The Open Allergy Journal最新文献_第3页

HRF-Interacting Molecules HRF-Interacting分子

The Open Allergy Journal Pub Date : 2012-05-18 DOI: 10.2174/1874838401205010041

T. Kawakami, T. Ando, Y. Kawakami

引用次数: 6

On the Mechanisms Underlying the Secretion and Export of Translationally Controlled Tumor Protein/Histamine Releasing Factor (TCTP/HRF) 翻译控制肿瘤蛋白/组胺释放因子(TCTP/HRF)分泌和输出的机制研究

The Open Allergy Journal Pub Date : 2012-05-18 DOI: 10.2174/1874838401205010033

J. Maeng, Miyoung Kim, Kyunglim Lee

{"title":"On the Mechanisms Underlying the Secretion and Export of Translationally Controlled Tumor Protein/Histamine Releasing Factor (TCTP/HRF)","authors":"J. Maeng, Miyoung Kim, Kyunglim Lee","doi":"10.2174/1874838401205010033","DOIUrl":"https://doi.org/10.2174/1874838401205010033","url":null,"abstract":"Numerous studies have demonstrated that TCTP/HRF is a unique cytokine, modulating the release of inflammatory mediators from various cell types including cells involved in allergic phenomena. Despite the absence of a leader sequence in its NH2-terminus, TCTP/HRF is regarded as a secreted protein found outside of cells as well as in fluids from allergic patients and parasitic organisms. Recent studies clarified several potential mechanisms leading to its secretion. For example, these studies showed that TCTP/HRF is exported from cells via a non-classical, endoplasmic reticulum (ER)/Golgi-independent mechanism associated with exosomal transport. TSAP6, a p53-inducible transmembrane protein, has been shown to enhance exosome production, and facilitate the secretion of TCTP/HRF into extracellular milieu. Additionally, H,K-ATPase also appears to play a role in the transport of TCTP/HRF, since inhibitors of H,K-ATPase also inhibit TCTP/HRF exit. The exact mechanisms involved in TCTP/HRF secretion has not yet emerged. Here we attempted to collate the available information in the current understanding of the mechanisms underlying the release of TCTP/HRF and of the factors that seem to influence these mechanisms.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"38 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2012-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88349618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Positive Correlation Between Japanese Cedar Pollen Numbers and the Development of Kawasaki Disease 杉木花粉数量与川崎病发生的正相关研究

The Open Allergy Journal Pub Date : 2012-05-04 DOI: 10.2174/1874838401205010001

A. Awaya, Koji Murayama

{"title":"Positive Correlation Between Japanese Cedar Pollen Numbers and the Development of Kawasaki Disease","authors":"A. Awaya, Koji Murayama","doi":"10.2174/1874838401205010001","DOIUrl":"https://doi.org/10.2174/1874838401205010001","url":null,"abstract":"Objective: Kawasaki disease (KD), an acute febrile disease that induces systemic vasculitis in infants, has been proposed by Awaya and Sahashi in 2003 to be epidemiologically linked with pollen exposure. In this report, seasonal variation patterns of the monthly development of KD in 5,917 patients (Pt.) in Kanagawa, Japan were compared with the monthly pollen release numbers (Nos.) from 1991 to 2002. Methodology: A correlation coefficient (c.c.) matrix was gen- erated using regression analyses of the correlation of KD onset and pollen exposure in each month. The percent of Japa- nese cedar pollen Nos. was calculated from the pollen numbers (Po.Nos.) of all the species surveyed in March and April throughout the years. Results: Significant c.c. associations were revealed between Po.Nos. from all species in March and KD Pt.Nos. in August (0.88), November (0.72), May (0.68), and April (0.66). Significant c.c. associations were also found between Po.Nos. from all species in April and KD Pt.Nos. in August (0.70), and between Po.Nos from all species in Feb- ruary and KD Pt.Nos. in July (0.62). Mean c.c. values of 0.60 in March, 0.47 in October, 0.45 in July, 0.35 in April, and 0.31 in February between Po.Nos. and KD Pt.Nos. were shown. February, March and April contributed 4.7%, 40.6% and 38.8% of the annual Po.Nos., respectively, of which 93.8%, 84.3% and 10.9% were from cedar pollen, respectively. Conclusions: A positive association was demonstrated between the Po.Nos. from all species, particularly cedar Po.Nos. in March, and the KD Pt.Nos. in the following several months.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"2 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2012-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88593581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Heating Affects Structure, Enterocyte Adsorption and Signalling, As Well as Immunogenicity of the Peanut Allergen Ara h 2. 加热影响花生过敏原Ara h2的结构、肠细胞吸附和信号传导以及免疫原性。

The Open Allergy Journal Pub Date : 2011-12-09 DOI: 10.2174/1874838401104010024

Philipp Starkl, Durga Krishnamurthy, Krisztina Szalai, Ferdinand Felix, Anna Lukschal, Dominik Oberthuer, Hugh A Sampson, Ines Swoboda, Christian Betzel, Eva Untersmayr, Erika Jensen-Jarolim

{"title":"Heating Affects Structure, Enterocyte Adsorption and Signalling, As Well as Immunogenicity of the Peanut Allergen Ara h 2.","authors":"Philipp Starkl, Durga Krishnamurthy, Krisztina Szalai, Ferdinand Felix, Anna Lukschal, Dominik Oberthuer, Hugh A Sampson, Ines Swoboda, Christian Betzel, Eva Untersmayr, Erika Jensen-Jarolim","doi":"10.2174/1874838401104010024","DOIUrl":"https://doi.org/10.2174/1874838401104010024","url":null,"abstract":"Previous studies have indicated that specific molecular properties of proteins may determine their allergenicity. Allergen interaction with epithelia as the first contact site could be decisive for a resulting immune response. We investigate here for the major peanut allergen Ara h 2 whether thermal processing results in structural changes which may impact the protein's molecular interactions with enterocytes, subsequent cellular signalling response, and immunogenicity.Ara h 2 was heat processed and analyzed in terms of patient IgE binding, structural alterations, interaction with human enterocytes and associated signalling as well as immunogenicity in a food allergy mouse model.Heating of Ara h 2 led to significantly enhanced binding to Caco-2/TC7 human intestinal epithelial cells. Structural analyses indicated that heating caused persistent structural changes and led to the formation of Ara h 2 oligomers in solution. Heated protein exhibited a significantly higher immunogenic potential in vivo as determined by IgG and IgE serum antibody levels as well as IL-2 and IL-6 release by splenocytes. In human Caco-2/TC7 cells, Ara h 2 incubation led to a response in immune- and stress signalling related pathway components at the RNA level, whereas heated allergen induced a stress-response only.We suggest from this peanut allergen example that food processing may change the molecular immunogenicity and modulate the interaction capacity of food allergens with the intestinal epithelium. Increased binding behaviour to enterocytes and initiation of signalling pathways could trigger the epimmunome and influence the sensitization capacity of food proteins.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"4 ","pages":"24-34"},"PeriodicalIF":0.0,"publicationDate":"2011-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272452/pdf/ukmss-40305.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30446755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Anti-idiotypic Fab Fragments Image a Conserved N-terminal Epitope Patch of Grass Pollen Allergen Phl p 1. 草花粉过敏原php1 n端保守表位片段抗独特型Fab片段图像。

The Open Allergy Journal Pub Date : 2011-05-23 DOI: 10.2174/1874838401104010016

Anna Lukschal, Jan Fuhrmann, Juryj Sobanov, Dirk Neumann, Julia Wallmann, Regina Knittelfelder, Wolfgang Hemmer, Otto Scheiner, Monique Vogel, Beda M Stadler, Erika Jensen-Jarolim, Krisztina Szalai

{"title":"Anti-idiotypic Fab Fragments Image a Conserved N-terminal Epitope Patch of Grass Pollen Allergen Phl p 1.","authors":"Anna Lukschal, Jan Fuhrmann, Juryj Sobanov, Dirk Neumann, Julia Wallmann, Regina Knittelfelder, Wolfgang Hemmer, Otto Scheiner, Monique Vogel, Beda M Stadler, Erika Jensen-Jarolim, Krisztina Szalai","doi":"10.2174/1874838401104010016","DOIUrl":"https://doi.org/10.2174/1874838401104010016","url":null,"abstract":"BACKGROUND AND AIMS: Naturally occurring anti-idiotypic antibodies structurally mimic the original antibody epitope. Anti-idiotypes, therefore, are interesting tools for the portrayal of conformational B-cell epitopes of allergens. In this study we used this strategy particularly for major timothy grass pollen (Phleum pratense) allergen Phl p 1. METHODS AND RESULTS: We used a combinatorial phage display library constructed from the peripheral IgG repertoire of a grass pollen allergic patient which was supposed to contain anti-idiotypic Fab specificities. Using purified anti-Phl p 1 IgG for biopanning, several Fab displaying phage clones could be isolated. 100 amplified colonies were screened for their binding capacity to anti-Phl p 1-specific antibodies, finally resulting in four distinct Fab clones according to sequence analysis. Interestingly, heavy chains of all clones derived from the same germ line sequence and showed high homology in their CDRs. Projecting their sequence information on the surface of the natural allergen Phl p 1 (PDB ID: 1N10) indicated matches on the N-terminal domain of the homo-dimeric allergen, including the bridging region between the two monomers. The resulting epitope patches were formed by spatially distant sections of the primary allergen sequence. CONCLUSION: In this study we report that anti-idiotypic specificities towards anti-Phl p 1 IgG, selected from a Fab library of a grass pollen allergic patient, mimic a conformational epitope patch being distinct from a previously reported IgE epitope area.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"4 ","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2011-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272436/pdf/ukmss-36989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30446893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Asthma in Southern Africa 非洲南部儿童哮喘

The Open Allergy Journal Pub Date : 2011-05-06 DOI: 10.2174/1874838401104010008

R. Green

引用次数: 8

Urticaria as Symptom of Parasite Migration Through the Biological Barriers 荨麻疹是寄生虫通过生物屏障迁移的症状

The Open Allergy Journal Pub Date : 2011-03-01 DOI: 10.2174/1874838401104010001

A. Bakiri, E. Mingomataj

{"title":"Urticaria as Symptom of Parasite Migration Through the Biological Barriers","authors":"A. Bakiri, E. Mingomataj","doi":"10.2174/1874838401104010001","DOIUrl":"https://doi.org/10.2174/1874838401104010001","url":null,"abstract":"The absence of a consistent link between parasitoses and urticarial symptoms in the clinical investigations con- trasts to the fact that some parasites are the most potent inducers of immunoglobulin E that exist in nature. To shed some light into this question, this review is focused on the actual knowledge regarding parasites life cycle, interactions with host immunity, the influence on host behavior, and finally the role of all these factors on the urticaria development. The col- lected data demonstrate that parasites could manipulate the host behavior for its own benefit in different ways, inducing urticarial reactions during penetration into different biological barriers. In this context, urticaria may be associated with certain stages of the parasites' life cycle or with host tissue location, but not necessarily only with their presence in the host organism. As compared to T helper (Th) 1, the Th2 response, the eosinophilic infiltration and the complement inhibi- tion could assure a more pleasant surrounding area for the development of some parasites. Taken together, these concepts could explain the epidemiological discrepancy between low rates of urticaria occurrence, and the usual parasites-induced Th2 response. However, further studies are necessary to provide better-based conclusions.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"8 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73693288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Basophil Activation Antigens: Molecular Mechanisms and Clinical Implications 嗜碱性粒细胞活化抗原:分子机制和临床意义

The Open Allergy Journal Pub Date : 2010-11-26 DOI: 10.2174/1874838401003010052

P. Valent

{"title":"Basophil Activation Antigens: Molecular Mechanisms and Clinical Implications","authors":"P. Valent","doi":"10.2174/1874838401003010052","DOIUrl":"https://doi.org/10.2174/1874838401003010052","url":null,"abstract":"Basophil activation is a key finding in allergic reactions and also observed quite frequently in infectious dis- eases and autoimmune disorders. In allergic reactions, basophil-derived mediators such as histamine, contribute essen- tially to clinical symptoms. During IgE-dependent degranulation of basophils, a number of cell surface membrane and cy- toplasmic molecules become activated, show altered expression, or are translocated into the cell surface. Although little is known so far about the exact role of these activation-linked cell surface antigens, several of them are employed as diag- nostic parameters in allergic disorders. Other molecules are involved in the process of signalling and the consecutive re- lease of pro-allergic mediators, and have therefore been proposed as potential targets of therapy. The current article pro- vides a summary on activation-linked cell surface and cytoplasmic antigens in basophils, with special reference to poten- tial mechanisms underlying re-translocation or over-expression in activated cells, relevant signalling pathways, and clini- cal implications. This study was supported by: Fonds zur Forderung der Wissenschaftlichen Forschung in Osterreich, SFB grant # 018-20.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"124 1","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2010-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81878625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Nonredundant Roles for Basophils in Immediate- and Delayed-onset Allergic Reactions 嗜碱性粒细胞在即发性和迟发性过敏反应中的非冗余作用

The Open Allergy Journal Pub Date : 2010-11-26 DOI: 10.2174/1874838401003010073

H. Karasuyama, K. Mukai, K. Obata, Y. Tsujimura, Y. Kawano, Y. Minegishi

{"title":"Nonredundant Roles for Basophils in Immediate- and Delayed-onset Allergic Reactions","authors":"H. Karasuyama, K. Mukai, K. Obata, Y. Tsujimura, Y. Kawano, Y. Minegishi","doi":"10.2174/1874838401003010073","DOIUrl":"https://doi.org/10.2174/1874838401003010073","url":null,"abstract":"Basophils circulate in the peripheral blood under physiological conditions, and they are recruited to affected tissues in allergic reactions, albeit in small numbers. Because of their rarity (less than 1% of peripheral blood leukocytes are basophils), and their similarity to mast cells, basophils have often been considered the lesser relatives of mast cells. Moreover, because basophils have been so difficult to identify, mice were erroneously believed for a long time to lack them. Therefore, the assumption that basophils have only redundant roles has remained unquestioned until recently. The flow-cytometric identification of basophils in mice and the development of in vivo models and reagents useful for their functional analyses have greatly advanced the field of basophil research. Previously unrecognized roles of basophils, dis- tinct from those of mast cells, have been shown in allergic responses and the regulation of acquired immunity. In this re- view, we mainly focus on roles of basophils in immediate- and delayed-onset allergic reactions. Basophils are crucial ini- tiators, rather than effectors, in the development of IgE-mediated, chronic cutaneous allergic inflammation, which is char- acterized by the massive infiltration of eosinophils and neutrophils and can be elicited even in the absence of mast cells and T cells. Basophils are dispensable for the induction of IgE-mediated systemic anaphylaxis, unlike mast cells, but play a major role in IgG-mediated passive and active systemic anaphylaxis, through the release of platelet-activating factor in response to stimulation with antigen-IgG immune complexes. Thus, basophils and their products appear to be promising therapeutic targets for allergic disorders.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"34 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2010-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89705969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basophil Functions During Type 2 Inflammation: Initiators, Regulators and Effectors 2型炎症中的嗜碱性细胞功能:启动者、调节者和效应者

The Open Allergy Journal Pub Date : 2010-11-26 DOI: 10.2174/1874838401003010046

M. Siracusa, D. Artis

引用次数: 3