Tissue antigens最新文献_第4页

New insights into the genetics of immune responses in rheumatoid arthritis. 类风湿关节炎免疫反应遗传学的新见解。

Tissue antigens Pub Date : 2012-08-01 DOI: 10.1111/j.1399-0039.2012.01939.x

A Ruyssen-Witrand, A Constantin, A Cambon-Thomsen, M Thomsen

{"title":"New insights into the genetics of immune responses in rheumatoid arthritis.","authors":"A Ruyssen-Witrand, A Constantin, A Cambon-Thomsen, M Thomsen","doi":"10.1111/j.1399-0039.2012.01939.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01939.x","url":null,"abstract":"Rheumatoid arthritis (RA) is a common autoimmune disease with a strong genetic component. Numerous aberrant immune responses have been described during the evolution of the disease. In later years, the appearance of anti-citrullinated protein antibodies (ACPAs) has become a hallmark for the diagnosis and prognosis of RA. The post-translational transformation of arginine residues of proteins and peptides into citrulline (citrullination) is a natural process in the body, but for unknown reasons autoreactivity towards citrullinated residues may develop in disposed individuals. ACPAs are often found years before clinical manifestations. ACPAs are present in about 70% of RA patients and constitute an important disease marker, distinguishing patient groups with different prognoses and different responses to various treatments. Inside the human leukocyte antigen (HLA) region, some HLA-DRB1 alleles are strongly associated with their production. Genome-wide association studies in large patient cohorts have defined a great number of single nucleotide polymorphisms (SNPs) outside of the HLA region that are associated with ACPA positive (ACPA+) RA. The SNPs are generally located close to or within genes involved in the immune response or signal transduction in immune cells. Some environmental factors such as tobacco smoking are also positively correlated with ACPA production. In this review, we will describe the genes and loci associated with ACPA+ RA or ACPA- RA and attempt to clarify their potential role in the development of the disease.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 2","pages":"105-18"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01939.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30791386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

HapMap SNP Scanner: an online program to mine SNPs responsible for cell phenotype. HapMap SNP扫描器:一个在线程序，以挖掘负责细胞表型的SNP。

Tissue antigens Pub Date : 2012-08-01 Epub Date: 2012-05-08 DOI: 10.1111/j.1399-0039.2012.01883.x

T Yamamura, J Hikita, M Bleakley, T Hirosawa, A Sato-Otsubo, H Torikai, T Hamajima, Y Nannya, A Demachi-Okamura, E Maruya, H Saji, Y Yamamoto, T Takahashi, N Emi, Y Morishima, Y Kodera, K Kuzushima, S R Riddell, S Ogawa, Y Akatsuka

{"title":"HapMap SNP Scanner: an online program to mine SNPs responsible for cell phenotype.","authors":"T Yamamura, J Hikita, M Bleakley, T Hirosawa, A Sato-Otsubo, H Torikai, T Hamajima, Y Nannya, A Demachi-Okamura, E Maruya, H Saji, Y Yamamoto, T Takahashi, N Emi, Y Morishima, Y Kodera, K Kuzushima, S R Riddell, S Ogawa, Y Akatsuka","doi":"10.1111/j.1399-0039.2012.01883.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01883.x","url":null,"abstract":"Minor histocompatibility (H) antigens are targets of graft-vs-host disease and graft-vs-tumor responses after human leukocyte antigen matched allogeneic hematopoietic stem cell transplantation. Recently, we reported a strategy for genetic mapping of linkage disequilibrium blocks that encoded novel minor H antigens using the large dataset from the International HapMap Project combined with conventional immunologic assays to assess recognition of HapMap B-lymphoid cell line by minor H antigen-specific T cells. In this study, we have constructed and provide an online interactive program and demonstrate its utility for searching for single-nucleotide polymorphisms (SNPs) responsible for minor H antigen generation. The website is available as 'HapMap SNP Scanner', and can incorporate T-cell recognition and other data with genotyping datasets from CEU, JPT, CHB, and YRI to provide a list of candidate SNPs that correlate with observed phenotypes. This method should substantially facilitate discovery of novel SNPs responsible for minor H antigens and be applicable for assaying of other specific cell phenotypes (e.g. drug sensitivity) to identify individuals who may benefit from SNP-based customized therapies.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 2","pages":"119-25"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01883.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30603098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

In vitro up-regulation of HLA-G using dexamethasone and hydrocortisone in first-trimester trophoblast cells of women experiencing recurrent miscarriage. 地塞米松和氢化可的松对妊娠早期复发性流产妇女滋养细胞HLA-G的体外上调作用。

Tissue antigens Pub Date : 2012-08-01 Epub Date: 2012-05-04 DOI: 10.1111/j.1399-0039.2012.01884.x

A Akhter, R M Faridi, V Das, A Pandey, S Naik, S Agrawal

{"title":"In vitro up-regulation of HLA-G using dexamethasone and hydrocortisone in first-trimester trophoblast cells of women experiencing recurrent miscarriage.","authors":"A Akhter, R M Faridi, V Das, A Pandey, S Naik, S Agrawal","doi":"10.1111/j.1399-0039.2012.01884.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01884.x","url":null,"abstract":"The trophoblast cells at the maternal-fetal interface express an unusual combination of human leukocyte antigen (HLA)-C, HLA-E and HLA-G. Altered expression of HLA-G on the extravillous cytotrophoblast has been implicated in the etiology of recurrent miscarriages (RMs). We have assessed HLA-G expression in extravillous cytotrophoblast in cell cultures prepared from RM patients and compared with those of first-trimester voluntarily terminated normal pregnancies (control). Glucocorticoids, dexamethasone and hydrocortisone were examined for their role in modulation of the HLA-G expression. HLA-G promoter and 3'UTR variants were investigated for their effect on the transcription of HLA-G. Cultured cytotrophoblast cells from the first-trimester RM patients were treated with dexamethasone and hydrocortisone (dose concentration 0-1000 ng/ml). HLA-G gene transcription was determined by semiquantitative and quantitative real-time polymerase chain reaction (RT-PCR), while protein expression was determined by a specific enzyme-linked immunosorbent assay (ELISA), flow cytometry and western blot analyses. HLA-G polymorphisms were detected by PCR and/or sequence-based typing. Low level of HLA-G was observed in untreated trophoblast cells obtained from RM patients as compared with controls. Upon treatment with glucocorticoids, the expression of HLA-G in these cells was up-regulated in a dose-dependent manner (P < 0.05), with no change in cellular proliferation and viability. There was no significant association between HLA-G polymorphism in RM patients and controls. HLA-G is minimally expressed in cultured trophoblast cells of RM patients. It can be up-regulated upon exposure with both dexamethasone and hydrocortisone. Glucocorticoids have the potential to modulate HLA-G expression in vitro, and can be further examined for their therapeutic applicability in RM.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 2","pages":"126-35"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01884.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30599532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

High resolution analysis of renal allograft rejection: HLA class I specific antibodies 肾移植排斥反应的高分辨率分析:HLA I类特异性抗体

Tissue antigens Pub Date : 2011-05-01 DOI: 10.1111/J.1399-0039.2011.01671.X

R. Vaughan, P. Mobillo, R. Collins, J. Theron, Emma Lougee, M. H. Fuentes, O. Shaw, I. Rebollo-Mesa

引用次数: 1

Full length sequence of a novel HLA-B*132202 allele. HLA-B*132202等位基因的全序列分析。

Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-09-02 DOI: 10.1111/j.1399-0039.2009.01355.x

H-Y Zou, L-H Cheng, Z Li, S-Z Jin

引用次数: 3

Full-length sequence of a novel allele, HLA-Cw*070205. 新等位基因HLA-Cw*070205的全序列分析。

Tissue antigens Pub Date : 2009-11-01 Epub Date: 2009-09-08 DOI: 10.1111/j.1399-0039.2009.01349.x

H-Y Zou, S-Z Jin, Z Li, L-H Cheng

引用次数: 4

Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. 芬兰和匈牙利人群染色体5q31-q33上CELIAC2位点的精细定位。

Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01359.x

L L E Koskinen, E Einarsdottir, I R Korponay-Szabo, K Kurppa, K Kaukinen, P Sistonen, Z Pocsai, G Széles, R Adány, M Mäki, J Kere, P Saavalainen

{"title":"Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.","authors":"L L E Koskinen, E Einarsdottir, I R Korponay-Szabo, K Kurppa, K Kaukinen, P Sistonen, Z Pocsai, G Széles, R Adány, M Mäki, J Kere, P Saavalainen","doi":"10.1111/j.1399-0039.2009.01359.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2009.01359.x","url":null,"abstract":"Celiac disease is a chronic inflammation of the small intestine, arising in genetically predisposed individuals as a result of ingestion of dietary gluten. The only confirmed and functionally characterised genetic risk factors for celiac disease are the DQ2 or DQ8 heterodimers at the major histocompatibility complex (MHC) class II locus (CELIAC1). These genes are necessary but alone not sufficient for disease onset. Genome-wide linkage scans have suggested chromosome 5q31-q33 (CELIAC2) as an important risk locus for celiac disease. This region has also been associated to other inflammatory disorders, although as yet, no clear gene associations have been found. In the current study, 11 celiac disease candidate loci were screened for genetic linkage in the Hungarian population. As the CELIAC2 locus showed the strongest evidence for linkage, this locus was selected for follow-up. Seventeen candidate genes were selected from the CELIAC2 locus, and genotyped using 48 haplotype tagging single nucleotide polymorphisms (SNPs) in large Finnish and Hungarian family materials. A subset of these, 40 tagging SNPs in 15 genes, were genotyped in an independent set of Finnish and Hungarian cases and controls. We confirmed linkage of this region with celiac disease and report strong linkage in both the Finnish and Hungarian populations. The association analysis showed modest associations throughout the whole region. These association findings were not replicated in the case-control datasets. Our study strongly supports the role of the CELIAC2 locus in celiac disease, but it also highlights the need for a more powerful study design in the region, to locate the true disease risk variants.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"74 5","pages":"408-16"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2009.01359.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28449419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

A novel HLA-B*54 allele, B*5417, identified in a Northern Chinese Han individual. 一种新的HLA-B*54等位基因B*5417在中国北方汉族个体中得到鉴定。

Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01341.x

L-H Cheng, W-G Zhu, Y-X Lan, H-Y Zou, Z Li, S-Z Jin

引用次数: 3

A novel HLA-B allele, B*4096 was identified by sequence-based typing in a Chinese individual. 利用序列分型方法，在中国人中鉴定出一种新的HLA-B等位基因B*4096。

Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01339.x

Y Zhang, H-X Lu, Y Liu, C-F Zhu

引用次数: 4

The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related. 预测的DRB1*0717蛋白结构与DRB1*0701蛋白结构高度相关。

Tissue antigens Pub Date : 2009-11-01 DOI: 10.1111/j.1399-0039.2009.01348.x

M Wurm, S Tischer, S Immenschuh, R Blasczyk, B Eiz-Vesper

引用次数: 3