Toxicologic Pathology最新文献

Deep Learning Methodology for Quantification of Normal Pancreas Structures. 用于定量正常胰腺结构的深度学习方法。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-16 DOI: 10.1177/01926233251341824

Zhiyong Xie, Stephane Thibault, Norimitsu Shirai, Yutian Zhan, Lindsay Tomlinson

引用次数: 0

Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology-The Current State, Challenges, and Future Directions. 数字病理学和人工智能在非临床毒理学病理学中的应用——现状、挑战和未来方向。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-03 DOI: 10.1177/01926233251340622

Gabriele Pohlmeyer-Esch, Charles Halsey, Julie Boisclair, Sripad Ram, Sarah Kirschner-Kitz, Brian Knight, Pierre Moulin, Anna-Lena Frisk

{"title":"Digital Pathology and Artificial Intelligence Applied to Nonclinical Toxicology Pathology-The Current State, Challenges, and Future Directions.","authors":"Gabriele Pohlmeyer-Esch, Charles Halsey, Julie Boisclair, Sripad Ram, Sarah Kirschner-Kitz, Brian Knight, Pierre Moulin, Anna-Lena Frisk","doi":"10.1177/01926233251340622","DOIUrl":"https://doi.org/10.1177/01926233251340622","url":null,"abstract":"Advancements in digital pathology and artificial intelligence (AI) have enormous transformative potential for nonclinical toxicologic pathology and are already changing the ways in which pathologists work. However, due to the rapid evolution of digital pathology and AI, the toxicologic pathology community would benefit from an update on these advancements, which can be used to aid drug development. Here we identify key articles published on the use of digital pathology and AI in the field and provide current regulatory statuses and guidelines. For digital pathology, we outline the requirements for equipment, validation processes, workflows, and archiving. Challenges to achieve system interoperability and to establish harmonization through Digital Imaging and Communications in Medicine compatibility are also discussed. For AI, we highlight considerations for model development, including the determination of ground truth, problems that may arise due to bias, and how the accuracy and precision of AI algorithms can be assessed. Finally, we discuss the challenges and potential for AI-assisted toxicologic pathology, picturing a future where technology and scientific expertise work hand-in-hand to improve the quality and efficiency of nonclinical drug safety evaluation. This publication is a deliverable of the European Innovative Medicines Initiative 2 Joint Undertaking, \"Bigpicture.\"","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"1926233251340622"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inaugural Special Issue Celebrating the 21st Annual Congress of the European Society of Toxicologic Pathology. 首期特刊庆祝第21届欧洲毒理学病理学会年会。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1177/01926233251337033

Dinesh S Bangari, Saravanan Kaliyaperumal

引用次数: 0

2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: "Medical Device Safety Assessment: Pathology and Toxicology Perspective". 2023 年国际毒理病理学学会 (IATP) 卫星研讨会："医疗设备安全评估：病理学和毒理学视角"。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-02-12 DOI: 10.1177/01926233251316283

Flora Wegener, Antoine Alves, Uta Bussmeyer, Nicole V Soucy

{"title":"2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: \"Medical Device Safety Assessment: Pathology and Toxicology Perspective\".","authors":"Flora Wegener, Antoine Alves, Uta Bussmeyer, Nicole V Soucy","doi":"10.1177/01926233251316283","DOIUrl":"10.1177/01926233251316283","url":null,"abstract":"Medical devices represent a complex category of medicinal products with varying definitions depending on the regional jurisdiction of regulatory agencies. A common aspect of these definitions is that a medical device is intended to be used for specific medicinal purpose where the primary intended action of the device is not achieved through pharmacologic (or other chemical) means. While regional regulatory frameworks for medical devices are different than for pharmaceutical or biological products, medical device manufacturers are required to evaluate the safety and performance of these products in the context of their intended use. In biological safety evaluation, histopathology plays a relevant role in assessing medical device biocompatibility. This manuscript provides a broad overview of biocompatibility assessment with a deeper look at the role of the toxicologic pathologist in assessing innovative and emerging bone therapies. The content of this manuscript is based on individual presentations delivered at the 2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium held in conjunction with the Annual Congress of the European Society of Toxicologic Pathology (ESTP) on 26 September, in Basel, Switzerland.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"405-422"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation. 形式与功能的方丹戈：临床神经病学与神经病理学评估之间的相互作用。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI: 10.1177/01926233251332210

Brad Bolon, Joe N Kornegay

{"title":"A Fandango of Form and Function: The Interplay Between Clinical Neurology and Neuropathology Evaluation.","authors":"Brad Bolon, Joe N Kornegay","doi":"10.1177/01926233251332210","DOIUrl":"10.1177/01926233251332210","url":null,"abstract":"The central (CNS) and peripheral (PNS) nervous systems of vertebrates represent divisions of a continuous, body-wide communication grid based on conserved principles of structural organization. Discrete neuroanatomic regions within this grid are associated with specific neural functions, so distinct patterns of neurological dysfunction (\"problems\") can provide guidance regarding neural regions to evaluate beyond those in published sampling schemes or institutional standard operating procedures. Each neurological problem or syndrome (i.e., a group of in-life signs indicating that a given neuroanatomic region is damaged) is associated with a particular list of differential diagnoses and causes. Vulnerability of neural cells and tissues is influenced by intrinsic tissue properties (e.g., high metabolic rates of neurons, presence of blood:tissue barriers, degree of collateral vascular supply) and extrinsic factors (bone protuberances and connective tissue partitions impinging on neural surfaces, fluid flow patterns in the cerebroventricular system and meninges, etc.). In the toxicologic pathology setting, expansion (when warranted) of routine neural sampling protocols to collect additional anatomic regions correlated to a specific neurological problem improves the likelihood that a neuropathological evaluation will identify lesions and causes responsible for neurological conditions as well as detect findings related to potential test item-related neurotoxicity.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"321-344"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromethods: Basic Techniques for Evaluating the Nervous System in Nonclinical Studies. 神经方法：在非临床研究中评估神经系统的基本技术。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-31 DOI: 10.1177/01926233251335326

Deepa B Rao, Xavier Palazzi, Alexandra Duetting, Ann Kathrin Haverkamp, Annette Romeike, Kristel Kegler, Klaus Weber, Brad Bolon, Amber Moser, Elizabeth Chlipala, Stefanie Arms, Enrico Vezzali, Erio Barale-Thomas, Jogile Kuklyte, Laoise Lord Bissett, Alok K Sharma, Ingrid D Pardo

{"title":"Neuromethods: Basic Techniques for Evaluating the Nervous System in Nonclinical Studies.","authors":"Deepa B Rao, Xavier Palazzi, Alexandra Duetting, Ann Kathrin Haverkamp, Annette Romeike, Kristel Kegler, Klaus Weber, Brad Bolon, Amber Moser, Elizabeth Chlipala, Stefanie Arms, Enrico Vezzali, Erio Barale-Thomas, Jogile Kuklyte, Laoise Lord Bissett, Alok K Sharma, Ingrid D Pardo","doi":"10.1177/01926233251335326","DOIUrl":"10.1177/01926233251335326","url":null,"abstract":"The first session of the 2025 European Society of Toxicologic Pathology (ESTP) Congress reviewed routine and specialized methods for microscopic evaluation of neural tissues during nonclinical studies. Three longer presentations reviewed brain sampling approaches in safety assessments, including an example to accentuate topographical analysis and integration of toxicology data; specific brain and spinal cord sampling for molecular and protein analyses; and an overview of technical aspects of intraparenchymal drug delivery. Four shorter talks discussed the uses, advantages, disadvantages, and interpretation of several special neurohistological techniques (stains and immunohistochemical markers) for assessing test item-associated responses. Common special methods used (when warranted) for nonclinical studies include Fluoro-Jade or silver stains for detecting neuronal death, Luxol fast blue (LFB) for examining myelin, anti-glial fibrillary acidic protein (GFAP) to demonstrate reactive astrocytes, and anti-ionized calcium-binding adaptor molecule 1 (IBA1) to highlight reactive microglia and macrophages, though alternatives methods were described. The last presentation discussed artificial intelligence as an aid in detecting subtle toxicant-induced lesions during digital pathology analyses (using the Olney lesion [acute neuronal vacuolation and necrosis in the cerebral cortex] as an example). Taken together, talks in this session provided a cohesive overview of traditional and innovative approaches to facilitate microscopic evaluation for potential neurotoxicity in nonclinical studies.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"355-363"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Basal Nuclei Vacuolar Lesions: A Novel and Emerging Potential Background Finding in Beagle Dogs. 双侧基底核空泡病变：在比格犬中发现的一种新的潜在背景。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1177/01926233251335320

Stefanie Arms, Stephen D Cahalan, Felix Goulet, Katja Hempel, Giovanni Pellegrini, Sophie Rau, Julia Schlichtiger, Thomas Nolte

引用次数: 0

Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies. 2023年法国毒理学病理学会（SFPT）关于基于mrna的技术的临床前开发和治疗应用的年度科学会议论文集。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1177/01926233251326089

Pierluigi Fant, Sébastien Laurent, Paul Desert, Behazine Combadière, Xavier Palazzi, Shambhunath Choudhary, Frédéric Gervais, Karine Broudic, Roberta Rossi, Béatrice E Gauthier

引用次数: 0

Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies. 神经生物标志物：基本方面及其在非临床研究中的相关性。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1177/01926233251335849

Andrea Greiter-Wilke, Nicolau Beckmann, Warren E Glaab, Diethilde J Theil, Ingrid D Pardo

{"title":"Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies.","authors":"Andrea Greiter-Wilke, Nicolau Beckmann, Warren E Glaab, Diethilde J Theil, Ingrid D Pardo","doi":"10.1177/01926233251335849","DOIUrl":"10.1177/01926233251335849","url":null,"abstract":"The second session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress highlighted the significance of neural biomarkers and functional endpoints in nonclinical studies for detecting acute or delayed peripheral (PNS) and central nervous system (CNS) alterations and /or injury caused by drugs during development. The session emphasized the potential clinical translation of these biomarkers and endpoints and critical role of pathologists in correlating these biomarkers with the microscopic findings. Key neural biomarkers discussed included fluid-based biomarkers such as Neurofilament Light Chain (NF-L), Nonspecific Enolase (NSE), Tubulin Associated Unit (TAU), and Glial Fibrillar Associated Protein (GFAP) in blood and/or cerebrospinal fluid (CSF). These were evaluated in 15 in-vivo studies conducted with CNS and PNS toxicants. Safety pharmacology evaluation, such as the Irwin screen/the functional observation battery (FOB), were presented for detecting drug effects on behavior, motor and sensory functions in both rodents and nonrodent species, with or without histopathological correlate. Follow-up tests like nerve conduction velocity assessment were also highlighted. The session underscored the usefulness of noninvasive imaging modalities, including magnetic resonance imaging (MRI), nuclear imaging techniques, X-ray computed tomography, and ultrasound in preclinical studies. Overall, integrating neural biomarkers, safety pharmacology endpoints, advanced imaging modalities, and detailed histopathological analysis aids in better predicting neurotoxicity.","PeriodicalId":23113,"journal":{"name":"Toxicologic Pathology","volume":" ","pages":"381-386"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Neuropathology Concepts. 近期神经病理学概念。

IF 1.4 4区医学

Toxicologic Pathology Pub Date : 2025-06-01 Epub Date: 2025-03-13 DOI: 10.1177/01926233251320056

Pierre Maliver, Julie Boisclair, Ingrid Pardo, Luisa Bell, Kerstin Hahn, Benedek Pesti, Stefanie Arms, Elizabeth Galbreath

引用次数: 0