The Open Natural Products Journal最新文献_第2页

Preliminary study on TNFα-blocker activity of Amygdalus lycioides spach extracts. 枸杞子提取物tnf α-阻断剂活性的初步研究。

The Open Natural Products Journal Pub Date : 2010-06-03 DOI: 10.2174/1874848101003010020

R. Gaggeri, D. Rossi, Narges Hajikarimian, E. Martino, F. Bracco, P. Grisoli, C. Dacarro, F. Leoni, G. Mascheroni, S. Collina, O. Azzolina

{"title":"Preliminary study on TNFα-blocker activity of Amygdalus lycioides spach extracts.","authors":"R. Gaggeri, D. Rossi, Narges Hajikarimian, E. Martino, F. Bracco, P. Grisoli, C. Dacarro, F. Leoni, G. Mascheroni, S. Collina, O. Azzolina","doi":"10.2174/1874848101003010020","DOIUrl":"https://doi.org/10.2174/1874848101003010020","url":null,"abstract":"Badam Talkh kuhi is an endemic species of Iran commonly used by native people as anti-inflammatory and an- timicrobial remedy. The present study was aimed at investigating the folk claims of this plant, identified by us as Amygdalus lycioides Spach. Several extracts were prepared using various extraction procedures combined with solvents of different polarity. A decoction was firstly prepared according to the procedure of the folk medicine. Maceration (ME), Ul- trasound-Assisted Extraction (USAE) and Microwave-Assisted Solvent Extraction (MASE) were then experimented using pure methanol (MeOH) and n-hexane-acetone (n-Hex-Ac, 50% v/v). Concerning biological investigation, the antimicro- bial potential of all extracts was firstly evaluated by employing the growth inhibition test. Then, the free radical scaveng- ing effect of each extract was measured, given that reactive oxygen species (ROS) are involved in TNF� -induced signal- ing pathways associated with inflammation. Finally, the anti-TNFactivity of the most active extracts was evaluated us- ing in vitro and in vivo assays. Regarding the anti-inflammatory activity, decoction and MASE n-Hex/Ac extract inhibited the production of TNFwith IC50 in the range of 120-390 � g/ml and 6-20 � g/ml, respectively. Interestingly, after oral administration in mice, MASE n-Hex/Ac extract was effective in reducing TNFof about 60%. Moreover, treated animals did not show any signs of toxicity. Results herein reported clearly evidenced that Amygdalus lycioides Spach could be a valuable source of TNF� -blockers effective against chronic inflammatory diseases.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"26 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2010-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85099993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Theoretical Investigation of the Structural Properties of Two Crotamines Isolated from the Venom of Crotalus durissus 从细爪蟾毒液中分离的两种Crotamines结构性质的理论研究

The Open Natural Products Journal Pub Date : 2010-05-30 DOI: 10.2174/1874848101104010016

A. Alcântara, D. Piló-Veloso, Antônio José do N. Fernandes, M. C. Dos-Santos

引用次数: 1

An Initial Evaluation of the Safety, Efficacy and Purity of VigRX, an Herbal Combination Formula, for the Enhancement of Male Sexual Health 提高男性性健康的中药复方VigRX的安全性、有效性和纯度的初步评价

The Open Natural Products Journal Pub Date : 2010-03-31 DOI: 10.2174/1874848101003010010

Y. Smitasiri, J. Neal-Kababick

{"title":"An Initial Evaluation of the Safety, Efficacy and Purity of VigRX, an Herbal Combination Formula, for the Enhancement of Male Sexual Health","authors":"Y. Smitasiri, J. Neal-Kababick","doi":"10.2174/1874848101003010010","DOIUrl":"https://doi.org/10.2174/1874848101003010010","url":null,"abstract":"A patented herbal combination formula, known as VigRX, has been studied for purity, and for safety and effi- cacy in a Sprague-Dawley rat model. Two separate assays determined that VigRX was free from pharmaceutical adulter- ants, including phosphodiesterase type 5 (PDE-5) inhibitors and related analogues. An in vitro assay determined that VigRX is able to inhibit the enzyme Rho-kinase, suggesting a potential mechanism of action for this product. A 2-week (14-day) study in rats demonstrated a marked enhancement in sexual behavior, including decreased intromission and ejaculation latencies, and increased intromission, ejaculation and mounting frequencies, upon oral administration of 30 mg/kg/day. A longer 12-week study using 15 mg/kg/day showed only a decrease in ejaculation latency with respect to sexual behavior. In both studies, the treatment led to increased intracavernosal pressure, increased sperm concentration, and increased width of erect penis (and an increase in erect penile length in the 14-day study only). There was a statisti- cally significant increase in blood testosterone levels in rats at the end of the 12-week study, which did not occur in the 14-day study. A non-dose dependent decrease in kidney and liver weights was found in the 14-day study that was not seen in the 12-week study, and neither study found any notable histopathological changes in any tissues studied. In conclusion, these preliminary results demonstrate safety and efficacy of VigRx for use in supporting male erectile function, and justify further investigation in these areas.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"40 2 1","pages":"10-19"},"PeriodicalIF":0.0,"publicationDate":"2010-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90975295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Volatiles Constituents from Leaves of Morinda morindoïdes (Rubiaceae): A Medicinal Plant from the Ivory Coast 桑达叶挥发物成分morindoïdes(茜草科):一种来自象牙海岸的药用植物

The Open Natural Products Journal Pub Date : 2010-02-08 DOI: 10.2174/1874848101003010006

François P. Kouame, G. Bedi, A. Koffi, J. Chalchat, T. Y. N'guessan

引用次数: 9

Protoxylogranatin B, a Key Biosynthetic Intermediate from Xylocarpus granatum: Suggesting an Oxidative Cleavage Biogenetic Pathway to Limonoid 原木浆蛋白B:一个关键的生物合成中间体:提示一个氧化裂解生物成因途径生成类柠檬素

The Open Natural Products Journal Pub Date : 2010-01-19 DOI: 10.2174/1874848101003010001

Weimin Hu, J. Wu

引用次数: 11

Seasonal and geographical variation of Laurus nobilis L. essential oil from Tunisia. 突尼斯野月桂精油的季节和地理变异。

The Open Natural Products Journal Pub Date : 2010-01-04 DOI: 10.2174/1874848100902010086

H. Marzouki, A. Elaissi, A. Khaldi, S. Bouzid, D. Falconieri, B. Marongiu, A. Piras, S. Porcedda

{"title":"Seasonal and geographical variation of Laurus nobilis L. essential oil from Tunisia.","authors":"H. Marzouki, A. Elaissi, A. Khaldi, S. Bouzid, D. Falconieri, B. Marongiu, A. Piras, S. Porcedda","doi":"10.2174/1874848100902010086","DOIUrl":"https://doi.org/10.2174/1874848100902010086","url":null,"abstract":"Yield and composition of the essential oil obtained by hydrodistillation from leaves of laurel coming from ten different sites in Tunisia were determined. From each locality, leaves were harvested during four different vegetative stages (October, production of seeds; January, dormancy; April, flowering; July, vegetative activity) to look for some cor- relation between composition and vegetative stage. All 40 essential oil samples produced similar GC profiles containing a total of 71 peaks. 60 Compounds were identified. 1,8-cineole was, in all samples, the main constituent among different compounds such as methyl eugenol, � -terpinyl acetate, sabinene and linalool. All essential oils considered were character- ized by a clear predominance of oxygenated compounds chiefly monoterpenes then phenylporpanoids and sesquiterpenes. The concentration of this class generally decreases during the period October - July; the values are in the range 67.5% - 86.1%. The yields of essential oil ranged between 0.65 and 2.2% by weight. With only one exception, the higher produc- tion of essential oil was obtained during the vegetative period. A seasonal variation in the yield and composition of essen- tial oil was revealed, while geographical variability was not pronounced and no chemotypes were observed among the samples of laurel leaf oil examined.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"9 1","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2010-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73839739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Nematicidal Activity of Plant Extracts Against the Root-Knot Nematode, Meloidogyne incognita 植物提取物对根结线虫的杀线虫活性研究

The Open Natural Products Journal Pub Date : 2009-10-21 DOI: 10.2174/1874848100902010077

Wiratno, D. Taniwiryono, H. V. D. Berg, J. Riksen, I. Rietjens, S. R. Djiwanti, J. Kammenga, A. Murk

{"title":"Nematicidal Activity of Plant Extracts Against the Root-Knot Nematode, Meloidogyne incognita","authors":"Wiratno, D. Taniwiryono, H. V. D. Berg, J. Riksen, I. Rietjens, S. R. Djiwanti, J. Kammenga, A. Murk","doi":"10.2174/1874848100902010077","DOIUrl":"https://doi.org/10.2174/1874848100902010077","url":null,"abstract":"Nematicidal activity of extracts from plants was assayed against Meloidogyne incognita. In laboratory assays extracts from tobacco (Nicotiana tabacum L), clove (Syzygium aromaticum L), betelvine (Piper betle L), and sweet flag (Acorus calamus L) were most effective in killing the nematode, with an EC50 that was 5-10 times lower than the EC50 of the synthetic pesticides chlorpyrifos, carbosulfan and deltamethrin. The shapes of the dead nematodes differed in a char- acteristic way, and groups of pesticides and plant extracts could clearly be distinguished based on this phenomenon, which may be an indicator for the modes of action of the tested pesticides. In a greenhouse bioassay clove bud and betelvine were tested as mulch. Experiments revealed that the total number of live nematodes on roots of pepper plants treated with mulch of the clove bud was 7% of that of the controls and did not differ significantly from that of plants treated with the recommended synthetic pesticide carbofuran. The application of clove buds as a botanical pesticide for future use against nematodes is highly promising since clove is the 6 th major plant grown on Bangka Island, and the market value of clove has decreased sharply over the last years.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"19 1","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2009-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74241650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 85

Gender-Differences in Mice Hypericin Plasma Levels Upon Long-Term Hypericum Administration 长期服用金丝桃后小鼠金丝桃素血浆水平的性别差异

The Open Natural Products Journal Pub Date : 2009-06-26 DOI: 10.2174/1874848100902010068

B. Radu, Valentina Anuța, G. Stoian

引用次数: 0

Herbal Photoprotective Formulations and their Evaluation 草药光防护制剂及其评价

The Open Natural Products Journal Pub Date : 2009-06-26 DOI: 10.2174/1874848100902010071

Deep Chanchal, S. Swarnlata

{"title":"Herbal Photoprotective Formulations and their Evaluation","authors":"Deep Chanchal, S. Swarnlata","doi":"10.2174/1874848100902010071","DOIUrl":"https://doi.org/10.2174/1874848100902010071","url":null,"abstract":"Photochemoprevention has become an important armamentarium in the fight against ultraviolet radiation in- duced damage to the skin. UV irradiation to skin results in erythema, edema, sunburn cells, hyperplasia, immunosuppres- sion, photoaging and photocarcinogenesis. Various synthetic agents have been used as photoprotectives but they have lim- ited use because of their potential toxicity in humans and their ability to interfere only in selected pathways of multistage process of carcinogenesis. Several botanical compounds have been shown to be antimutagenic, anticarcinogenic and non- toxic and have ability to exert striking inhibitory effects on a plethora of cellular events at various stages of carcinogene- sis. Since multiple pathways are involved in photocarcinogenesis so mixture of several botanical antioxidants working through various mechanisms, in conjunction with the use of sunscreens could also be an effective approach for reducing photoaging and skin cancer in humans. The performance of sunscreen substances could be improved by modification of their chemical, physical and technological properties or by the use of novel carriers like liposomes, nanoparticles, phyto- somes, transferosomes, nanospheres etc. The application of novel approaches can also improve its efficacy regarding con- tinuous action of herbs on the human body. This review will focus on list of herbs, formulations and evaluation parame- ters of photoprotective herbs.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"13 1","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2009-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75122542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

Soyasaponins and related glycosides of Desmodium canadense and Desmodium illinoense. 加拿大麦冬和薄壳麦冬的大豆皂苷及相关苷类。

The Open Natural Products Journal Pub Date : 2009-06-25 DOI: 10.2174/1874848100902010059

W. Taylor, Daniel H. Sutherland, K. Richards

{"title":"Soyasaponins and related glycosides of Desmodium canadense and Desmodium illinoense.","authors":"W. Taylor, Daniel H. Sutherland, K. Richards","doi":"10.2174/1874848100902010059","DOIUrl":"https://doi.org/10.2174/1874848100902010059","url":null,"abstract":"Seed extracts of Desmodium canadense (L.) DC., a native Canadian legume, were examined by HPLC and electrospray ionization mass spectrometry (LC/MS) for the presence of triterpenoid saponins of the oleanene type. An aqueous methanol extract, fractionated by use of a Diaion™ HP-20 macroporous resin, was found to possess soyasaponin III (soyasaponin Bb´) and the 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one conjugate of soyasaponin III (DDMP S-III) as major saponin components. Minor components were identified by LC/MS as C-24 aldehyde (sandosapogenol) derivatives, S-III al and DDMP S-III al. Soyasaponin I (soyasaponin Bb), soyasaponin VI (soyasaponin ￻ g) and dehydro- soyasaponin I (soyasaponin Be) were also found as minor components. These components were also detected in extracts obtained by Soxhlet extraction with water followed by partitioning into n-butanol. Extracts from foliage of greenhouse and field origins were essentially free of these saponins. Soyasaponin VI was the main seed saponin of Desmodium illi- noense A. Gray whereas soyasaponin III and DDMP S-III were found as minor components. Components corresponding in molecular mass to C-22 glycosides of soyasaponin I and soyasaponin III were also detected in saponin-enriched ex- tracts. Neither species was a good source of alkaloids.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"21 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2009-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74050919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10