Therapeutic Advances in Ophthalmology最新文献

{"title":"A cross-sectional study investigating the effects of argon laser retinal photocoagulation on lens clarity and corneal endothelial cells.","authors":"Uğur Yılmaz,&nbsp;Hüseyin Kaya,&nbsp;Selen Akbulut,&nbsp;Yasin Durkal","doi":"10.1177/25158414231189071","DOIUrl":"https://doi.org/10.1177/25158414231189071","url":null,"abstract":"<p><strong>Background: </strong>The mechanism of argon laser retinal photocoagulation (ALRP) treatment is to apply thermal-induced retinal pigment epithelium damage. Light passes through the anterior optical segments of the eye to reach the retina. Lens densitometry is a noninvasive and quantitative measurement providing information about corneal and lens clarity.</p><p><strong>Objectives: </strong>This study aimed to investigate whether laser light affects lens clarity and corneal endothelial cells.</p><p><strong>Design: </strong>This was a prospective, cross-sectional study.</p><p><strong>Methods: </strong>Lens densitometric (LD) analysis and specular microscopy were performed before, after, and 1 month after ALRP treatment, by an expert ophthalmologist, blinded to the medical status of the patients. LD analysis was performed using a Pentacam HR (Oculus, Wetzlar, Germany) and a Specular Microscope CEM-530 (Nidek, Japan) was used for endothelial cell analysis.</p><p><strong>Results: </strong>The evaluation was made on 81 eyes of 41 patients, with a mean age of 54.46 ± 6.7 years. LD, after ALRP, was significantly more than before ALRP (<i>p</i> < 0.001). There was no statistically significant difference in LD, before ALRP, and 1 month after ALRP (<i>p</i> = 0.262). There was a statistically significant increase in LD after ALRP compared to before ALRP, but it decreased after 1 month. There was an increase in the coefficient of variance (CV) after ALRP compared to before ALRP but it was not statistically significant (<i>p</i> = 0.188). There was no statistically significant difference in CV between before ALRP and 1 month after ALRP (<i>p</i> = 1.000). There was no statistically significant difference in the cell density, the hexagonality percentage between before ALRP, after ALRP, and 1 month after ALRP (<i>p</i> = 0.993, and 0.863, respectively).</p><p><strong>Conclusion: </strong>ALRP may affect the lens densitometry temporarily during the procedure. Thermal damage may be the reason for increased lens densitometry.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231189071"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/4f/10.1177_25158414231189071.PMC10395167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10295619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of macular pigment optical density in Arab population and its relationship to people's anthropometric data: a cross-sectional study.","authors":"Ali Alsaqr,&nbsp;Manal Alharbi,&nbsp;Noura Aldossary,&nbsp;Abdulaziz Alruwished,&nbsp;Mohammed Alharbi,&nbsp;Khalid Alghaib,&nbsp;Abeer Alabdulkarim,&nbsp;Shatha Alhamdan,&nbsp;Esam Almutleb,&nbsp;Ali Abusharha","doi":"10.1177/25158414231189099","DOIUrl":"https://doi.org/10.1177/25158414231189099","url":null,"abstract":"<p><strong>Background: </strong>Anthropometry facilitates the evaluation of risks associated with reduced macular pigment optical density (MPOD).</p><p><strong>Objectives: </strong>To investigate the predictors and anthropometric indices associated with MPOD in healthy adult in Arab population.</p><p><strong>Design: </strong>This is a cross-sectional study.</p><p><strong>Methods: </strong>The MPOD was measured at 0.5° from fovea using a heterochromatic flicker photometer. Healthy participants aged between 20 and 40 years were recruited. The study evaluated the following data of the participants: height, weight, body mass index, body fat percentage, basal metabolic rate, visceral fat level, muscle mass, bone mineral content, and percentage of protein and body water. The correlation between MPOD with anthropometrics and demographic data was evaluated using Spearman's correlation test. The differences among genders were investigated using the Mann-Whitney <i>U</i> test. The smoking effect on MPOD was analyzed using the Friedman test.</p><p><strong>Results: </strong>In all, 143 participants were recruited. The median ± interquartile range was calculated for age (23 ± 4 years), visual acuity (0.00 ± 0.00 logMAR), and MPOD (0.41 ± 0.18). The average MPOD was higher in males than in females but it was not statistically significant (<i>p</i> > 0.05); on the other hand, they were statistically significantly different in most of the anthropometric data. A significant relationship was found between MPOD and percentage of body fat, protein, and body water (<i>r</i> = 0.30, <i>p</i> < 0.05). The observed median MPOD value was higher in this study than that found in previous studies in white populations, but lower than that found in studies investigating Asian populations.</p><p><strong>Conclusion: </strong>One of the most important risk factors of age-related macular degeneration is associated with a relative absence of macular pigment. This study brought into focus percentage of protein and body water for further studies as well as the well-established links with body fat and obesity. Unknown predictors of MPOD remain uncovered. The study also provided first report on normative values of MPOD for Arab population and confirmed the differences from other ethnicities.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231189099"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/4b/10.1177_25158414231189099.PMC10436989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cycloplegic agents (1% cyclopentolate hydrochloride and 1% tropicamide) on anterior segment parameters.","authors":"Mustafa Duran,&nbsp;Selim Cevher","doi":"10.1177/25158414231180984","DOIUrl":"https://doi.org/10.1177/25158414231180984","url":null,"abstract":"<p><strong>Background: </strong>Cycloplegic drops are commonly used in ophthalmology practice. Changes in anterior segment parameters may occur after cycloplegia. These changes can be evaluated with corneal topography.</p><p><strong>Objective: </strong>This study aimed to compare the effects of 1% cyclopentolate hydrochloride and 1% tropicamide on anterior segment parameters using the Sirius Scheimpflug imaging technique.</p><p><strong>Design: </strong>A cross-sectional study.</p><p><strong>Methods: </strong>One hundred twenty eyes of sixty healthy volunteers with spherical equivalent (SE) values of 0 to ±1 diopter (D) were studied. The right eye of each subject had instillation of cyclopentolate hydrochloride 1% (Group 1) and the left eye of each subject had instillation of tropicamide 1% (Group 2). SE, intraocular pressure, and corneal topography measurements were performed before and 40 min after instillation were compared.</p><p><strong>Results: </strong>In Group 1, SE, aqueous depth, anterior chamber depth, iridocorneal angle (ICA), anterior chamber volume (ACV), and pupil size (PS) values were significantly increased (<i>p</i> < 0.001, <i>p</i> = 0.01, <i>p</i> < 0.001, <i>p</i> = 0.03, <i>p</i> < 0.001, and <i>p</i> < 0.001, respectively). In Group 2, SE, ICA, ACV, and PS were significantly increased (<i>p</i> < 0.001 for all). Keratometric values (K1 and K2) and central corneal thickness changed insignificantly in both groups (<i>p</i> > 0.05). The effects of the two administered agents on all parameters were similar (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Cyclopentolate hydrochloride and tropicamide affected SE, ICA, ACV, and PS values significantly. These parameters are important in intraocular lens (IOL) power calculations. PS is also important in refractive surgery and cataract surgery with multifocal IOL implantation. Although there was an insignificant difference between the agents, the effects of tropicamide on the parameters were smaller than those of cyclopentolate.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231180984"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/ac/10.1177_25158414231180984.PMC10331352.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9814475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immuno-inflammatory index in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma.","authors":"Nejla Tukenmez Dikmen,&nbsp;Yasemin Un","doi":"10.1177/25158414231197072","DOIUrl":"https://doi.org/10.1177/25158414231197072","url":null,"abstract":"<p><strong>Background: </strong>In recent years, the role of some hematological parameters used as chronic inflammation markers in the pathogenesis of many ocular and systemic diseases has been investigated. For ocular diseases such as uveitis, keratoconus, and retinal vein occlusion, the neutrophil/lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been reported to be useful inflammatory biomarkers. It has also been reported that low-grade chronic inflammation plays a role in the formation of pseudoexfoliation.</p><p><strong>Objective: </strong>To evaluate the NLR, SII, and platelet-lymphocyte ratio (PLR) in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliative glaucoma (PEXG).</p><p><strong>Design: </strong>This was a retrospective case-control study.</p><p><strong>Methods: </strong>This study evaluated the clinical and laboratory data of 34 patients with PEXS, 33 patients with PEXG, and 33 control patients. Detailed eye examination notes in patient files and blood count measurements were recorded.</p><p><strong>Results: </strong>SII values were the highest in the PEXS group, followed by the PEXG and control groups (582.01 ± 339.9, 478.14 ± 211.7, and 413.98 ± 129.5, respectively) (<i>p</i> = 0.043). In paired comparisons, the SII values of the PEXS group were significantly higher than the control group (<i>p</i> = 0.011). The mean NLR rate was highest in the PEXS group, followed by the PEXG and the control groups (2.46 ± 1.6, 2.17 ± 0.8, and 1.69 ± 0.4, respectively) (<i>p</i> = 0.023). In paired comparisons, the mean NLR levels were higher in the PEXS and the PEXG groups than in the control group (<i>p</i> = 0.03 and <i>p</i> = 0.01, respectively). There was no significant difference between the groups in terms of PLR. According to receiver operating characteristic curve analysis, the optimal cut-off value for estimating PEXS was found as >449.4 for SII and 1.78 for NLR (<i>p</i> = 0.011 and <i>p</i> = 0.031, respectively).</p><p><strong>Conclusions: </strong>In PEXS patients, both SII and NLR were significantly higher, albeit in a small group of patients, and SII may be a helpful and supportive parameter for NLR in risk estimation in these patients. There was a statistically significant difference only in NLR in patients with PEXG when compared with the control group. However, these results need to be supported by future longitudinal and larger studies to identify any possible link between hematological inflammatory markers and pseudoexfoliation.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231197072"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/10/10.1177_25158414231197072.PMC10504835.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10360401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoreceptor outer segment layer thinning as a biomarker in acute central serous chorioretinopathy.","authors":"Dmitrii S Maltsev,&nbsp;Alexey N Kulikov,&nbsp;Maria A Burnasheva,&nbsp;Jay Chhablani","doi":"10.1177/25158414231160689","DOIUrl":"https://doi.org/10.1177/25158414231160689","url":null,"abstract":"<p><strong>Background: </strong>The photoreceptor outer segment (PROS) layer demonstrates focal thinning above the fluorescein leakage in acute central serous chorioretinopathy (CSC); however, the nature of this phenomenon is not known.</p><p><strong>Objectives: </strong>To study the relationship between the PROS layer and thickness of the outer retinal layers above the fluorescein leakage in newly diagnosed acute CSC.</p><p><strong>Design: </strong>Single-center retrospective study.</p><p><strong>Methods: </strong>All participants received multimodal imaging, including fluorescein angiography and optical coherence tomography. Thickness of PROS, outer nuclear layer (ONL), and ONL-outer plexiform layer (OPL) complex was measured above the leakage and outside the leakage within the area of neurosensory detachment. The number of intraretinal hyperreflective foci of the outer retina was counted. The correlation between PROS thickness and ONL, OPL-ONL complex thickness, and the number of intraretinal hyperreflective foci was calculated.</p><p><strong>Results: </strong>Fifty eyes of 48 patients (38 males and 10 females, 43.8 ± 10.6 years) with a mean symptom duration of 1.4 ± 1.3 months were included. PROS thickness above the fluorescein leakage showed a statistically significant correlation with ONL thickness, OPL-ONL complex thickness, and the number of hyperreflective foci in the outer retina, 0.57, 0.60, and -0.46, respectively (<i>p</i> < 0.001). Measuring the extent of PROS thinning above the leakage in newly diagnosed CSC allowed to predict self-resolution of subretinal fluid. The greatest linear dimension of PROS thinning showed an area under the receiver operating curve (ROC) curve of 0.98. The cases without PROS thinning had the fastest resolution of subretinal fluid.</p><p><strong>Conclusion: </strong>PROS thinning above the fluorescein leakage in acute CSC is associated with thinning of the outer retinal layers and reveals mild outer retinal atrophy. The absence of PROS thinning predicts faster resolution of CSC.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231160689"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/f4/10.1177_25158414231160689.PMC10034278.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9192511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is ultra-thin Descemet stripping automated endothelial keratoplasty a viable alternative to Descemet membrane endothelial keratoplasty? A systematic review and meta-analysis.","authors":"Tanu Singh,&nbsp;Parul Ichhpujani,&nbsp;Rohan Bir Singh,&nbsp;Sudesh Arya,&nbsp;Suresh Kumar","doi":"10.1177/25158414221147823","DOIUrl":"https://doi.org/10.1177/25158414221147823","url":null,"abstract":"<p><strong>Background: </strong>Ultra-thin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) is a recently developed surgical procedure that has shown promising results for the management of various corneal endothelial diseases.</p><p><strong>Objectives: </strong>To evaluate the outcomes of the UT-DSAEK to the Descemet membrane endothelial keratoplasty (DMEK).</p><p><strong>Design: </strong>A systematic analysis of the studies comparing UT-DSAEK with DMEK by evaluating one or more outcomes (vision, complications, and post-operative endothelial cell counts) was performed. The meta-analysis was done if two or more studies reported a common outcome.</p><p><strong>Methods: </strong>We used PubMed, EMBASE, and SCOPUS databases to identify articles comparing the outcomes of UT-DSAEK with DMEK and performed a meta-analysis using RevMan, version 5.4.</p><p><strong>Results: </strong>A total of six studies were included in this review (two randomized clinical trials and four non-randomized comparative studies). Our analysis showed the patients who underwent DMEK cases showed better visual outcomes with a mean difference of 0.06 LogMAR (95% CI: 0.04-0.09) in BCVA, albeit with <i>i</i> ² of 52% (heterogenous values). The evidence was weak, with the most weightage on retrospective studies. UT-DSAEK showed significantly fewer complications such as graft dislocations, with an odds ratio of 0.25 (95% CI: 0.13-0.48). There was no significant difference in the endothelial cell counts with a mean difference of 86.34 (95%CI: -133.09 to -305.77).</p><p><strong>Conclusion: </strong>Although the literature is limited on UT-DSAEK with post-operative visual acuity that could be practically at par with DMEK, lesser complication rates and comparable post-operative endothelial cells could be a suitable alternative to DMEK for corneal endothelial pathologies.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414221147823"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/ff/10.1177_25158414221147823.PMC9909050.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Effect of laser peripheral iridotomy on contrast sensitivity using Spaeth/Richman Contrast Sensitivity test\".","authors":"","doi":"10.1177/25158414231158418","DOIUrl":"https://doi.org/10.1177/25158414231158418","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/25158414221078142.].</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231158418"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/52/10.1177_25158414231158418.PMC9941595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10770404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of minimally invasive glaucoma surgery on the ocular surface and quality of life in patients with glaucoma.","authors":"Lee Jones,&nbsp;Natalia Maes,&nbsp;Umair Qidwai,&nbsp;Gokulan Ratnarajan","doi":"10.1177/25158414231152765","DOIUrl":"https://doi.org/10.1177/25158414231152765","url":null,"abstract":"<p><strong>Background: </strong>Minimally invasive glaucoma procedures are emerging as clinically effective and safe glaucoma management approaches; however, evidence regarding quality-of-life outcomes is limited.</p><p><strong>Objectives: </strong>To explore the impact of minimally invasive glaucoma surgery (MIGS) combined with phacoemulsification on patient-reported outcomes and clinical parameters related to ocular surface disease in people with glaucoma.</p><p><strong>Design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>Fifty-seven consecutive patients were examined prior to undergoing iStent combined with phacoemulsification with or without adjunctive endocyclophotocoagulation and at 4-month follow-up.</p><p><strong>Results: </strong>At follow-up, on average patients returned statistically significantly improved scores on glaucoma-specific (GQL-15, <i>p</i> < 0.001; GSS, <i>p</i> < 0.001), general health (EQ-5D, <i>p</i> = 0.02) and ocular surface PROMs (OSDI, <i>p</i> = 0.001). Patients were using fewer eye drops on average after MIGS compared with before surgery (1.1 ± 0.9 <i>versus</i> 1.8 ± 0.8; <i>p</i> < 0.001). Undergoing MIGS was associated with improved tear film break-up time (<i>p</i> < 0.001) and reduced corneal fluorescein staining (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This retrospective audit shows quality of life and clinical parameters related to the ocular surface are improved following MIGS combined with phacoemulsification in patients previously treated with anti-glaucoma therapy.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231152765"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/07/10.1177_25158414231152765.PMC10107052.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of choroidal nevi in patients with central serous chorioretinopathy.","authors":"Dmitrii S Maltsev,&nbsp;Alexey N Kulikov,&nbsp;Alexander S Vasiliev,&nbsp;Ekaterina D Shapovalova,&nbsp;Jay Chhablani","doi":"10.1177/25158414231189080","DOIUrl":"https://doi.org/10.1177/25158414231189080","url":null,"abstract":"<p><strong>Background: </strong>A number of articles report the association of polypoidal lesions and choroidal nevi; however, the relationship between choroidal nevi and pachychoroidal disorders has not been studied.</p><p><strong>Objectives: </strong>To study the prevalence of choroidal nevi in central serous chorioretinopathy (CSCR) patients and to elucidate potential differences in the clinical characteristics of CSCR in patients with and without choroidal nevi.</p><p><strong>Design: </strong>Case-control study.</p><p><strong>Methods: </strong>This study included a retrospective analysis of medical records and multimodal imaging data of CSCR patients and a prospective evaluation of the prevalence of the choroidal nevi in age- and sex-matched healthy controls. All participants received comprehensive ophthalmic examination and multimodal imaging including infrared scanning laser ophthalmoscopy in dark-field mode to detect choroidal nevi in the central 40° × 60° region.</p><p><strong>Results: </strong>A total of 199 CSCR patients (160 males and 39 females, 47.9 ± 9.4 years) and 184 age-matched healthy individuals (139 males and 45 females, 44.8 ± 12.5 years) were included. Choroidal nevi were detected in 24 (12.1%) CSCR patients and 10 (5.4%) healthy controls (<i>p</i> = 0.01). CSCR patients with choroidal nevi had statistically significantly higher subfoveal choroidal thickness, lower best-corrected visual acuity, and lower central retinal thickness (<i>p</i> < 0.05) than CSCR patients without choroidal nevi. The odds ratio for the presence of chronic CSCR in patients with choroidal nevi was 27.0 (95% CI: 3.1-231.9, <i>p</i> = 0.003).</p><p><strong>Conclusion: </strong>The prevalence of choroidal nevi among patients with CSCR is higher than in age- and sex-matched healthy population. Choroidal nevi may be associated with chronic CSCR.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231189080"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/1f/10.1177_25158414231189080.PMC10387679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular complications of diabetes mellitus in a pediatric population and proposals for screening and follow-up programs.","authors":"Laura Diplotti,&nbsp;Silvia Pignatto,&nbsp;Francesca Franco,&nbsp;Manuela Zanatta,&nbsp;Daniele Veritti,&nbsp;Paola Cogo,&nbsp;Paolo Lanzetta","doi":"10.1177/25158414231174141","DOIUrl":"https://doi.org/10.1177/25158414231174141","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM) is one of the world's greatest health emergencies of the 21st century. Ocular complications of DM are commonly chronic and progressive, but vision loss can be effectively prevented or delayed with early detection and timely treatment. Therefore, regular comprehensive ophthalmologic examinations are mandatory. Ophthalmic screening and dedicated follow-up for adults with DM are well established, whereas, there is no consensus on optimal recommendations for the pediatric population, reflecting the lack of clarity about the current burden of disease in this age group.</p><p><strong>Objectives: </strong>To determine the epidemiology of ocular complications of diabetes and to assess optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) macular features in a pediatric population with DM. To review ophthalmological screening and follow-up plans for the diabetic pediatric population.</p><p><strong>Design: </strong>Observational study.</p><p><strong>Methods: </strong>Retrospective consecutive cohort study of all 165 diabetic patients (330 eyes) aged 0-18 years, examined between January 2006 and September 2018 at the Pediatric Department of 'S. Maria della Misericordia' Udine Hospital who underwent at least one complete ophthalmologic examination at the Ophthalmology University Clinic at the Udine Hospital. OCT and OCTA data were available for 37 patients (72 eyes, 2 excluded). The associations between ocular complications and selected potential risk factors were evaluated by univariate analyses.</p><p><strong>Results: </strong>No patient had signs of ocular diabetic complications or any macular morphological or micro-vascular impairment, regardless of any potential risk factor. The prevalence of strabismus and refractive errors in the study group, was found to be similar to non-diabetic pediatric populations.</p><p><strong>Conclusion: </strong>Screening and follow-up of ocular diabetic complications in children and adolescents could be performed less frequently than in adults with diabetes. There is no need to screen potentially treatable visual disorders in diabetic children earlier or more frequently than in the healthy children thus reducing time spent in hospital and permitting a better tolerance to medical examinations in diabetic pediatric patients. We described the OCT and OCTA patterns in a pediatric population with DM.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231174141"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/26/10.1177_25158414231174141.PMC10272666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}