Tissue antigens最新文献_第3页

Major histocompatibility complex class I chain related gene-A microsatellite polymorphism shows secondary association with type 1 diabetes and celiac disease in North Indians. 主要组织相容性复合体I类链相关基因- a微卫星多态性与北印度人1型糖尿病和乳糜泻的继发性关联

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-07-26 DOI: 10.1111/j.1399-0039.2012.01931.x

N Kumar, G Sharma, G Kaur, N Tandon, S Bhatnagar, N Mehra

引用次数: 22

HLA-DQ association and allele competition in Chinese narcolepsy. 中国嗜睡症患者HLA-DQ相关性及等位基因竞争。

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-08-04 DOI: 10.1111/j.1399-0039.2012.01948.x

F Han, L Lin, J Li, S X Dong, P An, L Zhao, N Y Liu, Q Y Li, H Yan, Z C Gao, J Faraco, K P Strohl, X Liu, H Miyadera, E Mignot

{"title":"HLA-DQ association and allele competition in Chinese narcolepsy.","authors":"F Han, L Lin, J Li, S X Dong, P An, L Zhao, N Y Liu, Q Y Li, H Yan, Z C Gao, J Faraco, K P Strohl, X Liu, H Miyadera, E Mignot","doi":"10.1111/j.1399-0039.2012.01948.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01948.x","url":null,"abstract":"In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype. Studies in African-Americans suggest a primary effect of DQB1*06:02, but this observation has been difficult to confirm in other populations because of high linkage disequilibrium between DRB1*15:01/3 and DQB1*06:02 in most populations. In this study, we studied human leucocyte antigen (HLA) class II in 202 Chinese narcolepsy patients (11% from South China) and found all patients to be DQB1*06:02 positive. Comparing cases with 103 unselected controls, and 110 and 79 controls selected for the presence of DQB1*06:02 and DRB1*15:01, we found that the presence of DQB1*06:02 and not DRB1*15:01 was associated with narcolepsy. In particular, Southern Chinese haplotypes such as the DRB1*15:01-DQA1*01:02-DQB1*06:01 and DRB1*15:01-DQA1*01:02-DQB1*05 were not associated with narcolepsy. As reported in Japanese, Koreans, African-Americans and Caucasians, additional protective effects of DQA1*01 (non-DQA1*01:02) and susceptibility effects of DQB1*03:01 were observed. These results illustrate the extraordinary conservation of HLA class II effects in narcolepsy across populations and show that DRB1*15:01 has no effect on narcolepsy susceptibility in the absence of DQB1*06:02. The results are also in line with a previously proposed 'HLA-DQ allelic competition model' that involves competition between non-DQA1*01:02, non-DQB1*06:02 'competent' (able to dimerize together) DQ1 alleles and the major DQα*01:02/ DQβ*06:02 narcolepsy heterodimer to reduce susceptibility.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 4","pages":"328-35"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01948.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30810265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Killer immunoglobulin-like receptors (KIR) and their HLA-ligands in Italian paroxysmal nocturnal haemoglobinuria (PNH) patients. 意大利阵发性夜间血红蛋白尿(PNH)患者的杀伤免疫球蛋白样受体(KIR)及其hla配体

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-07-17 DOI: 10.1111/j.1399-0039.2012.01932.x

E Cosentini, L Gargiulo, P Bruno, S Lastraioli, A Risitano, R Camerlingo, V Luongo, M Serra, M Sica, C Garzillo, U Giani, R Notaro, F Alfinito, G Ruggiero, G Terrazzano

{"title":"Killer immunoglobulin-like receptors (KIR) and their HLA-ligands in Italian paroxysmal nocturnal haemoglobinuria (PNH) patients.","authors":"E Cosentini, L Gargiulo, P Bruno, S Lastraioli, A Risitano, R Camerlingo, V Luongo, M Serra, M Sica, C Garzillo, U Giani, R Notaro, F Alfinito, G Ruggiero, G Terrazzano","doi":"10.1111/j.1399-0039.2012.01932.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01932.x","url":null,"abstract":"Paroxysmal nocturnal haemoglobinuria (PNH) is a haematopoietic disorder characterized by expansion of phosphatidylinositol glycan-A-defective progenitor(s). Immune-dependent mechanisms, likely involving a deranged T cell-dependent autoimmune response, have been consistently associated with the selection/dominance of PNH precursors. Natural killer (NK) lymphocytes might participate in PNH pathogenesis, but their role is still controversial. NK activity is dependent on the balance between activating and inhibiting signals. Key component in such regulatory network is represented by killer immunoglobulin-like receptors (KIR). KIR are also involved in the regulation of adaptive cytotoxic T cell response and associated with autoimmunity. This study investigated on the frequency of KIR genes and their known human leukocyte antigen (HLA) ligands in 53 PNH Italian patients. We observed increased frequency of genotypes characterized by ≤2 activating KIR as well as by the presence of an inhibitory/activating gene ratio ≥3.5. In addition, an increased matching between KIR-3DL1 and its ligand HLA-Bw4 was found. These genotypes might be associated with lower NK-dependent recognition of stress-related self molecules; this is conceivable with the hypothesis that an increased availability of specific T cell targets, not cleared by NK cells, could be involved in PNH pathogenesis. These data may provide new insights into autoimmune PNH pathogenesis.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 4","pages":"322-7"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01932.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30768325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A new HLA-C*07:244 allele identified by sequence-based typing in a Korean individual. 韩国人HLA-C*07:244等位基因序列分型分析

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-08-04 DOI: 10.1111/j.1399-0039.2012.01937.x

D Cho, M J Jang, C E Yoon, O J Kwon, M G Shin

引用次数: 4

Evaluation of sequence-specific priming and real-time polymerase chain reaction assays for detecting HLA-B*51 alleles confirmed by sequence-based typing. 序列特异性引物和实时聚合酶链反应检测经序列分型确认的HLA-B*51等位基因

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-08-02 DOI: 10.1111/j.1399-0039.2012.01942.x

Y Park, Y S Kim, S I Kim, H Kim, H S Kim

引用次数: 2

MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients. 在墨西哥患者中，MiR-146a多态性与哮喘相关，但与系统性红斑狼疮和幼年类风湿性关节炎无关。

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-07-24 DOI: 10.1111/j.1399-0039.2012.01929.x

S Jiménez-Morales, R Gamboa-Becerra, V Baca, B E Del Río-Navarro, D Y López-Ley, R Velázquez-Cruz, Y Saldaña-Alvarez, G Salas-Martínez, L Orozco

{"title":"MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients.","authors":"S Jiménez-Morales, R Gamboa-Becerra, V Baca, B E Del Río-Navarro, D Y López-Ley, R Velázquez-Cruz, Y Saldaña-Alvarez, G Salas-Martínez, L Orozco","doi":"10.1111/j.1399-0039.2012.01929.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01929.x","url":null,"abstract":"Extensive research has shown that aberrant expression of microRNAs (miRNAs) plays an important role in innate and adaptive immune responses. The rs2910164 polymorphism has been identified as a functional variant, which affects the transcription and expression level of miR-146a and, thereby, contributes to the pathogenesis of several inflammatory and autoimmune diseases. To investigate whether the rs2910164 G/C polymorphism was associated with asthma, systemic lupus erythematosus (SLE) or juvenile rheumatoid arthritis (JRA), we performed an association study in a pediatric Mexican cohort. We included 979 pediatric patients (asthma: 402, SLE: 367 and JRA: 210) and 531 control subjects without inflammatory or immune diseases. Genotyping was performed using the 5' exonuclease technique. The genotype distribution of the rs2910164 polymorphism was in Hardy-Weinberg equilibrium in each group. No significant differences were detected in the distribution of this polymorphism between cases and controls (P = 0.108, 0.609 and 0.553 for subjects with asthma, JRA and SLE, respectively). However, stratification by gender showed a statistically significant difference between asthmatic and control females, where the C allele was significantly associated with protection to asthma (odds ratio = 0.694, 95% confidence interval 0.519-0.929, P = 0.0138). Our results provide evidence that rs2910164 may play a role in the susceptibility to childhood-onset asthma, but not SLE or JRA in Mexicans. Further association studies may contribute to determining the role of miR-146a single-nucleotide polymorphisms in immune-mediated diseases.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 4","pages":"317-21"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01929.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30782981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 80

Identification of the novel allele HLA-A*33:22 by sequence-based typing in a Chinese individual. 中国人新型等位基因HLA-A*33:22的序列分型鉴定

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-07-15 DOI: 10.1111/j.1399-0039.2012.01924.x

J-H Xie, L-N Yan, S-Y Li, S-P An, Y-H Yuan

引用次数: 3

Detection of a novel HLA-DQB1 allele, designated DQB1*06:49. 检测到一种新的HLA-DQB1等位基因，命名为DQB1*06:49。

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-07-09 DOI: 10.1111/j.1399-0039.2012.01927.x

K Todorova, G Diederich, W Ebell, J-S Kühl, C Schönemann, H Schulze

引用次数: 3

The frequencies of human neutrophil alloantigens among the Japanese population. 日本人群中人类中性粒细胞异体抗原的频率。

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-07-09 DOI: 10.1111/j.1399-0039.2012.01930.x

M Matsuhashi, N H Tsuno, M Kawabata, Y Mishima, N Okochi, S Santoso, M Tozuka, K Takahashi

{"title":"The frequencies of human neutrophil alloantigens among the Japanese population.","authors":"M Matsuhashi, N H Tsuno, M Kawabata, Y Mishima, N Okochi, S Santoso, M Tozuka, K Takahashi","doi":"10.1111/j.1399-0039.2012.01930.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01930.x","url":null,"abstract":"Human neutrophil antigens (HNAs) play an important role in a variety of clinical conditions including immune-mediated neutropenia, non-hemolytic transfusion reactions, and transfusion-related acute lung injury. The aim of this study was to investigate the frequency distribution of HNAs-1 to -5 among the Japanese population. We analyzed samples from 570 healthy Japanese by molecular and serologic techniques to estimate the gene frequencies of HNAs-1 to -5. DNA samples were obtained and typed for the HNA-1 (n = 523), -3 (n = 570), -4 (n = 570), and -5 (n = 508), by molecular techniques. The HNA-1 genotype was determined by using a commercial polymerase chain reaction-reverse sequence-specific oligonucleotide probes (PCR-rSSOP) kit. The HNA-3 to -5 genotypes were determined by the PCR-sequence specific primer (PCR-SSP), previously described, with a small modification. The HNA-2a phenotype was determined in 301 donors by granulocyte immunofluorescence test. In Japanese, the gene frequencies of HNA-1a, -1b, and -1c were 0.623, 0.377, and 0.000, respectively. The frequency of HNA-2a phenotype was 0.987, and the gene frequencies of HNA-3a and -3b were 0.654 and 0.346, respectively. HNA-4a and -4b were found at 1.000 and 0.000, respectively, and HNA-5a and -5b at 0.840 and 0.160, respectively. We describe, for the first time, the frequencies of all HNAs (HNA-1 to -5) among the Japanese population. This study will be helpful for the prediction of the risk of alloimmunization to HNA, especially to determine the risk of HNA alloantibody production by transfusion of HNA incompatible blood and feto-maternal incompatibility.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 4","pages":"336-40"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01930.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30748057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers. 使用下一代测序仪在8位水平上对经典HLA位点进行单分子序列分型的超高分辨率。

Tissue antigens Pub Date : 2012-10-01 Epub Date: 2012-08-04 DOI: 10.1111/j.1399-0039.2012.01941.x

T Shiina, S Suzuki, Y Ozaki, H Taira, E Kikkawa, A Shigenari, A Oka, T Umemura, S Joshita, O Takahashi, Y Hayashi, M Paumen, Y Katsuyama, S Mitsunaga, M Ota, J K Kulski, H Inoko

{"title":"Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.","authors":"T Shiina, S Suzuki, Y Ozaki, H Taira, E Kikkawa, A Shigenari, A Oka, T Umemura, S Joshita, O Takahashi, Y Hayashi, M Paumen, Y Katsuyama, S Mitsunaga, M Ota, J K Kulski, H Inoko","doi":"10.1111/j.1399-0039.2012.01941.x","DOIUrl":"https://doi.org/10.1111/j.1399-0039.2012.01941.x","url":null,"abstract":"Current human leukocyte antigen (HLA) DNA typing methods such as the sequence-based typing (SBT) and sequence-specific oligonucleotide (SSO) methods generally yield ambiguous typing results because of oligonucleotide probe design limitations or phase ambiguity for HLA allele assignment. Here we describe the development and application of the super high-resolution single-molecule sequence-based typing (SS-SBT) of HLA loci at the 8-digit level using next generation sequencing (NGS). NGS which can determine an HLA allele sequence derived from a single DNA molecule is expected to solve the phase ambiguity problem. Eight classical HLA loci-specific polymerase chain reaction (PCR) primers were designed to amplify the entire gene sequences from the enhancer-promoter region to the 3' untranslated region. Phase ambiguities of HLA-A, -B, -C, -DRB1 and -DQB1 were completely resolved and unequivocally assigned without ambiguity to single HLA alleles. Therefore, the SS-SBT method described here is a superior and effective HLA DNA typing method to efficiently detect new HLA alleles and null alleles without ambiguity.","PeriodicalId":23105,"journal":{"name":"Tissue antigens","volume":"80 4","pages":"305-16"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1399-0039.2012.01941.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30809791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 148