoma in females, lymphoma, bronchioloalveolar adenoma, and harderian gland adenoma in both sexes were the most common tumors. Systemic amyloidosis, the most frequent non-tumoral lesion, was observed variably across studies without sex predilection. The analysis by cohort (3 time periods of 6 years) showed a tendency toward higher incidences of lymphoma and pituitary gland adenoma and lower incidences of amyloidosis over time. The results presented here provide for the first time a robust set of control historical data in untreated C57BL/6J mice kept for 18 months contributing to build in depth knowledge of this animal model.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop. 临床前毒性研究中临床病理结果的识别和传达注意事项：第 9 届 ESTP 国际专家研讨会的成果。

IF 1.5 4区医学

Toxicologic Pathology Pub Date : 2024-04-25 DOI: 10.1177/01926233241245108

Tara Arndt, Monika Keresztes, Blanck Olivier, L. Boone, Franck Chanut, D. Ennulat, Ellen Evans, Alexius Freyberger, S. Johannes, C. F. Kuper, P. Maliver, Peter O'Brien, L. Ramaiah, Ian Roman, Volker Strauss, Petra Vinken, Dana Walker, Michael Winter, G. Pohlmeyer-Esch, Lindsay Tomlinson

{"title":"Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop.","authors":"Tara Arndt, Monika Keresztes, Blanck Olivier, L. Boone, Franck Chanut, D. Ennulat, Ellen Evans, Alexius Freyberger, S. Johannes, C. F. Kuper, P. Maliver, Peter O'Brien, L. Ramaiah, Ian Roman, Volker Strauss, Petra Vinken, Dana Walker, Michael Winter, G. Pohlmeyer-Esch, Lindsay Tomlinson","doi":"10.1177/01926233241245108","DOIUrl":"https://doi.org/10.1177/01926233241245108","url":null,"abstract":"The European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information and opinions discussed and shared at the ninth ESTP International Expert Workshop, April 5 to 6, 2022. In addition to terminology usage, the workshop considered topics related to the identification and conveyance of the importance of test item-related findings. These topics included sources of variability, comparators, statistics, reporting, correlations to other study data, nonstandard biomarkers, indirect/secondary findings, and an overall weight-of-evidence approach.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion. 毒理病理学论坛的观点：冰冷生理盐水灌注后灵长类动物脑部细胞凋亡/单细胞坏死作为一种可能的程序效应。

IF 1.5 4区医学

Toxicologic Pathology Pub Date : 2024-04-25 DOI: 10.1177/01926233241247044

Brad Bolon, Joy M Gary

{"title":"Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion.","authors":"Brad Bolon, Joy M Gary","doi":"10.1177/01926233241247044","DOIUrl":"https://doi.org/10.1177/01926233241247044","url":null,"abstract":"Nonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the cerebral cortex and less often the hippocampus in animals from all groups, including vehicle-treated controls. Affected cells exhibit end-stage features such as cytoplasmic hypereosinophilia, nuclear condensation or fragmentation, and shape distortions, so their lineage(s) generally cannot be defined; classical apoptotic bodies are exceedingly rare. In addition, A/SCN is not accompanied by glial reactions, leukocyte infiltration/inflammation, or other parenchymal changes. The severity is minimal in controls but may be slightly exacerbated (to mild) by TA that accumulate in neural cells. One plausible hypothesis explaining this A/SCN exacerbation is that cold shock (perhaps complicated by concurrent tissue acidity and hypoxia) drives still-viable but TA-stressed cells to launch a self-directed death program. Taken together, these observations indicate that A/SCN in brain processed by cold saline perfusion with delayed immersion fixation represents a procedural artifact and not a TA-related lesion.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poster Abstracts of the 20th Congress of the European Society of Toxicologic Pathology (Basel, Switzerland, 26th - 29th of September 2023, Emerging Therapeutic Modalities) 欧洲毒理学病理学会第 20 届大会（瑞士巴塞尔，2023 年 9 月 26-29 日，新兴治疗模式）海报摘要

IF 1.5 4区医学

Toxicologic Pathology Pub Date : 2024-03-11 DOI: 10.1177/01926233241236845

引用次数: 0

Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats. 尿白蛋白和 KIM-1 变化的幅度可用于区分大鼠肾小球损伤和肾小管损伤

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2024-02-01 Epub Date: 2024-05-14 DOI: 10.1177/01926233241248656

Yi-Zhong Gu, Erina Paul, Katerina Vlasakova, Sean P Troth, Frank D Sistare, Lila Ramaiah, Oliver Potz, Santosh Sutradhar, Warren E Glaab

{"title":"Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats.","authors":"Yi-Zhong Gu, Erina Paul, Katerina Vlasakova, Sean P Troth, Frank D Sistare, Lila Ramaiah, Oliver Potz, Santosh Sutradhar, Warren E Glaab","doi":"10.1177/01926233241248656","DOIUrl":"10.1177/01926233241248656","url":null,"abstract":"Emerging urinary kidney safety biomarkers have been evaluated in recent years and have been shown to be superior to the serum parameters blood urea nitrogen (BUN) and creatinine (sCr) for monitoring kidney injury in the proximal tubule. However, their potential application in differentiating the location of the initial kidney injury (eg, glomerulus vs tubule) has not been fully explored. Here, we assessed the performance of two algorithms that were constructed using either an empirical or a mathematical model to predict the site of kidney injury using a data set consisting of 22 rat kidney toxicity studies with known urine biomarker and histopathologic outcomes. Two kidney safety biomarkers used in both models, kidney injury molecule 1 (KIM-1) and albumin (ALB), were the best performers to differentiate glomerular injury from tubular injury. The performance of algorithms using these two biomarkers against the gold standard of kidney histopathologic examination showed high sensitivity in differentiating the location of the kidney damage to either the glomerulus or the proximal tubules. These data support the exploration of such an approach for use in clinical settings, leveraging urinary biomarker data to aid in the diagnosis of either glomerular or tubular injury where histopathologic assessments are not conducted.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists. 复杂体外模型特征描述在毒理病理学中的应用：生物学家、生物工程师和病理学家合作团队的使用案例。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2024-02-01 Epub Date: 2024-06-18 DOI: 10.1177/01926233241253811

Nadine Stokar-Regenscheit, Luisa Bell, Brian Berridge, Daniel Rudmann, Danilo Tagle, Passley Hargrove-Grimes, Dirk Schaudien, Kerstin Hahn, Julia Kühnlenz, Randolph S Ashton, Min Tseng, Mike Reichelt, Steven T Laing, Tomomi Kiyota, Ronnie Chamanza, Radhakrishna Sura, Lindsay Tomlinson

{"title":"Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists.","authors":"Nadine Stokar-Regenscheit, Luisa Bell, Brian Berridge, Daniel Rudmann, Danilo Tagle, Passley Hargrove-Grimes, Dirk Schaudien, Kerstin Hahn, Julia Kühnlenz, Randolph S Ashton, Min Tseng, Mike Reichelt, Steven T Laing, Tomomi Kiyota, Ronnie Chamanza, Radhakrishna Sura, Lindsay Tomlinson","doi":"10.1177/01926233241253811","DOIUrl":"10.1177/01926233241253811","url":null,"abstract":"Complex in vitro models (CIVMs) offer the potential to increase the clinical relevance of preclinical efficacy and toxicity assessments and reduce the reliance on animals in drug development. The European Society of Toxicologic Pathology (ESTP) and Society for Toxicologic Pathology (STP) are collaborating to highlight the role of pathologists in the development and use of CIVM. Pathologists are trained in comparative animal medicine which enhances their understanding of mechanisms of human and animal diseases, thus allowing them to bridge between animal models and humans. This skill set is important for CIVM development, validation, and data interpretation. Ideally, diverse teams of scientists, including engineers, biologists, pathologists, and others, should collaboratively develop and characterize novel CIVM, and collectively assess their precise use cases (context of use). Implementing a morphological CIVM evaluation should be essential in this process. This requires robust histological technique workflows, image analysis techniques, and needs correlation with translational biomarkers. In this review, we demonstrate how such tissue technologies and analytics support the development and use of CIVM for drug efficacy and safety evaluations. We encourage the scientific community to explore similar options for their projects and to engage with health authorities on the use of CIVM in benefit-risk assessment.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Gliosis in the Central Nervous System of Control Nonhuman Primates and Rats. 控制非人灵长类动物和大鼠中枢神经系统的意外胶质增生

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2024-02-01 Epub Date: 2024-06-03 DOI: 10.1177/01926233241253255

Joy M Gary, Sarah Cramer, Brad Bolon, Alys E Bradley, Mark T Butt

{"title":"Incidental Gliosis in the Central Nervous System of Control Nonhuman Primates and Rats.","authors":"Joy M Gary, Sarah Cramer, Brad Bolon, Alys E Bradley, Mark T Butt","doi":"10.1177/01926233241253255","DOIUrl":"10.1177/01926233241253255","url":null,"abstract":"Gliosis, including microgliosis and astrocytosis, can be challenging to interpret in nonclinical studies. Incidences of glial foci in brains and spinal cords of control rats and nonhuman primates (NHPs) were reviewed in the historical control databases from two contract research organizations, including one specializing in neuropathology. In the brain, minimal to mild (grades 1-2) microgliosis was the most common diagnosis, especially in NHPs, although occasional moderate or marked microgliosis (grades 3 and 4) was encountered in both species. Microgliosis was more common in the cerebral cortex, cerebellum, and medulla oblongata in both species and was frequent in the white matter (brain), thalamus, and basal nuclei of NHPs. Gliosis (\"not otherwise specified\") of minimal severity was diagnosed in similar brain sub-sites for both species and was more common in NHPs compared with rats. Astrocytosis was most prominent in the cerebellum (molecular layer) of NHPs but was otherwise uncommon. In the spinal cord, microgliosis was most common in the lateral white matter tracts in rats and NHPs, and in the dorsal white matter tracts in NHPs. These data indicate that low-grade spontaneous glial responses occur with some frequency in control animals of two common nonclinical species.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0