Toxicologic Pathology最新文献_第3页

Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology. 动物研究中的解释性挑战：案例研究综述及其对毒理学病理学的影响。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-07-01 Epub Date: 2025-03-28 DOI: 10.1177/01926233251322767

Ruba Ibrahim, Abraham Nyska, Susan A Elmore, Molly Boyle, Yuval Ramot

{"title":"Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology.","authors":"Ruba Ibrahim, Abraham Nyska, Susan A Elmore, Molly Boyle, Yuval Ramot","doi":"10.1177/01926233251322767","DOIUrl":"10.1177/01926233251322767","url":null,"abstract":"Toxicologic pathologists play a crucial role in the evaluation of animal studies for drugs, environmental chemicals, medical devices, and other agents to determine their safety and potential toxic effects. A significant challenge in this domain is the differentiation between incidental or procedural changes and genuine treatment-related effects. Correct identification and interpretation of such findings are essential to ensure that safety assessments are accurate and reliable for subsequent approval for human use. This review presents several cases in which non-test item-related findings were encountered. By examining procedure-related findings and considering spontaneous background pathology, we underscore the need for meticulous pathological evaluation and proper contextual understanding to avoid misinterpretations that could lead to erroneous conclusions about a substance's safety profile. The insights shared in this review aim to enhance the proficiency of toxicologic pathologists in recognizing and managing various interpretative challenges, with the goal of ultimately improving the accuracy of toxicological assessments, thereby contributing to the safe development of new therapeutics and medical devices and sound characterization of potentially hazardous substances in our environment.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"440-455"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inaugural Special Issue Celebrating the 21st Annual Congress of the European Society of Toxicologic Pathology. 首期特刊庆祝第21届欧洲毒理学病理学会年会。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1177/01926233251337033

Dinesh S Bangari, Saravanan Kaliyaperumal

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2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: "Medical Device Safety Assessment: Pathology and Toxicology Perspective". 2023 年国际毒理病理学学会 (IATP) 卫星研讨会："医疗设备安全评估：病理学和毒理学视角"。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-02-12 DOI: 10.1177/01926233251316283

Flora Wegener, Antoine Alves, Uta Bussmeyer, Nicole V Soucy

{"title":"2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: \"Medical Device Safety Assessment: Pathology and Toxicology Perspective\".","authors":"Flora Wegener, Antoine Alves, Uta Bussmeyer, Nicole V Soucy","doi":"10.1177/01926233251316283","DOIUrl":"10.1177/01926233251316283","url":null,"abstract":"Medical devices represent a complex category of medicinal products with varying definitions depending on the regional jurisdiction of regulatory agencies. A common aspect of these definitions is that a medical device is intended to be used for specific medicinal purpose where the primary intended action of the device is not achieved through pharmacologic (or other chemical) means. While regional regulatory frameworks for medical devices are different than for pharmaceutical or biological products, medical device manufacturers are required to evaluate the safety and performance of these products in the context of their intended use. In biological safety evaluation, histopathology plays a relevant role in assessing medical device biocompatibility. This manuscript provides a broad overview of biocompatibility assessment with a deeper look at the role of the toxicologic pathologist in assessing innovative and emerging bone therapies. The content of this manuscript is based on individual presentations delivered at the 2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium held in conjunction with the Annual Congress of the European Society of Toxicologic Pathology (ESTP) on 26 September, in Basel, Switzerland.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"405-422"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation. 形式与功能的方丹戈：临床神经病学与神经病理学评估之间的相互作用。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI: 10.1177/01926233251332210

Brad Bolon, Joe N Kornegay

{"title":"A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation.","authors":"Brad Bolon, Joe N Kornegay","doi":"10.1177/01926233251332210","DOIUrl":"10.1177/01926233251332210","url":null,"abstract":"The central (CNS) and peripheral (PNS) nervous systems of vertebrates represent divisions of a continuous, body-wide communication grid based on conserved principles of structural organization. Discrete neuroanatomic regions within this grid are associated with specific neural functions, so distinct patterns of neurological dysfunction (\"problems\") can provide guidance regarding neural regions to evaluate beyond those in published sampling schemes or institutional standard operating procedures. Each neurological problem or syndrome (i.e., a group of in-life signs indicating that a given neuroanatomic region is damaged) is associated with a particular list of differential diagnoses and causes. Vulnerability of neural cells and tissues is influenced by intrinsic tissue properties (e.g., high metabolic rates of neurons, presence of blood:tissue barriers, degree of collateral vascular supply) and extrinsic factors (bone protuberances and connective tissue partitions impinging on neural surfaces, fluid flow patterns in the cerebroventricular system and meninges, etc.). In the toxicologic pathology setting, expansion (when warranted) of routine neural sampling protocols to collect additional anatomic regions correlated to a specific neurological problem improves the likelihood that a neuropathological evaluation will identify lesions and causes responsible for neurological conditions as well as detect findings related to potential test item-related neurotoxicity.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"321-344"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromethods: Basic Techniques for Evaluating the Nervous System in Nonclinical Studies. 神经方法：在非临床研究中评估神经系统的基本技术。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-31 DOI: 10.1177/01926233251335326

Deepa B Rao, Xavier Palazzi, Alexandra Duetting, Ann Kathrin Haverkamp, Annette Romeike, Kristel Kegler, Klaus Weber, Brad Bolon, Amber Moser, Elizabeth Chlipala, Stefanie Arms, Enrico Vezzali, Erio Barale-Thomas, Jogile Kuklyte, Laoise Lord Bissett, Alok K Sharma, Ingrid D Pardo

{"title":"Neuromethods: Basic Techniques for Evaluating the Nervous System in Nonclinical Studies.","authors":"Deepa B Rao, Xavier Palazzi, Alexandra Duetting, Ann Kathrin Haverkamp, Annette Romeike, Kristel Kegler, Klaus Weber, Brad Bolon, Amber Moser, Elizabeth Chlipala, Stefanie Arms, Enrico Vezzali, Erio Barale-Thomas, Jogile Kuklyte, Laoise Lord Bissett, Alok K Sharma, Ingrid D Pardo","doi":"10.1177/01926233251335326","DOIUrl":"10.1177/01926233251335326","url":null,"abstract":"The first session of the 2025 European Society of Toxicologic Pathology (ESTP) Congress reviewed routine and specialized methods for microscopic evaluation of neural tissues during nonclinical studies. Three longer presentations reviewed brain sampling approaches in safety assessments, including an example to accentuate topographical analysis and integration of toxicology data; specific brain and spinal cord sampling for molecular and protein analyses; and an overview of technical aspects of intraparenchymal drug delivery. Four shorter talks discussed the uses, advantages, disadvantages, and interpretation of several special neurohistological techniques (stains and immunohistochemical markers) for assessing test item-associated responses. Common special methods used (when warranted) for nonclinical studies include Fluoro-Jade or silver stains for detecting neuronal death, Luxol fast blue (LFB) for examining myelin, anti-glial fibrillary acidic protein (GFAP) to demonstrate reactive astrocytes, and anti-ionized calcium-binding adaptor molecule 1 (IBA1) to highlight reactive microglia and macrophages, though alternatives methods were described. The last presentation discussed artificial intelligence as an aid in detecting subtle toxicant-induced lesions during digital pathology analyses (using the Olney lesion [acute neuronal vacuolation and necrosis in the cerebral cortex] as an example). Taken together, talks in this session provided a cohesive overview of traditional and innovative approaches to facilitate microscopic evaluation for potential neurotoxicity in nonclinical studies.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"355-363"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Basal Nuclei Vacuolar Lesions: A Novel and Emerging Potential Background Finding in Beagle Dogs. 双侧基底核空泡病变：在比格犬中发现的一种新的潜在背景。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1177/01926233251335320

Stefanie Arms, Stephen D Cahalan, Felix Goulet, Katja Hempel, Giovanni Pellegrini, Sophie Rau, Julia Schlichtiger, Thomas Nolte

引用次数: 0

Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies. 2023年法国毒理学病理学会（SFPT）关于基于mrna的技术的临床前开发和治疗应用的年度科学会议论文集。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1177/01926233251326089

Pierluigi Fant, Sébastien Laurent, Paul Desert, Behazine Combadière, Xavier Palazzi, Shambhunath Choudhary, Frédéric Gervais, Karine Broudic, Roberta Rossi, Béatrice E Gauthier

引用次数: 0

Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies. 神经生物标志物：基本方面及其在非临床研究中的相关性。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1177/01926233251335849

Andrea Greiter-Wilke, Nicolau Beckmann, Warren E Glaab, Diethilde J Theil, Ingrid D Pardo

{"title":"Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies.","authors":"Andrea Greiter-Wilke, Nicolau Beckmann, Warren E Glaab, Diethilde J Theil, Ingrid D Pardo","doi":"10.1177/01926233251335849","DOIUrl":"10.1177/01926233251335849","url":null,"abstract":"The second session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress highlighted the significance of neural biomarkers and functional endpoints in nonclinical studies for detecting acute or delayed peripheral (PNS) and central nervous system (CNS) alterations and /or injury caused by drugs during development. The session emphasized the potential clinical translation of these biomarkers and endpoints and critical role of pathologists in correlating these biomarkers with the microscopic findings. Key neural biomarkers discussed included fluid-based biomarkers such as Neurofilament Light Chain (NF-L), Nonspecific Enolase (NSE), Tubulin Associated Unit (TAU), and Glial Fibrillar Associated Protein (GFAP) in blood and/or cerebrospinal fluid (CSF). These were evaluated in 15 in-vivo studies conducted with CNS and PNS toxicants. Safety pharmacology evaluation, such as the Irwin screen/the functional observation battery (FOB), were presented for detecting drug effects on behavior, motor and sensory functions in both rodents and nonrodent species, with or without histopathological correlate. Follow-up tests like nerve conduction velocity assessment were also highlighted. The session underscored the usefulness of noninvasive imaging modalities, including magnetic resonance imaging (MRI), nuclear imaging techniques, X-ray computed tomography, and ultrasound in preclinical studies. Overall, integrating neural biomarkers, safety pharmacology endpoints, advanced imaging modalities, and detailed histopathological analysis aids in better predicting neurotoxicity.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"381-386"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Neuropathology Concepts. 近期神经病理学概念。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-03-13 DOI: 10.1177/01926233251320056

Pierre Maliver, Julie Boisclair, Ingrid Pardo, Luisa Bell, Kerstin Hahn, Benedek Pesti, Stefanie Arms, Elizabeth Galbreath

引用次数: 0

Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery. 神经退行性疾病：转化药物发现的发病机制和临床前模型。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-15 DOI: 10.1177/01926233251339105

Laura Fusaro, Dinesh S Bangari, R Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A Youssef, Alok K Sharma

{"title":"Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery.","authors":"Laura Fusaro, Dinesh S Bangari, R Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A Youssef, Alok K Sharma","doi":"10.1177/01926233251339105","DOIUrl":"10.1177/01926233251339105","url":null,"abstract":"The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo models to investigate neurodegenerative diseases. Four presentations highlighted various aspects of neurodegenerative diseases including dementia, immune-mediated conditions, and neuromuscular disorders. The session began with an overview of animal models of dementia underscoring their critical role in understanding disease pathogenesis and supporting the development of effective therapeutic drugs. Subsequent presentations investigated immunological self-tolerance in autoimmune neurodegenerative diseases, such as multiple sclerosis and Guillain-Barré syndrome, and the application of in vitro models to study neuromuscular diseases such as amyotrophic lateral sclerosis. The final presentation examined cannabinoid-based therapeutic options for treating neurodegenerative diseases, highlighting their potential in neuroprotection and neurorepair. This session provided valuable insights into the latest research and advancements in neurodegenerative disease modeling and therapy, offering promising directions for improved modeling and therapeutic strategies.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"364-371"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0