Rapid Communications in Mass Spectrometry最新文献

{"title":"Professor Jean-Francois Muller (1940-2024) Mass Spectrometry and Laser Desorption/Ionisation.","authors":"Lionel Vernex-Loset, Gabriel Krier","doi":"10.1002/rcm.10001","DOIUrl":"https://doi.org/10.1002/rcm.10001","url":null,"abstract":"<p><p>Born in 1940, Jean-Francois Muller was one of the leading figures in mass spectrometry in France. In the 1980s, he understood the value of laser microprobes coupled to mass spectrometry for the study of organic and inorganic compounds. He became one of the pioneers of laser desorption/ionisation, highlighting the value of resonant ionisation coupled to mass spectrometry. Professor at the University of Metz, he created the Mass Spectrometry and Laser Chemistry Laboratory in 1983. Attentive to technological developments, he joined forces with Nicolet company in the mid-1980s to develop the first multi-wavelength Fourier transform ion cyclotron resonance MS laser microprobe in 1988. He had a pioneer contribution in the development of high magnetic field mass spectrometry, which led him to work with major industrial groups. As a keen teacher and researcher, he supervised around fifty doctoral theses and is the author and co-author of almost two hundred publications. Professor emeritus in 2006, a man of great scientific culture and a member of the Lorraine Academy of Sciences, Jean-François Muller gave his last lecture on elementary particles on 14 December 2023 at Metz city hall, his adopted city. This article is a tribute to his career and traces his significant contribution and his great impact on the scientific community at the local, national and international levels.</p>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":" ","pages":"e10001"},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing Assumptions for Stable Isotope Analysis of Marine Mammal Dentin Growth Layer Groups","authors":"Kelly R. Bowen,&nbsp;Carolyn M. Kurle","doi":"10.1002/rcm.9997","DOIUrl":"https://doi.org/10.1002/rcm.9997","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>Stable isotope analysis of growth layer groups (GLGs) in mammal dentin is an increasingly prevalent and noninvasive approach to study animal foraging ecology. However, empirical evidence to support assumed proper methodologies for sampling GLGs is lacking. Here, we examine the effects of intratooth and intertooth variations with respect to targeted GLGs, as well as the effects of common pretreatments (e.g., formic acid and graphite) to enhance GLG visibility, on stable isotope values (<i>δ</i>¹³C and <i>δ</i>¹⁵N) from dentin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We measured the <i>δ</i>¹³C and <i>δ</i>¹⁵N values of killer whale (<i>Orcinus orca</i>) dentin. We used dentin from 37 teeth to compare stable carbon (<i>δ</i>¹³C) and nitrogen (<i>δ</i>¹⁵N) isotope values from multiple locations within a GLG (intratooth variation), from corresponding GLGs among teeth of an individual (intertooth variation), and from treated and untreated teeth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We observed no significant differences in the <i>δ</i>¹³C or <i>δ</i>¹⁵N values when sampling a single GLG from multiple locations (intratooth variation) or when comparing the same GLG across duplicate teeth of individuals (intertooth variation). One tooth in a triplicate set showed a significantly different but likely biologically inconsequential <i>δ</i>¹³C value. Lastly, formic acid and graphite highlighting to accentuate GLGs did not significantly influence measured stable isotope values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We validate several previous assumptions in this field of study. First, dentin samples for stable isotope analysis can be sampled from different locations across a GLG. Second, researchers can compare stable isotope values from the same GLGs of different teeth collected from the same individual in most cases, as the <i>δ</i>¹³C and <i>δ</i>¹⁵N values did not vary with the sampled tooth. Third, a common protocol of formic acid and graphite treatment to enhance GLG visibility does not bias the <i>δ</i>¹³C and <i>δ</i>¹⁵N values from dentin. We also describe factors to consider and cautions associated with these conclusions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rcm.9997","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Impurity Profiling of Synthetic Pathways of Organophosphorus Chlorpyrifos Through LC-HRMS Metabolomics-Based Approaches.","authors":"C Orlandi, G Delaporte, C Albaret, E Joubert, A Bossée, L Debrauwer, E L Jamin","doi":"10.1002/rcm.9996","DOIUrl":"https://doi.org/10.1002/rcm.9996","url":null,"abstract":"<p><p>Sourcing in chemical forensic science refers to the attribution of a sample to a specific source using a characteristic signature. It relies on the identification of chemical attribution signatures (CAS), including chemical markers such as residual synthetic precursors, impurities, reaction by-products and degradation products, or even metabolites. Undertaking CAS for chemical threat agents (CTA) can be used to provide an evidentiary link between the use of a given chemical and its precursor(s) to support forensic investigations. Organophosphorus compounds, a class of nerve agents, can be produced by different, more or less complex synthesis routes that can lead to specific CAS. Chlorpyrifos (CPF), an organophosphorus pesticide, was selected as model compound. To assess the specificity of impurity markers originated from a chemical synthesis, untargeted fingerprints of crude CPF from different synthesis pathways were analyzed as a first use-case using metabolomics-based trace discovery strategies. Seven different CPF synthesis routes were considered, and their crude mixtures were analyzed with a minimal sample preparation. Analyses were performed on a trapped ion mobility spectrometry (TIMS) coupled to liquid chromatography (LC) and high-resolution mass spectrometry (HRMS). Chemometrics analyses were conducted with multivariate methods to extract discriminating features (i.e., relevant impurities), annotate, and identify them. Then, unknown samples were analyzed in blind conditions without any information of the synthesis pathway employed. The aim is to validate the methodology seeking some discriminating impurities identified in the first section to attribute and classify them according to the synthesis route.</p>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":" ","pages":"e9996"},"PeriodicalIF":1.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Profile of Oxylipins in Myocardial Infarction by Liquid Chromatography–Tandem Mass Spectrometry","authors":"Xin Tan,&nbsp;Hui Ni,&nbsp;Qin Li,&nbsp;Zhanglin Ma","doi":"10.1002/rcm.9999","DOIUrl":"10.1002/rcm.9999","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>Oxylipins play an important role in inflammatory processes, accompanying the occurrence of myocardial infarction. Analyzing a wide panel of oxylipins derived from more polyunsaturated fatty acids may provide valuable information to elucidate the relationships between the signaling mediator profile and myocardial infarction comprehensively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method for simultaneously measuring 74 oxylipins in 50-μL human samples with a 10-min chromatographic run and easy operation has been developed and validated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Accuracy and precision were below 15% of the relative errors in 99% of quality control. Recoveries and matrix effect were considered acceptable. Potential effects of different collecting tubes were also assessed. We successfully utilized our approach to measure plasma samples obtained from 99 healthy individuals and 302 myocardial infarction patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Profiles of oxylipins discovered potential biomarkers and clarified the pathological characteristics of oxylipin metabolism in myocardial infarction. Our approach was rapid, accurate, and precise, with high throughput, low sample volume, and easy operation, suitable for large-scale studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fentanyl and Fentanyl Analog Screening Using ASAP-MS With LiveID Confirmation","authors":"Karen A. Reyes Monroy,&nbsp;Rachel Koerber,&nbsp;Guido F. Verbeck","doi":"10.1002/rcm.9994","DOIUrl":"10.1002/rcm.9994","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>Fentanyl and fentanyl analogs continue to pose a serious threat to the public health. The vast number of fentanyl analogs emerging on the black-market call for optimized analytical methods for the detection, analysis, and characterization of these extremely dangerous drugs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Atmospheric pressure solids analysis probe (ASAP) mass spectrometry was used for the rapid analysis of 250 synthetic opioid standards, including 211 fentanyl analogs, 32 non-fentanyl related opioids, and 8 fentanyl precursors. Four cone voltages (5, 15, 35 and 50 V) were used to obtain fingerprint data for each opioid reference sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The generated and processed mass spectra of the 250 synthetic opioids analyzed was utilized to create an ASAP⁺ database that contains the largest compendium of mass spectra for fentanyl analogs. The built library was integrated into LiveID software, enabling real-time analyte identification. The efficacy of the software's ability to identify fentanyl analogs in a sample utilizing the spectral library was tested by analyzing five blind and four reaction mixtures. The correct identity of these nine samples was all within the top three ranked matches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We demonstrate how the RADIAN ASAP, alongside a real-time sample recognition software, can be utilized as a presumptive tool for the screening of fentanyl analogs within samples in question, making it a promising alternative to some of the most commonly used analytical screening techniques.</p>\u0000 </section>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of 115 Pesticide Residues in Textiles by Liquid Chromatography–Tandem Mass Spectrometry","authors":"Ying Li,&nbsp;Xiwen Ye,&nbsp;Xin Luo,&nbsp;Wenxuan Zhu,&nbsp;Zhixu Tang,&nbsp;Zengyuan Niu","doi":"10.1002/rcm.9992","DOIUrl":"10.1002/rcm.9992","url":null,"abstract":"<div>\u0000 \u0000 <p>The presence of pesticide residues in textiles poses a risk to human health. We established a robust and high-throughput liquid chromatography–tandem mass spectrometry method for the determination of 115 pesticide residues in textiles. In this study, we evaluated high-performance liquid chromatography–tandem mass spectrometry conditions and sample extraction methods, including separation performance of different columns, mass conditions, extraction solvent, and extraction time. Finally, we established the method as follows: After ultrasonic extraction with methanol, we blew the sample with nitrogen to dry and then took it to a fixed volume by a specific solvent. We used a C18 reversed-phase chromatographic column and detected the samples in the multiple reaction monitoring mass mode. And we verify the limit of detection (LOD), limit of quantitation (LOQ), linearity, recovery, and precision. The LOD and LOQ of the method was 10 and 20 μg/kg separately; the recoveries ranged from 71.3% to 118.4%; and the relative standard deviation was 0.2%–19.9%. We verified the applicability of the developed protocol through the analysis of 21 real textile products.</p>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Breaking Bad to Breaking Bonds-Mass Spectrometry in the Classroom.","authors":"Russell J Mortishire-Smith, Benjamin J Mortishire-Smith, John S Smith","doi":"10.1002/rcm.9970","DOIUrl":"https://doi.org/10.1002/rcm.9970","url":null,"abstract":"<p><p>We describe a workshop that prompts chemistry students in the final 2 years of secondary school to apply their understanding of modern analytical chemistry techniques to a 'real world' example. The scenario used is that of a forensic science laboratory that has been asked to determine the structure of an illicit compound, Revisomed (methamphetamine) being sold as a revision aid, and seized by police. Over the course of an hour, the students use a combination of infrared (IR) spectroscopy, liquid chromatography (LC), high-resolution mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy data to determine the structure of Revisomed from first principles. The bulk of the workshop is spent reviewing MS data and using m/z, the isotope pattern, elemental composition and product ion data to reach three plausible isomeric structures for Revisomed, which are then distinguished by NMR spectroscopy. More broadly, the workshop focusses on the use of the scientific method and the concept that 'no ideas are bad' when exploring hypotheses. We describe the structure of the workshop, and our experience delivering it to a local academy over the last 9 years.</p>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":" ","pages":"e9970"},"PeriodicalIF":1.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient Ionization Mass Spectrometry for Fatty Acids Composition Investigation of Natural Lipids: A Multidisciplinary Workshop.","authors":"Stanislav I Pekov","doi":"10.1002/rcm.9985","DOIUrl":"https://doi.org/10.1002/rcm.9985","url":null,"abstract":"<p><strong>Rationale: </strong>Teaching mass spectrometry essentials is usually connected with one of the basic courses for undergrads. Thus, specific previous knowledge is required from students. However, the necessity of teaching mass spectrometry essentials to students of different academic specializations and multidisciplinary groups can arise in every academic group. A specific workshop is needed to address such a demand.</p><p><strong>Methods: </strong>The presented workshop consisted of several thematic parts: assembling an ambient ionization ion source using improvised materials, preparing biological samples for analysis, data acquisition, and interpretation of data to solve a simple problem from the real world.</p><p><strong>Results: </strong>The first part of the work consisted of assembling an ambient ionization setup and obtaining mass spectra of substances from standard solutions, natural mixtures, and biological fluids such as saliva. The second half of the workshop consists of analyzing the composition of fatty acids of natural and artificial fats using the same ion source. The identification of oils is a simple model problem that makes the workshop attractive for attendees with different backgrounds.</p><p><strong>Conclusions: </strong>The workshop provides students with practical skills that are highly valuable in fundamental and applied mass spectrometry. Students familiarize themselves with the basic concepts, instrument use, and mass spectra interpretation. They achieve basic hands-on experience in experimentation procedures and the practice of using mass spectrometry to solve problems related to real life.</p>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":" ","pages":"e9985"},"PeriodicalIF":1.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Different Steaming Degrees of Panax quinquefolius L. Based on GC-IMS Combined With Machine Learning","authors":"Yuzhang Mi,&nbsp;Hongjing Dong,&nbsp;Xiao Wang,&nbsp;Shuang Liu,&nbsp;Min Jiang,&nbsp;Qi Liang,&nbsp;Jian Chen","doi":"10.1002/rcm.9991","DOIUrl":"10.1002/rcm.9991","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p><i>Panax quinquefolius</i> L. (PQ), a commonly used traditional Chinese medicine and a food, is usually processed into various products, including white PQ, red PQ (two- or three-time steamed PQ), and black PQ (nine-time steamed PQ). Previous studies demonstrated that volatile components (VOCs) were the important active substances of PQ, which had antibacterial, antiviral, and anti-leukemia activities. However, most research had focused on ginsenosides, and few studies on the volatile components (VOCs) of PQ.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used gas chromatography-ion mobility spectrometry to analyze the variation of VOCs in PQ during steaming process. Further, machine learning algorithms were used to quickly identify the steaming degrees of PQ samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 58 VOCs were identified, and 20 featured components with significant changes in the content were screened, including 2-methylundecanal, n-propanol, and n-octanol. Based on these 20 featured components, six machine learning algorithms were used to predict PQ samples with different steaming degrees. Among them, naive Bayes (NB) and linear discriminant analysis (LDA) exhibited good predictive performance, demonstrating significant potential application. This study provided a reference for understanding the variation of VOCs in PQ during steaming and offered a simple, rapid, and low-cost method for distinguishing the steaming degrees of PQ samples.</p>\u0000 </section>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Efficient Compositional and Compound Specific Isotopic Analysis of Volatile Primary Amines and Ammonia in the Murchison Meteorite Using SPME On-Fiber Derivatization: Optimization for Bennu Sample Analyses","authors":"Yongsong Huang,&nbsp;Ewerton Santos,&nbsp;Marcelo R. Alexandre,&nbsp;Philipp R. Heck,&nbsp;Ralph Milliken,&nbsp;Daniel P. Glavin,&nbsp;Jason P. Dworkin","doi":"10.1002/rcm.9979","DOIUrl":"10.1002/rcm.9979","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>Extraterrestrial amines and ammonia are critical ingredients for the formation of astrobiologically important compounds such as amino acids and nucleobases. However, conventional methods for analyzing the composition and isotopic ratios of volatile amines suffer from lengthy derivatization and purification procedures, high sample mass consumption, and chromatographic interferences from derivatization reagents and non-target compounds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Here we demonstrate a highly efficient method to analyze the composition and compound specific isotopic ratios of C₁ to C₆ amines as well as ammonia based on solid phase micro-extraction (SPME) on-fiber derivatization. 2,3,4,5,6-pentafluorobenzyl chloroformate (PFBCF) adsorbed on a solid phase SPME fiber is subsequently exposed to the headspace of the water extract of the Murchison meteorite to selectively extract, derivatize and concentrate volatile amines and ammonia. PFBCF does not directly contact the aqueous solution containing other soluble organics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>An aliquot of volatile amines and ammonia in the headspace are selectively derivatized on the SPME fiber and subsequently thermally desorbed onto the GC injector for analysis. Only the amounts of amines required for either compositional or isotopic analysis are derivatized and consumed in the process, preserving the bulk fraction of amines and ammonia for other analyses, and the process does not affect other volatile compound classes. Carbon and hydrogen isotopic ratios of amines are obtained by isotopic mass balance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The exceptional selectivity and sensitivity of SPME on-fiber derivatization of volatile amines in carbonaceous chondrite extracts allow minimization of sample consumption. Carbon and hydrogen isotopic values of individual amines in the Murchison meteorite are consistent with their extraterrestrial origin, with a substantial fraction inherited from interstellar molecular clouds. SPME on-fiber derivatization is well suited for analyzing extraterrestrial materials, especially precious asteroid return samples.</p>\u0000 </section>\u0000 </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}