Journal of Oral & Maxillofacial Research最新文献

{"title":"The 2nd Baltic Osseointegration Academy and Lithuanian University of Health Sciences Consensus Conference 2019. Summary and Consensus Statements: Group I - Biological Aspects of Tooth Extraction, Socket Healing and Indications for Socket Preservation","authors":"G. Juodzbalys, Povilas Daugela, Onurcem Duruel, M. Fernandes, Pedro de Sousa Gomes, Samir Goyushov, L. Mariano, L. Poskevicius, Arturas Stumbras, T. Tözüm","doi":"10.5037/jomr.2019.10304","DOIUrl":"https://doi.org/10.5037/jomr.2019.10304","url":null,"abstract":"ABSTRACT Introduction The task of Group I was to review and update the existing data concerning the physiologic process of socket healing, in the absence or presence of grafting materials or platelet concentrates, addressing the associated molecular and cellular events that culminate in the restoration of the lost tissue architecture and functionality. The second task was to review current literature concerning extraction socket classification immediately following tooth extraction and the rationales for socket preservation/augmentation procedures and with reference to it suggest novel clinical decision tree for extraction socket preservation/augmentation in aesthetic and non-aesthetic area. Material and Methods The main areas indicated by this group were as follows: socket healing process, including haemostasis and coagulation, inflammatory phase, proliferative phase, bone tissue modelling and remodelling; socket healing with graft materials and autologous platelet concentrates; extraction socket classifications; indications and reasons for extraction socket preservation/augmentation. The systematic reviews and/or meta-analyses were registered in PROSPERO, an international prospective register of systematic reviews: http://www.crd.york.ac.uk/PROSPERO/. The literature in the corresponding areas of interest was screened and reported following the PRISMA (Preferred Reporting Item for Systematic Review and Meta-Analysis) Statement: http://www.prisma-statement.org/. Method of preparation of the systematic reviews, based on comprehensive search strategies, was discussed and standardized. The summary of the materials and methods employed by the authors in preparing the systematic reviews and/or meta-analyses is presented in Preface chapter. Results The results and conclusions of the review process are presented in the respective papers. One theoretical review-analysis and one systematic review were performed. The group's general commentaries, consensus statements, clinical recommendations and implications for research are presented in this article.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127772880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2nd Baltic Osseointegration Academy and Lithuanian University of Health Sciences Consensus Conference 2019. Summary and Consensus Statements: Group II - Extraction Socket Preservation Methods and Dental Implant Placement Outcomes within Grafted Sockets","authors":"P. Galindo-Moreno, Fernando Suárez López del Amo, R. Faria‐Almeida, B. Almeida, Inesa Astramskaite-Januseviciene, S. Barootchi, Tiago Borges, A. Correia, Francisco Correia, J. Majzoub, M. Padial-Molina, Mindaugas Pranskunas, A. Puišys, A. Ramanauskaite, A. Ravidá, T. Starch-Jensen, M. Tattan","doi":"10.5037/jomr.2019.10309","DOIUrl":"https://doi.org/10.5037/jomr.2019.10309","url":null,"abstract":"ABSTRACT Introduction The task of Group II was to review and update the existing data concerning extraction socket preservation with or without membranes and soft tissue influence on post-extraction alveolar ridge preservation; extraction socket preservation using different biomaterials as bone grafts, growth factors, and stem cells. Special interest was paid to the dental implant placement outcomes within grafted sockets. Material and Methods The main areas evaluated by this group were as follows: quantitative and qualitative assessment of the effect of different alveolar preservation techniques performed immediately after tooth extraction, with or without membranes and/or soft tissue grafting, and the use of different bone substitutes, stem cells or growth factors in the postextraction socket. Evaluation of the treatment outcomes of dental implants placed in the grafted sockets in terms of primary and secondary outcomes were assessed. The systematic reviews and/or meta-analyses were registered in PROSPERO, an international prospective register of systematic reviews: http://www.crd.york.ac.uk/PROSPERO/. TThe literature in the corresponding areas of interest was screened and reported following the PRISMA guidelines (Preferred Reporting Item for Systematic Review and Meta-Analysis) Statement: http://www.prisma-statement.org/. Method of preparation of the systematic reviews, based on comprehensive search strategies, was discussed and standardized. The summary of the materials and methods employed by the authors in preparing the systematic reviews and/or meta-analyses is presented in the Preface chapter. Results The results and conclusions of the review process are presented in the respective papers. Three systematic reviews and one systematic review and meta-analysis were performed. The group's general commentaries, consensus statements, clinical recommendations and implications for research are presented in this article.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128453583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Different Grafting Materials on Alveolar Ridge Preservation: a Systematic Review","authors":"J. Majzoub, A. Ravidá, T. Starch-Jensen, M. Tattan, F. Suárez-López Del Amo","doi":"10.5037/jomr.2019.10306","DOIUrl":"https://doi.org/10.5037/jomr.2019.10306","url":null,"abstract":"ABSTRACT Objectives The purpose of the present review was to evaluate the effect of different bone substitutes used for alveolar ridge preservation on the post extraction dimensional changes. Material and Methods An electronic literature search in MEDLINE (PubMed), EMBASE (OVID) and Cochrane (CENTRAL) were performed, in addition to a manual search through all periodontics and implantology-related journals, up to December 2018. Inverse variance weighted means were calculated for all the treatment arms of the included trials for the quantitative analysis. Results Forty randomized controlled trials were included in the quantitative analysis. Dimensional changes were obtained from clinical measurements and three-dimensional imaging. The average amount of horizontal ridge resorption was 1.52 (SD 1.29) mm (allograft), 1.47 (SD 0.92) mm (xenograft), 2.31 (SD 1.19) mm (alloplast) and 3.1 (SD 1.07) mm for unassisted healing. Similarly, for all the evaluated parameters, the spontaneous healing of the socket led to higher bone loss rate than the use of a bone grafting material. Conclusions The utilization of a bone grafting material for alveolar ridge preservation reduces the resorption process occurring after tooth extraction. However, minimal differences in resorption rate were observed between allogeneic, xenogeneic and alloplastic grafting materials.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115482504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Classification of Extraction Sockets and Clinical Decision Tree for Socket Preservation/Augmentation after Tooth Extraction: a Systematic Review","authors":"G. Juodzbalys, Arturas Stumbras, Samir Goyushov, Onurcem Duruel, T. Tözüm","doi":"10.5037/jomr.2019.10303","DOIUrl":"https://doi.org/10.5037/jomr.2019.10303","url":null,"abstract":"ABSTRACT Objectives The aim of present study was to review current literature concerning extraction socket classification immediately following tooth extraction and the rationales for socket preservation/augmentation procedures and with reference to it suggest novel clinical decision tree for extraction socket preservation/augmentation in aesthetic and non-aesthetic area. Material and Methods The search protocol used the electronic MEDLINE (PubMed) and EMBASE databases for articles published between January 1 2009 and May 1 2019. The search included only human studies published in English. Outcomes were the indications and reasons for socket preservation/augmentation and classification of extraction sockets. Results Ten studies fulfilled the inclusion criteria and were selected for the study. Although there are various types of extraction socket classifications none of them could completely evaluate all morphological parameters of alveolar ridge. Furthermore, present study revealed that indications for extraction socket preservation/augmentation have wider spectrum than socket morphology and are related to surrounding tissue anatomy or dental implantation operation indications and timing. Based on currently proposed extraction socket classifications and rationales, a novel decision tree for extraction socket preservation/augmentation immediately after tooth extraction in aesthetic and non-aesthetic area was suggested. Conclusions The need of extraction socket preservation/augmentation immediately after tooth extraction should be determined by the aesthetic, functional and risk-related viewpoint. A novel clinical decision tree for extraction socket preservation/augmentation immediately after tooth extraction in aesthetic and non-aesthetic zones can be useful tool in socket preservation/augmentation procedures.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128888282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mouth Cancer Awareness in General Population: Results from Grampian Region of Scotland, United Kingdom","authors":"Michal M. Kawecki, I. Nedeva, J. Iloya, T. Macfarlane","doi":"10.5037/jomr.2019.10203","DOIUrl":"https://doi.org/10.5037/jomr.2019.10203","url":null,"abstract":"ABSTRACT Objectives The purpose of this project was to determine the level of mouth cancer awareness and to investigate the associated factors in a United Kingdom (UK) general population sample. Material and Methods Adult Dental Health Survey (2010) was conducted in a sample of 3,353 adult residents in the Grampian region of the UK (adjusted participation rate 58%). Participants completed a questionnaire consisting of questions on oral health, health behaviour, quality of life and cancer awareness. Results Overall, 81% of participants were aware of mouth cancer. This was associated with younger age, higher levels of education and better general health. Current smokers and alcohol drinkers were more aware of mouth cancer. When asked about risk factors for mouth cancer, the following were identified by the respondents: smoking (84%), poor oral hygiene (60%), drinking alcohol heavily (59%), poor diet (37%), stress (15%), being overweight (6%), drinking hot liquids (5%), eating spicy food (3%), using mouthwash (2%) and kissing someone (1%). Smokers were more likely to identify smoking as a risk factor for mouth cancer. Similarly, those who consumed alcohol almost daily were more likely to identify heavy alcohol drinking as a risk factor. Conclusions Awareness of mouth cancer is high in respondents from the general population, and participants were able to identify the most important risk factors. Knowledge of tobacco and alcohol as risk factors was highest amongst those exposed to them. The study proposed that the prevention strategies should focus not only on increasing knowledge, but also on changing health behaviour.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124571665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Buccal Bone Plate, Root Inclination and Alveolar Bone Dimensions in the Jawbone. A Descriptive Study Using Cone-Beam Computed Tomography","authors":"Joana Gomes dos Santos, Ana Paula Oliveira Reis Durão, António Cabral de Campos Felino, Ricardo Manuel Casaleiro Lobo de Faria de Almeida","doi":"10.5037/jomr.2019.10204","DOIUrl":"https://doi.org/10.5037/jomr.2019.10204","url":null,"abstract":"ABSTRACT Objectives This study aims to determine if there are enough buccal alveolar bone thickness to perform an immediate dental implant placement in anterior and posterior maxillary teeth. Material and Methods A total of 1463 teeth were examined, from 202 cone-beam computed tomography scans with voxel sizes of 0.15 mm. On each tooth, the following measures were determined: the alveolar bone thickness in two locations; the vertical distance between the buccal alveolar crest and cementoenamel junction; the angle between the tooth’s long axis and the alveolar bone axial inclination in the sagittal plane. Results In the most coronal location of maxillary teeth, the thickness of alveolar bone was lower than 0.6 (SD 0.6) mm in 50% of the teeth, and in the middle of the root the bone thickness was, on average, 0.96 (SD 0.6) mm. For the same maxillary teeth, the vertical distance between the buccal alveolar crest and cementoenamel junction and the angulation measured were, on average, 3.6 (SD 1.2) mm and 12.1º (SD 1.4º), respectively. Conclusions The present study revealed that in most cases the thickness of buccal alveolar bone was less than 1 mm. Consequently, in such cases, immediate dental implant placement operation is not recommended, or should be combined with bone regeneration techniques.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125428623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localization of the Mandibular Canal in a Turkish Population: a Retrospective Cone-Beam Computed Tomography Study","authors":"F. Kalabalık, E. Aytuğar","doi":"10.5037/jomr.2019.10202","DOIUrl":"https://doi.org/10.5037/jomr.2019.10202","url":null,"abstract":"ABSTRACT Objectives The aim of this study was to determine the location of the mandibular canal at the mental foramen region that is essential in order to prevent injuries to the inferior alveolar neurovascular bundle during mandibular surgical procedures. Material and Methods The position of the mandibular canal was analysed using cone-beam computed tomography images from 300 Turkish patients, who were referred to Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Izmir Katip Celebi University for various complaints. The distances of the mandibular canal to the outer superior (D1), inferior (D2), buccal (D3), and lingual (D4) cortical margins were measured at 2 mm distal to the mental foramen. Results There were 148 (49.3%) males and 152 (50.7%) females with ages ranging from 15 to 74 years (39.15 [SD 17.8]). D1 was significantly greater than D2 and D3 was significantly greater than D4 on both left and right sides. While the mean D1, D2, and D4 in males were significantly greater than in females on both left and right sides. There was no significant difference between D3 in males and females on both left and right sides. Conclusions The results showed that the mandibular canal was vertically located nearer to the inferior cortical border and horizontally nearer to the lingual cortical border of the mandible at the mental foramen region. Knowledge of the distances of mandibular canal to the outer cortical margins at this region of the mandible will be helpful for surgical procedures.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127203579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Cell Granulomas of Jaws: a Clinicopathologic Study","authors":"Shruti Gupta, A. Narwal, M. Kamboj, A. Devi, A. Hooda","doi":"10.5037/jomr.2019.10205","DOIUrl":"https://doi.org/10.5037/jomr.2019.10205","url":null,"abstract":"ABSTRACT Objectives The purpose of present study was to investigate and correlate the histological findings in central giant cell granuloma and peripheral giant cell granuloma of jaws with clinical and radiographic interpretations of the lesion. Material and Methods In present study, data from 14 cases of central giant cell granuloma (CGCG) and 9 cases of peripheral giant cell granuloma (PGCG) were analysed, focusing on demographic, clinical and radiographic features. For each patient, microscopic slides were assessed in terms of histologic features of giant cells i.e. number of giant cells, mean number of nuclei/giant cell, pattern of distribution, size and relative size index of giant cells, percentage fractional surface area (FSA) occupied by giant cells and stromal characteristics. Data collected was subjected to statistical analysis. Fisher-exact test, Pearson’s correlation coefficient, one-way ANOVA test and Student’s t-test were used for analysis. Results No significant difference was found between PGCG and CGCG in relation to all the traits that were evaluated. It was observed that mean number of giant cells and mean FSA was more in aggressive CGCG as compared to non-aggressive CGCG. Conclusions Further studies on large sample size are required to confirm the relationship between histomorphometric features of giant cells and behaviour of giant cell granulomas of jaws.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123705883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial Cysts in the Temporomandibular Joint: a Case Report and Critical Review of the Literature.","authors":"Ynn Maribo,&nbsp;Kasper Stokbro,&nbsp;Esben Aagaard,&nbsp;Stine Rosenkilde Larsen,&nbsp;Torben Thygesen","doi":"10.5037/jomr.2019.10104","DOIUrl":"https://doi.org/10.5037/jomr.2019.10104","url":null,"abstract":"<p><strong>Background: </strong>Synovial cysts of the temporomandibular joint are rare and treatment is based on consensus from cases reporting unilateral successful outcomes. A patient with a synovial cyst is presented, treated with successful surgical excision of the cyst, but without remission of joint symptoms. Furthermore, the case is supplemented by a critical, literature review.</p><p><strong>Methods: </strong>This case report deals with a patient with a synovial cyst that presented with temporomandibular joint (TMJ) pain and reduced mouth opening. Magnetic resonance imaging verified a TMJ cyst.</p><p><strong>Results: </strong>Surgical excision removed the synovial cyst, and the patient was followed-up for 4 years, with no recurrence of the cyst. Despite successful excision of the cyst, the symptoms did not subside, and the patient is still in treatment. The critical, literature review found 23 case reports describing 24 synovial cysts. In addition, 4 cases were included as their synovial cysts were erroneously described as ganglion cysts. In 4 cases, histological diagnosis could not be confirmed, and they were excluded. All cases described treatment by surgical excision without recurrence. The reported median follow-up was 10 months and postoperative TMJ symptoms were rarely examined or described.</p><p><strong>Conclusions: </strong>The temporomandibular joint symptoms may persist despite successful removal of the synovial cyst. Furthermore, the 4 identified synovial cysts, mislabelled as ganglion cysts, represents almost a quarter of the cases of the reported synovial cysts. Correct labelling and reporting of synovial cysts are still imperative to describe the diverse aspects of treatment outcomes following surgical excision.</p>","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"10 1","pages":"e4"},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/b0/jomr-10-e4.PMC6498815.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37221986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Peri-Implantitis in Implants with Turned and Rough Surfaces: a Systematic Review.","authors":"Nikola Saulacic,&nbsp;Benoit Schaller","doi":"10.5037/jomr.2019.10101","DOIUrl":"https://doi.org/10.5037/jomr.2019.10101","url":null,"abstract":"<p><strong>Objectives: </strong>Moderately-rough implant surface may improve implant therapy in terms of bone integration, but the increased surface roughness might affect the initiation and development of peri-implantitis. The aim of the present review was to compare the prevalence of peri-implantitis in implants with rough and turned (machined) implant surfaces.</p><p><strong>Material and methods: </strong>An electronic literature search was conducted of the MEDLINE and EMBASE databases for articles published between 1 January 1990 and 1 March 2018. Clinical human studies in the English language that had reported on prevalence of peri-implantitis in tuned and rough surface implants were searched. The initial search resulted in 690 articles.</p><p><strong>Results: </strong>Eight articles with 2992 implants were included in the systematic review. The incidence of peri-implantitis for two implant surfaces varied between studies. A meta-analysis was not feasible due to the heterogeneity among studies. Implant with rough surfaces were more favourable for plaque accumulation during short-term follow-up. On a long-term, turned implants surfaces were associated with more plaque and higher peri-implant bone loss. Peri-implant clinical parameters and survival rate for two implant surfaces was similar.</p><p><strong>Conclusions: </strong>Within the limitations of the present study, rough implant surface does not seem to increase the incidence of peri-implantitis in comparison to turned implants surface.</p>","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"10 1","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5037/jomr.2019.10101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37221983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}