Toxicologic Pathology最新文献

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2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives. 2024国际毒理学病理学会(IATP)卫星研讨会:神经毒性评估和监管前景的新方法方法(NAMs)。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-15 DOI: 10.1177/01926233251335719
Helena T Hogberg, Ellen Fritsche, Sibylle Gröters, Ramesh C Kovi, Deepa B Rao, Andrea Terron, Matthew J Winter
{"title":"2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives.","authors":"Helena T Hogberg, Ellen Fritsche, Sibylle Gröters, Ramesh C Kovi, Deepa B Rao, Andrea Terron, Matthew J Winter","doi":"10.1177/01926233251335719","DOIUrl":"10.1177/01926233251335719","url":null,"abstract":"<p><p>The International Academy of Toxicologic Pathology (IATP) Satellite Symposium on \"New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives,\" organized in Spain, addressed the growing need for improved assessment of neurotoxicity. Traditional neurotoxicity assessment using in vivo animal studies are impractical for testing the substantial number of environmental chemicals that currently lack data and in the early detection of neuro-related adverse reactions in drug discovery. The NAMs, including human in vitro assays and small model organisms, have been developed for faster and cost-effective assessment of neurotoxic potential. While NAMs offer improved practicality, utility, and valuable mechanistic insights, their integration into regulatory decision-making requires robust scientific validation and technical characterization. Confidence in and regulatory application of NAMs data can be supported by mapping cellular outcomes to neuropathological findings in mammals, including humans, through the Adverse Outcome Pathway (AOP) framework, and the Integrated Approach to Testing and Assessment (IATA). Case studies presented demonstrated the application of NAMs in chemical and drug safety evaluations, focusing on developmental neurotoxicity (DNT), Parkinson's disease, and drug-induced seizures. In conjunction with in vivo toxicology studies, NAMs represent a significant step toward advancing chemical and drug toxicity assessment via hazard identification and drug screening safety assessments.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"305-320"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery. 神经退行性疾病:转化药物发现的发病机制和临床前模型。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-15 DOI: 10.1177/01926233251339105
Laura Fusaro, Dinesh S Bangari, R Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A Youssef, Alok K Sharma
{"title":"Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery.","authors":"Laura Fusaro, Dinesh S Bangari, R Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A Youssef, Alok K Sharma","doi":"10.1177/01926233251339105","DOIUrl":"10.1177/01926233251339105","url":null,"abstract":"<p><p>The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo models to investigate neurodegenerative diseases. Four presentations highlighted various aspects of neurodegenerative diseases including dementia, immune-mediated conditions, and neuromuscular disorders. The session began with an overview of animal models of dementia underscoring their critical role in understanding disease pathogenesis and supporting the development of effective therapeutic drugs. Subsequent presentations investigated immunological self-tolerance in autoimmune neurodegenerative diseases, such as multiple sclerosis and Guillain-Barré syndrome, and the application of in vitro models to study neuromuscular diseases such as amyotrophic lateral sclerosis. The final presentation examined cannabinoid-based therapeutic options for treating neurodegenerative diseases, highlighting their potential in neuroprotection and neurorepair. This session provided valuable insights into the latest research and advancements in neurodegenerative disease modeling and therapy, offering promising directions for improved modeling and therapeutic strategies.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"364-371"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini Review: Spatial Transcriptomics to Decode the Central Nervous System. 小型评论:空间转录组学解码中枢神经系统
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1177/01926233251325204
Benedek Pesti, Xavi Langa, Nadine Kumpesa, Alberto Valdeolivas, Marc Sultan, Sven Rottenberg, Kerstin Hahn
{"title":"Mini Review: Spatial Transcriptomics to Decode the Central Nervous System.","authors":"Benedek Pesti, Xavi Langa, Nadine Kumpesa, Alberto Valdeolivas, Marc Sultan, Sven Rottenberg, Kerstin Hahn","doi":"10.1177/01926233251325204","DOIUrl":"10.1177/01926233251325204","url":null,"abstract":"<p><p>Spatial transcriptomics (ST) is revolutionizing our understanding of the central nervous system (CNS) by providing spatially resolved gene expression data. This mini review explores the impact of ST on CNS research, particularly in neurodegenerative diseases like Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis. We describe two foundational ST methods: sequencing-based and imaging-based. Key studies are reviewed highlighting the power of ST data sets to map transcriptomes to disease-specific histomorphology, elucidate molecular mechanisms of regional and cellular vulnerability, integrate single-cell data with tissue mapping, and reveal receptor-ligand interactions. Despite current challenges like data interpretation and resolution limits, ST holds promise for identifying novel drug targets, evaluating their therapeutic potential, and bridging gaps between animal models and human studies to advance development of CNS-targeting compounds.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"397-402"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myelin Methods: A Mini-Review. 髓磷脂方法:一个小型回顾。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-01-19 DOI: 10.1177/01926233241309332
Brad Bolon, Amber Moser, Elizabeth Chlipala
{"title":"Myelin Methods: A Mini-Review.","authors":"Brad Bolon, Amber Moser, Elizabeth Chlipala","doi":"10.1177/01926233241309332","DOIUrl":"10.1177/01926233241309332","url":null,"abstract":"<p><p>Hematoxylin and eosin (H&E) staining is a suitable approach for detecting substantial structural changes in neural tissues but is less sensitive for identifying subtle alterations to subcellular structures and various chemical constituents, including myelin. Neurohistological methods to better evaluate myelin integrity by light microscopy include acidophilic dyes (eg, eriochrome cyanine R, toluidine blue [used with hard plastic sections]); lipoprotein-binding dyes (eg, Luxol fast blue [LFB], Weil's iron hematoxylin); lipid impregnation with metals (eg, Marchi's, which uses osmium tetroxide for en bloc staining before embedding); and immunohistochemical (IHC) methods to highlight various antigens (eg, myelin basic protein [MBP] and peripheral myelin protein 22 [PMP22]). Some IHC methods reveal enhanced marker expression in damaged myelin (eg, matrix metalloproteinase-9 [MMP9], S100). In neuropathology investigations, H&E is the first-tier screening method, whereas myelin stains (often LFB alone or in combination with dyes that highlight other structural elements) are second-tier procedures performed in combination with other neurohistological procedures to examine neuroaxonal injury and/or glial responses. The choice of myelin method depends on such considerations as cost, institutional preference, the procedure (fixation and embedding medium), and the study objective.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"345-354"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid Hormone Imbalance in Pregnant Rats and its Impact on Neurodevelopment in Pups: A Minireview on Histopathological Endpoints. 妊娠大鼠甲状腺激素失衡及其对幼鼠神经发育的影响:组织病理学终点的综述。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-31 DOI: 10.1177/01926233251335846
Babunilayam Gangadharan, Frédéric Schorsch
{"title":"Thyroid Hormone Imbalance in Pregnant Rats and its Impact on Neurodevelopment in Pups: A Minireview on Histopathological Endpoints.","authors":"Babunilayam Gangadharan, Frédéric Schorsch","doi":"10.1177/01926233251335846","DOIUrl":"10.1177/01926233251335846","url":null,"abstract":"<p><p>Market authorization of a pesticide or biocide in Europe requires the hazard assessment of endocrine-disrupting properties, including the thyroid modality. Substances inducing thyroid histopathological and/or thyroid hormone effects in rodent studies need to be further investigated to rule out whether the substance can be considered as an endocrine disruptor for the thyroid pathway, including neurodevelopmental impact in pups and its relevance in humans. Histopathological assessment for identifying reliable biomarkers for assessing neurodevelopmental effects is an important aspect of this testing scheme in rats. Periventricular heterotopia in the corpus callosum and persistence of the external granular layer in the cerebellum have been proposed as potential histopathological biomarkers in the brain. The correlation in the cochlea for hearing impairment seen in rat pups derived from hypothyroid dams is another potential biomarker. Herein, we provide a brief overview of the histopathological endpoints. The technical challenges in correctly identifying these changes during brain development and their significance in detecting the impact of maternal hypothyroidism in rodents are discussed. This mini review is part of a scientific presentation by Dr Gangadharan during the developmental neurotoxicity (DNT) session at the 21st ESTP's Annual Congress (2024).</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"387-392"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental Neurotoxicity (DNT) Studies for Chemical Safety Assessments: Basic Concepts, Experimental Strategies, and Future Directions. 化学安全评价的发育神经毒性研究:基本概念、实验策略和未来方向。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-31 DOI: 10.1177/01926233251340670
Wolfgang Kaufmann, Frederic Schorsch, Heike Marxfeld, Stephanie Melching-Kollmus, Kathrin Becker, Babunilayam Gangadharan, Sibylle Gröters, Deepa B Rao
{"title":"Developmental Neurotoxicity (DNT) Studies for Chemical Safety Assessments: Basic Concepts, Experimental Strategies, and Future Directions.","authors":"Wolfgang Kaufmann, Frederic Schorsch, Heike Marxfeld, Stephanie Melching-Kollmus, Kathrin Becker, Babunilayam Gangadharan, Sibylle Gröters, Deepa B Rao","doi":"10.1177/01926233251340670","DOIUrl":"10.1177/01926233251340670","url":null,"abstract":"<p><p>The 21st ESTP's (European Society of Toxicology Pathology) Annual Congress (2024) included a 3-hour scientific session on developmental neurotoxicity (DNT) as applied to chemical safety assessments. Key concepts of this session were to provide an introduction to public concerns around this endpoint, a status update on practical aspects of DNT studies, insights into the use of DNT studies within a regulatory context, as well as some pointers on how to evaluate specific parameters. Understanding the biological and technical variability in performing neuropathology examinations (such as morphometric evaluation) is critical during the course of DNT evaluation. Using thyroid hormone disruption as an example, challenges and pitfalls impacting data interpretation were discussed. Results from the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Thyroid Task Force regarding thyroid hormone-related neurodevelopmental toxicity in humans and rodents were presented. Histopathological findings in the brain and potential changes in the cochlea of pups associated with thyroid hormone imbalance in dams during pregnancy were shown. A case presentation from an Extended One-Generation Reproductive Toxicity Study (EOGRTS) showing histopathological findings in the absence of changes with morphometric endpoints was included. In conclusion, all session participants underscored the need for integrated data evaluation for DNT risk assessment.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"372-380"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies. 毒理学病理论坛*:关于表达非临床毒性研究中临床病理终点变化幅度的定性严重性描述符的意见。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-05-31 DOI: 10.1177/01926233251341271
N K Tripathi, L Ramaiah, T Arndt, L Cregar, A O Adedeji, D Meyer, J Whalan, A E Schultze
{"title":"Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies.","authors":"N K Tripathi, L Ramaiah, T Arndt, L Cregar, A O Adedeji, D Meyer, J Whalan, A E Schultze","doi":"10.1177/01926233251341271","DOIUrl":"https://doi.org/10.1177/01926233251341271","url":null,"abstract":"<p><p>Clinical pathology endpoints are routinely assessed in nonclinical toxicity studies and the magnitude of test article-related changes is frequently expressed using quantitative and/or qualitative severity descriptors. Quantitative descriptors (ie, percent or fold change) are easily calculated to express numerical magnitude of a change but may not adequately convey biological relevance. A specific quantitative magnitude may be associated with vastly different levels of pathophysiologic relevance depending on several factors, including the nature of the endpoint, the animal species/strain, and the magnitude and direction of change. Qualitative descriptors (eg, minimal and mild) offer a succinct way to provide additional context to the pathophysiologic relevance but are more challenging to ascribe to a change. The assignment of qualitative descriptors often requires a subjective, comprehensive, and multifaceted approach using various factors in addition to numerical calculation. Because of the subjectivity involved, the qualitative severity descriptor assigned to a specific change may differ among clinical pathology endpoints, species/strain, contributing scientists, and studies/programs. Quantitative and qualitative severity descriptors may provide complementary information and may be used individually or in combination. This opinion piece primarily explains the process and discusses caveats and various factors taken into consideration by clinical pathologists while ascribing qualitative severity descriptors.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"1926233251341271"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies. 毒理学病理学论坛*:对非临床安全性研究中解剖和临床病理数据统计显著性检验结果的解释的意见。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-05-31 DOI: 10.1177/01926233251339113
Lila Ramaiah, Tara Arndt, Gareth Thomas, Norimitsu Shirai, Manu Sebastian, Cory Sims, Steven Bailey
{"title":"Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies.","authors":"Lila Ramaiah, Tara Arndt, Gareth Thomas, Norimitsu Shirai, Manu Sebastian, Cory Sims, Steven Bailey","doi":"10.1177/01926233251339113","DOIUrl":"https://doi.org/10.1177/01926233251339113","url":null,"abstract":"<p><p>Toxicologic pathologists assess large data sets from nonclinical studies to identify treatment-related effects to assist in predicting human safety hazards. Statistical testing can facilitate data interpretation by highlighting group differences that have a low probability of random occurrence based on a pre-determined <i>P</i>-value cut-off (eg, <i>P</i> < .05). While this method has been used in the interpretation of pathology data for decades, the appropriateness of utilizing statistical testing in this way has been challenged. Here, we discuss common statistical pitfalls in the analysis of toxicologic pathology data, with emphasis on clinical pathology, reaffirming that appropriate use of statistical analysis requires an understanding of (1) the parameters assessed; (2) the inherent strengths and weaknesses of the statistical method used; and (3) that appropriate interpretation of pathology data is based on the pathologist's expertise. The presence or absence of statistical significance should not supersede expert judgment but should be one of many tools used to reach a conclusion.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"1926233251339113"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of an Attention-Based Multiple Instance Learning (MIL) With a Visual Transformer Model: Two Weakly Supervised Deep Learning (DL) Algorithms for the Detection of Histopathologic Lesions in the Rat Liver to Distinguish Normal From Abnormal. 基于注意力的多实例学习(MIL)与视觉变形模型的比较:两种弱监督深度学习(DL)算法用于大鼠肝脏组织病理学病变的检测以区分正常与异常。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-05-30 DOI: 10.1177/01926233251339653
Juergen Funk, Gregoire Clement, Matteo Togninalli, Yaniv Cohen, Tom Albrecht, Ruth Sullivan, Josep Arus Pous, Marco Tecilla, Fernando Romero-Palomo, Amadeusz Abramowski, Angelo D'Annunzio, Yun Yvonna Li, Trung Nguyen, Fangyao Hu, Vanessa Schumacher
{"title":"Comparison of an Attention-Based Multiple Instance Learning (MIL) With a Visual Transformer Model: Two Weakly Supervised Deep Learning (DL) Algorithms for the Detection of Histopathologic Lesions in the Rat Liver to Distinguish Normal From Abnormal.","authors":"Juergen Funk, Gregoire Clement, Matteo Togninalli, Yaniv Cohen, Tom Albrecht, Ruth Sullivan, Josep Arus Pous, Marco Tecilla, Fernando Romero-Palomo, Amadeusz Abramowski, Angelo D'Annunzio, Yun Yvonna Li, Trung Nguyen, Fangyao Hu, Vanessa Schumacher","doi":"10.1177/01926233251339653","DOIUrl":"https://doi.org/10.1177/01926233251339653","url":null,"abstract":"<p><p>The histopathologic evaluation of regulatory toxicity studies using artificial intelligence (AI) has the potential to increase study efficiency. For example, AI could initially identify and exclude all organs without histopathologic lesions, allowing pathologists to focus solely on evaluating organs with identified lesions. In this study, whole slide images (WSIs) of liver sections from 58 different rat toxicity studies were collected, along with their corresponding histopathologic lesion diagnoses. Each WSI was labeled as either \"lesion\" or \"no lesion\" based on the presence or absence of reported histopathologic lesions. Multiple instance learning (MIL) approaches, including a transformer variant, were tested to predict lesions within a weakly supervised framework. Both methods achieved acceptable to excellent area under the receiver operating characteristic curve (AUROC) scores. Heatmap overlays were employed to visually assess the MIL model's effectiveness in detecting lesions, confirming the accuracy of targeted areas on the WSIs. In addition, using transfer learning principles, the MIL model initially developed for liver WSIs was adapted to kidney WSIs, demonstrating the model's versatility. This study showcases the application of weakly supervised learning for lesion detection in rat WSIs from toxicity studies, with the potential to significantly enhance the efficiency of the histopathologic evaluation process.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"1926233251339653"},"PeriodicalIF":1.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uveodermatologic Syndrome in a Laboratory Beagle Dog: Histological and Immunohistochemical Features. 实验室比格犬葡萄膜皮肤病综合征:组织学和免疫组织化学特征。
IF 1.4 4区 医学
Toxicologic Pathology Pub Date : 2025-05-15 DOI: 10.1177/01926233251339116
Giulia Tosi, Elisavet Karamanavi, Zuhal Dincer, Michela Levi
{"title":"Uveodermatologic Syndrome in a Laboratory Beagle Dog: Histological and Immunohistochemical Features.","authors":"Giulia Tosi, Elisavet Karamanavi, Zuhal Dincer, Michela Levi","doi":"10.1177/01926233251339116","DOIUrl":"https://doi.org/10.1177/01926233251339116","url":null,"abstract":"<p><p>This brief communication details the clinical, macroscopic, histological, and immunohistochemical features of a spontaneous case of uveodermatologic syndrome (UDS) in a laboratory beagle dog. A bilateral and symmetrical panuveitis, rich in macrophages and T lymphocytes, with distinctive extracellular clumped or phagocytised melanin pigment granules, and Dalen-Fuchs nodules was diagnosed following occurrence of ocular symptoms and subsequent blindness in a female peripubertal 9.5-month-old beagle dog. Although no macroscopic lesions were visible in the skin, microscopic examination revealed a histiocytic and lymphocytic lichenoid dermatitis with pigmentary incontinence. UDS has not been described as a background finding in laboratory beagle dogs before, although it is a well-known immune-mediated disease in certain canine breeds. Knowledge that UDS can occur in laboratory beagle dogs involved in preclinical studies, especially ocular studies, is essential for toxicologic pathologists.</p>","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"1926233251339116"},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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