The Open Natural Products Journal最新文献_第4页

Limnophila (Scrophulariaceae): Chemical and Pharmaceutical Aspects 玄参科:化学和药学方面

The Open Natural Products Journal Pub Date : 2008-10-30 DOI: 10.2174/1874848100801010034

G. Brahmachari

引用次数: 18

Antifungal Properties of Some Mexican Medicinal Plants 一些墨西哥药用植物的抗真菌特性

The Open Natural Products Journal Pub Date : 2008-08-29 DOI: 10.2174/1874848100801010027

Luz Maria Damián-Badillo, R. Salgado-Garciglia, Rosa E. Martínez-Muñoz, M. Martínez-Pacheco

{"title":"Antifungal Properties of Some Mexican Medicinal Plants","authors":"Luz Maria Damián-Badillo, R. Salgado-Garciglia, Rosa E. Martínez-Muñoz, M. Martínez-Pacheco","doi":"10.2174/1874848100801010027","DOIUrl":"https://doi.org/10.2174/1874848100801010027","url":null,"abstract":"The antifungal properties of some extracts from Artemisia ludoviciana Nutt., Heliopsis longipes 'A. Gray' Blake., Satureja macrostema Benth. and Tagetes lucida Cav. were analyzed, using the agar disc diffusion method. After 72 h incubation, the plant extracts inhibited the growth of fungi, but the ethyl acetate and methanol-chloroform extracts from A. ludoviciana, H. longipes and T. lucida inhibited all the fungi assayed: Candida albicans, Colletotrichum linde- muthianum, Mucor circinelloides, Saccharomyces cerevisiae, and Sporothrix schenckii. The spore germination inhibition assay suggested that methanol-chloroform extract from A. ludoviciana was the most active against the fungi tested. The methanol-chloroform and ethyl acetate extracts from A. ludoviciana and T. lucida had pronounced antifungal activity against fungi tested. Compounds found in the leaves methanol-chloroform extracts from A. ludoviciana were analyzed by using GC/MS; the major compounds were: 1-8-cineole, camphor, borneol, cis-verbenol, myrtenol, eugenol, cariophyllene, � -farnesene, spathulenol, derivatives of caryophyllene and derivatives of spathulenol.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"57 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2008-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78621976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Clinical Improvement of Active Tuberculosis Patients with Complex Treatment and Nutritional Supplementation 综合治疗和营养补充对活动性肺结核患者临床疗效的改善

The Open Natural Products Journal Pub Date : 2008-07-24 DOI: 10.2174/1874848100801010020

V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath

{"title":"Clinical Improvement of Active Tuberculosis Patients with Complex Treatment and Nutritional Supplementation","authors":"V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath","doi":"10.2174/1874848100801010020","DOIUrl":"https://doi.org/10.2174/1874848100801010020","url":null,"abstract":"Global incidence of tuberculosis, especially multiple-drug resistant tuberculosis, has been increasing, despite development and use of various antimicrobial drugs for decades, leading to 2 million deaths a year. We evaluated the ef- fect of micronutrient supplementation as an adjunct to standard treatment of patients with active pulmonary tuberculosis, on clinical improvement and frequency of adverse events on 120 patients aged 20 to 65 years diagnosed with active pul- monary tuberculosis at the Kiev Department of Phthisiatry. All participants (Test group) were prescribed standard medica- tion supplemented with vitamin/essential nutrients. A Control group (n=100) of patients recently treated with standard medication alone at this facility were selected by matching to Test patients by stage of disease, confounding conditions, gender, and alcohol consumption. Standard clinical and diagnostic methods were applied to determine baseline values and at the termination of the study. After a two-month period of intensive chemotherapy, cavity healing (primary measure) oc- curred in 98% of the Test Group, but only in 69% of the Control Group. Furthermore, the Ziehl-Neelson sputum test was negative in 100% of the Test group, but only in 88% of the Control group. Resolution of respiratory compromise was higher in the Test group (87%) than in the Control group (78%). Furthermore, supplementation with vitamin/essential nu- trients resulted in a significant decrease in the frequency and severity of adverse events from chemotherapy; only 11% in the Test group experienced adverse events while 46% did so in the Control group. In conclusion, clinical efficacy of che- motherapy was enhanced significantly with adjunctive use of nutrient supplementation. In addition, micronutrient sup- plementation decreased the frequency and severity of adverse effects from chemotherapy.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"77 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2008-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73421945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Oleoylsalicylate Derivatives: Synthesis and Antifungal Activity 油基水杨酸衍生物:合成及抗真菌活性

The Open Natural Products Journal Pub Date : 2008-06-13 DOI: 10.2174/1874848100801010014

A. Bassoli, Gigliola Borgonovo, S. Caimi, G. Farina, M. Moretti

引用次数: 3

Radical Scavenging and Inhibition of Platelet Function by a Polyphenol-Rich Fraction from Salvia miltiorrhiza Bunge 富多酚丹参提取物清除自由基及抑制血小板功能的研究

The Open Natural Products Journal Pub Date : 2008-06-13 DOI: 10.2174/1874848100801010007

Seun-ah Yang, Nam-Kyung Im, Young-Joo Ji, Dong-Chan Yoo, K. Jhee, In‐Seon Lee

{"title":"Radical Scavenging and Inhibition of Platelet Function by a Polyphenol-Rich Fraction from Salvia miltiorrhiza Bunge","authors":"Seun-ah Yang, Nam-Kyung Im, Young-Joo Ji, Dong-Chan Yoo, K. Jhee, In‐Seon Lee","doi":"10.2174/1874848100801010007","DOIUrl":"https://doi.org/10.2174/1874848100801010007","url":null,"abstract":"A diet rich in polyphenols has previously been shown to be associated with a lower risk for cardiovascular dis- ease. Specifically, inhibition of platelet hyperactivation by polyphenols decreases platelet-dependent thrombosis, reducing the risk for cardiovascular disease. However, whether polyphenols in Salvia miltiorrhiza Bunge (SMB) affect platelet functions has not been clearly determined. Here, we investigated the effects of methanol and ethyl acetate (EtOAc) ex- tracts from SMB on free radical scavenging activities, and platelet aggregation and adhesion. We found that the EtOAc fraction was the most effective at scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals (concentration for 50% reduction, RC50 = 2.4 ± 1.5 and 27.9 ± 1.4 μg/mL, respectively), and that, especially for DPPH radicals, the EtOAc fraction showed better scavenging activity than butylated hydroxyanisole (BHA, RC50 = 5.5 ± 0.1 μg/mL). Measurements with a turbidimetric aggregometer revealed that the EtOAc fraction was the most potent inhibitor of ADP- and collagen-induced rat platelet aggregation. In addition, the methanol and EtOAc fraction dose-dependently inhibited thrombin-stimulated platelet adhesion to collagen or fibrino- gen. Collectively, these results suggest that the polyphenol-rich EtOAc fraction from SMB can reduce platelet hyperacti- vation by scavenging free radicals. Thus, the EtOAc fraction of SMB is a potential source of inhibitors of platelet- dependent thrombosis.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"51 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2008-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73103220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Phenolic Profiles and Antioxidant Activity of Extracts from Peanut Plant Parts 花生植物部位提取物的酚类特征及其抗氧化活性

The Open Natural Products Journal Pub Date : 2008-04-11 DOI: 10.2174/1874848100801010001

L. Dean, Jack Parker Davis, B. Shofran, T. Sanders

引用次数: 11