The Pharma Innovation Journal最新文献_第7页

Financial performance analysis of mango pulp processing unit: A case analysis 芒果果肉加工单位财务绩效分析:案例分析

The Pharma Innovation Journal Pub Date : 2020-12-01 DOI: 10.22271/tpi.2020.v9.i12sa.5421

D. Kalaiarasi, N. Palanichamy, S. Praveena

引用次数: 1

The human milk microbiota-origin, probiotics properties and its benefits for Newborns babies 母乳微生物来源、益生菌特性及其对新生儿的益处

The Pharma Innovation Journal Pub Date : 2020-10-01 DOI: 10.22271/TPI.2020.V9.I10E.5251

Meenakshi, Vivek Sharma

引用次数: 0

The defense mechanism of plant 植物的防御机制

The Pharma Innovation Journal Pub Date : 2020-10-01 DOI: 10.22271/tpi.2020.v9.i10e.5258

R. Raj, K. Lata, V. Raj, Mukul Kumar

{"title":"The defense mechanism of plant","authors":"R. Raj, K. Lata, V. Raj, Mukul Kumar","doi":"10.22271/tpi.2020.v9.i10e.5258","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i10e.5258","url":null,"abstract":"According to the state of food security and nutrition, Hunger has increased in many countries in which the economy has slowed down, mostly in middle-income countries. If nothing changes, the immense challenge of achieving the Zero Hunger Target by 2030. The causes of food scarcity might include factors such as unavailability of food due to less production of particular crops/vegetables (due to attack of pests/microbes), it becomes harder to fulfill the basic needs of life especially for poor. Therefore, we need to primarily focus on understanding the interaction between plants and microbes at the molecular level and underlying mechanisms of plant disease and which will help out to solve the global needs of food and resources. Plants have a natural defense mechanism/immune system to react to infections which subdivides into two parts. The first part identifies and reacts to molecules common to different classes of microbes, including non-pathogen. The function of the second part is to react to pathogens virulence factors, either directly or by affecting the host targets. We can also see the intricacies or reciprocation between plants and pathogen attackers. A vast and deep comprehension of plant defense mechanisms will defiantly solve the issue, like food scarcity.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"32 1","pages":"355-360"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85897437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood contamination in cerebrospinal fluid and its effect on biogenic amines and vitamins 脑脊液中的血液污染及其对生物胺和维生素的影响

The Pharma Innovation Journal Pub Date : 2020-10-01 DOI: 10.22271/TPI.2020.V9.I10D.5243

Ankit Kamboj, Jagdish Kaur, Paramjit Singh, H. Kaur

{"title":"Blood contamination in cerebrospinal fluid and its effect on biogenic amines and vitamins","authors":"Ankit Kamboj, Jagdish Kaur, Paramjit Singh, H. Kaur","doi":"10.22271/TPI.2020.V9.I10D.5243","DOIUrl":"https://doi.org/10.22271/TPI.2020.V9.I10D.5243","url":null,"abstract":"Cerebrospinal fluid (CSF) analysis offers the most innocuous analytical tool for assessing the cellular and biochemical environment of CNS and hence aids in studying neurometabolomic conditions. The aim of this study was to assess the effect of blood contamination of CSF on the levels of selected biogenic amines and vitamins. CSF samples were spiked with increasing volumes of whole fresh blood (2.5%, 5%, 10% and 20%) under conditions: (a) spiking of pooled CSF samples followed by freezing to cause red blood cell (RBC) lysis; (b) spiking of pooled CSF samples followed by centrifugation to remove RBCs. CSF concentrations of two biogenic amines Homovanillic acid (HVA) and 5-hydroxyindoleaceticacid (5-HIAA); and three vitamins Pyridoxal 5’-phosphate (PLP),5-methyltetrahydrofolate (MTHF) and Thiamine were analysed by HPLC coupled with electrochemical detection. HVA and 5-HIAA illustrated lower values when RBC lysis was caused. However, PLP, 5-MTHF, and thiamine depicted higher concentrations on RBC lysis in contrast to RBC removal. CSF metabolomic investigations involving biogenic amines and vitamins as biomarkers is possible even when remarkable RBC CSF contamination occurs provided that CSF is centrifuged for the removal of RBC prior to freezing.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"28 1","pages":"294-298"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87476530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology, molecular characterization and antimicrobial resistance of Necrotoxigenic Escherichia coli in diarrhoeic calves 腹泻犊牛中产坏死性大肠杆菌的流行病学、分子特征和耐药性

The Pharma Innovation Journal Pub Date : 2020-09-01 DOI: 10.22271/tpi.2020.v9.i9d.5125

M. Srivani, Y. N. Reddy, K. Subramanyam, M. Lakshman, K. Kavitha, R. Pushpa

{"title":"Epidemiology, molecular characterization and antimicrobial resistance of Necrotoxigenic Escherichia coli in diarrhoeic calves","authors":"M. Srivani, Y. N. Reddy, K. Subramanyam, M. Lakshman, K. Kavitha, R. Pushpa","doi":"10.22271/tpi.2020.v9.i9d.5125","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i9d.5125","url":null,"abstract":"A study was carried out to investigate the epidemiology, molecular characterization and antibiotic resistance of Necrotoxigenic E. coli (NTEC) isolated from diarrhoeic calves in Andhra Pradesh (AP) and Telangana States (TS). A total of 129 faecal samples from diarrhoeic buffalo calves of 1 to 90 days were collected from various districts in AP and TS, of which 60 E.coli were isolated. The cnf2 gene was detected by PCR and In vitro antibiotic susceptibility was tested by disk diffusion methods. The prevalence of E.coli associated diarrhea in calves was 46.51% of which 5.0% was due to NTEC based on the presence of cnf2 gene and none of the E.coli isolates possessed cnf1 gene. The NTEC isolates from diarrhoeic calves showed higher antibiotic resistance to tetracyclin and aztreonam (66.67%) and sensitive to ampicillin, cefotaxime, ceftazidime, amoxycillinclavulinicacid, gentamycin, kanamycin, streptomycin, sulfisoxazole, cotrimoxazole, ciprofloxacin, chloramphenicol and imipenem antibiotics. The present study provides baseline data on epidemiology of E.coli associated diarrhoeia, NTEC prevalence and antimicrobial resistance in calves which will help in formulating prophylactic and preventive measures in this geographic region.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73413985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Patients’ belief and adherence to their medication therapy in the Bawku municipality 包库市患者对药物治疗的信念和坚持

The Pharma Innovation Journal Pub Date : 2020-08-01 DOI: 10.22271/tpi.2020.v9.i8a.5033

F. Owusu, E. Amenuke, P. Entsie, G. Yeboah, Rachel Aboagye

{"title":"Patients’ belief and adherence to their medication therapy in the Bawku municipality","authors":"F. Owusu, E. Amenuke, P. Entsie, G. Yeboah, Rachel Aboagye","doi":"10.22271/tpi.2020.v9.i8a.5033","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i8a.5033","url":null,"abstract":"One important requirement for patients to believe and adhere to their medication is for them to have enough knowledge about the medications being dispensed to them. This can easily be achieved by effective counselling and motivation by health care professionals. The manner in which drugs are taken by the patient is often influenced by the way drugs are dispensed and the type of information given to the patient during the dispensing process. The aim of this study was to determine patient beliefs and adherence to their prescribed medications in the Bawku Municipality. The survey was carried out by the use of designed questionnaires. Out of the 100 patients interviewed, 62 % were males and 38 % were females. 14 % of the patients were illiterates and 86 % were literates. Side effects of drugs accounted for 84 % of patients skipping one or more of their medications. 67 % of patient missed their medication due to high cost. 51% also missed their medication due to lack of knowledge on their therapy and 83% were those having received inadequate advice by health care professionals. Also, lack of belief of patients in their medication was 65 %. In conclusion, patient’s beliefs and adherence to their medication was rated bad, and this is largely as a result of insufficient counselling to patients by health care professionals, lack of belief in their medications and high cost of prescribed medications.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"111 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80616424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful recovery of holstein friesian crossbred prepartum downer: A case report 成功恢复荷斯坦弗里西亚杂交预备降噪犬1例

The Pharma Innovation Journal Pub Date : 2020-08-01 DOI: 10.22271/tpi.2020.v9.i8sc.5070

Raghavendran Vb, S. Sureshbabu, S Rajasokkappan, Alex Albert, N. Tamilselvan

引用次数: 1

Performance evaluation of improved cook stoves 改进炉灶的性能评价

The Pharma Innovation Journal Pub Date : 2020-08-01 DOI: 10.22271/tpi.2020.v9.i8b.5012

S. Mallesh, J. T. Raju, Vinay Gautam

引用次数: 1

Avoiding warning letters in pharmaceutical industry: A qualitative study in the Indian context 制药行业避免警告信:印度背景下的定性研究

The Pharma Innovation Journal Pub Date : 2020-07-01 DOI: 10.22271/tpi.2020.v9.i6a.4767

Sanjay K Jain, R. Jain

{"title":"Avoiding warning letters in pharmaceutical industry: A qualitative study in the Indian context","authors":"Sanjay K Jain, R. Jain","doi":"10.22271/tpi.2020.v9.i6a.4767","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i6a.4767","url":null,"abstract":"The purpose of this paper is to identify the cause and effect of increased number of warning letters (www.fda.gov) issued by the Food and Drug Administration (FDA) of United States year after year in spite of clarity in the guidance published by the agency. Increased number of warning letters is matter of concern for the drug product / drug substance manufacturer, drug authority and end consumers (patients). Author identified six pharma professionals through their personal contacts and interviewed each of them. Poor quality management systems and lack of management oversight were found to be the key reasons for issuance of warning letters. Issuance of warning letters had adverse financial impact on business, delay in approvals thus loss of business opportunity and negative image of the organization among regulators, customers. Quality culture in the organization plays an important role to ensure regulatory compliance and building up the right quality culture in the organization is vital. Involvement of top management and participation in the management review meetings is essential for monitoring the compliance level in the organization.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"47 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81428287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gas chromatography-mass spectrometry (GC-MS) determination of phytoconstituents from ethanolic and aqua-ethanolic root extracts of Uraria picta Desv. (Fabaceae) 气相色谱-质谱(GC-MS)联用法测定牡丹乙醇根提取物和水乙醇根提取物中植物成分。(豆科)

The Pharma Innovation Journal Pub Date : 2020-07-01 DOI: 10.22271/tpi.2020.v9.i7g.4973

B. Mohan, H. Saxena, S. Parihar, A. Kakkar

引用次数: 3