The Korean Journal of Helicobacter and Upper Gastrointestinal Research最新文献_第5页

Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication 钾竞争性酸阻滞剂:根除幽门螺杆菌的新治疗策略

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-15 DOI: 10.7704/kjhugr.2023.0041

Byeong Yun Ahn, Soo-Jeong Cho

引用次数: 0

Bifurcated Lumen Observed on Capsule Endoscopy 胶囊内窥镜观察到分岔管腔

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-15 DOI: 10.7704/kjhugr.2023.0036

Byeong Yun Ahn, Bokyung Kim, Hyun-Chae Chung, Sang Gyun Kim, Soo-Jeong Cho

引用次数: 0

Scratch Sign as an Endoscopic Marker for Predicting the Absence of Current Helicobacter pylori Infection 抓痕征作为内镜标记物预测当前幽门螺杆菌感染的缺失

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-15 DOI: 10.7704/kjhugr.2023.0032

Su Jin Kim

引用次数: 0

History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs 抑胃酸药物的历史及药理机制

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-09-15 DOI: 10.7704/kjhugr.2023.0040

Dong Han Yeom, Yong Sung Kim

{"title":"History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs","authors":"Dong Han Yeom, Yong Sung Kim","doi":"10.7704/kjhugr.2023.0040","DOIUrl":"https://doi.org/10.7704/kjhugr.2023.0040","url":null,"abstract":"Gastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells. Histamine plays a decisive role in the transformation of parietal cells into acid-secreting forms. The H+, K+- ATPase proton pump, which represents the final step of acid secretion, translocates from cytoplasmic tubulovesicles to secretory canaliculi upon parietal cell stimulation and facilitates exchange of intracellular H+ with extracellular K+ in a 1:1 ratio. Histamine-2 receptor antagonists and proton pump inhibitors (PPIs) are widely used in clinical practice, and potassium-competitive acid blockers (P-CABs) have gained attention in recent times. P-CABs address the unmet needs of patients who receive conventional PPIs and have broadened the spectrum of drug choices; however, further research is warranted to confirm long-term safety of these drugs. Comprehensive understanding of the mechanisms of actions, characteristics, advantages and disadvantages, and the adverse effect profile is essential for appropriate prescription of gastric acid-suppressive drugs. In this review, we provide a developing history and outline the pharmacological mechanisms underlying various gastric acid-suppressive drugs used in clinical settings.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42444338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Series 内镜下粘膜剥离治疗局部胃粘膜相关淋巴组织淋巴瘤:一个病例系列

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-08-30 DOI: 10.7704/kjhugr.2023.0025

J. Seo, Kee Don Cho, I. Song, Y. S. Park, H. Na, J. Ahn, Jeong Hoon Lee, K. Jung, D. Kim, H. Song, G. Lee, H. Jung

{"title":"Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Series","authors":"J. Seo, Kee Don Cho, I. Song, Y. S. Park, H. Na, J. Ahn, Jeong Hoon Lee, K. Jung, D. Kim, H. Song, G. Lee, H. Jung","doi":"10.7704/kjhugr.2023.0025","DOIUrl":"https://doi.org/10.7704/kjhugr.2023.0025","url":null,"abstract":"Background/Aims: The treatment for gastric mucosa-associated lymphoid tissue lymphoma (MALToma) generally involves eradication of Helicobacter pylori . However, MALToma lesions may recur even without H. pylori re-infection. Furthermore, the remission rate of H. pylori -negative MALToma after eradication is low. Therefore, herein, we report on endoscopic submucosal dissection (ESD) as a treatment strategy for gastric MALToma. Methods: We retrospectively reviewed the data of all patients of gastric MALToma who underwent endoscopic resection at our institution between January 2000 and December 2021. Clinical remission was defined as complete histological remission or probable minimal residual disease according to the GELA grading system for post-treatment evaluation of gastric MALToma. Results: Six patients with gastric MALToma underwent ESD. Two patients were diagnosed with gastric MALToma, which improved after eradication treatment and relapsed approximately 36 and 41 months later, respectively. These patients had singular lesions localized to the mucosa and did not experience H. pylori re-infection. The lesions were successfully removed via ESD. The remaining four patients had H. pylori -negative gastric MALToma. These patients also had single, localized lesions that were removed via ESD. All the patients remained in clinical remission until the final follow-up. Conclusions: ESD is a safe and effective intervention for H. pylori -negative gastric MALToma when the lesion is single and confined to the mucosal layer. (Korean J Helicobacter Up Gastrointest Res 2023 Aug 30. [Epub ahead of print])","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49081723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Primary Esophageal Mucosa-associated Lymphoid Tissue Lymphoma: A Rare Case Report and Review of Other Published Data 原发性食管黏膜相关淋巴组织淋巴瘤:一例罕见病例报告和其他已发表资料的回顾

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-08-30 DOI: 10.7704/kjhugr.2023.0026

Ji Hea Bang, Jin Hyong Kang, Seung Han Kim, Jong-Jae Park, B. Lee, M. Joo, Tae-Sung Jeon

{"title":"Primary Esophageal Mucosa-associated Lymphoid Tissue Lymphoma: A Rare Case Report and Review of Other Published Data","authors":"Ji Hea Bang, Jin Hyong Kang, Seung Han Kim, Jong-Jae Park, B. Lee, M. Joo, Tae-Sung Jeon","doi":"10.7704/kjhugr.2023.0026","DOIUrl":"https://doi.org/10.7704/kjhugr.2023.0026","url":null,"abstract":"The gastrointestinal tract is the most common extranodal site for lymphomas, and mucosa-associated lymphoid tissue lymphoma is the second most common histological lymphoma subtype. However, primary esophageal mucosa-associated lymphoid tissue lymphomas are extremely rare. Few such cases are documented, and the reports demonstrate inconsistent diagnostic and therapeutic strategies. Herein, a 54-year-old man was referred to our hospital for treatment of dysphagia. Esophagogastroduodenoscopy revealed a large, horseshoe-shaped subepithelial mass in the upper esophagus. Endoscopic ultrasonography and computed tomography revealed that the mass was well-demarcated and confined to the muscularis mucosa, with no abnormalities in other organs or lymph nodes. The mass was presumptively diagnosed as benign, and the patient underwent endoscopic mucosal dissection for pathological confirmation and symptom relief. Pathological examination of the dissection specimen revealed that it was a primary esophageal mucosa-associated lymphoid tissue lymphoma. As the patient had an elevated immunoglobulin G level and Helicobacter pylori infection, we administered adjuvant eradication therapy. The patient remains under surveillance and is free of lymphoma recurrence 36 months postoperatively. This case report demonstrates that endoscopic resection and H. pylori eradication are effective treatment strategies for early-stage esophageal mucosa-associated lymphoid tissue lymphoma. (Korean J Helicobacter Up Gastrointest Res 2023 Aug 30. [Epub ahead of print])","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48175416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of a Novel Endoscopic Feature that Predicts Helicobacter pylori-negative Status: Does the Scratch Sign Reflect H. pylori Non-infection? 预测幽门螺杆菌阴性状态的新内镜特征的验证：抓痕标志是否反映幽门螺杆菌未感染？

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-08-30 DOI: 10.7704/kjhugr.2023.0029

J. Seo, Hyo-Jin Cho, Sang Jong Park, Ah Young Lee, Sang-Jung Kim, Ji Yong Ahn

{"title":"Validation of a Novel Endoscopic Feature that Predicts Helicobacter pylori-negative Status: Does the Scratch Sign Reflect H. pylori Non-infection?","authors":"J. Seo, Hyo-Jin Cho, Sang Jong Park, Ah Young Lee, Sang-Jung Kim, Ji Yong Ahn","doi":"10.7704/kjhugr.2023.0029","DOIUrl":"https://doi.org/10.7704/kjhugr.2023.0029","url":null,"abstract":"Background/Aims: Identification of Helicobacter pylori infection status is necessary as H. pylori is associated with gastric malignancy. Recently, a red linear scrape-like appearance on the gastric mucosa, called the “scratch sign,” was reported to be associated with H. pylori -negative gastric mucosal status. Herein, we aimed to validate the association between the scratch sign and H. pylori infection status. Methods: The data of patients who underwent screening endoscopy at Bundang Jesaeng General Hospital between March 2023 and April 2023 were reviewed. Patients were classified as having an H. pylori current infection or non-infection status based on the re-sults of rapid urease tests. Patients who had undergone H. pylori eradication therapy were excluded. Endoscopic features of the gastric mucosa were assessed using the Kyoto classification of gastritis. Results: The scratch sign appeared more frequently in patients with non-infection than in those with current infection status (32.7% vs. 10.6%, respectively; P <0.001). Multivariate analysis showed that only the presence of sticky mucus was significantly associated with the presence of the scratch sign. Patient without the scratch sign had a higher prevalence of open-type atrophy, intestinal meta-plasia, enlarged folds, and diffuse redness, which reflected a higher Kyoto score. Conclusions: Presence of the gastric mucosal scratch sign, a novel endoscopic marker, is indicative of H. pylori -negative status and appears to be inversely correlated with the presence of sticky mucus. In addition to the Kyoto classification of gastritis, detection of the scratch sign may facilitate identification of the H. pylori infection status. (Korean J Helicobacter Up Gastrointest Res 2023 Aug 30. [Epub ahead of print])","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45340205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Findings of Common Gastritis in Koreans 韩国人常见胃炎的内镜表现

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-06-15 DOI: 10.7704/kjhugr.2023.0012

J. Oh

引用次数: 0

Bismuth, An Indispensable Component of Helicobacter pylori Eradication Therapy 铋，幽门螺杆菌根除治疗不可或缺的成分

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-06-15 DOI: 10.7704/kjhugr.2023.0028

Kyung Ho Song

引用次数: 0

Evidence-based Therapy: A Rational Approach to Helicobacter pylori Eradication 循证疗法:根除幽门螺杆菌的理性途径

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-06-15 DOI: 10.7704/kjhugr.2023.0027

Y. Kwon

引用次数: 0