Therapeutic Advances in Ophthalmology最新文献

{"title":"Prophylactic effect of brimonidine to minimize the incidence of subconjunctival hemorrhage in the early postoperative period after 23G pars plana vitrectomy.","authors":"Mari Carmen Desco,&nbsp;Julio Cesar Molina Martín,&nbsp;Jorge Mataix-Boronat,&nbsp;Isabel Pascual-Camps,&nbsp;Elena Palacios-Pozo,&nbsp;Marisa Barón-García,&nbsp;David P Piñero,&nbsp;Amparo Navea-Tejerina","doi":"10.1177/25158414211045753","DOIUrl":"https://doi.org/10.1177/25158414211045753","url":null,"abstract":"<p><strong>Background: </strong>Several studies have investigated and demonstrated the prophylactic effect of brimonidine drops in preventing subconjunctival hemorrhage in some microincisional ophthalmic surgeries, such as intravitreal injections or cataract surgery. However, there are no previous studies investigating this prophylactic effect after 23G microincisional vitreoretinal surgery.</p><p><strong>Aim: </strong>The aim of the current study was to determine whether subconjunctival hemorrhage after 23G pars plana vitrectomy (PPV) could be prevented with the use of prophylactic topical brimonidine.</p><p><strong>Methods: </strong>This was a phase III, prospective, interventional, randomized, controlled single-center clinical trial with a follow-up of 2 weeks. A total of 77 eyes (mean age: 68.4 ± 10.7 years) undergoing 23G PPV were included and randomized into two groups: group 1 including 41 patients receiving prophylactic preoperative treatment with brimonidine, and group 2 (control group) including 36 patients not receiving this prophylactic treatment. Differences in terms of number of conjunctival quadrants affected with subconjunctival hemorrhage were evaluated in each of the follow-up visits.</p><p><strong>Results: </strong>The presence of subconjunctival hemorrhage was similar in both groups the first days after surgery (<i>p</i> > 0.05). At the last visit (10-14 days after surgery), this condition was significantly more frequent in control group where there was a significant difference, being more frequent in the control group (7.3% vs 28.6%, <i>p</i> = 0.022). The number of conjunctival quadrants affected was also similar in both groups, except for the last visit in which most of the patients treated with brimonidine (92.7%) showed no bleeding compared to 71.4% in control group. No effect on the efficacy of brimonidine treatment of the presence of blood hypertension, diabetes, and antiplatelet or anticoagulant treatment was observed.</p><p><strong>Conclusion: </strong>Brimonidine seems to be a useful option to decrease subconjunctival hemorrhage after microincisional vitreoretinal surgery or improve its resolution during the first postoperative week. This finding should be mainly due to the vasoconstrictor effect of brimonidine.</p><p><strong>Trial registration: </strong>EudraCT, 2012-002895-15 (registered 19 December 2012); https://www.clinicaltrialsregister.eu/ctr-search/search?query=2012-002895-15.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211045753"},"PeriodicalIF":2.5,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/83/10.1177_25158414211045753.PMC8495506.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39504026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term medication reduction in controlled glaucoma with iTrack ab-interno canaloplasty as a standalone procedure and combined with cataract surgery.","authors":"Mahmoud A Khaimi","doi":"10.1177/25158414211045751","DOIUrl":"https://doi.org/10.1177/25158414211045751","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term effectiveness of iTrack (Nova Eye Medical, Fremont, USA) ab-interno canaloplasty performed as a standalone procedure, or combined with cataract surgery, in reducing antiglaucoma medication dependence and maintaining intraocular pressure within target range in patients with controlled primary open-angle glaucoma.</p><p><strong>Methods: </strong>This is a retrospective, single-center, case series study of patients who underwent iTrack ab-interno canaloplasty as a standalone procedure (<i>n</i> = 34) or in combination with cataract surgery (<i>n</i> = 11). Eyes with controlled mild or moderate glaucoma (intraocular pressure ⩽17 mmHg) were included; those with prior glaucoma surgeries were excluded. The primary outcome was the mean reduction in glaucoma medication and the secondary outcome was the maintenance of controlled intraocular pressure postoperatively.</p><p><strong>Results: </strong>A total of 35 patients (45 eyes) with a mean age of 73 ± 9.7 years were included in the study. For all eyes, a significant decrease (61%) in the mean number of medications was seen at 36 months (1.89 ± 0.93 <i>versus</i> 0.60 ± 0.82; <i>p</i> < 0.001), with 56% (14/25) of eyes medication free. No significant difference was observed in the reduction of medication use whether iTrack was performed with or without cataract surgery at 12 and 36 months. Mean baseline intraocular pressure of 14.42 ± 2.2 mmHg for all eyes was maintained at the 12-, 24-, and 36-month follow-up visits (14.6 ± 3.65, 15.06 ± 2.26, and 14.19 ± 2.91, respectively), with no significant difference between the two groups (<i>p</i> = 0.08).</p><p><strong>Conclusion: </strong>The iTrack ab-interno canaloplasty significantly reduced medication dependency and maintained intraocular pressure within target range in patients with controlled mild or moderate primary open-angle glaucoma, while showing a good safety profile, both as a standalone procedure or in combination with cataract surgery.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211045751"},"PeriodicalIF":2.5,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/75/10.1177_25158414211045751.PMC8481718.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39484591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-device measurement variability of vital data parameters for keratorefractive and cataract refractive surgery.","authors":"Piotr Kanclerz,&nbsp;Katarzyna Przewłócka,&nbsp;Xiaogang Wang","doi":"10.1177/25158414211045750","DOIUrl":"https://doi.org/10.1177/25158414211045750","url":null,"abstract":"<p><strong>Introduction: </strong>The measurements of corneal white-to-white (WTW) diameter and pupil size are critical for decision making in refractive surgery. Currently, automatic measurement of keratometry, corneal WTW, and pupil size are implemented in several ocular devices. The purpose of this study was to examine the agreement between two commonly used devices, an autorefractor and an optical biometer, for these parameters.</p><p><strong>Methods: </strong>Measurements were performed with both a Lenstar LS-900 and Nidek ARK-1 by an experienced examiner in random order. The devices were placed in close proximity within the same dimly lit room.</p><p><strong>Results: </strong>The measurements of 65 right eyes were analyzed. The results of the flat, steep, and mean keratometric reading were not significantly different (<i>p</i> = 0.96, <i>p</i> = 0.90, <i>p</i> = 0.93, respectively). Corneal WTW distances showed only moderate agreement between devices and were found to be significantly different (<i>r</i> = 0.8071; <i>p</i> < 0.01). Pupil diameters showed poor agreement between devices and were significantly different (<i>r</i> = 0.4890; <i>p</i> < 0.01). Agreement between implantable contact lens sizing, based on the measurements obtained by the two devices, was achieved for 19 of the 51 eyes (37.3%).</p><p><strong>Conclusion: </strong>We found a significant difference in WTW and pupil size measurements between ARK-1 and Lenstar. Results for both of the devices cannot be considered interchangeable for these data parameters.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211045750"},"PeriodicalIF":2.5,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/83/10.1177_25158414211045750.PMC8458669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39453179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of amblyopia on clinical outcomes of children with astigmatism.","authors":"Burçin Çakır, Nilgün Özkan Aksoy, Sedat Özmen, Özlem Bursalı","doi":"10.1177/25158414211040898","DOIUrl":"10.1177/25158414211040898","url":null,"abstract":"<p><strong>Background: </strong>Amblyopia is more common in children with high astigmatism, but factors contributing to development of amblyopia and visual outcomes are not fully understood.</p><p><strong>Objective: </strong>To evaluate the effect of amblyopia on the clinical outcomes in children with ⩾1.75 diopter (D) astigmatism.</p><p><strong>Methods: </strong>We reviewed the medical records of children with ⩾1.75 D astigmatism with and without amblyopia (amblyopes group and non-amblyopes group). The mean age, gender, amount and type of ocular deviation, presence of convergence insufficiency (CI), stereopsis, time of initial spectacle use and follow-up time, differences in best-corrected visual acuity (VoD) and spherical equivalent (SE) between eyes were assessed and compared between the groups. Best-corrected visual acuity (BCVA), mean SE, astigmatism measurements were assessed and compared between amblyopic, fellow, and non-amblyopic eyes.</p><p><strong>Results: </strong>The records included 68 eyes of 34 children with amblyopia and 56 eyes of 28 children without amblyopia. The mean age, gender, amount and type of ocular deviation, presence of CI, stereopsis, time of initial spectacle use, follow-up time, and the difference in SE did not differ between groups. In amblyopes, exodeviation was more common and statistically greater in near (33 cm) than at distance (6 m) (p = 0.005). The mean BCVA and astigmatism values were statistically different between amblyopic, fellow, and non-amblyopic eyes.</p><p><strong>Conclusion: </strong>A greater near than distance exodeviation and higher mean astigmatism value were found in amblyopic children with astigmatism.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211040898"},"PeriodicalIF":2.3,"publicationDate":"2021-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/4d/10.1177_25158414211040898.PMC8442477.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39431648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthreshold micropulse laser adjuvant to bevacizumab versus bevacizumab monotherapy in treating diabetic macular edema: one- year- follow-up.","authors":"Leila El Matri,&nbsp;Ahmed Chebil,&nbsp;Khaled El Matri,&nbsp;Yousra Falfoul,&nbsp;Zouheir Chebbi","doi":"10.1177/25158414211040887","DOIUrl":"https://doi.org/10.1177/25158414211040887","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the therapeutic impact of combining intravitreal injections of bevacizumab (IVB) with micropulse laser (MPL) in central diffuse diabetic macular edema (DME) versus IVB monotherapy during 12 months follow-up.</p><p><strong>Methods: </strong>We conducted a retrospective comparative study of 98 treatment-naive eyes (63 patients) with central diffuse DME. The first group of patients (IVB + MPL group, <i>n</i> = 49) was treated with 3 monthly IVB followed by MPL within 1 week after the third injection. Patients were then followed and treated on a pro re nata (PRN) basis, with MPL retreatment if necessary. The changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), number of IVB injections and MPL sessions were evaluated at 4, 8, and 12 months. A control group of diabetic patients with treatment-naive DME was treated with standard protocol of 3 monthly IVB as monotherapy then followed on a PRN basis (IVB group, <i>n</i> = 49). Statistic comparaison of BCVA, CMT, and IVB number variation was interpreted at 12 months between both groups.</p><p><strong>Results: </strong>In IVB + MPL group, baseline BCVA improvement was not significant at 4 and 8 months (<i>p</i> = 0.90, <i>p</i> = 0.08), and was statistically significant (<i>p</i> = 0.01) at 12 months. Mean CMT significantly decreased at 4, 8, and 12 months (<i>p</i> < 0.01) in IVB + MPL group. The difference in BCVA (p = 0.091) and CMT (p = 0.082) variation at 12 months between both groups was not significant but the number of injections was significantly lower in IVB + MPL group (4.1 ± 1.5 injections) compared to IVB group (7.2 ± 1.3 injections) (<i>p</i> < 0.005).</p><p><strong>Conclusion: </strong>Combining intravitreal injections of bevacizumab and MPL in the treatment of DME is effective and safe. This protocol may decrease the number of IVB and its frequency. It offers the advantage of lasting therapeutic response with fewer recurrences.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211040887"},"PeriodicalIF":2.5,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/95/10.1177_25158414211040887.PMC8419546.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39396434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye-tunes: role of music in ophthalmology and vision sciences.","authors":"Shruti Muralidharan,&nbsp;Parul Ichhpujani,&nbsp;Shibal Bhartiya,&nbsp;Rohan Bir Singh","doi":"10.1177/25158414211040890","DOIUrl":"https://doi.org/10.1177/25158414211040890","url":null,"abstract":"<p><p>Although the healing effect of music has been recognized since time immemorial, there has been a renewed interest in its use in modern medicine. This can be attributed to the increasing focus on holistic healing and on the subjective and objective aspects of well-being. In ophthalmology, this has ranged from using music for patients undergoing diagnostic procedures and surgery, as well as for doctors and the operation theatre staff during surgical procedures. Music has proven to be a potent nonpharmacological sedative and anxiolytic, allaying both the pain and stress of surgery. This review aims to explore the available evidence about the role of music as an adjunct for diagnostic and surgical procedures in current ophthalmic practices.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211040890"},"PeriodicalIF":2.5,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/b3/10.1177_25158414211040890.PMC8419534.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39396433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic antiplatelet agents and anticoagulants in eyes with branch retinal vein occlusion.","authors":"Pali P Singh,&nbsp;Durga S Borkar,&nbsp;Cason B Robbins,&nbsp;Jane S Kim,&nbsp;Faith Birnbaum,&nbsp;Maria Gomez-Caraballo,&nbsp;Akshay S Thomas,&nbsp;Sharon Fekrat","doi":"10.1177/25158414211040894","DOIUrl":"https://doi.org/10.1177/25158414211040894","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to investigate the effect of systemic antiplatelet agents and anticoagulants on the structural and functional outcomes of eyes with branch retinal vein occlusion (BRVO).</p><p><strong>Methods: </strong>A retrospective longitudinal cohort study was performed on BRVO patients evaluated at a single tertiary care referral center between 2009 and 2017. Medical records were reviewed for antiplatelet agent and anticoagulant use including aspirin, clopidogrel, warfarin, rivaroxaban, apixaban, or dabigatran prior to BRVO onset. In addition, optical coherence tomography (OCT) parameters, clinical outcomes, and treatment patterns were also recorded.</p><p><strong>Results: </strong>A total of 354 BRVO eyes were identified with a mean follow-up time of 36 months. Antiplatelet or anticoagulant use was associated with presence of cystoid macular edema (CME) at presentation after controlling for potential confounding variables in a multivariate logistic regression. Multivariate regression also revealed an association between foveal hemorrhage at presentation and use of antiplatelet or anticoagulant medications. There were no significant differences in visual acuity or prevalence of CME at the final visit in those with antiplatelet/anticoagulant use compared to those not on these agents.</p><p><strong>Conclusion: </strong>Although the use of systemic antiplatelet or anticoagulant agents was associated with increased prevalence of CME and foveal hemorrhage at presentation of BRVO, the use of these medications was not associated with different visual or structural outcomes at the final visit.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211040894"},"PeriodicalIF":2.5,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/10/10.1177_25158414211040894.PMC8419548.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39396435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant supplements in age-related macular degeneration: are they actually beneficial?","authors":"Mousumi Banerjee,&nbsp;Rohan Chawla,&nbsp;Atul Kumar","doi":"10.1177/25158414211030418","DOIUrl":"10.1177/25158414211030418","url":null,"abstract":"<p><p>Age-related macular degeneration (ARMD) is one of the prominent causes of central visual loss in the older age group in the urbanized, industrialized world. In recent years, many epidemiological studies and clinical trials have evaluated the role of antioxidants and micronutrients to prevent the progression of ARMD. In this article, we review some of these major studies. In addition, we review the absorption and bioavailability and possible undesirable effects of these nutrients after ingestion. The role of genotypes and inappropriate use of these supplements are also discussed. From all the above evidence, we conclude that it may not be prudent to prescribe these formulations without a proper assessment of the individual's health and dietary status. The effectiveness of all the components in antioxidant formulations is controversial. Thus, these supplements should not be prescribed just for the purpose of providing patients some kind of therapy, which may give a false sense of mental satisfaction.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211030418"},"PeriodicalIF":2.5,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/28/10.1177_25158414211030418.PMC8404659.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39376456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pattern scanning laser on macular thickness in diabetic retinopathy.","authors":"Nadine Hamed,&nbsp;Logan Vander Woude,&nbsp;Ramak Roohipourmoallai,&nbsp;Collin Ohning,&nbsp;Kathleen A Regan,&nbsp;Siva S R Iyer","doi":"10.1177/25158414211035860","DOIUrl":"https://doi.org/10.1177/25158414211035860","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the effect of pattern scanning laser (PASCAL) panretinal photocoagulation (PRP) on central macular thickness (CMT) and visual acuity (VA) in patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>This retrospective non-randomized comparative case series included 262 eyes (163 with macular edema) of 177 patients with PDR. Treatment was PRP alone (137), PRP + anti-vascular endothelial growth factor (VEGF) (69), PRP + focal laser (28), or all three (89). CMT and central macular volume 3 and 6 mm from fovea were analyzed before and 1, 3, and 6 months after PRP. Spot number was plotted against CMT, and linear regression analysis was performed.</p><p><strong>Results: </strong>For each treatment group and time point, there was a non-significant relationship between spot number and CMT. In eyes receiving all three treatment modalities, a significant negative relationship was found between spot number and 3-mm volume at 6 months (<i>p</i> = 0.04) and 6-mm volume at 1 month (<i>p</i> = 0.002) and 6 months (<i>p</i> = 0.011). There was no significant change in VA in any treatment group at the 6-month time point.</p><p><strong>Conclusion: </strong>PASCAL PRP ± focal laser or anti-VEGF was not associated with increased development of macular edema or change in VA. PASCAL PRP with focal laser and anti-VEGF may result in a decrease in macular edema.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211035860"},"PeriodicalIF":2.5,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/83/10.1177_25158414211035860.PMC8366200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39324303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The change of anterior chamber angle parameters after cataract surgery in diabetic patients.","authors":"Alper Halil Bayat,&nbsp;Cetin Akpolat","doi":"10.1177/25158414211034717","DOIUrl":"https://doi.org/10.1177/25158414211034717","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to investigate the change of anterior chamber angle morphology after cataract surgery in patients with type 2 diabetes mellitus (DM2) using anterior segment optical coherence tomography (AS-OCT).</p><p><strong>Methods: </strong>In this prospective and comparative study, 57 eyes of the patients with cataract were investigated. The patients were divided into two groups. The DM2 group included cataractous type 2 diabetic patients without diabetic retinopathy (<i>n</i> = 30) and the non-DM2 group included nondiabetic participants with cataract (<i>n</i> = 27). The AS-OCT examinations were performed at baseline and 1 month after the cataract surgery. The corrected distance visual acuity (CDVA), intraocular pressure (IOP), angle-opening distance at 500 µm (AOD-500) and trabecular iris space area at 500 µm (TISA-500), and scleral spur angle (SSA) in temporal quadrant were analyzed.</p><p><strong>Results: </strong>The mean age, sex, and axial length values were similar in both groups (<i>p</i> > 0.05 for all). The CDVA was significantly improved in both groups (<i>p</i> < 0.001). The mean AOD-500, TISA-500, and SSA were increased and the mean IOP was decreased after cataract surgery in both groups (<i>p</i> < 0.001 for all). There were not any statistically significant intergroup differences in CDVA, IOP, and AS-OCT measurements between the DM2 and non-DM2 groups (<i>p</i> > 0.05 for all).</p><p><strong>Conclusion: </strong>Cataract surgery showed significant increases in mean anterior chamber angle parameters and reductions in IOP values in both diabetic and nondiabetic patients without intergroup significant differences. These results suggested the safety and effectiveness of cataract surgery, especially regarding anterior chamber angle parameters and so IOP changes.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211034717"},"PeriodicalIF":2.5,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/cd/10.1177_25158414211034717.PMC8365015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}