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The Japanese journal of experimental medicine最新文献

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Effect of recombinant human granulocyte colony-stimulating factor on Pneumocystis carinii infection in nude mice. 重组人粒细胞集落刺激因子对卡氏肺囊虫裸鼠感染的影响。
The Japanese journal of experimental medicine Pub Date : 1989-04-01
R Ieki, T Furuta, S Asano, S Mori, S Kudoh, H Kimura, F Takaku
{"title":"Effect of recombinant human granulocyte colony-stimulating factor on Pneumocystis carinii infection in nude mice.","authors":"R Ieki,&nbsp;T Furuta,&nbsp;S Asano,&nbsp;S Mori,&nbsp;S Kudoh,&nbsp;H Kimura,&nbsp;F Takaku","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Repeated subcutaneous (s.c.) injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to Pneumocystis carinii (P. carinii)-infected balb/c nude (nu/nu) mice had no effects on the number of the P. carinii cysts in the lungs, despite neutrophilic infiltration in the tissues and a marked increase in blood neutrophil count. This finding indicates that neutrophils in the absence of T cells do not play an important role in the killing of P. carinii. However, survival periods of the rhG-CSF treated mice seemed to extend to some extent compared with the controls presumably because of the prevention of mixed bacterial infections.</p>","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 2","pages":"51-8"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13925926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological study of skin, nose, ear and tail in experimental leprosy. 实验性麻风病皮肤、鼻、耳、尾的组织病理学研究。
The Japanese journal of experimental medicine Pub Date : 1989-04-01
C Vaishnavi, N K Ganguly, B Kumar, R Chakravarti, S Kaur
{"title":"Histopathological study of skin, nose, ear and tail in experimental leprosy.","authors":"C Vaishnavi,&nbsp;N K Ganguly,&nbsp;B Kumar,&nbsp;R Chakravarti,&nbsp;S Kaur","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 2","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13885899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of atrial natriuretic peptide on regional renal blood flow measured by a thermal diffusion technique. 热扩散法测定心房利钠肽对局部肾血流的影响。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
K Tsuchiya, T Sanaka, K Nitta, A Ando, N Sugino
{"title":"Effects of atrial natriuretic peptide on regional renal blood flow measured by a thermal diffusion technique.","authors":"K Tsuchiya,&nbsp;T Sanaka,&nbsp;K Nitta,&nbsp;A Ando,&nbsp;N Sugino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of atrial natriuretic peptide (ANP) on the regional renal blood flow were examined in anesthetized dogs. A thermal diffusion technique was applied in an attempt to observe the intrarenal blood distribution. Tissue blood flow was continuously measured according to the changes of the thermal gradient produced by a semiconductor (Peltier effect). The data (x) obtained by these probes were closely related to those (y) of the ion gas clearance method (the probe for cortical blood flow; y = 1.08x-6.23 r = 0.99, the probe for medullary blood flow; y = 1.00x +0.26 r = 0.99). The basal values of cortical and medullary blood flows measured with the flow probe in anesthetized mongrel dogs were 85 +/- 16 and 55 +/- 9 ml/min/100 g kidney weight, respectively. ANP was infused into renal artery at doses of 0.01 (n = 6), 0.05 (n = 8), 0.3 (n = 6) micrograms/kg/min and the effect on renal hemodynamics and renal excretory functions was observed. The effect was also compared with that of furosemide. Low dose of ANP did not affect renal blood distribution. Intermediate dose of ANP selectively increased medullary blood flow from 46 +/- 8 to 62 +/- 7 ml/min/100 g kidney weight, and higher dose significantly increased both cortical and medullary blood flow. ANP produced diuresis and natriuresis in a dose-dependent manner, which was not necessarily related to the changes of intrarenal blood distribution. Furosemide did not affect the renal hemodynamics. Several parameters of renal functions such as lithium and free water clearances, showed changes different from those with ANP infusion.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13669873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of monoclonal antibody to thyroglobulin from malignant thyroid carcinoma. 恶性甲状腺癌甲状腺球蛋白单克隆抗体的产生。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
K Kusakabe, E Mori, K Kano, Y Ohta, Y Fujimoto, T Mori
{"title":"Production of monoclonal antibody to thyroglobulin from malignant thyroid carcinoma.","authors":"K Kusakabe,&nbsp;E Mori,&nbsp;K Kano,&nbsp;Y Ohta,&nbsp;Y Fujimoto,&nbsp;T Mori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this study, the production of anti-human thyroglobulin (Tg) monoclonal antibodies was attempted to detect Tg levels in serum and to study the localization of thyroid metastases in patients with thyroid-gland ablation. As a result four clones of hybridoma cell lines were obtained. By means of enzyme immunoassay (EIA) and immunohistochemical method, it was found that one of them, 2G4, produced a monoclonal antibody recognizing a malignant structural change of Tg and other three clones produced monoclonal antibodies recognizing not only the normal human Tg but also the malignant Tg. Our monoclonal antibody, 2G4, will be a hopeful reagent for the diagnosis in thyroid carcinoma.</p>","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13879503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the biochemical background of cinchophen-induced gastric ulcer in the dog. 金鸡芬致犬胃溃疡的生化背景研究。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
G A Balint
{"title":"On the biochemical background of cinchophen-induced gastric ulcer in the dog.","authors":"G A Balint","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"47-9"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13618006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amplification of N-myc oncogene in various childhood cancers. N-myc癌基因在各种儿童癌症中的扩增。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
T Jinbo, M Kaneko, Y Iwamura, S Sawaguchi
{"title":"Amplification of N-myc oncogene in various childhood cancers.","authors":"T Jinbo,&nbsp;M Kaneko,&nbsp;Y Iwamura,&nbsp;S Sawaguchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"43-6"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13879504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of malnutrition during different periods on the small intestine of the rat. 不同时期营养不良对大鼠小肠的影响。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
A Firmansyah, Sunoto, Suharyono
{"title":"Effect of malnutrition during different periods on the small intestine of the rat.","authors":"A Firmansyah,&nbsp;Sunoto,&nbsp;Suharyono","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parameters of nutritional and small intestinal status were studied in 3 groups of rats which had been subjected to malnutrition during different periods (pre- and postnatal, postweaning and adulthood). Malnutrition was induced by restriction of feeds (50% of controls). Compared with controls, malnourished rats from all 3 groups had reduced body weight and length, thoracic diameters, small intestinal weight, length and diameters, small intestinal mucosal weight, total mucosal DNA and protein/DNA ratios. However, there was no difference in DNA contents between malnourished rats and corresponding controls, indicating no changes in cell number (hypotrophic). Prenatally malnourished rats had reduced specific activities of lactase, sucrase and maltase. But in other malnourished groups, the activities of these enzymes were higher compared with corresponding controls. Prenatally malnourished rats had the lowest percentage of control values in all parameters measured compared with the other malnourished rats.</p>","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13644979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased sensitivity of tumor cells to immune defense cells following treatment with antineoplastic agents in vitro. 体外抗肿瘤药物治疗后肿瘤细胞对免疫防御细胞的敏感性增加。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
T Ujiie
{"title":"Increased sensitivity of tumor cells to immune defense cells following treatment with antineoplastic agents in vitro.","authors":"T Ujiie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Murine EL-4 thymoma cells became highly sensitive to attack by cytotoxic T-lymphocytes (CTL) and allo-reactive T-cells in a 4-hr 51Cr release assay when the target EL-4 cells had been either incubated with 5-fluorouracil, cytosine arabinoside or hydroxyurea at 37 degrees C for 16 hr (nearly one generation period), or exposed for 30 min to adriamycin, actinomycin D, bleomycin, mitomycin C, 1-(4-amino-2-methylpyrimidine-5-yl)-methyl-3-(2-chloroethyl)-3-nitros our ea, cis-diamminedichloroplatinum(II) or 4-hydroperoxycyclophosphamide followed by incubation for 16 hr. In contrast, short-term exposure of EL-4 cells to the latter group of drugs had no effects on immune lysis in vitro. Target cells treated with these antineoplastic agents were enlarged in volume, resulting from the blockade of cell division, and the major histocompatibility complex (MHC) class I antigens detectable on the cell surface were significantly increased in the treated cells. CTL can lyse altered cells by recognizing foreign antigens in association with MHC class I antigens. Thus, these data suggest that the enhanced sensitivity of target tumor cells to CTL lysis following treatment with antineoplastic agents could be at least partly due to increases in the expression of MHC class I antigens. These treatments made natural killer (NK)-resistant EL-4 cells susceptible to NK lysis, hence, their relation to chemoimmunotherapy for cancer is discussed.</p>","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13926801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of Tyzzer's disease in rats by ingestion of bacterial spores. 大鼠因摄入细菌孢子而患泰泽氏病。
The Japanese journal of experimental medicine Pub Date : 1989-02-01
T Itoh, N Kagiyama, K Fujiwara
{"title":"Production of Tyzzer's disease in rats by ingestion of bacterial spores.","authors":"T Itoh,&nbsp;N Kagiyama,&nbsp;K Fujiwara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tyzzer's disease was produced in rats by peroral inoculation with spores of Bacillus piliformis (Tyzzer's organism) of rat origin. After ingestion of 10(6) spores necrotized lesions with intracellular bacterial propagation were seen in the intestines, liver and heart on days 2 to 14 postinoculation (p.i.). A number of B. piliformis were present within enterocytes of the cecum and colon. Infected cells were also seen in the liver, myocardium and intestinal muscle layers on days 3 to 7 p.i. Infective spores were found to be shed in feces during 3 to 10 days p.i.</p>","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13879505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental ocular toxoplasmosis with RH strain of Toxoplasma gondii. 刚地弓形虫RH株的实验性眼弓形虫病。
The Japanese journal of experimental medicine Pub Date : 1988-12-01
N Malla, M Goyal, P Pillai, N K Ganguly, R C Mahajan
{"title":"Experimental ocular toxoplasmosis with RH strain of Toxoplasma gondii.","authors":"N Malla,&nbsp;M Goyal,&nbsp;P Pillai,&nbsp;N K Ganguly,&nbsp;R C Mahajan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"58 6","pages":"279-81"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14382772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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