The primary care companion for CNS disorders最新文献

{"title":"Prevalence of Anxiety, Depressive Symptoms, and Substance Use in Schizophrenia.","authors":"Prabhas Pandey, Ajeet Sidana, Prinka Arora","doi":"10.4088/PCC.26m04210","DOIUrl":"10.4088/PCC.26m04210","url":null,"abstract":"<p><p><b>Background:</b> Schizophrenia is a chronic and debilitating psychiatric disorder often accompanied by comorbid conditions, notably anxiety, depressive symptoms, and substance use disorders. These comorbidities further complicate the clinical profile, reduce treatment compliance, and worsen prognosis, particularly in first-episode schizophrenia, which is less discussed in the Indian context. While extensive research exists globally, data from the Indian context, particularly on early-phase schizophrenia, remain sparse.</p><p><p><b>Methods:</b>This cross-sectional observational study was conducted over 18 months (November 2023 to May 2025) in the department of psychiatry of a tertiary care teaching hospital in Northern India. The study included 170 patients aged 18-60 years, diagnosed with schizophrenia of less than 5 years duration per <i>International Classification of Diseases, Eleventh Revision</i> criteria. Assessment tools included the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), and World Health Organization Alcohol, Smoking and Substance Involvement Screening Test Version 3.0 for substance use evaluation.</p><p><p><b>Results:</b> Results revealed that 32.9% of patients had moderate to severe anxiety symptoms (HAM-A score ≥ 25), and 16.5% had moderate to severe depressive symptoms (HAM-D score ≥ 20). Substance use was common, particularly tobacco (31.2%), alcohol (12.9%), cannabis (11.8%), and opioids (5.3%); however, substance use did not correlate highly with the severity of schizophrenia as measured by the PANSS. Significant positive correlations emerged between anxiety (HAM-A) and PANSS total, negative, and general psychopathology scores, while depressive symptoms (HAM-D) correlated moderately with all PANSS components (ρ=0.242-0.439, <i>P</i><.001). However, substance use showed no significant correlation with schizophrenia severity.</p><p><p><b>Conclusion:</b> These findings highlight the critical need for early screening and comprehensive management for anxiety and depressive symptoms in schizophrenia, as their presence significantly correlates with illness severity and may influence long-term functional outcomes.</p><p><p><b>Trial Registration:</b> Clinical Trials Registration-India identifier: CTRI/2023/11/059495.</p><p><p><i>Prim Care Companion CNS Disord</i> <i>2026;28(4):26m04210</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peduncular Hallucinosis With Right Thalamic Cavernous Angioma.","authors":"Mizuki Kudo, Yuko Daa, Hirofumi Hirakawa","doi":"10.4088/PCC.26cr04179","DOIUrl":"https://doi.org/10.4088/PCC.26cr04179","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-Resistant Schizophrenia in a Patient With Unilateral Renal Agenesis and Dysmorphic Facial Features: A Case Report.","authors":"Anirudh Bakam, Rajdeep Birdi, Kanika Dhiman, Sai Spoorthy Mamidipalli","doi":"10.4088/PCC.26cr04230","DOIUrl":"https://doi.org/10.4088/PCC.26cr04230","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion.","authors":"Juan Miguel Riestra, Zoya Munsar, Douglas J Opler","doi":"10.4088/PCC.26cr04209","DOIUrl":"https://doi.org/10.4088/PCC.26cr04209","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homelessness and Housing Insecurity: Challenges and Opportunities to Improve Care.","authors":"Sofia E Matta, Luis Velez Figueroa, Margarita Bobonis-Babilonia, Andrea C DeSimone, Lynne D Boone, Katherine A Koh, Theodore A Stern","doi":"10.4088/PCC.26f04188","DOIUrl":"https://doi.org/10.4088/PCC.26f04188","url":null,"abstract":"<p><p>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.</p><p><p><i>Prim Care Companion CNS Disord</i> <i>2026;28(4):26f04188</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulatory and Wearable Technologies for Central Nervous System Disorders: Clinical Applications and Contraindications.","authors":"James K Rustad, Amit Chopra, Joseph L Bonvie, Mara Joy, Kaitlin M Picard, Sofia E Matta, Anne Felde, Theodore A Stern","doi":"10.4088/PCC.26f04189","DOIUrl":"https://doi.org/10.4088/PCC.26f04189","url":null,"abstract":"<p><p>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.</p><p><p><i>Prim Care Companion CNS Disord</i> <i>2026;28(4):26f04189</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining Clozapine and Xanomeline/Trospium Chloride: Mechanisms of Action and the Genesis of Catatonia.","authors":"Rika Matsuo, Matthew R Caldwell, Warren Cheng, Patrick A Ho, James K Rustad, Theodore A Stern","doi":"10.4088/PCC.26f04194","DOIUrl":"https://doi.org/10.4088/PCC.26f04194","url":null,"abstract":"<p><p>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.</p><p><p><i>Prim Care Companion CNS Disord</i> <i>2026;28(4):26f04194</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silence as Defiance: A Case of Volitional Mutism in Adulthood.","authors":"Garrett Hill, Gregory Noe, Sahil Munjal","doi":"10.4088/PCC.26cr04195","DOIUrl":"https://doi.org/10.4088/PCC.26cr04195","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exacerbation of Psychotic Symptoms Associated With Mushroom-Based Supplementation in a Patient With Cerebral Palsy.","authors":"Kirat Kaur, Shobit Garg","doi":"10.4088/PCC.26cr04200","DOIUrl":"https://doi.org/10.4088/PCC.26cr04200","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Spirituality and Religious Practices on Health and Mental Health.","authors":"Sofia E Matta, Seth Mattson, Michalla B Braford, John R Peteet, Danny A Schieffler, Theodore A Stern","doi":"10.4088/PCC.26f04213","DOIUrl":"https://doi.org/10.4088/PCC.26f04213","url":null,"abstract":"<p><p>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.</p><p><p><i>Prim Care Companion CNS Disord</i> <i>2026;28(4):26f04213</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p><p><p></p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}