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[Pharmacotherapeutic treatment in an adolescent with bipolar disorders]. [青少年双相情感障碍的药物治疗]。
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
L Van de Steen
{"title":"[Pharmacotherapeutic treatment in an adolescent with bipolar disorders].","authors":"L Van de Steen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bipolar disorder (BD) frequently occurs in children and adolescents, but pharmacological treatment in this group presents significant challenges. Clinicians often struggle to find appropriate treatment guidelines due to the primary focus of current guidelines on adults, leaving specific recommendations for the acute and maintenance treatment of BD in children and adolescents either insufficient or entirely absent. This gap is partly due to the lack of targeted studies in this age group, leading practitioners to rely on clinical experience and studies conducted in adults. I describe a case of the treatment of a 14-year-old girl with BD type 1, who received both psychotherapy and psychopharmacotherapy. The combination of aripiprazole, olanzapine, and lithium proved effective for this patient, but formal evidence for this regimen is lacking in the guidelines. This underscores the need for further research and the development of updated guidelines for the pharmacological treatment of BPSS in children and adolescents.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Organ donation after euthanasia]. [安乐死后的器官捐赠]。
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
W N K A van Mook, N M van Dijk, W C de Jongh, R C Oude Voshaar, R M Marijnissen, J A M Bollen, J A Godschalx-Dekker
{"title":"[Organ donation after euthanasia].","authors":"W N K A van Mook, N M van Dijk, W C de Jongh, R C Oude Voshaar, R M Marijnissen, J A M Bollen, J A Godschalx-Dekker","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In the Netherlands, it is possible for patients to donate organs after having received euthanasia. In many cases of organ donation after euthanasia (ODE), tissues, as well as the liver, heart, kidneys, lungs, and pancreas, can be donated. The procedure for ODE is described in the national guideline for organ donation after euthanasia by the Dutch Transplant Foundation (NTS). In case of suffering due to a psychiatric disorder, the guideline of the Dutch Psychiatric Association is directional. Recently, the Erasmus MC suggested an assessment by an additional local psychiatrist.</p><p><strong>Aim: </strong>To argue that current guidelines on euthanasia and organ donation offer a sufficient foundation for providing careful and conscientious care.</p><p><strong>Method: </strong>Discussion of the background and practice of euthanasia and organ donation and the guidelines relevant for assessment.</p><p><strong>Results: </strong>By following the current Euthanasia Code, the Dutch Psychiatric Association guideline and the NTS ODE guideline, the euthanasia and donation processes are separated and the carefulness of the assessment is guaranteed.</p><p><strong>Conclusion: </strong>In case of suffering from a psychiatric disorder, extra caution is currently guaranteed by involving a second independent psychiatrist. An structural additional assessment by a local psychiatrist can disrupt both the euthanasia and organ donation assessment procedures, stigmatize psychiatric patients compared to those suffering from somatic disorders, and is unnecessarily burdensome for the patient.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 1","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[De toekomst die we willen versus de toekomst die we krijgen].
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
L M Tak, J De Fruyt, M J Konings, P Bracke, K R Goethals, A Dols
{"title":"[De toekomst die we willen versus de toekomst die we krijgen].","authors":"L M Tak, J De Fruyt, M J Konings, P Bracke, K R Goethals, A Dols","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 2","pages":"65-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hope for a future with less psychiatric stigma].
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
K C E E R Catthoor, E Thys
{"title":"[Hope for a future with less psychiatric stigma].","authors":"K C E E R Catthoor, E Thys","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric stigma is a destructive and complex social phenomenon that hinders patients with a mental vulnerability from participating and seeking help.</p><p><strong>Aim: </strong>Exploring possible arguments for a decreasing negative impact of stigma in healthcare, in the media, and among young people.</p><p><strong>Method: </strong>Discussion of relevant literature and initiatives.</p><p><strong>Results: </strong>Integrated somatic-psychological healthcare, providing accurate information about mental health issues and advice on empathetic connection to journalists, and the use of social media by young people are successful strategies to address stigma.</p><p><strong>Conclusion: </strong>Although the negative impact of stigma is still palpable and requires vigilance, there are positive signs of reduced influence that may give rise to hope.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 2","pages":"144-147"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Underexposed consequences of assisted death on psychiatric grounds for mental health care]. [在精神卫生保健方面，以精神病学为理由协助死亡的后果曝光不足]。
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
S M P van Veen, M M Palm, E Elzinga, L J S Schweren, A T F Beekman
{"title":"[Underexposed consequences of assisted death on psychiatric grounds for mental health care].","authors":"S M P van Veen, M M Palm, E Elzinga, L J S Schweren, A T F Beekman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Medical Assistance in Dying (MAID) on psychiatric grounds is a subject of increasing relevance to Dutch mental health care. In addition to different advantages, there are disadvantages.</p><p><strong>Aim: </strong>To highlight some consequences of MAID on psychiatric grounds and to offer solutions to mitigate these.</p><p><strong>Method: </strong>Based on an experience story, we highlight some relevant consequences.</p><p><strong>Results: </strong>Various relevant themes emerge. Firstly, patients can experience pressure to choose MAID. Secondly, psychiatric disorders and suicidality in particular are dynamic and difficult to predict, which conflicts with the static nature of the MAID law. Thirdly, the possibility of MAID is an additional argument to keep the quality of mental health care sufficient, even with increasing scarcity. Finally, we have to stop talking about &lsquo;exhausted treatment options&rsquo;.</p><p><strong>Conclusion: </strong>By recognising and minimising the disadvantages of MAID on psychiatric grounds, we create space for a practice where safety and accessibility are in balance.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Promoting citizenship and supporting recovery in severe mental illness]. [促进公民意识和支持严重精神疾病的康复]。
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
J van Weeghel, Ph A E G Delespaul, F Bovenberg, C L Mulder
{"title":"[Promoting citizenship and supporting recovery in severe mental illness].","authors":"J van Weeghel, Ph A E G Delespaul, F Bovenberg, C L Mulder","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The problems of people with a (serious) mental illness are rarely limited to mental health care.</p><p><strong>Aim: </strong>Exploring whether citizenship can be a guiding concept for providing care to this group.</p><p><strong>Method: </strong>Reflection based on relevant literature and healthcare practices.</p><p><strong>Results: </strong>Citizenship brings the social backgrounds and consequences of mental health problems into focus, and connects people with and without such problems. In addition to the relations are rights, roles and resources of great importance. A process of subjectivation of citizenship is underway, which offers perspectives for our target group. Human rights guarantee that everyone is a citizen. Conversely, citizenship provides the institutional framework to implement human rights. Recovery and citizenship are each other&rsquo;s terms.</p><p><strong>Conclusion: </strong>Promoting citizenship is a joint task for mental health care, social domain and government.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 1","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From AI to polygenic risk scores: which innovations will shape the future of psychiatry?]
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
J M van Gaalen, A Ten Hagen, C H Vinkers, J J Luykx
{"title":"[From AI to polygenic risk scores: which innovations will shape the future of psychiatry?]","authors":"J M van Gaalen, A Ten Hagen, C H Vinkers, J J Luykx","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In recent years, developments have been made in various research domains, from treatments with (es)ketamine to large-scale genome-wide association studies (GWAS).</p><p><strong>Aim: </strong>To map some of the most promising scientific developments, that may have an impact on clinical practice in psychiatry or are already doing so.</p><p><strong>Method: </strong>We summarized recent developments in the field of epidemiology, artificial intelligence (AI) and genetics, supported by and illustrated with recent relevant scientific literature.</p><p><strong>Results: </strong>Triangulation of data and innovative trial designs, such as n=1 trials and platform trials, carry the potential to contribute to more reliable results and developments in precision psychiatry. AI has various possibilities for daily practice: from searching for evidence to applying therapeutic interventions via chatbots. GWAS enable individual genetic risk profile generation with ever-growing precision.</p><p><strong>Conclusion: </strong>Multifaceted developments in psychiatric research are projected to render clinical psychiatry more efficient and treatment options more personalized. Bolstering (international) collaborations and co-creating with experts by experience are indispensable elements in determining the scientific course in the field for the years ahead.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 2","pages":"100-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[On the future of prediction modeling for precision psychiatry]. [精准精神病学预测模型的未来]。
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
E van Dellen
{"title":"[On the future of prediction modeling for precision psychiatry].","authors":"E van Dellen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Precision psychiatry is an emerging field focusing on individualized approaches to mental health care, aiming to reduce uncertainty regarding prognosis and treatment response.</p><p><strong>Aim: </strong>To identify challenges that hinder the implementation of precision psychiatry and to propose directions for future research.</p><p><strong>Method: </strong>A narrative review of challenges within the field of precision psychiatry.</p><p><strong>Results: </strong>Significant emphasis has been placed on technical innovation for data-driven predictive models of treatment outcomes. However, the complex and dynamic nature of mental health presents major challenges for successful implementation. Research in representative populations, relevant outcome definitions, and integration of contextual and behavioral factors is essential. Furthermore, validation and implementation currently remain understudied.</p><p><strong>Conclusion: </strong>A shift is needed from retrospective research based on linear and static disease concepts to prospective research that considers the impact of contextual factors and the dynamic and complex nature of mental health.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 2","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurosteroids as treatment of postpartum depression: a critical literature review].
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
J Sondervan, A Hostens, G Lemmens
{"title":"[Neurosteroids as treatment of postpartum depression: a critical literature review].","authors":"J Sondervan, A Hostens, G Lemmens","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Brexanolone (Zulresso) and zuranolone (Zurzuvae) are two synthetic neuroactive steroids that were approved by the U.S. Food and Drug Administration in March&nbsp;2019 (as an intravenous treatment) and August&nbsp;2023 (as an oral treatment) respectively, for the treatment of postpartum depression. To date, these products are not available in Belgium and The Netherlands.</p><p><strong>Aim: </strong>To evaluate the effectiveness and side effects of brexanolone and zuranolone in the treatment of postpartum depression through the evaluation of previous double-blind placebo-controlled trials.</p><p><strong>Method: </strong>A clinically oriented literature study.</p><p><strong>Results: </strong>Brexanolone and zuranolone are effective in the treatment of postpartum depression with a clinically significant rapid response compared to placebo. The main reported side effects are dizziness, somnolence, and sedation.</p><p><strong>Conclusion: </strong>Placebo-controlled studies support the effectiveness of treatment with brexanolone and zuranolone in postpartum depression, showing a rapid and statistically significant improvement in mood symptoms. However, the place of neurosteroids in practice is still unclear and needs to be clarified by future research and clinical experience.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Towards a future-proof psychotherapy: some recommendations]. [面向未来的心理疗法：一些建议]。
Tijdschrift voor psychiatrie Pub Date : 2025-01-01
W J M W Cuijpers
{"title":"[Towards a future-proof psychotherapy: some recommendations].","authors":"W J M W Cuijpers","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Mental health care has improved considerably over the past decades, maar there are also still too many people who do not get better or too late.</p><p><strong>Results: </strong>In order to further improve psychological treatments, we can do several things. We can do more research on mechanisms of change, develop interventions that are scalable (for use in low- and middle-income countries), and we can personalize treatments with innovative machine learning techniques and &lsquo;individual patient data&rsquo; (network) meta-analyses. We should not develop new general therapies, because they are typically not better than the ones that already existed. We should develop new therapies for more complex problems, like chronic conditions and comorbid disorders. We should also think of sequential treatments because many patients do not respond after the first treatment.</p><p><strong>Conclusion: </strong>If we could make all these improvements, we could much faster provide treatments to patients to which they respond, we could reduce drop-out and make mental health care much more efficient.</p>","PeriodicalId":23100,"journal":{"name":"Tijdschrift voor psychiatrie","volume":"67 2","pages":"68-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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