Journal of Diagnostic Pathology最新文献

{"title":"A clinical audit on pap smears reported in a tertiary care centre in Sri Lanka","authors":"L. De Silva, R. Gunawardene, E. Siriweera, R. Waduge, P. M. R. Deniyegedara, S. Wijetunge","doi":"10.4038/jdp.v16i1.7785","DOIUrl":"https://doi.org/10.4038/jdp.v16i1.7785","url":null,"abstract":"Submitted on 24.05.2021. Accepted for publication on 27.07.2021. ________________________________________________________________________________ Introduction Cervical cancer is the most common gynecological cancer worldwide, with developing countries bearing a disproportionately high disease burden (1). This is the second most common cancer among Sri Lankan women. According to the World Health Organization (WHO) there were 604,127 new cases of cervical carcinoma diagnosed worldwide in the year 2020, while 341,831 deaths were reported following the diagnosis of cervical cancer (2). Studies have shown that early detection and treatment can reduce morbidity and mortality by more than 70% (3).","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121414356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmacytoid urothelial carcinoma; A series of two cases and the approach to diagnosis","authors":"L. de Silva, W. D. De Silva, H. Wijesinghe, W. D. De Silva, A. Malalasekara, M. D. de Silva","doi":"10.4038/jdp.v16i1.7761","DOIUrl":"https://doi.org/10.4038/jdp.v16i1.7761","url":null,"abstract":"Plasmacytoid urothelial carcinoma (PUC) is a rare and aggressive variant of urothelial carcinoma. PUC can occur in any part of the urinary tract, but the upper ureteric origin is extremely rare, with only two cases reported to date. The diagnosis of this specific variant of urothelial carcinoma has prognostic implications and necessitates close oncological follow up after surgical resection. We report two cases of urothelial carcinoma with plasmacytoid differentiation in two different locations of the urinary tract. The first case was of a 59-year-old man who was investigated for right loin pain. He was found to have a lesion in the right upper ureter with imaging evidence of right side hydronephrosis and upper hydroureter. The lesion was sampled with ureteroscopic and cup biopsy and later underwent a nephroureterectomy following the diagnosis of urothelial carcinoma. The second case was of a 77-year-old man who was investigated for painless macroscopic haematuria. Imaging revealed a lesion in the anterior wall of the bladder. Transurethral resection of bladder tumour was performed. Histology and immunocytochemistry of both lesions were compatible with PUC. These cases highlight the importance of identifying and reporting this rare variant of invasive urothelial carcinoma as it has a poor outcome compared to usual urothelial carcinoma.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127730159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Answer to Quiz, Discussion and Conclusion","authors":"C. Sosai, Anoj Dharmawardhane","doi":"10.4038/jdp.v15i2.7791","DOIUrl":"https://doi.org/10.4038/jdp.v15i2.7791","url":null,"abstract":"Answer to Quiz The histopathology of the jejunal lesions revealed a tumour in the submucosa (Fig2) with typical features of choriocarcinoma, comprising of a plexiform pattern of syncytiotrophoblasts and cytotrophoblasts amidst much haemorrhage (Fig. 3&4). The cytotrophoblastic cells appear sheetlike with large, bland, vesicular nuclei and prominent nucleoli. The cytoplasm is abundant and clear with sharp cytoplasmic margins. The syncitiotrophoblastic cells show the typical multinucleation with abundant, eosinophilic cytoplasm and are arranged around the cytotrophoblastic cells. Mitoses are many. On retrospective inquiry, it was found that she had undergone evacuation of retained products of conception a year ago and the histopathology was a hydatidiform mole. She had defaulted follow up.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"22 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125781924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondroblastoma with Atypical Features","authors":"K. H. Silva, B. Mahendra, S. J. De S. Hewavisenthi","doi":"10.4038/jdp.v15i2.7788","DOIUrl":"https://doi.org/10.4038/jdp.v15i2.7788","url":null,"abstract":"Chondroblastoma (CB) is a rare bone tumour usually occurring in long bones of males in the second decade. Though these are considered benign, rare cases show aggressive behaviour and metastases. However, there are no defined histological criteria to diagnose aggressiveness, except soft tissue (ST) infiltration. With the identification of specific immunohistochemical and genetic signatures, recent research has nurtured the concept of malignant CB and raised concerns that malignant CBs are being frequently misdiagnosed. Here we report a case of a CB with unusual features, in a 62-year-old woman which includes rare location in the scapula, recurrence following a long period after excision, extensive soft tissue invasion, and predominant small round cell morphology. This case intends to add to the limited literature on aggressive CB as well as to the evolving concept of malignant CB. The case also highlights the importance of follow up of patients with CB preventing mutilating surgery.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122753092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Indispensable Ally - The Pathologist’s Pre-eminent Role in Renal Medicine through the Ages","authors":"C. Herath","doi":"10.4038/jdp.v15i2.7787","DOIUrl":"https://doi.org/10.4038/jdp.v15i2.7787","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130821280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathology Quiz","authors":"C. Sosai, Anoj Dharmawardhane","doi":"10.4038/jdp.v15i2.7789","DOIUrl":"https://doi.org/10.4038/jdp.v15i2.7789","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130439053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucinous Cystic Neoplasm of the Liver- Three Rare Cases with Different Clinical Impressions","authors":"N. Amarasinghe, J. D. S. Manoharee, D. N. U. Jayathunga, S. Hewavisenthi, T. Bopagoda","doi":"10.4038/jdp.v15i2.7790","DOIUrl":"https://doi.org/10.4038/jdp.v15i2.7790","url":null,"abstract":"Mucinous Cystic Neoplasm of the Liver (MCN-L) is a rare cystic epithelial tumour that does not communicate with bile ducts and comprising ovarian-type mesenchymal stroma and mucinous epithelium. Though it is a benign tumour it may be associated with invasive carcinoma. Therefore, complete surgical excision and extensive sampling is important to prevent recurrence and detect associated malignancy. Its rarity precludes its recognition as it can mimic other cystic liver lesions. Awareness of this rare entity is essential as it lacks well-defined characteristics and poses a considerable diagnostic challenge preoperatively. Here we present three cases of MCN-L with different clinical impressions preoperatively. All three were women who presented with abdominal pain or discomfort and were found to have cystic lesions in the liver which subsequently underwent excision. The preoperative diagnoses were hydaticd cyst, hepatic abscess and simple liver cyst in case 1 ,2 and 3 respectively. Histopathology of all three cysts were MCN-L with no high grade dysplasia or invasive carcinoma.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115947373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dedifferentiated chordoma: a case report of a rare subtype of chordoma","authors":"P. M. S. Hiroshini, T. Jayamaha, R. Ratnayake","doi":"10.4038/jdp.v15i1.7782","DOIUrl":"https://doi.org/10.4038/jdp.v15i1.7782","url":null,"abstract":"Chordoma is a malignant tumour showing notochordal differentiation with three identified subtypes including chordoma not otherwise specified, chondroid chordoma and dedifferentiated chordoma. Dedifferentiated chordoma is rare and carries the worst prognosis of all subtypes due to rapid progression and potential for metastases. It is characterized by a high-grade sarcomatous component juxtaposed to conventional chordoma. We report a case of a dedifferentiated chordoma in a 71 year old woman who presented with pain in the lower back, numbness of feet and loss of weight of recent onset. Per-rectal examination revealed a soft tissue mass in the presacral region while imaging showed a solid and cystic lesion with calcifications in the presacral region. The radiological impression was of a retro rectal cystic hamartoma, an epidermoid cyst, or a chronic abscess. The resected specimen comprised a lobulated mass of soft, gelatinous tissue with haemorrhage and necrosis. Microscopy showed a biphasic tumour composed of conventional chordoma juxtaposed with high-grade sarcomatous component. Morphology and immunohistochemistry were compatible with a chordoma with a focal high-grade spindle cell sarcomatous component in keeping with a dedifferentiated chordoma.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121604317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assurance in immunohistochemistry for better patient care","authors":"L. Mudduwa","doi":"10.4038/jdp.v15i1.7777","DOIUrl":"https://doi.org/10.4038/jdp.v15i1.7777","url":null,"abstract":"","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116816531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological spectrum of two common conditions encountered in renal biopsies: acute diffuse proliferative glomerulonephritis and lupus nephritis","authors":"E. Wickramaratne, L. D. Silva, S. Wijetunge, N. Ratnatunga, R. Thalgahagoda, N. Nanayakkara, A. Wazil","doi":"10.4038/jdp.v15i1.7779","DOIUrl":"https://doi.org/10.4038/jdp.v15i1.7779","url":null,"abstract":"Background: Acute diffuse proliferative glomerulonephritis (ADPGN) and lupus nephritis (LN) are commonly encountered conditions in renal biopsies. ADPGN is usually a self-limiting childhood disease occurring commonly after streptococcal infection. LN is a common complication of systemic lupus erythematosus (SLE) with diverse clinical and histological features. Objectives: The objective of this study is to describe the clinico-pathological spectrum of ADPGN and LN in renal biopsies. Method: A retrospective-descriptive study was done by retrieving all renal biopsies (1225) received in the year 2018 at the Department of Pathology, Faculty of Medicine, University of Peradeniya. Biopsies diagnosed as ADPGN and LN were selected. Results: Out of all renal biopsies (1225), 63(5.1%) were diagnosed as ADPGN and 92(7.5%) as LN. ADPGN was seen in an age range of 3-78 years. 24(38.1%) were children and 39(61.9%) were adults. Nephritic syndrome (NS) was the commonest presentation in both children and adults (n=23,36.5%) while 13(20.6%) showed nephrotic-nephritic mixed picture (NNMP). Cellular crescents were seen in 11 patients (17.4%) and most were adults with NNMP. Tubular injury was seen in 19 (30.1%) and most were children with NNMP. 34 (53.9%) patients showed classic uncomplicated ADPGN. Immunofluorescence showed IgG-positivity in 9(14.2%). C3 was positive in 27(42.8%). In LN cases, 47(51.09%) patients were women with Class IV lesions, which was the commonest group. Of the class IV patients (n=56) most presented with non-nephrotic range proteinuria (NNRP), while 35 (62.5%) had microscopic haematuria (MH) and 26(46.4%) showed elevated serum creatinine. All class II patients(n=15) were women (100%). 9 (60%) patients showed NNRP, 9 (60%) MH and 4(26.7%) elevated SC. All class III patients(n=5) were also women who had NNRP and MH. SC was elevated in 1(20%) patient. Conclusions: Most children and adults who underwent renal biopsy for ADPGN had presented with NS while a lesser number had NNMP. A study done by Wijewickrama et al. in 2015 also revealed that NS was the commonest presentation of ADPGN in adults. Common complications detected in our study were cellular crescents and tubular injury which were found more in patients with NNMP than NS. C3-positivity was commoner than IgG possibly because biopsies were performed during the latter phase of the disease. Common classes of LN were class IV, II and III. Most of these patients had NNRP and MH while a lesser number showed elevated serum creatinine.","PeriodicalId":225127,"journal":{"name":"Journal of Diagnostic Pathology","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133174082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}