Thrombosis research最新文献

{"title":"Inferior vena cava contrast reflux grade is associated with a reduced cardiac index in acute pulmonary embolism","authors":"Eugene Yuriditsky ,&nbsp;Robert S. Zhang ,&nbsp;Peter Zhang ,&nbsp;James M. Horowitz ,&nbsp;Samuel Bernard ,&nbsp;Allison A. Greco ,&nbsp;Radu Postelnicu ,&nbsp;Vikramjit Mukherjee ,&nbsp;Kerry Hena ,&nbsp;Lindsay Elbaum ,&nbsp;Carlos L. Alviar ,&nbsp;Norma M. Keller ,&nbsp;Sripal Bangalore","doi":"10.1016/j.thromres.2024.109177","DOIUrl":"10.1016/j.thromres.2024.109177","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Patients with intermediate-risk pulmonary embolism (PE) commonly present with a significantly reduced cardiac index (CI). However, the identification of this more severe profile requires invasive hemodynamic monitoring. Whether inferior vena cava (IVC) contrast reflux, as a marker of worse right ventricular function, can predict invasive hemodynamics has not been explored.</div></div><div><h3>Methods</h3><div>This was a single-center retrospective study over a 3-year period of consecutive patients with PE undergoing mechanical thrombectomy and simultaneous pulmonary artery catheterization. CT pulmonary angiograms were reviewed, and contrast reflux was graded as no/minimal reflux (limited to the IVC) or substantial (opacification including hepatic veins) based on an established scale.</div></div><div><h3>Results</h3><div>Substantial contrast reflux was present in 29 of 85 patients (34 %) and associated with a lower CI (1.8 ± 0.4 L/min/m² v. 2.6 ± 1.0 L/min/m², <em>p</em> &lt; 0.001), higher pulmonary artery systolic pressure (53.2 ± 19.5 mmHg v. 44.0 ± 12.1 mmHg, <em>p</em> = 0.025), and worse right ventricular systolic function. An IVC contrast reflux grade &gt; 3 was a significant predictor for a CI ≤2.2 L/min/m² (OR: 22.5, 95 % CI: 4.8, 104.4, <em>p</em> &lt; 0.001). Sensitivity, specificity, positive predictive value, and negative predictive value for substantial contrast reflux for a CI ≤2.2 L/min/m² were 62.6 %, 93.1 %, 94.6 %, and 56.2 %, respectively. These findings remained significant in a multivariable model and were similar when isolating for intermediate-risk patients (<em>n</em> = 72, 85 %).</div></div><div><h3>Conclusions</h3><div>The degree of contrast reflux is highly specific for a reduced cardiac index in PE even when isolating for intermediate-risk patients. Real-time prediction of a hemodynamic profile may have added value in the risk-stratification of PE.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109177"},"PeriodicalIF":3.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated levels of pro-thrombotic eNOS-negative platelets in COVID-19 patients","authors":"Amir Asgari ,&nbsp;Aleksandra Franczak ,&nbsp;Alex Herchen ,&nbsp;Glen C. Jickling ,&nbsp;Paul Jurasz","doi":"10.1016/j.thromres.2024.109178","DOIUrl":"10.1016/j.thromres.2024.109178","url":null,"abstract":"<div><h3>Background</h3><div>Platelet-rich microvascular thrombi are common in severe COVID-19. Endogenous nitric oxide (NO)-signaling limits thrombus formation and previously we identified platelet subpopulations with a differential ability to produce NO based on the presence or absence of endothelial nitric oxide synthase (eNOS). eNOS expression is counter-regulated by cytokines, and COVID-19-associated immune/inflammatory responses may affect the transcriptome profile of megakaryocytes and their platelet progeny.</div></div><div><h3>Objectives</h3><div>We investigated whether the percentage of eNOS-negative to eNOS-positive platelets increases in COVID-19 patients and whether this change may be due to the actions of pro-inflammatory cytokines on megakaryocytes.</div></div><div><h3>Methods</h3><div>Platelets were isolated from hospitalized COVID-19 patients and COVID-19-negative controls. Platelet eNOS was measured by flow cytometry and plasma inflammatory cytokines by ELISA. Megakaryocytes from eNOS-GFP transgenic mice and the Meg-01 cell line were characterized to identify an appropriate model to study eNOS-based platelet subpopulation formation in response to inflammatory cytokines.</div></div><div><h3>Results</h3><div>COVID-19 patients demonstrated a significant increase in eNOS-negative and a concomitant decrease in eNOS-positive platelets compared to controls, and this change was associated with disease severity as assessed by ICU admission. A higher eNOS-negative to –positive platelet percentage was associated with enhanced platelet activation as measured by surface CD62P. Accordingly, COVID-19 patients demonstrated higher TNF-α, IL-6, and IL-1β plasma concentrations than controls. Inflammatory cytokines associated with COVID-19 promoted eNOS-negative Meg-01 formation and enhanced subsequent eNOS-negative platelet-like particle formation.</div></div><div><h3>Conclusions</h3><div>COVID-19 patients have a higher percentage of eNOS-negative to –positive platelets, likely as a result of inflammatory response reducing megakaryocyte eNOS expression, which predisposes to thrombosis.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"244 ","pages":"Article 109178"},"PeriodicalIF":3.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the CanVECTOR 2024 Annual Conference October 25th, 2024","authors":"","doi":"10.1016/j.thromres.2024.109155","DOIUrl":"10.1016/j.thromres.2024.109155","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109155"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Suspected Pulmonary Embolism During Pregnancy: A Narrative Review","authors":"Meriem Hammache ,&nbsp;Camille Simard ,&nbsp;Sandrine Hamel ,&nbsp;Suzie Ouellet ,&nbsp;Gisèle Jolicoeur ,&nbsp;Karen Wou ,&nbsp;Ramy El Jalbout ,&nbsp;Ghada Bourjeily ,&nbsp;Maral Koolian ,&nbsp;Vicky Tagalakis ,&nbsp;Leslie Skeith ,&nbsp;Jayson Potts ,&nbsp;Grégoire Le Gal ,&nbsp;Isabelle Malhamé","doi":"10.1016/j.thromres.2024.109158","DOIUrl":"10.1016/j.thromres.2024.109158","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109158"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Management and Outcomes of Traumatic Cerebral Sinus Vein Thrombosis","authors":"Lior Kapitanski ,&nbsp;Kartiga Thiyagarajah ,&nbsp;Ferco Berger ,&nbsp;Ilia Makedonov ,&nbsp;Robert Fowler ,&nbsp;Jameel Abdulrehman ,&nbsp;William Geerts ,&nbsp;Jean-Philippe Galanaud","doi":"10.1016/j.thromres.2024.109163","DOIUrl":"10.1016/j.thromres.2024.109163","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109163"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiphospholipid antibodies: Evaluating Testing Discrepancy Between Two Platforms and Its Implication on Antiphospholipid Syndrome (APS) Classification and Risk Stratification","authors":"Linchuan Wang ,&nbsp;Alexandra Bohm ,&nbsp;Fernando Chang ,&nbsp;Chieh Min Benjamin Lai","doi":"10.1016/j.thromres.2024.109170","DOIUrl":"10.1016/j.thromres.2024.109170","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109170"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Designing a Communication-Support Tool for Pregnant Individuals Requiring Urgent Imaging to Rule out Pulmonary Embolism","authors":"Gisèle Jolicoeur ,&nbsp;Luz A. Paczka Giorgi ,&nbsp;Aya Al-Katat ,&nbsp;Nirushi Mohan ,&nbsp;Camille Simard ,&nbsp;Amal Bessissow ,&nbsp;Suzie Ouellet ,&nbsp;Sandrine Hamel ,&nbsp;Mariana Tayler ,&nbsp;Antony Robert ,&nbsp;Karen Wou ,&nbsp;Stéphanie Lam ,&nbsp;Andrew Fox ,&nbsp;Jessica Zambito ,&nbsp;Dennis Christopher ,&nbsp;Grégoire Le Gal ,&nbsp;Shreya Karnik ,&nbsp;Gabriela Roselli Ferrari ,&nbsp;Vicky Tagalakis ,&nbsp;Linda Snell ,&nbsp;Isabelle Malhamé","doi":"10.1016/j.thromres.2024.109160","DOIUrl":"10.1016/j.thromres.2024.109160","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109160"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Perspective on Superficial Vein Thrombosis in Pregnancy and Postpartum: Interim Results from a Tertiary Care Centre","authors":"Camille Simard ,&nbsp;Neyra Mekideche ,&nbsp;Vicky Tagalakis ,&nbsp;Leslie Skeith ,&nbsp;Grégoire Le Gal ,&nbsp;Isabelle Malhamé","doi":"10.1016/j.thromres.2024.109166","DOIUrl":"10.1016/j.thromres.2024.109166","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109166"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a Simplified Diagnostic Algorithm for Deep Vein Thrombosis","authors":"Sasha Sharma ,&nbsp;Linnea Soon ,&nbsp;Kerstin de Wit ,&nbsp;Alejandro Lazo-Langner ,&nbsp;Grégoire Le Gal ,&nbsp;Shannon Bates ,&nbsp;Sameer Parpia","doi":"10.1016/j.thromres.2024.109165","DOIUrl":"10.1016/j.thromres.2024.109165","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109165"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Predictive Model to Identify Pulmonary Embolism in Unselected Emergency Department Patients: Model Validation and Improvement During the COVID Era","authors":"Dennis Christopher ,&nbsp;Keerat Grewal ,&nbsp;Dorsa Ghahramani ,&nbsp;Soheila Nadalia ,&nbsp;Kerstin de Wit","doi":"10.1016/j.thromres.2024.109157","DOIUrl":"10.1016/j.thromres.2024.109157","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"242 ","pages":"Article 109157"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}