Galila Mokhtar, Ashraf Abdelbaky, Amira Adly, Dina Ezzat, Hanafy Hafez, Hoda Hassab, Ilham Youssry, Iman Ragab, Laila M Sherief, Marwa Zakaria, Mervat Hesham, Mervat Mansour, Naglaa Shaheen, Tarek Omar, Rasha Abdel-Raouf Abdelaziz Afifi, Sara Makkeyah, Sonia Adolf, Yasser Amer, Heba Hussein, Hanan Ibrahim, Khaled Salama, Ahmad Darwish, Leonardo R Brandao, Ivan Florez, Gehan Lotfy Abdel Hakeem Khalifa
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引用次数: 0
Abstract
Background: Thrombosis is a major pediatric health problem with a spectrum of etiologies, clinical presentations, and morbidities. Establishing the diagnosis and treatment of pediatric thrombosis with different site-related presentations may be challenging. This article adapts the high-quality Clinical Practice Guidelines (CPGs) for pediatric thrombosis management to suit the Egyptian healthcare context.
Methods: The adapted ADAPTE methodology was used to identify the high-quality CPGs published between 2012 and 2023. An expert panel screened, reviewed, and assessed the CPGs and formulated the adapted consensus recommendations based on the best available evidence.
Results: The final CPG document provides consensus recommendations and implementation tools for managing thrombosis with different etiologies in children and adolescents in Egypt. There is no evidence to support strong recommendations for various management approaches.
Conclusions: In general, a complete clinical and radiological assessment and some laboratory tests are indicated at the initial diagnosis to confirm a thrombotic disorder and to further choose the type of workup required. Future research should report the outcome of this adapted guideline and include cost-analysis evaluations.
期刊介绍:
Thrombosis Journal is an open-access journal that publishes original articles on aspects of clinical and basic research, new methodology, case reports and reviews in the areas of thrombosis.
Topics of particular interest include the diagnosis of arterial and venous thrombosis, new antithrombotic treatments, new developments in the understanding, diagnosis and treatments of atherosclerotic vessel disease, relations between haemostasis and vascular disease, hypertension, diabetes, immunology and obesity.