The Japanese journal of experimental medicine最新文献_第7页

Lymphokine mediated microbicidal activity of peritoneal macrophages from Leishmania donovani infected and drug treated BALB/c mice. 淋巴因子介导的多诺瓦利什曼原虫感染和药物治疗BALB/c小鼠腹腔巨噬细胞的杀微生物活性

The Japanese journal of experimental medicine Pub Date : 1989-06-01

S Sodhi, N K Ganguly, N Malla, R C Mahajan

{"title":"Lymphokine mediated microbicidal activity of peritoneal macrophages from Leishmania donovani infected and drug treated BALB/c mice.","authors":"S Sodhi, N K Ganguly, N Malla, R C Mahajan","doi":"","DOIUrl":"","url":null,"abstract":"The resident peritoneal macrophages from untreated mice develop potent microbicidal activity against amastigotes of Leishmania major and Leishmania donovani after in vitro exposure to lymphokines (LK) from mitogen stimulated spleen cells. However, to the best of our knowledge, the response of L. donovani infected peritoneal macrophages from already infected/treated animals to LK has not been investigated. Therefore in the present study, the effect of LK on infected macrophages from BALB/c mice following specific infection and subsequent treatment with sodium stibogluconate has been investigated. As the infection progressed, a decrease in percent microbicidal activity was noticed. An attempt was also made to treat the animals on different post infection days and reinfect them in vitro. Infection could not be produced in vitro in late treatment groups when the treatment was given on 14 days and 21 days post infection. Whereas, macrophages obtained from animals treated on 7 days post infection (early treatment) could be infected in vitro. However, only 50% of the cells got infection. This infection was eliminated when the cells were exposed to LK for 72 hours.","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 3","pages":"103-8"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13697667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of prostacyclin treatment on the changes of cyclic nucleotide levels of rat antral and fundic gastric mucosa in different experimental ulcer models. 前列环素对不同实验性溃疡模型大鼠胃胃窦和胃底粘膜环核苷酸水平变化的影响。

The Japanese journal of experimental medicine Pub Date : 1989-06-01

G A Balint

引用次数: 0

Elevation of laminin and beta-subunit of prolyl 4-hydroxylase in the sera of human subjects with Schistosomiasis mansoni. 曼氏血吸虫病患者血清中层粘连蛋白和脯氨酰4-羟化酶β亚基的升高。

The Japanese journal of experimental medicine Pub Date : 1989-06-01

M Tanabe, T Sekiguchi, N Kaneko, S Kobayashi, T Takeuchi, A Coutinho, S Tateno, K Maruyama, I Okazaki

{"title":"Elevation of laminin and beta-subunit of prolyl 4-hydroxylase in the sera of human subjects with Schistosomiasis mansoni.","authors":"M Tanabe, T Sekiguchi, N Kaneko, S Kobayashi, T Takeuchi, A Coutinho, S Tateno, K Maruyama, I Okazaki","doi":"","DOIUrl":"","url":null,"abstract":"Serum levels of several markers for liver fibrosis were measured utilizing three groups of human subjects related with schistosomiasis mansoni in northeast Brazil; (1) 20 Schistosoma mansoni egg-positives, who have never been administered with anti-schistosomal drugs, (2) 29 egg-negative inhabitants in the endemic area of schistosomiasis, and (3) 23 egg-negative Japanese immigrants in the non-endemic area. None of these sera were positive for antibody to the surface antigen of human hepatitis B (HBs) and circulating HBs antigen. There was no significant difference in the serum levels of N-terminal peptide of procollagen type-III between the egg-positive subjects and either of the egg-negative Brazilian or Japanese immigrants, whereas the mean value of serum laminin significantly increased in the egg-positive subjects. A significantly higher concentration of serum immunoreactive beta-subunit of prolyl 4-hydroxylase (IR beta PH) was also observed in the egg-positive subjects only in comparison with that of the egg-negative Brazilian. Serum laminin and IR beta PH concentrations of the egg-positive subjects did not correlate with the absorbance of enzyme-linked immunosorbent assay (ELISA) which utilized crude antigens isolated from schistosome adults or eggs. No significant difference in these two parameters was observed between two subgroups of the egg-negative Brazilian or Japanese immigrants divided according to the serological data by ELISA. These findings suggest that serum laminin and IR beta PH levels are worth further evaluation for their usefulness as the marker for liver fibrosis in schistosomiasis.","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 3","pages":"109-19"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13697668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vasectomy on serum lipids, platelet aggregability and development of ischaemic heart disease in rhesus monkeys. 输精管切除术对恒河猴血脂、血小板聚集性及缺血性心脏病发展的影响。

The Japanese journal of experimental medicine Pub Date : 1989-06-01

N Sharda, R N Chakravarti

{"title":"Effect of vasectomy on serum lipids, platelet aggregability and development of ischaemic heart disease in rhesus monkeys.","authors":"N Sharda, R N Chakravarti","doi":"","DOIUrl":"","url":null,"abstract":"In this study the long term effects of vasectomy on serum lipid profile, in vitro platelet aggregability and the risk of developing acute myocardial infarction have been elucidated in a monkey model. Four groups were made viz. (I) atherogenic diet fed vasectomised, (II) atherogenic diet fed control, (III) stock diet fed vasectomised and (IV) stock diet fed control. The respective diets were fed for first 6 months and then half of the atherogenic and stock diet fed monkeys were bilaterally vasectomised. The remaining monkeys were sham-vasectomised. At the end of one year, norepinephrine infusion was given to all the monkeys each day for 2 hrs, for 3 consecutive days and animals sacrificed after 96 hrs. Although serum lipids were not altered following vasectomy, platelet aggregation response was significantly enhanced in atherogenic diet fed animals. ECG changes were suggestive of acute myocardial ischaemia in 4 monkeys, 2 each from gp. I and II. Histopathology of heart revealed patchy myocardial necrosis and haemorrhage only in one monkey of gp. I, while others had fuchsinorrhagia indicating ischaemic change. These findings are in contrast to those seen in vasectomised human subjects.","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 3","pages":"121-6"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13949422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental conditions favorable for tumor progression in peritoneal cavity induced by peritoneal cells without tumor selectivity. 无肿瘤选择性的腹膜细胞诱导腹腔肿瘤进展的有利环境条件。

The Japanese journal of experimental medicine Pub Date : 1989-06-01

K Segawa, Y Ueno, T Kataoka

{"title":"Environmental conditions favorable for tumor progression in peritoneal cavity induced by peritoneal cells without tumor selectivity.","authors":"K Segawa, Y Ueno, T Kataoka","doi":"","DOIUrl":"","url":null,"abstract":"The incidence of the lethal growth of 10(1) L1210 murine leukemia cells in mice was higher in intraperitoneal (i.p.) (97%) than in intradermal (i.d.) (17%) inoculation, and survival time of mice was shorter in i.p. than i.d. inoculation. It was supposed that resident peritoneal cells (PC) enhanced tumor progression. I.d. inoculation of 10(1) L1210 cells mixed with 10(6) PC induced a lethal tumor growth at higher incidence than that of 10(1) L1210 cells alone or the mixture of 10(1) L1210 cells and 10(4) peripheral blood mononuclear cells (PBM) did. Furthermore, co-inoculation of a tumorigenic number of L1210 cells (10(3] with 10(6) PC resulted in marked shortening of median survival time of mice. Similar growth enhancing effect of PC was observed in Meth 1 fibrosarcoma. Meth A fibrosarcoma and colon carcinoma 26 (C26). Further study showed that PC, intact or X-rayed, helped the in vitro tumor growth under the conditions in which L1210 alone did not grow at all, whereas PBM had no enhancing effect to L1210 growth. We characterized the cells involved in tumor growth enhancement by the in vivo and in vitro tests. Plastic dish adherent cells of PC which were Mac-1 positive, large in size and resistant to X-ray, enhanced L1210 growth, whereas non-adherent cells which were Mac-1 negative and small in size, did not. These data suggest that the cells responsible for enhancing activity of tumor progression in the peritoneal cavity were macrophages (M phi).","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 3","pages":"127-33"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13822691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventricular aneurysms: a geometrical-dynamical model. 心室动脉瘤:一个几何动力学模型。

The Japanese journal of experimental medicine Pub Date : 1989-06-01

H E Castagnino, F A Toranzos

{"title":"Ventricular aneurysms: a geometrical-dynamical model.","authors":"H E Castagnino, F A Toranzos","doi":"","DOIUrl":"","url":null,"abstract":"A geometrical-dynamical model has been designed with the aim to reproduce the early phases of ventricular aneurysms formation. Possible deleterious forces within a solidary-dynamic structure start when a partial or localized loss of contractility arises. A following important aspect is related to the compressive effects of those altered cells over the normally contracting neighborhood. An abnormal packing of elements within a cyclic-dynamic structure has taken place and consequently new abnormal forces of compression between altered and normal cells will result in a longitudinal course of progression. When this circle crosses itself, a ventricular aneurysm will be completed. The process could be ascribed to an elastic phenomenon activated by a compressive stress. The chain of events included in this model has been matched with usual pathological findings of ventricular aneurysms, i.e. wavy and broken fibres neatness of aneurysmatic borders, and apical outstanding incidence of aneurysms etc. The proposed geometrical-dynamical model admits the possibility of an interruption in the 7 steps process of ventricular aneurysm formation by means of a \"barrier effect\". This effect has been related to the fibrous extracellular matrix with its differences in amount and quality of scar formation, which is possible to be observed in ischemic heart disease and chronic Chagas' cardiomyopathy and in some other illustrative entities. An analysis of this particular aspect of scar formation on diverse aneurismogenic entities with different reactions of collagen and particularly different figures of incidence of aneurysmatic formation, show a high correlation with possible alternatives disclosed by this geometrical-dynamical model.","PeriodicalId":22530,"journal":{"name":"The Japanese journal of experimental medicine","volume":"59 3","pages":"89-102"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13949423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of human heterophile antibodies. III. In vitro specific stimulation and immortalization of human lymphocytes. 人嗜异性抗体的产生。3体外特异性刺激和人淋巴细胞的永生化。

The Japanese journal of experimental medicine Pub Date : 1989-04-01

T Mori, H Kanzaki, E Mori

引用次数: 0

Humoral and cell mediated immune responses to porins of Salmonella typhi. 伤寒沙门氏菌孔蛋白的体液和细胞介导免疫应答。

The Japanese journal of experimental medicine Pub Date : 1989-04-01

P Sharma, N K Ganguly, B K Sharma, S Sharma, I J Rawal, S N Saxena, R Sehgal

引用次数: 0

Biochemical characterization of peripheral blood in an outpatient with atypical Gaucher's disease type 1 like myelodysplastic syndrome. 非典型戈谢病1型骨髓增生异常综合征门诊患者外周血生化特征分析

The Japanese journal of experimental medicine Pub Date : 1989-04-01

T Taketomi, K Uemura, A Hara, H Saito