[Management of early-onset schizophrenia with resistance to treatment in a rapid metabolizer patient].

In this case report we describe the search for treatment of early onset schizophrenia, in a 16-year-old patient, who did not respond to treatment. Possible causes explaining the non-response were presence of a secondary cause of the psychotic episode, non-compliance, treatment resistance and an increased metabolization of the medication. The challenges in finding an appropriate treatment plan are analyzed. The main focus lies on the complex interplay between several causes of treatment resistance, dealing with non-compliance and aggression towards patients and carers. Lastly, we regret the absence of clear guidelines for use of pharmacogenetics in Belgium.