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Flavonoid Glycosides from the Aerial Parts of Polygonatum odoratum(Mill.) Druce Growing in Mongolia 黄酮类苷类化合物的研究蒙古的大麻种植
The Open Natural Products Journal Pub Date : 2015-07-31 DOI: 10.2174/1874848101508010001
Chunsriimyatav Ganbaatar, M. Gruner, Dumaa Mishig, Regdel Duger, Arndt W. Schmidt, H. Knölker
{"title":"Flavonoid Glycosides from the Aerial Parts of Polygonatum odoratum(Mill.) Druce Growing in Mongolia","authors":"Chunsriimyatav Ganbaatar, M. Gruner, Dumaa Mishig, Regdel Duger, Arndt W. Schmidt, H. Knölker","doi":"10.2174/1874848101508010001","DOIUrl":"https://doi.org/10.2174/1874848101508010001","url":null,"abstract":"We describe the isolation, identification, and structural elucidation of natural products from the Mongolian me- dicinal plant Polygonatum odoratum (Mill.) Druce. Six flavonoid glycosides, isorhamnetin-3-O-rutinoside (narcissoside, narcissin) (1), kaempferol-3-O-rutinoside (nicotiflorin) (2), quercetin-3-O-rutinoside (rutin) (3), apigenin-6-C-� -D- glucoside (isovitexin) (4), apigenin-6-C-(2�� -O-� -D-xylopyranosyl-� -D-glucopyranoside) (desmodin) (5), and isovitexin-7- O-� -D-glucoside (saponarin) (6), were isolated from the aerial parts of Polygonatum odoratum (Mill.) Druce. The struc- tures of 1-6 have been confirmed by UV, IR, MS, and NMR ( 1 H, 13 C, COSY, HSQC, HMBC, NOESY, and ROESY) data. Graphical Abstract:","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75610954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Limnophila (Scrophulariaceae): Chemical and Pharmaceutical Aspects - An Update 林芝属植物(玄参科):化学和药学方面的最新进展
The Open Natural Products Journal Pub Date : 2015-01-09 DOI: 10.2174/1874848101407010001
G. Brahmachari
{"title":"Limnophila (Scrophulariaceae): Chemical and Pharmaceutical Aspects - An Update","authors":"G. Brahmachari","doi":"10.2174/1874848101407010001","DOIUrl":"https://doi.org/10.2174/1874848101407010001","url":null,"abstract":"The present resume covers an up-to-date literature on Limnophila species. The botanical classification, ethno- pharmacology, and chemical constituents of Limnophila plants, as well as the biological activities and pharmacological applications of both distinct phytochemicals and medicinally active plant materials (formulations, extracts, etc.) are dis- cussed in detail.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"22 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2015-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73706128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Synthetic Approaches Towards Tubulysins and Derivatives Thereof 微管溶素及其衍生物的合成方法
The Open Natural Products Journal Pub Date : 2013-11-01 DOI: 10.2174/1874848101306010012
U. Kazmaier, Angelika Ullrich, J. Hoffmann
{"title":"Synthetic Approaches Towards Tubulysins and Derivatives Thereof","authors":"U. Kazmaier, Angelika Ullrich, J. Hoffmann","doi":"10.2174/1874848101306010012","DOIUrl":"https://doi.org/10.2174/1874848101306010012","url":null,"abstract":"Tubulysins, linear tetrapeptides produced by several strains of myxobacteria, show an extremely high toxicity towards a wide range of cancer cell lines, with IC50 values in the nano or even picomolar range. Therefore, tubulysins and their derivatives might be suitable candidates for the development of antitumor drugs. Several synthetic approaches for tubulysins and derivates have been developed, which will be discussed in the review.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"40 1","pages":"12-30"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79295654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Antioxidant Polyphenolic Constituents of Vitis × Labruscana cv. 'Isabella' Leaves 枸杞抗氧化多酚类成分研究“伊莎贝拉”叶子
The Open Natural Products Journal Pub Date : 2013-05-17 DOI: 10.2174/1874848101306010005
S. Pacifico, B. D’Abrosca, M. Scognamiglio, M. Gallicchio, Silvia Galasso, P. Monaco, A. Fiorentino
{"title":"Antioxidant Polyphenolic Constituents of Vitis × Labruscana cv. 'Isabella' Leaves","authors":"S. Pacifico, B. D’Abrosca, M. Scognamiglio, M. Gallicchio, Silvia Galasso, P. Monaco, A. Fiorentino","doi":"10.2174/1874848101306010005","DOIUrl":"https://doi.org/10.2174/1874848101306010005","url":null,"abstract":"The polyphenolic composition and antioxidant properties of the methanol leaf extract of Vitis × labruscana cv. 'Isabella' has been performed by means of different spectrophotometric antioxidant methods. Intracellular ROS produc- tion was measured by cell fluorescence after loading with 2',7'-H2DCF-DA. The extract promising efficacy has laid the basis to its phytochemical characterization. Three hydroxycinnamoyl tartaric acids (1-3), isoquercitrin 4, and five flavonol glycuronides (5-9) were isolated from Vitis × labruscana cv. 'Isabella' leaves. Chemical structures were elucidated on the basis of their spectroscopic features. Metabolites 6, 7, and 9, characterized by glucuronic or galacturonic acid methyl es- ter, are described from the genus Vitis for the first time. The metabolites isolated as major constituents were investigated for their DPPH radical scavenging capacity.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"6 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2013-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82180285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Evaluating the Anticancer Activity of Hedyotis diffusa Water Extract Against Human Breast Cancer MCF7 Cells 白花蛇舌草水提取物对人乳腺癌MCF7细胞的抗癌活性评价
The Open Natural Products Journal Pub Date : 2013-04-05 DOI: 10.2174/1874848101306010001
Binbing Ling, Qiulin Dong, Wanpeng Sun, D. Michel, R. Jiao, R. Sammynaiken, Yijiang Zhou, Jian Yang
{"title":"Evaluating the Anticancer Activity of Hedyotis diffusa Water Extract Against Human Breast Cancer MCF7 Cells","authors":"Binbing Ling, Qiulin Dong, Wanpeng Sun, D. Michel, R. Jiao, R. Sammynaiken, Yijiang Zhou, Jian Yang","doi":"10.2174/1874848101306010001","DOIUrl":"https://doi.org/10.2174/1874848101306010001","url":null,"abstract":"Hedyotis diffusa has been used to treat cancers in traditional Chinese medicine for many years. Recently, sev- eral anthraquinone compounds were extracted from Hedyotis diffusa and identified as its anticancer ingredients. These compounds are able to induce apoptosis in several types of cancer cells. In this study, we showed that the anticancer activ- ity of Hedyotis diffusa was highly selective, possessing high cytotoxicity towards human breast cancer MCF7 cells but almost no cytotoxicity against the mammary epithelial MCF12A cells. The Hedyotis diffusa water extract also elevated the energy metabolism in both MCF12A and MCF7 cells; but the ATP/ADP ratio was still maintained at about 1.0 in the MCF12A cells to avoid either apoptosis or uncontrolled proliferation. In addition, Sheshecaojing, a health product of He- dyotis diffusa marketed in China, gave a dose-dependent cytotoxic response against the MCF7 cells.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"03 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88904002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
β-Sitosterol Lithospermate from Salvia Columbariae 从鼠尾草中提取的谷甾醇
The Open Natural Products Journal Pub Date : 2012-11-16 DOI: 10.2174/1874848101205010013
J. J. D. Adams, S. Tran, Vincent Wong, P. Fontaine, J. Petrosyan
{"title":"β-Sitosterol Lithospermate from Salvia Columbariae","authors":"J. J. D. Adams, S. Tran, Vincent Wong, P. Fontaine, J. Petrosyan","doi":"10.2174/1874848101205010013","DOIUrl":"https://doi.org/10.2174/1874848101205010013","url":null,"abstract":"Salvia columbariae extracts were examined for the presence of salvianolic acids by HPLC-MS and NMR. A new salvianolic acid, β-sitosterol lithospermic acid, was found.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"49 1","pages":"13-15"},"PeriodicalIF":0.0,"publicationDate":"2012-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88007508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Complete Assignment of the 1H and 13C NMR Spectra of the Camelliagenin A and A1-Barrigenol from the seed of Barringtonia asiatica 亚洲巴林桐种子中茶花素A和A1-Barrigenol的1H和13C NMR谱的完整分配
The Open Natural Products Journal Pub Date : 2012-07-20 DOI: 10.2174/1874848101205010007
R. Rumampuk, E. Pongoh, Ponis Tarigan, A. Herlt, L. Mander
{"title":"Complete Assignment of the 1H and 13C NMR Spectra of the Camelliagenin A and A1-Barrigenol from the seed of Barringtonia asiatica","authors":"R. Rumampuk, E. Pongoh, Ponis Tarigan, A. Herlt, L. Mander","doi":"10.2174/1874848101205010007","DOIUrl":"https://doi.org/10.2174/1874848101205010007","url":null,"abstract":"The 1 H and 13 C NMR spectra of camelliagenin A and A1-barrigenol from the seeds of Barringtonia asiatica were completely assigned for the first time by one- and two-dimensional homo- and heteronuclear studies ( 1 H, 13 C, DQCOSY, TOCSY, HMQC, HMBC) at 600 and 150.89 MHz. The article reports standard data that may be important for potential authors needing such information.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"36 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2012-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74725874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Correlation Between Experimental and DFT/GIAO Computed 13C NMR Chemical Shifts of Organic Compounds. Effects of Asymmetry 有机化合物的实验与DFT/GIAO计算13C NMR化学位移的相关性不对称效应
The Open Natural Products Journal Pub Date : 2012-05-28 DOI: 10.2174/1874848101205010001
E. Borkowski, M. A. Álvarez, F. Suvire, R. Enriz
{"title":"Correlation Between Experimental and DFT/GIAO Computed 13C NMR Chemical Shifts of Organic Compounds. Effects of Asymmetry","authors":"E. Borkowski, M. A. Álvarez, F. Suvire, R. Enriz","doi":"10.2174/1874848101205010001","DOIUrl":"https://doi.org/10.2174/1874848101205010001","url":null,"abstract":"The experimental 13 C chemical shifts of five different series of organic compounds are compared with pre- dicted 13 C NMR chemical shifts obtained via empirically scaled GIAO shieldings. Our results indicate that the inclusion of a scaling factor allow to obtain an excellent correlation between δcalc and δexp. Although the inclusion of asymmetry im- proves this correlation, such enhancement was not observed for all the 54 tested compounds. We found RMS, a parameter related with the structural feature of the whole molecule, which could indicate the benefits of including asymmetry in these calculations.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"52 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2012-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87223670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Biological Activities of Emetine 艾美汀的生物活性
The Open Natural Products Journal Pub Date : 2011-02-07 DOI: 10.2174/1874848101104010008
Emmanuel S. Akinboye, O. Bakare
{"title":"Biological Activities of Emetine","authors":"Emmanuel S. Akinboye, O. Bakare","doi":"10.2174/1874848101104010008","DOIUrl":"https://doi.org/10.2174/1874848101104010008","url":null,"abstract":"Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug. It inhibits both ribosomal and mitochondrial protein synthesis and interferes with the synthesis and activities of DNA and RNA. For this reason, it has been a vital tool to pharmacologists and has demonstrated many biological properties, such as antiviral, anticancer, antiparasitic and contraceptive activities. Also, it has been reported to cause the up-regulation and down-regulation of a number of genes. Some synthetic analogs with interesting biological activities have been prepared. This article reviews the biological activities of emetine and some emetine derived molecules.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"58 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2011-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84049881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 87
Activity and Mode of Action of Flavonoids Compounds Against Intracellular and Extracellular Forms of Trypanosoma cruzi 黄酮类化合物对克氏锥虫胞内和胞外的活性和作用方式
The Open Natural Products Journal Pub Date : 2011-02-04 DOI: 10.2174/1874848101104010001
Samira Boutaleb-Charki, M. Sánchez-Moreno, Jesús Díaz, M. Rosales, Óscar Huertas, R. Gutiérrez-Sánchez, C. Marín
{"title":"Activity and Mode of Action of Flavonoids Compounds Against Intracellular and Extracellular Forms of Trypanosoma cruzi","authors":"Samira Boutaleb-Charki, M. Sánchez-Moreno, Jesús Díaz, M. Rosales, Óscar Huertas, R. Gutiérrez-Sánchez, C. Marín","doi":"10.2174/1874848101104010001","DOIUrl":"https://doi.org/10.2174/1874848101104010001","url":null,"abstract":"This study investigates the in vitro activity of a number of flavonoids (kaempferol, quercetin, trifolin, and ace- tyl hyperoside) and their acetylated products: kaempferol acetate, quercetin acetate, trifolin acetate, and acetyl hyperoside acetate) isolated from the aerial parts of plant Consolida oliveriana against epimastigote, amastigote and metacyclic forms of T. cruzi, their cytotoxic against a host Vero-cell line and analyse the possible mechanism by which these molecules act. Acetylated compounds were potent T. cruzi epimastigote growth inhibitors with activity levels similar to those of benzni- dazole, used as the reference drug. These compounds, at the dosage IC25, decreased the ability of metacyclic forms to in- vade mammalian cells, their intracellular replications and transformation in trypomastigotes, with no toxicity to the host cells. The cells treated presented severe damage in their ultrastructure: intense vacuolization, and appearance of lysosomes as well as other residual bodies. The mitochondrial section appeared larger in size, with a swollen matrix. In addition, these compounds changed the excretion of end metabolites, primarily affecting acetate and succinate excretion, possibly by directly influencing certain enzymes or their synthesis. The potent tripanocidal activities of the flavons described here represent an exciting advance in the search for new antiprotozoal agents.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"17 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2011-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80979338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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