The primary care companion for CNS disorders最新文献

{"title":"Efficacy of GLP-1 Agonists in Psychiatric Illnesses: A Scoping Review.","authors":"Mohsan Ali, Ayesha Ahmed, Basim Ahmed Khan, Syeda Taleha Shah, Sadiq Naveed, Nauman Ashraf","doi":"10.4088/PCC.24nr03828","DOIUrl":"10.4088/PCC.24nr03828","url":null,"abstract":"<p><p><b>Importance:</b> GLP-1 receptor agonists (GLP-1 RAs) are widely recognized for their antidiabetic properties, primarily due to their insulin secretagogue action. However, their potential therapeutic effects extend beyond the endocrine system, suggesting a promising role in the treatment of psychiatric disorders. Despite this potential, there is limited consolidation of evidence regarding their psychiatric applications. This scoping review aims to address this gap by exploring the effects of GLP-1 RAs across various psychiatric conditions, highlighting their therapeutic promise and the need for further investigation.</p><p><p><b>Observations:</b> A comprehensive literature search was conducted using PubMed, Web of Science, Scopus, ClinicalTrials.gov, and PsycNet to identify studies examining the effects of GLP-1 RAs on psychiatric disorders. Original articles were included in the analysis. The findings suggest that GLP-1 RAs show efficacy in several areas, including autism-related disorders and depression. Conversely, GLP-1 RAs demonstrated no significant benefits in improving neurocognition or psychosocial functioning in schizophrenia, cocaine addiction, or dementia. Limited evidence also points to their effects on anxiety and cognitive functioning in dementia, but these findings were inconclusive.</p><p><p><b>Conclusions and Relevance:</b> The current evidence underscores the potential of GLP-1 RAs as a novel therapeutic approach for certain psychiatric disorders, particularly alcohol-related disorders, depression, and autism-related food behaviors. However, their utility in other conditions, such as schizophrenia, cocaine addiction, and dementia, remains unsupported by robust evidence. The findings highlight the importance of conducting well-designed, long-term studies to elucidate the mechanisms and clinical applications of GLP-1 RAs in psychiatry. With further research, GLP-1 RAs could expand the therapeutic arsenal for psychiatric care, offering new hope for conditions with limited treatment options.</p><p><p><i>Prim Care Companion CNS Disord 2025;27(3):24nr03828</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excited Catatonia in the Setting of Concurrent Opioid and Benzodiazepine Withdrawal.","authors":"Joe G Levey, VaKara M Meyer Karre, Alëna A Balasanova","doi":"10.4088/PCC.25cr03927","DOIUrl":"https://doi.org/10.4088/PCC.25cr03927","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Blocker and Colchicine Coingestion in the Setting of Cocaine Intoxication.","authors":"Olivia Levine, Souparno Mitra","doi":"10.4088/PCC.25cr03920","DOIUrl":"https://doi.org/10.4088/PCC.25cr03920","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Approaches to Pain Management: Analgesics, Adjuvants, and Nonpharmacologic Interventions.","authors":"Sofia E Matta, Olga Terechin, Joseph L Bonvie, Kaitlin M Picard, Gregory Acampora, Theodore A Stern","doi":"10.4088/PCC.24f03885","DOIUrl":"https://doi.org/10.4088/PCC.24f03885","url":null,"abstract":"<p><p>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss the diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.</p><p><p><i>Prim Care Companion CNS Disord 2025;27(3):24f03885</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Adverse Effects From Hydroxychloroquine Use: A Systematic Review.","authors":"Madhuri Jakkam Setty, Ramananda Kishore Kavi, Parveen Sulthana, Nishant Prabhakaran","doi":"10.4088/PCC.24r03857","DOIUrl":"https://doi.org/10.4088/PCC.24r03857","url":null,"abstract":"<p><p><b>Objective:</b> To conduct a systematic review of the available evidence on hydroxychloroquine (HCQ)-induced psychiatric side effects and their management.</p><p><p><b>Data sources:</b> A literature search was conducted in PubMed, MEDLINE, PsycINFO, and Cochrane collaboration databases from 2000 to 2024 using the keywords \"hydroxychloroquine\" AND \"psychiatry\" OR \"psychosis\" OR \"depression\" OR \"anxiety\" OR \"bipolar disorder\" OR \"delirium\" OR \"psychotic disorders\" OR \"psychiatric side effects\" OR \"psychiatric disorders.\"</p><p><p><b>Study selection:</b> English-language articles with studies reporting HCQ-induced psychiatric/neuropsychiatric side effects were included. Duplicate records and studies reporting only chloroquine side effects were excluded.</p><p><p><b>Results:</b> The review included 16 case reports, 8 original articles, and 3 review articles. HCQ was found to trigger symptoms of psychosis, depression, suicidal ideation, mania/hypomania, anxiety, sleep disturbances, and cognitive impairments. The onset of these psychiatric side effects varied, appearing shortly after starting the medication to a more extended period.</p><p><p><b>Conclusion:</b> Based on the literature, HCQ may be associated with short-term psychiatric adverse effects. A psychiatric consultation for a thorough clinical and risk factor evaluation to differentiate a primary psychiatric disorder from a drug induced adverse effect would help guide the management. Dosage adjustments, discontinuing HCQ if feasible, and psychotropic medications like olanzapine or risperidone may be necessary when psychiatric side effects are secondary to HCQ. Further studies are needed to validate these findings.</p><p><p><i>Prim Care Companion CNS Disord 2025;27(3):24r03857</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Reversible Encephalopathy Syndrome Presenting With Obstructive Hydrocephalus: A Rare Presentation.","authors":"Oreoluwa Morakinyo, Shireen M Jacob, Syed Zain B Waqar, Muhammad U Hafeez","doi":"10.4088/PCC.24cr03907","DOIUrl":"https://doi.org/10.4088/PCC.24cr03907","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Antibiotic-Related Psychotic Episodes in Adolescents.","authors":"Katelyn D Li, Karina Irani, Kaushal Shah, Sahil Munjal","doi":"10.4088/PCC.24cr03854","DOIUrl":"https://doi.org/10.4088/PCC.24cr03854","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Psychotic Illnesses in Primary Care Settings.","authors":"Matthew G Gunther, Cristine Oh, Chanel Zhan, Shixie Jiang, Theodore A Stern","doi":"10.4088/PCC.24f03872","DOIUrl":"https://doi.org/10.4088/PCC.24f03872","url":null,"abstract":"<p><p>The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.</p><p><p><i>Prim Care Companion CNS Disord 2025;27(3):24f03872</i>.</p><p><p>\u0000 <i>Author affiliations are listed at the end of this article.</i>\u0000 </p>","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Prolonged Delirium After Electroconvulsive Therapy.","authors":"Garrett W Hill, Nathan R Luzum, Kaushal Shah, Sahil Munjal","doi":"10.4088/PCC.24cr03888","DOIUrl":"https://doi.org/10.4088/PCC.24cr03888","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Munchausen or Is It Dementia?","authors":"Ana Monteiro Fernandes, Sofia Ferreira Albuquerque, Rita André, Filipe Félix Almeida","doi":"10.4088/PCC.24cr03901","DOIUrl":"https://doi.org/10.4088/PCC.24cr03901","url":null,"abstract":"","PeriodicalId":22814,"journal":{"name":"The primary care companion for CNS disorders","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}