The Open Allergy Journal最新文献_第6页

Comparison of Two Analytical Methods for Detecting (1-3)-β-D-Glucan in Pure Fungal Cultures and in Home Dust Samples 纯真菌培养物与家庭粉尘样品中(1-3)-β- d -葡聚糖两种检测方法的比较

The Open Allergy Journal Pub Date : 2008-07-09 DOI: 10.2174/1874838400801010026

Y. Iossifova, T. Reponen, M. Daines, L. Levin, G. Hershey

引用次数: 22

Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life § 季节性变应性鼻炎对驾驶能力、记忆功能、持续注意力和生活质量的影响

The Open Allergy Journal Pub Date : 2008-07-09 DOI: 10.2174/1874838400801010019

M. Mets, E. Volkerts, E. Dunnebier, L. D. S. Domis, B. Olivier, J. Verster

{"title":"Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life §","authors":"M. Mets, E. Volkerts, E. Dunnebier, L. D. S. Domis, B. Olivier, J. Verster","doi":"10.2174/1874838400801010019","DOIUrl":"https://doi.org/10.2174/1874838400801010019","url":null,"abstract":"Background: Seasonal allergic rhinitis (SAR) has shown to affect quality of life and impair cognitive function- ing. Objective: The objective of this study was to compare driving ability, memory, and psychomotor performance during grass pollen season with winter season in untreated patients with SAR. Methods: Patients with SAR were trained and tested during the grass pollen season (summer) and winter. An on-the-road driving test during normal traffic conditions was performed. Primary parameter is the Standard Deviation of Lateral Posi- tion (SDLP), i.e. the weaving of the car. In addition, a word learning test and continuous performance test were performed and quality of life was assessed. Patients were included if in winter the Total 5-Symptoms Score (T5SS) was 3. Results: 70 patients were recruited of which 22 started the study. Fifteen patients completed the study of which 11 met the inclusion criteria. These 11 patients had a mean T5SS of 6.8 in summer and 0.6 in winter. Patient reported a significantly reduced overall quality of life during grass pollen season (p<0.0001). No significant effects were found on the driving test, except a significant (but not relevant) decrease in mean speed during the grass pollen season (p<0.035). No significant ef- fects were found on the word learning test and continuous performance test. Conclusion: Our data suggest that moderate SAR symptoms do not impair driving ability, memory functioning and con- tinuous performance. However, given the small sample size future studies should confirm these findings.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"15 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2008-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87061228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease 哮喘儿童的食物过敏:患病率及其与呼吸道疾病临床严重程度的相关性

The Open Allergy Journal Pub Date : 2008-06-17 DOI: 10.2174/1874838400801010005

E. Calamelli, G. Ricci, V. Dell'Omo, B. Bendandi, M. Masi

引用次数: 6

A review of the efficacy and safety of Nasaleze TM in the prevention and management of allergic rhinitis Nasaleze TM预防和治疗变应性鼻炎的疗效和安全性综述

The Open Allergy Journal Pub Date : 2008-05-20 DOI: 10.2174/1874838400801010001

P. Bouic

引用次数: 8

Maintenance of Airway Hyperresponsiveness in Chronic Asthma May Be Mediated by Th2-Independent Mechanisms 慢性哮喘患者气道高反应性的维持可能由不依赖th2的机制介导

The Open Allergy Journal Pub Date : 2004-02-01 DOI: 10.2174/1874838400801010012

N. Lin, Jane M. Schuh, C. Hogaboam

{"title":"Maintenance of Airway Hyperresponsiveness in Chronic Asthma May Be Mediated by Th2-Independent Mechanisms","authors":"N. Lin, Jane M. Schuh, C. Hogaboam","doi":"10.2174/1874838400801010012","DOIUrl":"https://doi.org/10.2174/1874838400801010012","url":null,"abstract":"Abstract Rationale CD4+, Th2-mediated inflammation is an important component of airway hyperresponsiveness (AHR) in allergic airway disease. IL-4 and IL-13, the prototypic Th2 cytokines, mediate their effects through a common receptor complex made up of IL-4Rα and IL-13Rα1. In this study, we examined the effects of impaired Th2 signaling on AHR using IL-4Rα −/− mice in a murine model of allergic asthma. Methods IL-4Rα −/− mice and control BALB/c (IL-4Rα +/+ ) mice were sensitized to and challenged with Aspergillus fumigatus . Airway disease was assessed at days 14, 28, 51, and 57 after intratracheal conidia challenge. AHR was evaluated by plethysmography after intravenous methacholine. Whole lung levels of cytokines, chemokines, and immunoglobulins were measured by specific ELISA. Paraffin-embedded lung sections were stained for histology. Bronchoalveolar lavage (BAL) fluid was cytospun for differential cell counts. Results While AHR was significantly reduced in IL-4Rα −/− mice (p Conclusions These results demonstrate that airway hyperresponsiveness and mucus production in allergic asthma can be maintained in the absence of a predominant Th2 signaling pathway, suggesting that Th2-independent mechanisms may arbitrate chronic stages of the disease.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"28 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2004-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76417506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0