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Journal of Diagnostic Pathology最新文献

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Answer to Quiz, Discussion, and Conclusion 测验、讨论和结论的答案
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i1.7770
M. Munasinghe, P. G. A. N. Jayathilaka, S. J. De S. Hewavisenthi
{"title":"Answer to Quiz, Discussion, and Conclusion","authors":"M. Munasinghe, P. G. A. N. Jayathilaka, S. J. De S. Hewavisenthi","doi":"10.4038/jdp.v14i1.7770","DOIUrl":"https://doi.org/10.4038/jdp.v14i1.7770","url":null,"abstract":"Microscopy showed focal collections of round to polygonal cells with round to oval nuclei, abundant and eosinophilic cytoplasm with indistinct cell borders resembling squamous morules. Some cells with elongated nuclei resembling epithelioid cells forming granulomas (Figure 1 and 2 page 9) were noted in the stratum compactum of the endometrium. There was no cytological atypia or caseous necrosis. The extensively sampled endometrium showed non phasic glands and superficial pseudodecidualized foci of the stroma. Acid-fast stain, PAS and gram stain performed failed to demonstrate acid-fast bacilli, fungal elements or bacteria respectively.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131820929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Mucin Patterns in Colonic Pathologies by Histochemistry 用组织化学方法比较结肠病理中粘蛋白的分布
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i2.7773
R. Ratnayake, C. Epitakaduwa, D. Jayatunge, D. Ediriweera, S. Hewavisenthi
{"title":"Comparison of Mucin Patterns in Colonic Pathologies by Histochemistry","authors":"R. Ratnayake, C. Epitakaduwa, D. Jayatunge, D. Ediriweera, S. Hewavisenthi","doi":"10.4038/jdp.v14i2.7773","DOIUrl":"https://doi.org/10.4038/jdp.v14i2.7773","url":null,"abstract":"Introduction: High Iron Diamine Alcian blue (HID-AB) is a well-established technique for demonstrating colonic acid mucins namely sulphomucins (brown- black) and sialomucins (blue). In certain colonic pathologies expression of sulphomucin, the predominant mucin in normal colonic epithelium is altered. Objective: To compare the changes in the pattern of mucin staining in, adenocarcinoma (AC), normal colonic epithelium, solitary rectal ulcer (SRU), transitional zone mucosa (TZ) (i.e.: normal non dysplastic mucosa adjacent to adenocarcinoma) and in ulcerative colitis (UC). Method: AC-21, normal colonic epithelium-30, SRU-23, TZ-20, UC-29 biopsies were stained with the HID-AB stain. Two investigators assessed the percentages of mucin staining by counting the number of cells staining for sulphomucin and sialomucin in an area of colonic epithelium measuring 1mm in length. The differences in these 5 categories were assessed for statistical significance using the one-way ANOVA test and a Post Hoc Comparison of the mean values was carried out to establish which groups were different. Results: ACs showed no sulphomucin or sialomucin staining while normal colonic epithelium showed nearly 100% sulphomucin staining.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125397666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The protean clinical endoscopic and histological manifestations of solitary rectal ulcer syndrome 孤立性直肠溃疡综合征的多种临床内镜和组织学表现
Journal of Diagnostic Pathology Pub Date : 2019-06-30 DOI: 10.4038/jdp.v15i1.7778
D. Jayatunge, R. Ratnayake, E. Epitakaduwa, S. J. De S. Hewavisenthi
{"title":"The protean clinical endoscopic and histological manifestations of solitary rectal ulcer syndrome","authors":"D. Jayatunge, R. Ratnayake, E. Epitakaduwa, S. J. De S. Hewavisenthi","doi":"10.4038/jdp.v15i1.7778","DOIUrl":"https://doi.org/10.4038/jdp.v15i1.7778","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126014624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Cases of Synchronous Classic Hodgkin Lymphoma and Tuberculosis 经典霍奇金淋巴瘤合并结核2例
Journal of Diagnostic Pathology Pub Date : 2018-12-30 DOI: 10.4038/jdp.v13i2.7758
L. De Silva, S. Wijetunge, T. Jayamaha
{"title":"Two Cases of Synchronous Classic Hodgkin Lymphoma and Tuberculosis","authors":"L. De Silva, S. Wijetunge, T. Jayamaha","doi":"10.4038/jdp.v13i2.7758","DOIUrl":"https://doi.org/10.4038/jdp.v13i2.7758","url":null,"abstract":"In countries endemic for tuberculosis, coexistence with other diseases are not uncommon. This poses a diagnostic challenge since the granulomatous reaction and extensive caseous necrosis can conceal the concurrent lesion often missing the second diagnosis. Hodgkin lymphoma has been not uncommonly reported with concurrent tuberculosis and there are case reports that the possibility of a concurrent lesion has been suspected and diagnosed only when the patient is not responding to anti-tuberculosis drugs (1). We report two cases of classic Hodgkin lymphoma masked by concurrent tuberculoses lymphadenitis.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126806586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastroesophageal Reflux Disease: New evidence defining the pathology and pathogenesis of early GERD 胃食管反流病:定义早期胃食管反流病病理和发病机制的新证据
Journal of Diagnostic Pathology Pub Date : 2018-12-30 DOI: 10.4038/jdp.v13i2.7756
M. Chandrasoma
{"title":"Gastroesophageal Reflux Disease: New evidence defining the pathology and pathogenesis of early GERD","authors":"M. Chandrasoma","doi":"10.4038/jdp.v13i2.7756","DOIUrl":"https://doi.org/10.4038/jdp.v13i2.7756","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is a common human disease. In the western world, it has a prevalence of 30% (1). In the Eastern world, the prevalence is lower, but shows signs of increase (1). The cause of GERD is conceptually simple; it results when the mechanism that normally prevents reflux of gastric contents into the esophagus fails. That mechanism is the lower esophageal sphincter (LES). In a patient with a competent LES, reflux does not occur.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115779134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genital tuberculosis in a Woman Manifested as Secondary Subfertility 女性生殖器结核表现为继发性生育能力低下
Journal of Diagnostic Pathology Pub Date : 2018-12-30 DOI: 10.4038/jdp.v13i2.7757
E. Wickramaratne, K. A. P. Idirisinghe, K. U. Samaranayake
{"title":"Genital tuberculosis in a Woman Manifested as Secondary Subfertility","authors":"E. Wickramaratne, K. A. P. Idirisinghe, K. U. Samaranayake","doi":"10.4038/jdp.v13i2.7757","DOIUrl":"https://doi.org/10.4038/jdp.v13i2.7757","url":null,"abstract":"Introduction Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, which remains as a major public health problem despite the advances in antibiotic treatment and vaccination. Tuberculosis can be categorized into pulmonary and extrapulmonary forms based on the affected organ. Genital tuberculosis (GTB) represents 1520% of cases of extrapulmonary TB and affects 12.1% of patients with pulmonary TB (1). GTB mainly affects women in the reproductive age group (20-40 years). Usually, this is a silent disease and the most common presentation amongst these patients is subfertility. In addition to that, menstrual disturbances, dyspareunia and abdominal pain may occur. Approximately 5-10% subfertile women worldwide have GTB. The worldwide incidence varies from less than 1% in developed countries to more than 13% in developing countries (2,3). In our literature review, accurate statistics of GTB among subfertile women in Sri Lanka could not be found.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"399 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129208680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the pathologist in the assessment of disease activity in ulcerative colitis 病理学家在溃疡性结肠炎疾病活动性评估中的作用
Journal of Diagnostic Pathology Pub Date : 2018-07-28 DOI: 10.4038/JDP.V13I1.7749
B. Mahendra, S. Hewavisenthi
{"title":"The role of the pathologist in the assessment of disease activity in ulcerative colitis","authors":"B. Mahendra, S. Hewavisenthi","doi":"10.4038/JDP.V13I1.7749","DOIUrl":"https://doi.org/10.4038/JDP.V13I1.7749","url":null,"abstract":"In order to determine the role of the pathologist in assessing disease activity in UC, clinical and histological correlation of disease activity, correlation between endoscopy and histology and determining the most satisfactory method of scoring histological activity were assessed. A cohort of 41 patients attending a gastroenterology clinic in a tertiary hospital in Sri Lanka was studied. Their clinical activity was determined based on the simple clinical colitis activity index (SCCAI), endoscopically visible inflammation was recorded with reference to the extent of involvement and histology was assessed using three different histological scoring systems. The Spearman rank correlation coefficients between SCCAI and the three histological scoring systems were 0.298, 0.286, and 0.238 respectively denoting  poor correlation.  The kappa value of agreement between endoscopy and histology was poor (k=0.136). The Spearman rank correlation coefficients between the three histological scoring systems were 0.883,  0.883  and  0.952, reaching a level of statistical significance (p<0.01). The clinical activity and histological activity do not correlate and this is especially when assessing the more proximal colon. Endoscopy and histology also shows  no correlation highlighting the importance of microscopic assessment of endoscopically normal mucosa. Finally, the histological scoring systems correlate fairly closely with one another enabling histopathologists to choose one that is most practical for routine use.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131335060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Presidential address: annual academic sessions of college of pathologists of Sri Lanka 2017 主席致辞:斯里兰卡病理学家学院2017年度学术会议
Journal of Diagnostic Pathology Pub Date : 2018-07-28 DOI: 10.4038/JDP.V13I1.7748
B. Seneviratne
{"title":"Presidential address: annual academic sessions of college of pathologists of Sri Lanka 2017","authors":"B. Seneviratne","doi":"10.4038/JDP.V13I1.7748","DOIUrl":"https://doi.org/10.4038/JDP.V13I1.7748","url":null,"abstract":"The College of Pathologists of Sri Lanka has bestowed a great honour on me by electing me as its President. It is with great humility and a sense of responsibility that I accept this post and thank the members for electing me. It is indeed an honour and a privilege to be the President of this prestigious association. The illustrious array of past presidents with their respective councils have steered this organization to great heights. I too pledge to serve the college to the best of my ability and do my utmost to be worthy of the trust that has been placed in me. I will fulfil the objectives and aspirations of our college.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122533129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary mucinous adenocarcinoma of renal pelvis: a case report 原发性肾盂粘液腺癌1例
Journal of Diagnostic Pathology Pub Date : 2018-07-28 DOI: 10.4038/JDP.V13I1.7738
S. M. J. Islam, W. S. Hoque, D. Maheen, S. Akhter
{"title":"Primary mucinous adenocarcinoma of renal pelvis: a case report","authors":"S. M. J. Islam, W. S. Hoque, D. Maheen, S. Akhter","doi":"10.4038/JDP.V13I1.7738","DOIUrl":"https://doi.org/10.4038/JDP.V13I1.7738","url":null,"abstract":"Primary mucinous adenocarcinoma of the renal pelvis is a very rare tumour which is usually associated with urolithiasis and hydronephrotic changes due to chronic irritation and infection, leading to glandular metaplasia of lining urothelial cells. We present a 62- year old male with a history of ureteric calculi 7 years back now presenting with pain in the left flank and a palpable mass at left loin who was diagnosed clinically and radiologically to have hydronephrosis with a non functioning kidney. He underwent radical nephrectomy. On histopathological examination he was diagnosed to have mucinous adenocarcinoma of the renal pelvis stage PT4N1M0. Immunohistochemically the tumour cells were positive for CK7 and negative for CK20 and focally positive for CDX2.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129045114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathologists as life long learners 组织病理学家是终身学习者
Journal of Diagnostic Pathology Pub Date : 2018-07-28 DOI: 10.4038/JDP.V13I1.7750
M. D. Lokuhetty
{"title":"Histopathologists as life long learners","authors":"M. D. Lokuhetty","doi":"10.4038/JDP.V13I1.7750","DOIUrl":"https://doi.org/10.4038/JDP.V13I1.7750","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115660800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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