The Open Allergy Journal最新文献_第2页

Adrenaline Autoinjector Needle Interlocking in the Thumb Due to Im- proper Injection 肾上腺素自动注射器针因注射不当而锁在拇指内

The Open Allergy Journal Pub Date : 2013-05-17 DOI: 10.2174/1874838420130508001

M. Schmid, I. Weidenhoffer, A. Udvardi, K. Lomoschitz, B. Volc-Platzer, S. Wöhrl

引用次数: 2

Skin Scrape Test: An Inexpensive and Painless Skin Test For Recognition Of Immediate Hypersensitivity In Children And Adults 皮肤刮擦试验:一种廉价和无痛的皮肤试验，用于识别儿童和成人的即时过敏

The Open Allergy Journal Pub Date : 2013-04-19 DOI: 10.2174/1874838401306010009

C. Olivier, Daiana Guedes Pinto Argentão, R. A. P. G. Santos, Mariana Dias da Silva, R. P. S. Lima, R. L. Zollner

{"title":"Skin Scrape Test: An Inexpensive and Painless Skin Test For Recognition Of Immediate Hypersensitivity In Children And Adults","authors":"C. Olivier, Daiana Guedes Pinto Argentão, R. A. P. G. Santos, Mariana Dias da Silva, R. P. S. Lima, R. L. Zollner","doi":"10.2174/1874838401306010009","DOIUrl":"https://doi.org/10.2174/1874838401306010009","url":null,"abstract":"Background: Skin testing is a mainstay in allergology, and its importance is increasing in several fields. The ability to choose the most suitable technique according to the clinical setting is an advantage for the medical team. Objectives: To describe in detail an alternative technique of the coetaneous allergy test (skin scrape test) conceived as a variation of the former skin scratch test; to evaluate its value as a tool for diagnosis of immune sensitization; and to com- pare its accuracy with the skin prick test. Methods: The skin scrape test and skin prick test were performed side by side with the same allergen extracts in 162 hu- man subjects classified in two groups according to the known presence or absence of serum specific-IgE to these aller- gens. Results: The sensitivity of the skin scrape test to detect immediate reactions was 85.0%. The sensitivity of the skin prick test was 86.5%. The sensitivity of both techniques analyzed together as a unique procedure was 94.2%. The specificity of the skin scrape test was 90.1%.The specificity of the skin prick test was 72.9%.The specificity of both tests analyzed to- gether as a unique procedure was 70.5%. Conclusions: The skin scrape test is an alternative and complementary technique for allergic skin testing, and it is able to detect IgE-specific immune sensitization without the disadvantages of the skin scratch test. The skin scrape test has simi- lar outcomes to the skin prick test.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"146 4 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2013-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83088850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Life's Limitations of Uncontrolled Asthma in a Developing Country: Results of an Albanian Survey 发展中国家未控制哮喘的生命限制:阿尔巴尼亚调查的结果

The Open Allergy Journal Pub Date : 2013-03-18 DOI: 10.2174/1874838401306010001

F. Xhixha, E. Gjata, Mirela Hitaj, A. Bakiri, E. Hyso, Alkerta Ibranji, Kastriot Shytaj, A. Ndreu, B. Resuli, E. Mingomataj

{"title":"The Life's Limitations of Uncontrolled Asthma in a Developing Country: Results of an Albanian Survey","authors":"F. Xhixha, E. Gjata, Mirela Hitaj, A. Bakiri, E. Hyso, Alkerta Ibranji, Kastriot Shytaj, A. Ndreu, B. Resuli, E. Mingomataj","doi":"10.2174/1874838401306010001","DOIUrl":"https://doi.org/10.2174/1874838401306010001","url":null,"abstract":"Introduction: Studies conducted across Western Europe reported that bronchial asthma (BA) has an important impact on patients' lives quality. We present Albanian asthmatic patients' views based on the questionnaire generated from the European Federation of Allergy and Airways Diseases Patients Associations (EFA). Materials and methodology: In this study participated 145 Caucasian patients consecutively and prospectively diagnosed with BA. Results: The vast majority of patients reported lifestyle' limitations because of uncontrolled BA, three-fourth of them re- ported restriction of physical activity, and 20% felt their professional perspectives were limited. Additionally, up to 80% of the subjects were not optimistic about achieving the guideline goals but they were optimistic regarding the availability of more qualitative medicines and improvement of healthcare level over the next years. Our patients indicated that optimal treatments should be fast-acting and long-lasting, should be working immediately and should stop the symptoms com- pletely. Conclusions: These results demonstrate the high impact of uncontrolled asthma, despite its severity, on .patients' lives in a developing country.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"29 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2013-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90175980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaphylaxis After Ingesting Ibuprofen Liquid Gelatin-Capsule 服用布洛芬液体明胶胶囊后的过敏反应

The Open Allergy Journal Pub Date : 2012-12-28 DOI: 10.2174/1874838401205010065

F. Al-Ghimlas, Nasser Al-Ahmed, S. Mace

引用次数: 0

The Danish Atopy Database (DAD): Rationale and Methods 丹麦特异性数据库(DAD):基本原理和方法

The Open Allergy Journal Pub Date : 2012-10-19 DOI: 10.2174/1874838401205010062

S. Thomsen, J. M. Jungersted, Maja-Lisa Clausen, T. Agner

引用次数: 1

Suppression of PAMPs, Pathogen-Associated Microbial Patterns, Induced Cytokine Synthesis of PBMC, Human Blood Mononuclear Cells, by Immunoglobulin Preparation 免疫球蛋白制剂抑制PAMPs，病原体相关微生物模式，诱导PBMC，人血单核细胞的细胞因子合成

The Open Allergy Journal Pub Date : 2012-08-24 DOI: 10.2174/1874838401205010053

A. Yamamoto, N. Miura, T. Oharaseki, Kei Takahashi, S. Naoe, Kazuo Suzuki, N. Ohno

{"title":"Suppression of PAMPs, Pathogen-Associated Microbial Patterns, Induced Cytokine Synthesis of PBMC, Human Blood Mononuclear Cells, by Immunoglobulin Preparation","authors":"A. Yamamoto, N. Miura, T. Oharaseki, Kei Takahashi, S. Naoe, Kazuo Suzuki, N. Ohno","doi":"10.2174/1874838401205010053","DOIUrl":"https://doi.org/10.2174/1874838401205010053","url":null,"abstract":"The applications of immunoglobulin preparation for intravenous injection (IVIg) for various intractable dis- eases are increasing. The two major clinical indications for IVIg are the replacement therapy and the anti-inflammation therapy for a variety of acute and chronic autoimmune diseases. One of the proposed mechanisms of IVIg activity is the modulation of cytokine expression and function; therefore, we analyzed the effect of IVIg on pathogen-associated mo- lecular pattern (PAMP)-induced cytokine production by peripheral blood mononuclear cells (PBMCs). The production of tumor necrosis factor-￻ (TNF-￻ ) as a result of stimulation with lipopolysaccharide (LPS), polyinosinic-polycytidylic acid sodium salt (Poly I:C), or Pam3CysSerLys4 (Pam3) was significantly inhibited by sulfonated-IVIg (S-IVIg), or by F(ab')2. Assessed by one-color microarray analysis, the expressions of 229 genes were inhibited to 1/200 or less by F(ab')2. On the other hand, the expressions of 159 genes were increased by more than 100-fold by F(ab')2. According to these results, it was suggested that IVIg inhibits inflammatory PAMPs-induced cytokine production by PBMCs, due to the modulation of varieties of gene expression.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"2 1","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2012-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78509393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Mechanisms of Allergen-Specific Immunotherapy 过敏原特异性免疫治疗的免疫机制

The Open Allergy Journal Pub Date : 2012-08-23 DOI: 10.2174/1874838401205010047

M. Yacoub, C. Incorvaia, M. Caminati, G. Colombo

{"title":"Immune Mechanisms of Allergen-Specific Immunotherapy","authors":"M. Yacoub, C. Incorvaia, M. Caminati, G. Colombo","doi":"10.2174/1874838401205010047","DOIUrl":"https://doi.org/10.2174/1874838401205010047","url":null,"abstract":"Allergen immunotherapy (AIT) has the exclusive ability to modify the natural history of allergy and to maintain its clinical efficacy also after stopping the treatment. This occurs because of the AIT mechanism of action, mainly consist- ing in a specific induction of tolerance to the causative allergen. Such tolerance takes place as a result of a complex inter- action of innate and adaptive immunity processes, that involve inflammatory cells, cytokines and chemokines. The first response to allergens is provided by the antigen-presenting cells, and particularly by dendritic cells (Dcs) that, following activation, acquire chemokine receptors (CCRs), useful for migration to lymphoid organs, where adaptive immune re- sponse is induced. DCs act by presenting the antigen(s) to effectors T cells (T helper CD4 + and T suppressor CD8 +) de- rived from naive T cells. The development of different cell subtypes from naive T cells (Th0) may follow various path- ways and depends on both individual genetic background (atopic/non atopic) and environmental factors. The T cell re- sponse in atopic subjects is influenced by the Th2 polarization promoting the production of cytokines such as IL-4 and IL- 5. On the contrary, the expression of CD80 may determine a Th1 cytokines production, and ICOS-L supports the T- regulatory cells activation that significantly reduce allergic inflammation. The suppressive effect of Treg is due to the ex- pression of high level of the transcription factor Foxp3 on their surface, to the production of IL-10 and TGF-s and to the expression of membrane molecules as CTL-4 PD-1 and BTLA. Recent advances highlighted a role also for Th9 and Th17 lymphocytes. Such immunologic modification leads to the long noted events in studies on mechanisms of action, such as the decrease of specific IgE and the increase of specific IgG1 and IgG4, and ultimately on the inhibition of inflammatory cells such as mast cells, basophils and eosinophils and on the control of clinical symptoms.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"59 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2012-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74281804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Editorial - Histamine-Releasing Factor and TCTP 编辑-组胺释放因子与ttp

The Open Allergy Journal Pub Date : 2012-05-18 DOI: 10.2174/1874838401205010011

T. Kawakami

引用次数: 0

Histamine releasing factor/translationally controlled tumor protein: History, functions and clinical implications 组胺释放因子/翻译控制肿瘤蛋白:历史、功能和临床意义

The Open Allergy Journal Pub Date : 2012-05-18 DOI: 10.2174/1874838401205010012

S. Macdonald

引用次数: 2

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP 翻译控制肿瘤蛋白TCTP的细胞功能和调控

The Open Allergy Journal Pub Date : 2012-05-18 DOI: 10.2174/1874838401205010019

U. Bommer

{"title":"Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP","authors":"U. Bommer","doi":"10.2174/1874838401205010019","DOIUrl":"https://doi.org/10.2174/1874838401205010019","url":null,"abstract":"The 'translationally controlled tumour protein' TCTP was originally discovered 30 years ago by researchers in- terested in proteins regulated at the translational level. Cloning and sequencing confirmed the conservation of this protein among all eukaryotic kingdoms, but did not reveal any functional clue, and TCTP was listed in the databases as a 'family' of its own. The functional characterisation of this protein extended over more than a decade, leading to a plethora of indi- vidual functions and interactions that have been ascribed to this protein. A major addition to the functional characterisa- tion of TCTP was the identification in 1995 of its histamine releasing factor (HRF) activity in allergic conditions, which for the first time described an extracellular activity for TCTP in human disease. This triggered a host of additional publi- cations aimed at characterising this HRF activity, which are discussed in other articles of this issue. Another milestone in the elucidation of TCTP's function was the demonstration of its anti-apoptotic activity in 2001. Evidence is also accumu- lating for a role of TCTP in the cell cycle and in early development. This article provides an overview of the main cellular activities of TCTP. The second part will summarise our current knowledge on the mechanisms involved in regulating in- tracellular TCTP levels.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"13 1","pages":"19-32"},"PeriodicalIF":0.0,"publicationDate":"2012-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77700754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41