Therapeutic Advances in Endocrinology and Metabolism最新文献

{"title":"Analysis of vitamin D nutritional status and disease risk factors in patients with subacute thyroiditis.","authors":"Rongrong Wang, Dehuan Kong, Xiaoqing Ma","doi":"10.1177/20420188251321600","DOIUrl":"10.1177/20420188251321600","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D (VD) deficiency has become a global public health problem, and published studies have demonstrated that patients with subacute thyroiditis (SAT) have worse VD nutritional status and that VD supplementation may alleviate thyroid-related diseases by fighting against infections and mediating autoimmunity.</p><p><strong>Objectives: </strong>This study explored the correlation between serum VD levels and the risk and extent of disease in patients with SAT.</p><p><strong>Design: </strong>A case-control study.</p><p><strong>Methods: </strong>We included patients with SAT diagnosed at the First People's Hospital of Jining City between September 2021 and September 2023 and a healthy population during the same period. We collected clinical and laboratory data to determine differences in VD levels between the two populations and identify risk factors for the onset and extent of SAT.</p><p><strong>Results: </strong>The 25(OH)D level of SAT patients was significantly lower than that of the healthy population (<i>p</i> < 0.05). Multifactorial logistic regression analysis showed that low 25(OH)D level, low body mass index (BMI), elevated leukocytes, and low lymphocyte count were independent risk factors for SAT. No significant difference was noted in VD levels between patients with mild SAT and those with moderately severe SAT (<i>p</i> > 0.05). Additionally, fever, thyroid tenderness, high BMI, and elevated free thyroxine (FT4) were independent risk factors for SAT severity; serum 25(OH)D levels were positively correlated with FT4/FT3 levels in SAT patients.</p><p><strong>Conclusion: </strong>VD levels are lower in patients with SAT than in healthy controls, and low VD levels increase SAT risk. Although VD levels are not related to SAT severity, adequate VD inhibits the conversion of FT4 to FT3, likely playing a protective role in SAT development.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251321600"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum parathyroid hormone within normal range with the prevalence and prognosis among adults with diabetes and prediabetes: insight from NHANES 2003-2006 data.","authors":"Guangshu Chen, Li Che, Xueman Wen, Meizheng Lai, Ting Wei, Ping Zhu, Jianmin Ran","doi":"10.1177/20420188251328806","DOIUrl":"10.1177/20420188251328806","url":null,"abstract":"<p><strong>Background: </strong>Previous research has established a link between high blood levels of parathyroid hormone (PTH) levels and hyperglycemia, as well as early mortality. However, the extent of this relationship and the predictive value of PTH for mortality risk in hyperglycemic populations have been minimally explored.</p><p><strong>Methods: </strong>The National Health and Nutrition Examination Survey study conducted from 2003 to 2006 identified 932 adults with diabetes and 1645 adults with prediabetes. A weighted multivariate logistic regression analysis was utilized to examine the association between PTH levels and hyperglycemia. Furthermore, Cox proportional hazards regression models were employed to examine the correlation between PTH levels and both cardiovascular and overall mortality within the hyperglycemia cohort.</p><p><strong>Results: </strong>(1) The research findings revealed a negative association between PTH levels (per 10-pg/mL increase) and diabetes status (OR, 0.79; 95% confidence interval (CI), 0.73-0.86). (2) There was a significant correlation between the risk of all-cause mortality (hazard ratios (HR), 1.13; 95% CI, 1.01-1.29) and cardiovascular disease mortality (HR, 1.39; 95% CI, 1.05-1.84) among individuals with diabetes for every 10-pg/mL increase in PTH levels.</p><p><strong>Conclusion: </strong>The current research shows that individuals with elevated PTH spectrum within the normal range are less likely to have diabetes, while those with higher PTH levels in adults with diabetes are linked to worse outcomes, particularly cardiovascular mortality.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251328806"},"PeriodicalIF":3.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical illness and sex hormones: response and impact of the hypothalamic-pituitary-gonadal axis.","authors":"Yicheng Ma, Xiude Fan, Junming Han, Yiping Cheng, Jiajun Zhao, Wei Fang, Ling Gao","doi":"10.1177/20420188251328192","DOIUrl":"10.1177/20420188251328192","url":null,"abstract":"<p><p>Understanding the hypothalamic-pituitary-gonadal (HPG) axis is essential for grasping human responses under extreme physiological and pathological conditions. The HPG axis regulates reproductive and gonadal hormone activities and significantly impacts the body's response to acute and chronic illnesses. This review explores the fundamental functions of the HPG axis, modifications under critical conditions, and impacts on disease progression and treatment outcomes. In addition, it examines interactions between sex hormones and biomolecules like cytokines and gastrointestinal microorganisms, highlighting their roles in immune response regulation. Clinically, this knowledge can enhance patient prognoses. The review aims to provide a comprehensive framework, based on existing research, for understanding and applying the functions of the HPG axis in managing critical diseases, thereby broadening clinical applications and guiding future research.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251328192"},"PeriodicalIF":3.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic fibrosis-related bone disease: an update on screening, diagnosis, and treatment.","authors":"Crystal Cobb, Malinda Wu, Vin Tangpricha","doi":"10.1177/20420188251328210","DOIUrl":"10.1177/20420188251328210","url":null,"abstract":"<p><p>Cystic fibrosis-related bone disease (CFBD) is a common endocrinopathy in people living with cystic fibrosis (CF) that is complex and multifactorial in origin. People with CF experience high rates of progressive bone density loss and increased fracture risk. Focus on prevention and treatment of CFBD is of increasing importance in a now aging CF population. This review will discuss current practices in CFBD, gaps in knowledge, and potential future studies with the goal of advancing the clinical care of patients with CFBD.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251328210"},"PeriodicalIF":3.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index and lipid ratios in women with and without polycystic ovary syndrome: a systematic review and meta-analysis.","authors":"Juan R Ulloque-Badaracco, Esteban A Alarcon-Braga, Enrique A Hernandez-Bustamante, Juan C Cabrera-Guzmán, Giuseppe Dotto-Vasquez, Gian F Maldonado-Basurto, Germán Rivera-Cabrera, Sherelym H Maita-Arauco, Andres A Horruitiner-Mendoza, Percy Herrera-Añazco, Vicente A Benites-Zapata, Faustino R Pérez-López","doi":"10.1177/20420188251328840","DOIUrl":"10.1177/20420188251328840","url":null,"abstract":"<p><strong>Background: </strong>The pathophysiology of polycystic ovary syndrome (PCOS) is complex and heterogeneous. This systematic review and meta-analysis aimed to determine the triglyceride-glucose index and lipid ratios in women with and without PCOS.</p><p><strong>Methods: </strong>Literature searches were performed in PubMed, Scopus, Web of Science, Scielo, and Embase for studies reporting the triglyceride-glucose index and total cholesterol/high-density lipoprotein (HDL)-cholesterol, triglyceride/HDL-cholesterol, and low-density lipoprotein (LDL)-cholesterol/HDL-cholesterol ratios. Results are reported as standardized mean differences (SMDs) along with their 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The search identified 61 observational studies, including case-control (<i>n</i> = 37), cohort (<i>n</i> = 2), and cross-sectional (<i>n</i> = 22) studies reporting results of interest according to different PCOS diagnosis criteria. Compared with the control group, the PCOS group presented increased circulating triglyceride-glucose index (<i>n</i> = 9 studies, SMD, 0.41; 95% CI, 0.08-0.74) and total cholesterol/HDL-cholesterol (<i>n</i> = 35 studies, SMD, 1.70; 95% CI, 0.69-2.70), triglyceride/HDL-cholesterol (<i>n</i> = 31 studies; SMD, 0.81; 95% CI, 0.43-1.19), and LDL-cholesterol/HDL-cholesterol (<i>n</i> = 25 studies, SMD, 2.40; 95% CI, 0.45-4.35) ratios. Statistical heterogeneity values were very high (<i>I</i> ² > 90%). The PCOS group displayed significantly higher body mass index and homeostatic model assessment of insulin resistance. The PCOS group was younger than the control group and had a higher total cholesterol/HDL-cholesterol ratio, and other lipid variables were comparable in all groups.</p><p><strong>Conclusion: </strong>Patients with PCOS show significantly higher triglyceride-glucose index and total cholesterol/HDL-cholesterol, triglyceride/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol ratios than those without the syndrome.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251328840"},"PeriodicalIF":3.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 12-week combined interval running and resistance training on cardiac structure and performance in patients with type 1 diabetes.","authors":"Hossein Saki, Farzad Nazem, Omid Khaiyat, Farnaz Fariba","doi":"10.1177/20420188251325148","DOIUrl":"10.1177/20420188251325148","url":null,"abstract":"<p><strong>Background: </strong>Exercise has been suggested to effectively improve cardiac performance in children with type 1 diabetes (T1D) by enhancing the glycemic control. The purpose of this study was to investigate (1) effects of a 12-week combined interval running and resistance training (CIRRT) and (2) 1 month of detraining on cardiac structure and myocardial performance in adolescent males with T1D.</p><p><strong>Methods: </strong>A total of 72 participants, including 48 adolescent males with T1D (fasting blood glucose (FBG): 274.67 ± 52.99 mg/dL, age: 15.20 ± 1.78 years) and 24 healthy adolescents (FBG: 90.75 ± 5.47 mg/dL, age: 15.08 ± 1.67 years), were recruited to the study. Participants were allocated into diabetes exercise (DE), diabetes control (DC), and healthy controls (HC) groups. The DE group performed 12 weeks of a CIRRT program three times per week. Blood glucose profile, echocardiography (ECHO) indices, and peak oxygen consumption (VO_2peak) were measured pre- and post-intervention and following 1-month detraining period. Repeated measures ANOVA was used for pre- and post-intervention comparisons within the DE group and across the three study groups. Significance level was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Exercise intervention resulted in decreased hemoglobin A1c (HbA1c% = Pre: 10.44 ± 2.03, Post: 9.38 ± 1.66, <i>p</i> < 0.05), FBG, left ventricular (LV) internal diameter, and both tricuspid and mitral deceleration time (DT) in the DE group. VO_2peak, ejection fraction (EF% = Pre: 62.38 ± 1.6, Post: 64.08 ± 1.18, <i>p</i> < 0.05), fractional shortening, early tricuspid diastolic inflow E velocity, and tricuspid velocity during atrial contraction were also increased following the exercise training. HbA1c (Pre vs Follow-up: 9.83 ± 1.73, <i>p</i> < 0.05), EF (Pre vs Follow-up: 62.97 ± 1.56, <i>p</i> < 0.05), LV, and DT tricuspid remained significantly improved after detraining period compared to the baseline. In the baseline, the glycemic index and ECHO variable significantly differed in the DE and DC groups with the HC group (<i>p</i> < 0.05). However, after the intervention, the DC and HC groups did not change significantly (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The CIRRT intervention was associated with improved cardiac structure and performance in male adolescents with T1D potentially due to exercise-induced adaptations. Meanwhile, the results indicate that most cardiac morphological and functional changes are reversible following periods of inactivity in patients with T1D.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251325148"},"PeriodicalIF":3.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of anti-peptic ulcer disease medications on type 2 diabetes mellitus risk in patients with PUD: a population-based retrospective cohort study.","authors":"Yi-Jen Fang, Hui-Hsia Hsieh, Cheng-Li Lin, Wan-Yi Lee, Chi-Hua Chen, Fuu-Jen Tsai, Bang-Jau You, Ni Tien, Yun-Ping Lim","doi":"10.1177/20420188251323945","DOIUrl":"10.1177/20420188251323945","url":null,"abstract":"<p><strong>Background: </strong>The etiology of type 2 diabetes mellitus (T2DM) is complex, with environmental factors playing a significant role in its pathophysiology. Nonsteroidal anti-inflammatory drugs usage and <i>Helicobacter pylori</i> infection are the two most frequent causes of peptic ulcer disease (PUD). The link between PUD and T2DM is unclear, and comprehensive analyses of anti-PUD medications' impact on T2DM risk, especially in Asian populations, are lacking. This study aimed to determine the relationship between PUD, anti-PUD medications, and the likelihood of developing T2DM.</p><p><strong>Objectives: </strong>Using a population-based cohort study conducted in Taiwan, we investigated the impact of PUD and anti-PUD medications on the risk of T2DM.</p><p><strong>Design: </strong>This is a retrospective, population-based cohort study using the largest database used in Taiwan.</p><p><strong>Methods: </strong>An 18-year follow-up period study was conducted on a cohort of patients with PUD diagnosed between 2001 and 2018 using the Taiwan National Health Insurance Research Database. The risk of PUD as well as anti-PUD medications use were examined using Cox proportional regression model.</p><p><strong>Results: </strong>Based on multivariable Cox proportional hazards regression analysis, patients with PUD had a higher overall T2DM incidence (22.7 vs 21.3 per 1000 person-years) than patients without PUD. The adjusted hazard ratio was 1.12 (95% confidence interval = 1.10, 1.13). Patients with PUD have a higher risk of T2DM in both genders and age groups. Patients with anti-PUD medications, such as H2 receptor antagonists, proton-pump inhibitors, antibiotics, prostaglandin analogs, anticholinergics, and antacids usage, are associated with a lower risk of developing T2DM than those without. Patients with PUD who underwent surgery were found to have a higher risk of T2DM.</p><p><strong>Conclusion: </strong>Patients with PUD are more likely to develop T2DM. Nevertheless, patients receiving anti-PUD medications have a lower incidence of T2DM.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251323945"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and pathological characteristics of metabolic dysfunction-associated steatotic liver disease and the key role of epigenetic regulation: implications for molecular mechanism and treatment.","authors":"Yijing Li, Lijie Li, Yishuo Zhang, Jing Lu, Xiaolei Tang, Chaoran Bi, Yanan Qu, Jingmei Chai","doi":"10.1177/20420188251321602","DOIUrl":"10.1177/20420188251321602","url":null,"abstract":"<p><p>Nonalcoholic fatty liver disease (NAFLD), also called metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent syndrome marked by liver fat accumulation in the absence of significant alcohol consumption, encompassing simple fatty liver, nonalcoholic steatohepatitis (NASH), and advanced stages such as fibrosis and cirrhosis. Its incidence has surged globally, impacting up to 40% of the population, with a doubling of cases in China over a decade. NASH, a severe form, can progress to liver cirrhosis and cancer, posing a substantial health burden, especially among individuals with type 2 diabetes. Projections indicate a steep rise in NASH cases, necessitating urgent interventions beyond lifestyle modifications, such as innovative pharmaceuticals. Early diagnosis is crucial, yet current tools have limitations, highlighting the need for noninvasive, scalable diagnostic approaches. Advances in imaging and biomarker identification offer hope for early detection. Epigenetic factors play a significant role in MASLD pathogenesis, regulating key molecular mechanisms. Addressing MASLD requires a multifaceted approach, integrating lifestyle interventions, pharmacotherapy, and emerging therapeutics, against the backdrop of an evolving landscape in disease management.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251321602"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful management of hypercalcemic crisis by continuous renal replacement therapy with regional citrate anticoagulation and surgery: a case report.","authors":"Hanh-Duyen Bui-Thi, Thao Le-Phuong, Thang Tran-Viet, Phuc Nguyen-Huu","doi":"10.1177/20420188251323953","DOIUrl":"10.1177/20420188251323953","url":null,"abstract":"<p><p>A hypercalcemic crisis (HC) is a life-threatening endocrine emergency if not promptly diagnosed and treated. Initial management for HC includes fluid resuscitation, diuresis, bisphosphonates, calcitonin, and glucocorticoids, along with diagnosing the underlying etiology of HC. However, for the refractory HC, continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA) should be considered. We report a case of severe refractory HC successfully managed with CRRT using RCA and surgery. A 56-year-old female patient was admitted to University Medical Center Ho Chi Minh City due to a decrease in consciousness. Laboratory tests and clinical manifestations suggested the diagnosis of primary hyperparathyroidism. The patient was managed with strategies to lower calcium levels, including intravenous normal saline, oral fluid replacement via nasogastric tube, calcitonin, and bisphosphonate; however, the patient did not respond to the initial treatment. Subsequently, the patient underwent CRRT with RCA and calcium-free replacement fluid to reduce the calcium level before parathyroidectomy. The patient was discharged after 10 days of hospitalization. CRRT with RCA appears to be a potential, effective, and safe method for treating refractory hypercalcemic crises. Further research is required to investigate the role of CRRT with RCA in refractory hypercalcemia.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251323953"},"PeriodicalIF":3.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity among adults with type 2 diabetes mellitus in Jordan: a qualitative study.","authors":"Aaliyah Momani, Zalikha Al-Marzouqi, Amani Abu-Shhadeh, Kamel Ajlouni, Mohammed ALBashtawy, Maysa H Almomani, Samiha Jarrah, Shaikha Ali AlQahtani, Anas Ababneh","doi":"10.1177/20420188251315658","DOIUrl":"10.1177/20420188251315658","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus is a growing epidemic condition that is expected to reach pandemic levels in the upcoming decades. Physical activity among individuals with type 2 diabetes is beneficial. A deeper understanding of physical activity among adults with type 2 diabetes in Jordan using a qualitative approach is needed.</p><p><strong>Aim: </strong>This study aimed at exploring physical activity among adults with type 2 diabetes in Jordan.</p><p><strong>Design: </strong>A constructivist grounded theory methodology guided this study.</p><p><strong>Methods: </strong>Data were collected using semi-structured and audio-recorded interviews and then analysed simultaneously using coding, constant comparative analysis and writing reflexive memos.</p><p><strong>Findings: </strong>Two themes emerged including 'The Perception about Physical Activity' and 'Factors Influencing Adherence to Physical Activity'. The first theme included four sub-themes: physical activity definition; importance; duration and types. The second theme included five sub-themes: the belief that diet is superior to physical activity; ageing and presence of diabetes or comorbidities; job and family obligations; social support and weather.</p><p><strong>Conclusion: </strong>This study provided insights into patients' perceptions and adherence to physical activity including facilitators and barriers. Clinicians and policymakers may consider the findings of this study to develop health promotion programmes and to suggest a suitable environment for individuals with type 2 diabetes to enhance their physical activity.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":"16 ","pages":"20420188251315658"},"PeriodicalIF":3.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}