Thrombosis research最新文献

{"title":"CXCL13/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia","authors":"Zhenyu Chen ,&nbsp;Qiaoyun Zheng ,&nbsp;Yali Wang ,&nbsp;Xing An ,&nbsp;Shimuye Kalayu Yirga ,&nbsp;Donghong Lin ,&nbsp;Qizhen Shi ,&nbsp;Meijuan Huang ,&nbsp;Yingyu Chen","doi":"10.1016/j.thromres.2024.109196","DOIUrl":"10.1016/j.thromres.2024.109196","url":null,"abstract":"<div><h3>Background</h3><div>Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder defined by a diminished platelet count. ITP pathogenesis involves intricate changes to both cellular and humoral immunity. The pivotal roles of follicular helper T (TFH) cells in the maturations of B cells and the production of antibodies are well-established. However, the specific role of TFH to the immunopathogenesis of ITP remain incompletely understood. This study aimed to clarify the association of CXCL13/CXCR5 axis with TFH in adults with ITP.</div></div><div><h3>Methods</h3><div>A total of 97 ITP patients and 41 healthy controls were enrolled. CD4⁺CXCR5⁺ TFH, CD4⁺CXCR5⁺PD-1⁺ TFH, CD4⁺CXCR5⁺Foxp3⁺ follicular regulatory T cells (TFR), and desialylated platelets in peripheral blood were measured by flow cytometry. Plasma cytokines were assessed by enzyme-linked immunosorbent assay. CD4⁺ T cells cocultured with chemokine CXCL13 <em>in vitro</em> was performed for the measurement of TFH proliferation. Intracellular production of reactive oxygen species (ROS) was examined by dichlorodihydrofluorescein diacetate (DCFH-DA) probe staining.</div></div><div><h3>Results</h3><div>We observed a significant increase in circulating TFH and a marked decrease in circulating TFR in the entire ITP cohort. The ratio of TFH/TFR was elevated, accompanied by heightened levels of platelet desialylation, cytokines BAFF, HMGB1, and IL-21, while levels of IL-10 were downregulated in adults with ITP. Notably, patients with ITP exhibiting platelet count below 50 × 10⁹/L had dramatically elevated levels in both chemokine CXCL13 and its receptor CXCR5⁺ TFH compared to those with platelet count above 100 × 10⁹/L. High frequencies of TFH correlated with poor therapeutic response. Furthermore, <em>in vitro</em> CD4⁺ T cell proliferation assay demonstrated a CXCL13 dose-dependent increase in the frequencies in both CD4⁺CXCR5⁺ TFH and CD4⁺CXCR5⁺PD-1⁺ TFH from ITP patients. Intriguingly, DCFH-DA assay illustrated a significant enhancement in intracellular ROS generation in CXCR5⁺ T cell subsets, especially in CD4⁺CXCR5⁺PD-1⁺ TFH from 4 patients with ITP.</div></div><div><h3>Conclusions</h3><div>These results underscore the pivotal role of CXCL13/CXCR5 axis-drived TFH expansion in the pathogenesis of ITP, providing a potential disease severity biomarker.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109196"},"PeriodicalIF":3.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an in vitro model to study thrombin generation on the surface of catheters in platelet-poor and platelet-rich plasma","authors":"M. Hardy ,&nbsp;J. Douxfils ,&nbsp;O. Xhaet ,&nbsp;B. Robaye ,&nbsp;S. Lessire ,&nbsp;T. Lecompte ,&nbsp;F. Mullier","doi":"10.1016/j.thromres.2024.109194","DOIUrl":"10.1016/j.thromres.2024.109194","url":null,"abstract":"<div><h3>Introduction</h3><div>Coagulation activation on medical devices remains a significant problem as it can lead to dramatic thromboembolic complications. Understanding its poorly described mechanisms and finding optimal pharmacological prevention means is crucial to improve patient safety.</div></div><div><h3>Methods</h3><div>We developed an <em>in vitro</em> model to study thrombin generation (TG) initiated by the contact of plasma with the surface of catheters. Interventional cardiology catheters were cut into segments and inserted in the bottom of multi-well plates; TG was then measured with the calibrated automated thrombogram (CAT). Model performance (analytical, intra- and inter-individual variability) was investigated and compared with activation of thrombin generation by tissue factor (TF) or contact pathway activator (ellagic acid), in the presence (PRP) and absence (PPP) of platelets. Model response to unfractionated heparin (UFH) was also assessed.</div></div><div><h3>Results</h3><div>TG was greater when measured in presence of catheter segments, compared to conditions without activators. The analytical variability of the model was good (CV ≤ 5 %), both with PPP and PRP. Intra-individual variability was between 15 and 30 % with PPP and between 10 and 15 % with PRP. Inter-individual variability was between 15 and 30 % with both kinds of plasma samples. The analytical performance of the catheter-initiated TG model was equivalent to that observed when TG was initiated with TF or ellagic acid. Catheter-initiated TG was measurable until 0.1 IU/mL UFH with PPP and until 1.0 IU/mL UFH with PRP, highlighting the crucial requirement of platelets.</div></div><div><h3>Conclusion</h3><div>Our model is suitable for studying TG initiated with catheters. Inhibition of TG by UFH is overestimated in the absence of platelets.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109194"},"PeriodicalIF":3.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymidine phosphorylase mediates SARS-CoV-2 spike protein enhanced thrombosis in K18-hACE2TG mice","authors":"Renat Roytenberg ,&nbsp;Hong Yue ,&nbsp;Autumn DeHart ,&nbsp;Eugene Kim ,&nbsp;Fang Bai ,&nbsp;Yongick Kim ,&nbsp;Krista Denning ,&nbsp;Alec Kwei ,&nbsp;Quan Zhang ,&nbsp;Jiang Liu ,&nbsp;X. Long Zheng ,&nbsp;Wei Li","doi":"10.1016/j.thromres.2024.109195","DOIUrl":"10.1016/j.thromres.2024.109195","url":null,"abstract":"<div><h3>Introduction</h3><div>Thymidine phosphorylase (TYMP), which facilitates platelet activation and thrombosis, is significantly increased in COVID-19 patients. We hypothesize that TYMP mediates SARS-CoV-2 spike protein (SP)-induced thrombosis.</div></div><div><h3>Materials and methods</h3><div>Plasmids encoding wildtype SP or empty vector (p3.1) were transfected into COS-7 cells, and cell lysates were prepared as a reservoir for SP or p3.1 (control), respectively. K18-h<em>ACE2</em>^TG and K18-h<em>ACE2</em>^TG<em>/Tymp</em>^{<em>−/−</em>} mice were treated with a single dose of SP or p3.1 by intraperitoneal injection and then subjected to thrombosis studies three days later. The role of SP on inflammatory signaling activation was assessed in BEAS-2B cells.</div></div><div><h3>Results</h3><div>SARS-CoV-2 SP increased the expression of TYMP, resulting in the activation of STAT3 and NF-κB in BEAS-2B cells. A siRNA-mediated knockdown of TYMP attenuated SP-enhanced activation of STAT3. SP significantly promoted arterial thrombosis in K18-h<em>ACE2</em>^TG mice. SP-accelerated thrombosis was attenuated by inhibition or genetic ablation of TYMP. SP treatment did not influence ADP- or collagen-induced platelet aggregation but significantly increased platelet adhesion to fibrinogen. SP treatment also significantly shortened activated partial thromboplastin time, which was reversed and even prolonged by TYMP deficiency. Additionally, SP binds to platelet factor 4 (PF4) and TYMP. TYMP does not bind PF4 but enhances the formation of the SP/PF4 complex, which may augment the procoagulant and prothrombotic effect of PF4.</div></div><div><h3>Conclusions</h3><div>We conclude that SP is prothrombotic and upregulates TYMP expression, and TYMP inhibition or knockout mitigates SP-enhanced thrombosis. These findings suggest that inhibition of TYMP may be a novel therapeutic strategy for COVID-19-associated thrombosis.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109195"},"PeriodicalIF":3.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic valve dysfunction in patients with mechanical heart valves: Results from the Emergency Salam Centre cohort","authors":"Nicoletta Erba ,&nbsp;Alberto Tosetto ,&nbsp;Suha Abdelwahab Abdallah ,&nbsp;Martin Langer ,&nbsp;Elena Giovanella ,&nbsp;Salvatore Lentini ,&nbsp;Franco Masini ,&nbsp;Alessandro Mocini ,&nbsp;Gennarina Portella ,&nbsp;Alessandro Cristian Salvati ,&nbsp;Alessandro Squizzato ,&nbsp;Sophie Testa ,&nbsp;Daniela Poli","doi":"10.1016/j.thromres.2024.109183","DOIUrl":"10.1016/j.thromres.2024.109183","url":null,"abstract":"<div><h3>Introduction</h3><div>Mechanical heart valve (MHV) replacement requires long-life anticoagulation due to the risk of Prosthetic Valve Dysfunction (PVD) and cardioembolism.</div></div><div><h3>Methods</h3><div>We report data from a prospective observational study conducted on MHV patients in the Khartoum Salam Centre for Cardiac Surgery built by ‘Emergency,’ an Italian Non-Governmental Organization, to evaluate the occurrence of PVD and associated risk factors.</div></div><div><h3>Results</h3><div>We prospectively followed 3647 patients, and 38 patients (rate 1.04 × 100 pt-years) had PVD during follow-up. The time in therapeutic range (TTR) among patients without PVD was 53 % (IQR 37–67), and it was 43 % (IQR 19–58) among patients with PVD (<em>p</em> = 0.04). Twenty-three over 38 patients (60.5 %) were symptomatic, 18 (47.4 %) had obstructive valvular stenosis, 24 patients (63.2 %) had INR &lt;2.0 at diagnosis, and 21 patients (55.3 %) had been off warfarin for a long time: 3 patients for 1 week, 1 patient for 2 weeks, and 17 patients for &gt;4 weeks (6 patients were off warfarin from 3 to 12 months). Ten were uncompliant to treatment, and 8 were pregnant women. Ten patients (26.3 %) with PVD had had a previous episode of PVD, and 14 patients (36.8 %) had 2 or more associated risk factors. Only in 6 cases were no associate risk factors found.</div></div><div><h3>Conclusions</h3><div>Among MHV patients on warfarin treatment with a sub-optimal quality of anticoagulation, the rate of PVD is 1.04 % pt-years, and the most frequent associated risk factor for PVD occurrence is warfarin withdrawal lasting more than one week.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109183"},"PeriodicalIF":3.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heparin-binding protein and sepsis-induced coagulopathy: Modulation of coagulation and fibrinolysis via the TGF-β signalling pathway","authors":"Zixuan Liu ,&nbsp;Xu Li ,&nbsp;Mingming Chen ,&nbsp;Yini Sun ,&nbsp;Yuteng Ma ,&nbsp;Ming Dong ,&nbsp;Liu Cao ,&nbsp;Xiaochun Ma","doi":"10.1016/j.thromres.2024.109176","DOIUrl":"10.1016/j.thromres.2024.109176","url":null,"abstract":"<div><h3>Background</h3><div>Heparin-binding protein (HBP) levels have been linked to organ failure and may represent an inflammatory biomarker of sepsis. We found disseminated intravascular coagulation (DIC) is associated with higher HBP levels in patients and in <em>in vivo</em> and <em>in vitro</em> models. This prospective, single-center observational study investigated the effects and underlying mechanisms of HBP on the coagulation cascade in sepsis.</div></div><div><h3>Methods</h3><div>538 patients with sepsis from June 2016 to December 2019 were enrolled. Mechanisms underlying HBP and the coagulation system were investigated in human umbilical vein endothelial cells (HUVEC) and C57 mice.</div></div><div><h3>Results</h3><div>Increased HBP was associated with sepsis-induced DIC. The optimal cutoff value was 37.5 ng/mL (sensitivity: 56 %, specificity: 65 %). Antithrombin-III (AT-III) activity, plasmin-a2 plasmin inhibitor complex (PIC), procalcitonin (PCT), hemoglobin, and HBP ≥37.5 ng/mL were associated with of DIC occurrence. In HUVECs &amp;C57 mice models, Western blotting, qPCR, and immunohistochemistry analysis showed that the binding between HBP and TGF-β receptor 2 (TGFBR2) caused elevation of plasminogen activator inhibitor-1 (PAI-1) levels. Furthermore, we found that mice stimulated with HBP had higher levels of fibrinogen and D-dimer in the blood. HBP treatment caused the accumulation of fibrinogen in mice lung tissue. Treatment with TGFBR2-small interfering RNAs inhibited the effects.</div></div><div><h3>Conclusion</h3><div>Patients with sepsis having HBP ≥37.5 ng/mL at admission were more likely to develop DIC. HBP upregulates the expression of fibrinogen and PAI-1 <em>via</em> TGFBR2 and the TGF-β signalling pathway.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109176"},"PeriodicalIF":3.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of recurrent venous thromboembolism and major bleeding in patients with cancer: A secondary analysis of the CANVAS trial","authors":"Hajime Uno ,&nbsp;Hong Xiong ,&nbsp;Christine Cronin ,&nbsp;Deborah Schrag ,&nbsp;Jean M. Connors","doi":"10.1016/j.thromres.2024.109184","DOIUrl":"10.1016/j.thromres.2024.109184","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with cancer have an increased risk of developing venous thromboembolism (VTE) but also have an increased risk of both recurrent VTE and bleeding with anticoagulation compared to anticoagulated patients without cancer. CANVAS, a randomized pragmatic effectiveness trial, compared the direct oral anticoagulants a class to low molecular weight heparin for treatment of a new VTE in patients with cancer. The aim of this prespecified secondary analysis of the CANVAS trial is to identify predictors of both recurrent VTE and major bleeding in patients with cancer and new VTE.</div></div><div><h3>Methods</h3><div>Data from the 671 participants in the analysis population were used to identify predictors of recurrent VTE and bleeding during the 6-month treatment period. Significant predictors identified in the univariable models were carried forward in the multivariable models to identify independent predictors of both risks.</div></div><div><h3>Results</h3><div>Independent predictors of recurrent VTE include ECOG performance status ≥2 (HR, 3.19 [95 % CI, 1.45–7.02]; <em>P</em> &lt; .005), presence of metastatic disease (HR, 2.57 [95 % CI, 1.14–5.80]; <em>P</em> = .023), treatment with bevacizumab (HR, 2.50 [95 % CI, 1.04–5.99]; <em>P</em> = .041), and deep vein thrombosis without pulmonary embolus as index VTE (HR, 1.86 [95 % CI, 1.04–3.33]; <em>P</em> = .037). Independent predictors of major bleeding include serum albumin &lt;3.5 g/dL (HR 1.97 [95 % CI, 1.02–3.79]; <em>P</em> = .044) and metastatic disease (HR 2.80 [95 % CI, 1.08–7.22]; <em>P</em> = .034).</div></div><div><h3>Conclusion</h3><div>Findings from this pre-specified analysis of the CANVAS trial identified risk factors for recurrent VTE and major bleeding in a population of participants with cancer and new VTE that reflect current oncology clinical practice. Results can be used to identify at risk patients in practice and inform new risk prediction models to improve the care of these patients.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109184"},"PeriodicalIF":3.7,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of hematuria with a natural language processing model and validation of hematuria diagnosecodes","authors":"Rasmus Søgaard Hansen ,&nbsp;Rasmus Bank Lynggaard ,&nbsp;Martin Sundahl Laursen ,&nbsp;Freja Maack Lykke ,&nbsp;Pernille Just Vinholt","doi":"10.1016/j.thromres.2024.109182","DOIUrl":"10.1016/j.thromres.2024.109182","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109182"},"PeriodicalIF":3.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental, emotional and social dimensions of quality of life and their relationship with physical and functional status in adults with haemophilia","authors":"Marta Aguilar Rodríguez ,&nbsp;Sofía Pérez-Alenda ,&nbsp;Juan J. Carrasco ,&nbsp;Juan Eduardo Megías-Vericat ,&nbsp;Santiago Bonanad ,&nbsp;Felipe Querol ,&nbsp;Ana Chimeno-Hernández","doi":"10.1016/j.thromres.2024.109181","DOIUrl":"10.1016/j.thromres.2024.109181","url":null,"abstract":"<div><h3>Introduction</h3><div>A comprehensive treatment for patients with haemophilia (PwH) should focus on how the disease interferes with their mental, emotional and social environment to analyse if all the therapeutic efforts invested in their physical status have positive impact on a life worth living.</div></div><div><h3>Aim</h3><div>To analyse the correlation between the physical status of a cohort of adults with haemophilia and their mental, emotional and social states regarding their treatment modality; Also, to investigate which variables are most related to quality of life (QoL), joint health and emotional, mental and social states.</div></div><div><h3>Methods</h3><div>In this cross-sectional, 102 adults with haemophilia divided into a prophylactic group (G1, <em>n</em> = 77) and on-demand group (G2, <em>n</em> = 25) were included. Demographic and clinical characteristics, health joint (HJHS), presence of synovitis with ultrasound, self-perceived functionality (HAL) and QoL (A36-HaemoQoL), were analysed.</div></div><div><h3>Results</h3><div>In G1 all the variables that defined the physical status correlated (rho: 0.33 to 0.72) to the mental and social spheres. The emotional state correlated with the self-perceived ones. In G2 physical status did not correlate with the three states. According to the regression models, HAL was the variable that most influenced the QoL (together with the bleedings in the last year, R² = 0.61), emotional (R² = 0.16), mental (together with HJHS, R² = 0.41) and social states (R² = 0.39). In addition, the HJHS was influenced by synovitis, HAL, mental health, age and the bleeding history (R² = 0.83).</div></div><div><h3>Conclusion</h3><div>Emotional, mental and social states of PwH in prophylaxis are correlated to their physical status, being the self-perceived functionality the variable that most influenced in their QoL.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109181"},"PeriodicalIF":3.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suitability and readiness assessment of organizational resources for the implementation of gene therapy in hemophilia in Spain and Portugal: A survey-based study","authors":"Jose Manuel Calvo Villas ,&nbsp;Manuel Rodríguez López ,&nbsp;Jorge Cuesta Tovar ,&nbsp;Santiago Bonanad Boix ,&nbsp;Juan Carlos Reverter Calatayud ,&nbsp;María Teresa Álvarez-Román","doi":"10.1016/j.thromres.2024.109180","DOIUrl":"10.1016/j.thromres.2024.109180","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109180"},"PeriodicalIF":3.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of saddle pulmonary embolism a post hoc analysis of the PROTECT cohort study","authors":"Winnifer Briceño ,&nbsp;Sara González ,&nbsp;Carmen Rodríguez ,&nbsp;Ana Castillo ,&nbsp;Ignacio Jara ,&nbsp;Laura Lago ,&nbsp;Edwin Yong ,&nbsp;Alfonso Muriel ,&nbsp;Álvaro Dubois-Silva ,&nbsp;Behnood Bikdeli ,&nbsp;Gema Díaz ,&nbsp;David Jiménez","doi":"10.1016/j.thromres.2024.109179","DOIUrl":"10.1016/j.thromres.2024.109179","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109179"},"PeriodicalIF":3.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}