Thrombosis Journal最新文献

{"title":"A post-marketing surveillance study on the safety and effectiveness of recombinant antithrombin gamma in patients with congenital antithrombin deficiency in Japan.","authors":"Hidesaku Asakura, Manabu Iwabuchi, Masaki Fujita, Satoru Ito, Yuka Kanda, Hiroshi Kuwazawa","doi":"10.1186/s12959-026-00844-x","DOIUrl":"10.1186/s12959-026-00844-x","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and disparities in disseminated intravascular coagulation-related mortality among adults aged 25 and above in the U.S., 1999-2020: CDC WONDER insights.","authors":"Muhammad Yousuf Saleem, Muhammad Salman Mustafa, Areeba Shafiq, Sameer Khan, Mudassir Rauf, Hasibullah Aminpoor, Muhammad Bilal Khan, Deep Birjani, Maryam Ahmed, Jazza Amir","doi":"10.1186/s12959-026-00848-7","DOIUrl":"10.1186/s12959-026-00848-7","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":"24 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades of prenatal diagnosis in hemophilia A and B: a systematic review of global trends and current practices.","authors":"Seyed Mehrab Safdari, Mehdi Bakhtiyaridovvombaigi, Fatemeh Damerchiloo, Akram Sadat Jaafarian, Fateme Amiri Samani, Majid Safa, Shadi Tabibian","doi":"10.1186/s12959-026-00847-8","DOIUrl":"10.1186/s12959-026-00847-8","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":"24 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifactorial thrombotic risk in Evans syndrome: a case report and review of the literature.","authors":"Hande Nur Erolmez, Semih Eker, Fakiha Siddiqui, Ayse Nilgun Kul, Gulbuz Sezgin, Jawed Fareed, Bulent Kantarcioglu","doi":"10.1186/s12959-026-00846-9","DOIUrl":"10.1186/s12959-026-00846-9","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus anticoagulant hypoprothrombinemia syndrome successfully treated with rituximab - case report.","authors":"Michael Iarossi, Angelo Rizzolo, Michèle Stanciu, Valérie Leclair, Marc Blostein, Maral Koolianl","doi":"10.1186/s12959-026-00832-1","DOIUrl":"10.1186/s12959-026-00832-1","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis induced coagulopathy (SIC): is it monolithic?","authors":"Lu Wang, Xiang Zhou","doi":"10.1186/s12959-026-00845-w","DOIUrl":"10.1186/s12959-026-00845-w","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between disseminated intravascular coagulation and time series change of Von Willebrand factor in patients with out-of-hospital cardiac arrest: a retrospective observational study.","authors":"Yuki Itagaki, Yuki Chiba, Misako Suzuki, Mariko Hayamizu, Hisanori Horiuchi, Mineji Hayakawa","doi":"10.1186/s12959-026-00842-z","DOIUrl":"10.1186/s12959-026-00842-z","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematologic safety of caplacizumab in immune-mediated thrombotic thrombocytopenic purpura: insights from platelet-related signal detection in the FAERS database.","authors":"Zhenqi Liu, Xu Ye","doi":"10.1186/s12959-026-00840-1","DOIUrl":"10.1186/s12959-026-00840-1","url":null,"abstract":"<p><strong>Background: </strong>Caplacizumab, a nanobody targeting von Willebrand factor, has transformed the management of immune-mediated thrombotic thrombocytopenic purpura (iTTP) by rapidly restoring platelet counts and improving survival. However, comprehensive real-world evidence regarding its hematologic safety profile remains limited.</p><p><strong>Methods: </strong>We conducted a post-marketing pharmacovigilance study using reports from the U.S. FDA Adverse Event Reporting System (FAERS) from 2019 to Q1 2025. Disproportionality analyses were performed using four signal-detection algorithms-reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS)-with false discovery rate adjustment. Time-to-onset was assessed among reports with available dates, and Weibull modeling was applied to characterize onset patterns.</p><p><strong>Results: </strong>A total of 1,306 caplacizumab-related reports were identified, predominantly involving adult female patients with iTTP. Frequently reported adverse events included hematologic and hemorrhagic events (e.g., epistaxis and thrombocytopenia), as well as fatigue and laboratory abnormalities. Significant positive signals were consistently observed for bleeding-related preferred terms across multiple algorithms. The median time to onset was 10 days after treatment initiation, and Weibull modeling suggested an early-failure pattern, indicating greater susceptibility during the initial treatment cycles.</p><p><strong>Conclusions: </strong>In FAERS post-marketing data, caplacizumab-associated adverse events were mainly bleeding-related, generally predictable, and tended to occur early during therapy. Close clinical and laboratory monitoring-particularly of hematologic parameters-during the initial treatment period is warranted to balance bleeding vigilance with therapeutic efficacy. These findings provide real-world evidence to inform hematologists about the safety profile of caplacizumab in iTTP management.</p>","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is congenital thrombotic thrombocytopenic purpura a risk factor for ischemic osteonecrosis of the hip joint (Legg-Calvé-Perthes disease)?","authors":"Alexander Laemmle, Bernhard Lämmle","doi":"10.1186/s12959-026-00838-9","DOIUrl":"10.1186/s12959-026-00838-9","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":"24 1","pages":"23"},"PeriodicalIF":2.2,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High thrombotic burden in severe Chinese wAIHA patients: a single-center retrospective study.","authors":"Jing Xiong, Li Wan, Huixin Chen, Bicheng Hu","doi":"10.1186/s12959-026-00843-y","DOIUrl":"10.1186/s12959-026-00843-y","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}