M Wurm, S Tischer, S Immenschuh, R Blasczyk, B Eiz-Vesper
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The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related.
This article describes the identification of the novel human leukocyte antigen (HLA) allele DRB1*07 7 that was detected in a potential stem-cell donor of Caucasian origin. Compared to DRB1*070101, the new allele is characterized by a nonsynonymous nucleotide exchange of C-->T at position 201 in exon 2 replacing Arg by Trp in codon 72. As this sequence variation has not been seen earlier in any other HLA-DRB allele, it is most probably the result of a point mutation.
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