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Journal of Diagnostic Pathology最新文献

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Molecular Classification of Breast Cancers using Immunohistochemical Surrogates; The Sri Lankan Experience 利用免疫组织化学替代物对乳腺癌进行分子分类斯里兰卡之旅
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i1.7767
L. Mudduwa, Harshini Peiris, T. Liyanage, D. Abeysiriwardhana
{"title":"Molecular Classification of Breast Cancers using Immunohistochemical Surrogates; The Sri Lankan Experience","authors":"L. Mudduwa, Harshini Peiris, T. Liyanage, D. Abeysiriwardhana","doi":"10.4038/jdp.v14i1.7767","DOIUrl":"https://doi.org/10.4038/jdp.v14i1.7767","url":null,"abstract":"Background: Breast cancer diagnosis has evolved over the past decades. Today, it is vital to classify breast cancers according to genetic expression. Immunohistochemical surrogates have been identified as a cost-effective routine method to address the genetic diversity of breast cancers. Aim: To describe the survival pattern of a cohort of breast cancer patients in the Sri Lankan setting, according to the molecular classification using IHC surrogates. Method: Breast cancer (BC) patients investigated in our laboratory from 2006-2015 were included. Tissue microarrays were constructed using their archived BC tissue. Immunohistochemical assessment of hormone receptors, Her2, Ki67, CK5/6 and EGFR were done. The Pearson chi-square test, Kaplan-Meier model and Cox-regression model were used for analysis. Results: The study cohort comprised 1122 patients. The complete molecular classification could be performed only for 939 patients with 27.7% -Luminal - A, 10.5% - luminal - B (Her2-), 9.1%-luminal -B (Her2+), 14.6% Her2 enriched, 9.9% - triple negative and 8.2% -basal-like BC. tumour size (p=0.001), Nottingham grade (p<0.000), lymph node stage (p=0.001) and prevalence of lympho-vascular invasion (p=0.003). Five-year BC specific survival (BCSS) of the study cohort was 75.5% (92.3% in luminal-A, 54.2% in Her2-enriched, 72.2% in triple-negative and 64.4% in basal-like groups; p<0.001). The molecular subtype (p<0.000, p=0.003) and lymph node stage (p<0.001) had an independent effect on the BCSS and RFS respectively. Conclusion: The molecular classification using immunohistochemical surrogates, classify breast cancers into clinically useful groups with distinctively different survival rates.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"188 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128972236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to quiz, discussion, and conclusion 回答小测验、讨论和结论
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v15i1.7781
A. B. A. K. Jayarathna, S. Fernandopulle
{"title":"Answer to quiz, discussion, and conclusion","authors":"A. B. A. K. Jayarathna, S. Fernandopulle","doi":"10.4038/jdp.v15i1.7781","DOIUrl":"https://doi.org/10.4038/jdp.v15i1.7781","url":null,"abstract":"The smears showed clusters and sheets of spindle cells in a myxoid stromal background. (Figure 1-3). These spindle cells showed ovoid vesicular nuclei with mild nuclear pleomorphism. The cytoplasm is eosinophilic and ill defined. There were no mitoses or necrosis. Cytology was concluded as a low grade myxoid spindle cell neoplasm and histological assessment was recommended for a definite diagnosis.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130053173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathology Quiz 组织病理学测验
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v15i1.7780
A. B. A. K. Jayarathna, S. Fernandopulle
{"title":"Histopathology Quiz","authors":"A. B. A. K. Jayarathna, S. Fernandopulle","doi":"10.4038/jdp.v15i1.7780","DOIUrl":"https://doi.org/10.4038/jdp.v15i1.7780","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"601 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134004199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing the Progress of Pathology in Sri Lanka – Part II: Undergraduate and postgraduate teaching in Pathology 追溯病理学在斯里兰卡的进展-第二部分:病理学的本科和研究生教学
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i2.7771
J. Hewavisenthi, L. Mudduwa
{"title":"Tracing the Progress of Pathology in Sri Lanka – Part II: Undergraduate and postgraduate teaching in Pathology","authors":"J. Hewavisenthi, L. Mudduwa","doi":"10.4038/jdp.v14i2.7771","DOIUrl":"https://doi.org/10.4038/jdp.v14i2.7771","url":null,"abstract":"Dr. S.A Cabraal, the first Director of the Post Graduate Institute of Medicine (PGIM), University of Colombo, writing in the Journal of Pathology on postgraduate training in Sri Lanka states, that “prior to the establishment of the PGIM in 1974, the University of Colombo conferred the Degree of Doctor of Medicine in Pathology on candidates who had passed such examinations or submitted material as prescribed by the then regulation”. Since there was no organized teaching or training taking place in the island at that time, the training was done in the UK and the postgraduate Diploma of The Royal College of Pathologists was a recognized qualification for consultant appointments.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114299676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathology Quiz 组织病理学测验
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i1.7769
M. Munasinghe, P. G. A. N. Jayathilaka, S. J. De S. Hewavisenthi
{"title":"Histopathology Quiz","authors":"M. Munasinghe, P. G. A. N. Jayathilaka, S. J. De S. Hewavisenthi","doi":"10.4038/jdp.v14i1.7769","DOIUrl":"https://doi.org/10.4038/jdp.v14i1.7769","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121817800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing the Progress of Pathology in Sri Lanka – Part I Development of clinical pathology services 追踪病理学在斯里兰卡的进展-第一部分临床病理学服务的发展
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i1.7766
M. D. J. Hewavisenthi
{"title":"Tracing the Progress of Pathology in Sri Lanka – Part I Development of clinical pathology services","authors":"M. D. J. Hewavisenthi","doi":"10.4038/jdp.v14i1.7766","DOIUrl":"https://doi.org/10.4038/jdp.v14i1.7766","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129339963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in Clinico-pathological and Risk Factor Profile of Breast Cancer; 10-year Experience at a Single Center in Sri Lanka 乳腺癌临床病理及危险因素变化趋势在斯里兰卡一个中心工作10年
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i2.7772
L. Mudduwa, Harshini Peiris, T. Liyanage, S. Gunasekera, Nadeeka Ranawaka
{"title":"Trends in Clinico-pathological and Risk Factor Profile of Breast Cancer; 10-year Experience at a Single Center in Sri Lanka","authors":"L. Mudduwa, Harshini Peiris, T. Liyanage, S. Gunasekera, Nadeeka Ranawaka","doi":"10.4038/jdp.v14i2.7772","DOIUrl":"https://doi.org/10.4038/jdp.v14i2.7772","url":null,"abstract":"Background The incidence of breast cancer in Sri Lanka is increasing on par with the rest of Asia. Lifestyle changes increasing the prevalence of risk factors of breast cancer among Asian women are claimed to be one of the reasons for this trend. Aim To analyze the clinico-pathological and risk factor profile of a cohort of breast cancer patients to detect any change in the patterns, over time. Method","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129154908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Granular Cell Tumour of the Thigh with Lung Metastases in a Young Woman; A Rare Presentation 年轻女性大腿恶性颗粒细胞瘤伴肺转移1例罕见的演讲
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i2.7775
P. M. S. Hiroshini, A. Vithanage, R. Ratnayake
{"title":"Malignant Granular Cell Tumour of the Thigh with Lung Metastases in a Young Woman; A Rare Presentation","authors":"P. M. S. Hiroshini, A. Vithanage, R. Ratnayake","doi":"10.4038/jdp.v14i2.7775","DOIUrl":"https://doi.org/10.4038/jdp.v14i2.7775","url":null,"abstract":"Granular Cell Tumour (GCT) is an uncommon soft tissue neoplasm. Majority of GCT are benign involving the soft tissue of the head and neck region. However, few show malignant behaviour with local recurrence and distant metastases often involving the lower extremities. Here we report a rare case of malignant granular cell tumour in a 33-year-old woman involving the left thigh with regional lymph node and multiple lung metastases.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"401 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114378075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of the Pathologist beyond the Microscope 病理学家在显微镜下的角色
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i1.7765
P. Ratnayake
{"title":"The Role of the Pathologist beyond the Microscope","authors":"P. Ratnayake","doi":"10.4038/jdp.v14i1.7765","DOIUrl":"https://doi.org/10.4038/jdp.v14i1.7765","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115265087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Hepatocellular Carcinoma: Presentation in a Rare Site 转移性肝细胞癌:罕见部位的表现
Journal of Diagnostic Pathology Pub Date : 2019-12-30 DOI: 10.4038/jdp.v14i1.7768
P. G. A. N. Jayathilaka, M. Munasinghe, S. Fernandopulle
{"title":"Metastatic Hepatocellular Carcinoma: Presentation in a Rare Site","authors":"P. G. A. N. Jayathilaka, M. Munasinghe, S. Fernandopulle","doi":"10.4038/jdp.v14i1.7768","DOIUrl":"https://doi.org/10.4038/jdp.v14i1.7768","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a common malignancy showing extra-hepatic metastases in 30-50% of the patients at the time of diagnosis. However, Patients presenting with metastatic hepatocellular carcinoma are rare and soft tissue metastases in head and neck area are extremely rare. We report a 54-year-old man presenting with hoarseness of voice and a neck lump. Radiological impression was of a laryngeal carcinoma with local infiltration. Fine Needle Aspiration Cytology (FNAC) revealed a neoplastic lesion, with the incisional biopsy confirming a metastatic hepatocellular carcinoma. A primary HCC was discovered subsequently. Although cytological features are those of HCC, this case highlights the diagnostic dilemma due to its rare metastatic location.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132431499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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