The Korean Journal of Helicobacter and Upper Gastrointestinal Research最新文献_第5页

[Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders]. 钾竞争酸阻滞剂在胃酸相关疾病治疗中的作用

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-09-08 DOI: 10.7704/kjhugr.2023.0043

Mun Young Cho, Yu Kyung Cho

引用次数: 0

[Vonoprazan-based Dual and Triple Therapy for Helicobacter pylori Eradication]. Vonoprazan为基础的双重和三重疗法根除幽门螺杆菌

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-09-08 DOI: 10.7704/kjhugr.2023.0022

Jin Hee Noh, Kee Don Choi

引用次数: 0

[Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication]. 钾竞争性酸阻滞剂:根除幽门螺杆菌的新治疗策略

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-09-08 DOI: 10.7704/kjhugr.2023.0041

Byeong Yun Ahn, Soo-Jeong Cho

引用次数: 0

Bifurcated Lumen Observed on Capsule Endoscopy. 胶囊内窥镜观察到分岔管腔

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-09-08 DOI: 10.7704/kjhugr.2023.0036

Byeong Yun Ahn, Bokyung Kim, Hyunsoo Chung, Sang Gyun Kim, Soo-Jeong Cho

引用次数: 0

[History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs]. 抑胃酸药物的历史及药理机制

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-09-08 DOI: 10.7704/kjhugr.2023.0040

Dong Han Yeom, Yong Sung Kim

{"title":"[History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs].","authors":"Dong Han Yeom, Yong Sung Kim","doi":"10.7704/kjhugr.2023.0040","DOIUrl":"10.7704/kjhugr.2023.0040","url":null,"abstract":"Gastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells. Histamine plays a decisive role in the transformation of parietal cells into acid-secreting forms. The H+, K+- ATPase proton pump, which represents the final step of acid secretion, translocates from cytoplasmic tubulovesicles to secretory canaliculi upon parietal cell stimulation and facilitates exchange of intracellular H+ with extracellular K+ in a 1:1 ratio. Histamine-2 receptor antagonists and proton pump inhibitors (PPIs) are widely used in clinical practice, and potassium-competitive acid blockers (P-CABs) have gained attention in recent times. P-CABs address the unmet needs of patients who receive conventional PPIs and have broadened the spectrum of drug choices; however, further research is warranted to confirm long-term safety of these drugs. Comprehensive understanding of the mechanisms of actions, characteristics, advantages and disadvantages, and the adverse effect profile is essential for appropriate prescription of gastric acid-suppressive drugs. In this review, we provide a developing history and outline the pharmacological mechanisms underlying various gastric acid-suppressive drugs used in clinical settings.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":"159-166"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42444338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Scratch Sign as an Endoscopic Marker for Predicting the Absence of Current Helicobacter pylori Infection]. 抓痕征作为内镜标记物预测当前幽门螺杆菌感染的缺失

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-09-08 DOI: 10.7704/kjhugr.2023.0032

Su Jin Kim

引用次数: 0

Validation of a Novel Endoscopic Feature that Predicts Helicobacter pylori-negative Status: Does the Scratch Sign Reflect H. pylori Non-infection? 预测幽门螺杆菌阴性状态的新内镜特征的验证：抓痕标志是否反映幽门螺杆菌未感染？

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-01 Epub Date: 2023-08-30 DOI: 10.7704/kjhugr.2023.0029

Jun-Young Seo, Hyo-Jin Cho, Sang Jong Park, Ah Young Lee, Sang-Jung Kim, Ji Yong Ahn

{"title":"Validation of a Novel Endoscopic Feature that Predicts Helicobacter pylori-negative Status: Does the Scratch Sign Reflect H. pylori Non-infection?","authors":"Jun-Young Seo, Hyo-Jin Cho, Sang Jong Park, Ah Young Lee, Sang-Jung Kim, Ji Yong Ahn","doi":"10.7704/kjhugr.2023.0029","DOIUrl":"10.7704/kjhugr.2023.0029","url":null,"abstract":"Background/aims: Identification of Helicobacter pylori infection status is necessary as H. pylori is associated with gastric malignancy. Recently, a red linear scrape-like appearance on the gastric mucosa, called the \"scratch sign,\" was reported to be associated with H. pylori-negative gastric mucosal status. Herein, we aimed to validate the association between the scratch sign and H. pylori infection status.Methods: The data of patients who underwent screening endoscopy at Bundang Jesaeng General Hospital between March 2023 and April 2023 were reviewed. Patients were classified as having an H. pylori current infection or non-infection status based on the results of rapid urease tests. Patients who had undergone H. pylori eradication therapy were excluded. Endoscopic features of the gastric mucosa were assessed using the Kyoto classification of gastritis.Results: The scratch sign appeared more frequently in patients with non-infection than in those with current infection status (32.7% vs. 10.6%, respectively; P<0.001). Multivariate analysis showed that only the presence of sticky mucus was significantly associated with the presence of the scratch sign. Patient without the scratch sign had a higher prevalence of open-type atrophy, intestinal metaplasia, enlarged folds, and diffuse redness, which reflected a higher Kyoto score.Conclusions: Presence of the gastric mucosal scratch sign, a novel endoscopic marker, is indicative of H. pylori-negative status and appears to be inversely correlated with the presence of sticky mucus. In addition to the Kyoto classification of gastritis, detection of the scratch sign may facilitate identification of the H. pylori infection status.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":"197-206"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45340205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Importance of Early Surveillance Endoscopy in Patients at a High Risk of Gastric Cancer]. 早期监测内镜在癌症高危患者中的重要性

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-06-01 Epub Date: 2023-04-10 DOI: 10.7704/kjhugr.2022.0066

Sang Hoon Kim

引用次数: 0

[Clinical Application of the Kyoto Classification of Gastritis]. 胃炎京都分型的临床应用

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-06-01 Epub Date: 2023-06-02 DOI: 10.7704/kjhugr.2023.0013

Gwang Ha Kim

{"title":"[Clinical Application of the Kyoto Classification of Gastritis].","authors":"Gwang Ha Kim","doi":"10.7704/kjhugr.2023.0013","DOIUrl":"10.7704/kjhugr.2023.0013","url":null,"abstract":"Recent advances in endoscopic technology, including high-definition and image-enhanced endoscopy such as narrow-band imaging have facilitated close observation and detailed imaging of the gastric mucosa. Currently, endoscopy is performed in Korea primarily for evaluation of premalignant conditions and gastric cancer detection. Recent research has established the Kyoto classification of gastritis, a novel grading system for endoscopic gastritis, which enables prediction of Helicobacter pylori (H. pylori) infection. The Kyoto classification score is calculated based on the sum of scores for five main items (of 19 endoscopic findings indicative of H. pylori infection) such as atrophy, intestinal metaplasia, enlarged gastric folds, nodularity, and diffuse redness with/without regular arrangement of collecting venules (RAC). Of these five endoscopic findings, atrophy, intestinal metaplasia, enlarged gastric folds, and nodularity are associated with an increased risk and RAC with a decreased risk of gastric cancer. Previous studies have reported that a Kyoto classification score ≥2 indicates current or past H. pylori infection. An increase in the Kyoto classification score is associated with a high risk of gastric cancer; specifically, a Kyoto classification score ≥4 indicates a high risk of gastric cancer. However, H. pylori eradication is followed by disappearance of enlarged gastric folds, nodularity, and diffuse redness; therefore, this grading system cannot accurately reflect the gastric cancer risk in patients with previous H. pylori infection. Limited studies have discussed the Kyoto classification of gastritis in Korea. Therefore, further large-scale multicenter studies are warranted for validation of the Kyoto classification to predict H. pylori infection and gastric cancer risk.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":"89-98"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49211780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Bismuth, An Indispensable Component of Helicobacter pylori Eradication Therapy]. 铋，幽门螺杆菌根除治疗不可或缺的成分

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-06-01 Epub Date: 2023-06-12 DOI: 10.7704/kjhugr.2023.0028

Kyung Ho Song

引用次数: 0