Thrombosis Journal最新文献

{"title":"Physical activity patterns in people with haemophilia with and without arthropathy: a cross-sectional study using wearable sensors.","authors":"Yuya Mawarikado, Midori Shima, Naoki Matsumoto, Asuka Sakata, Ryohei Kawasaki, Kohei Tatsumi, Tetsuhiro Soeda, Suguru Harada, Naoto Seriu, Yusuke Inagaki, Akira Kido, Keiji Nogami","doi":"10.1186/s12959-026-00869-2","DOIUrl":"https://doi.org/10.1186/s12959-026-00869-2","url":null,"abstract":"<p><strong>Background: </strong>In haemophilia, recurrent joint bleeding often results in joint destruction, which in turn leads to reduced physical activity (PA) and decreased quality of life (QOL). While maintaining high PA levels is important in the care of people with haemophilia (PwH), it remains unclear whether PwH without joint disease can maintain adequate activity levels.</p><p><strong>Aim: </strong>This descriptive cross-sectional study sought to compare moderate-to-vigorous physical activity (MVPA) levels among 19 PwH with haemophilic arthropathy (HA), 12 PwH without HA, and 15 non-PwH.</p><p><strong>Methods: </strong>A total of 46 males wore a triaxial accelerometer (wGT3X-BT, ActiGraph) during daily activities for seven consecutive days. A bout of MVPA was defined as at least 10 consecutive minutes of moderate-intensity or higher activity. MVPA was expressed as the percentage of the total wear time spent in MVPA, and the total number of MVPA bouts was also recorded.</p><p><strong>Results: </strong>Both PwH groups demonstrated significantly lower MVPA percentages and fewer MVPA bouts than the controls (p < 0.01). No MVPA bouts were recorded among 52.6% of PwH with HA versus 25% of PwH without HA. No significant differences were observed in sedentary or light activity between the PwH groups.</p><p><strong>Conclusions: </strong>PA levels were significantly reduced in PwH, regardless of joint status, suggesting that factors beyond joint damage, such as fear of bleeding or behavioural avoidance, may play a role. These findings highlight the need for individualized, evidence-based interventions to safely promote physical activity and improve long-term health outcomes in PwH.</p>","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition to Emicizumab from standard-dose FVIII prophylaxis in young children with hemophilia A: a real-world study.","authors":"Juan Ye, Kun Huang","doi":"10.1186/s12959-026-00868-3","DOIUrl":"https://doi.org/10.1186/s12959-026-00868-3","url":null,"abstract":"<p><strong>Background: </strong>Real-world evidence on transition from standard-dose FVIII to Emicizumab prophylaxis in young children with hemophilia A remains limited, particularly in developing countries.</p><p><strong>Methods: </strong>We performed a single-center, retrospective, self-controlled study in boys with severe hemophilia A without inhibitors. Outcomes during 12 months of standard-dose factor VIII (FVIII) prophylaxis were compared with outcomes during 12 months after transition to Emicizumab prophylaxis (in this real-world cohort, most patients received reduced-dose maintenance regimens). Annualized bleeding rates (overall, treated, joint, and spontaneous) and zero-bleeding proportions were assessed. Direct annual prophylaxis drug costs were calculated using locally applicable drug prices and converted to USD.</p><p><strong>Results: </strong>Thirty-one boys were included with a median age of 4.5 years. During FVIII prophylaxis, the median FVIII dose was 32.3 IU/kg/infusion with a median 3.1 infusions/week; median trough FVIII was 3.9 IU/dL. After transition, mean Emicizumab exposure was 4.2 mg/kg/month (range 3.0-6.0) with a mean dosing interval of 14 days. Overall ABR decreased from 2.48 to 0.32, treated ABR from 1.64 to 0.29, joint ABR from 0.83 to 0.13, and spontaneous ABR from 0.26 to 0 (all P < 0.05). The proportion of patients with zero bleeds increased from 35% to 81% (P < 0.001), and zero treated bleeds from 52% to 69% (P < 0.05). Mean annual prophylaxis drug costs were lower with Emicizumab than with FVIII (34,417 vs. 47,168 USD; P < 0.001).</p><p><strong>Conclusions: </strong>In this selected pediatric cohort of children who transitioned from standard-dose FVIII to Emicizumab and remained on treatment for at least 12 months, lower observed bleeding rates and lower direct prophylaxis drug costs were seen during the Emicizumab period. These findings should be interpreted descriptively because the retrospective design and eligibility criteria introduced substantial selection bias.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Heparin coagulant super-sensitivity during leech therapy.","authors":"Zhan Rong, Adam Daniels, Kevin Luu, Lukasz Czerwonka, Wadie F Bahou","doi":"10.1186/s12959-026-00866-5","DOIUrl":"https://doi.org/10.1186/s12959-026-00866-5","url":null,"abstract":"<p><strong>Background: </strong>Leech therapy is used in diverse ways in the medical field, such as for flap salvation and for treatment of osteoarthritis. While bleeding is a recognized adverse effect, severe coagulopathy is rare and underreported, especially when compounded by concurrent anticoagulant use.</p><p><strong>Case presentation: </strong>We present a case of a 76-year-old female undergoing leech therapy in combination with systemic heparin for free flap salvage following partial glossectomy and neck dissection. Shortly after initiating both therapies, the patient developed marked coagulopathy, evidenced by prolonged activated partial thromboplastin time (aPTT), elevated thrombin time, and persistent bleeding from the surgical site. Laboratory results suggested synergistic anticoagulant effects of heparin and hirudin, the potent direct thrombin inhibitor secreted by medicinal leeches. Despite discontinuation of systemic heparin, bleeding persisted until leech therapy was halted. The patient received 8 units of packed red blood cells (pRBCs) during the treatment course. Coagulation markers normalized after cessation of leech therapy, with no further bleeding events.</p><p><strong>Conclusions: </strong>This case highlights a potentially underrecognized risk of coagulopathy in patients undergoing combined leech and systemic anticoagulation therapy. The mechanistically distinct pathways of heparin and hirudin may act synergistically to impair both free and clot-bound thrombin activity. Given the absence of formal guidelines for coagulopathy monitoring in such cases, we propose daily assessment of coagulation markers including aPTT, PT/INR, and a one-time measurement of thrombin time and anti-Xa levels after treatment initiation. This report underscores the need for standardized protocols and further research to guide safe implementation of leech therapy, particularly in patients receiving systemic anticoagulation.</p>","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrinogen-to-albumin ratio and risk of thrombotic diseases incidence.","authors":"Bo Zhu, Xinxin Feng, Bolin Li, Rong Fan, Hui Liu, Xinping Kang, Shuyi Deng, Lele Cheng, Zuyi Yuan, Yue Wu, Tao Zheng","doi":"10.1186/s12959-026-00867-4","DOIUrl":"https://doi.org/10.1186/s12959-026-00867-4","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of direct oral anticoagulants in pediatric congenital and acquired heart disease: a systematic review and meta-analysis of randomized controlled trials.","authors":"Hanan El-Sayed Bakry, Mai Ibrahim Abdellah, Hani Abdelshafook Khalaf, Ahmed Ali Assem, Mohamad Mahmoud ElGamal, Mohamed Ibrahim Abdo, Mohamed Hamouda Elkasaby, Atef A Hassan","doi":"10.1186/s12959-026-00850-z","DOIUrl":"https://doi.org/10.1186/s12959-026-00850-z","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":"24 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and associated factors of venous thromboembolism in patients with gastric cancer across treatment settings after diagnosis: a systematic review and meta-analysis.","authors":"Xing Jin, Zhiting Dong, Ningjing Tang, Qingyu Zhang, Jing Li","doi":"10.1186/s12959-026-00864-7","DOIUrl":"https://doi.org/10.1186/s12959-026-00864-7","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired circulating heparin-like anticoagulants associated with multiple myeloma: three cases reports and literature review.","authors":"Yan Wang, Mingqian Zhang, Feifei Zhang, Yujie Guo, Xuquan Zhou","doi":"10.1186/s12959-026-00863-8","DOIUrl":"https://doi.org/10.1186/s12959-026-00863-8","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of patients with protein s deficiency: focus on clinical course and direct oral anticoagulants.","authors":"Altamura Nicola, Di Girolamo Filippo Giorgio, Pradella Paola, Cavalet Martina, Pellicori Federica, Vinci Pierandrea, Panizon Emiliano, Cominotto Giovanni, Zaccari Michele, Galasso Irma, La Rocca Paola, Teraž Kaja, La Raja Massimo, Fiotti Nicola, Biolo Gianni","doi":"10.1186/s12959-026-00861-w","DOIUrl":"10.1186/s12959-026-00861-w","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired dysfibrinogenemia with discordant fibrinogen assays preceding the diagnosis of λ light-chain multiple myeloma: a case report.","authors":"Xuehan Mao, Fan Yu, Yanying Wang, Bianhong Wang, Jingxian Li, Jiao Li, Lihong Li, Yuehua Huang","doi":"10.1186/s12959-026-00862-9","DOIUrl":"https://doi.org/10.1186/s12959-026-00862-9","url":null,"abstract":"<p><strong>Background: </strong>Acquired dysfibrinogenemia is a rare and often underrecognized coagulation disorder characterized by impaired fibrinogen function rather than absolute deficiency. In plasma cell dyscrasias, including multiple myeloma, monoclonal gammopathy of undetermined significance, and monoclonal gammopathy of clinical significance, monoclonal immunoglobulins or light chains may interfere with fibrin polymerization, resulting in discordant fibrinogen assay results and diagnostic challenges.</p><p><strong>Case presentation: </strong>A middle-aged woman exhibited persistently prolonged thrombin time (TT) and markedly reduced fibrinogen by the Clauss method, while PT-derived fibrinogen remained relatively preserved, yielding a stable elevated PT-derived/Clauss ratio (~ 4.0-4.7) suggestive of qualitative fibrinogen dysfunction. These abnormalities were detected more than three years before the diagnosis of λ light-chain multiple myeloma (MM), in the absence of CRAB features. Following anti-myeloma therapy, TT and fibrinogen parameters normalized in parallel with hematologic response.</p><p><strong>Conclusions: </strong>This case illustrates that acquired dysfibrinogenemia with discordant fibrinogen assays may serve as an early laboratory clue to an underlying plasma cell dyscrasia and may precede overt multiple myeloma in some patients. Similar coagulation abnormalities may also occur in MGUS or MGCS and should not be interpreted as specific predictors of progression, but rather as potential manifestations of paraprotein-related hemostatic dysfunction.</p>","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research advances on platelet glycoprotein VI in ischemic stroke.","authors":"Hanlu Xiang, Ke Ding, Fanqiang Meng, Mengjie Huo, Wentao Yao, Hebo Wang","doi":"10.1186/s12959-026-00859-4","DOIUrl":"10.1186/s12959-026-00859-4","url":null,"abstract":"","PeriodicalId":22982,"journal":{"name":"Thrombosis Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147532956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}