The Egyptian Journal of Chemistry最新文献_第2页

Role of CNK1, Ephrin B1, GPR19 and SMURF1 in breast cancer early diagnosis, metastasis and drug resistance CNK1、Ephrin B1、GPR19和SMURF1在乳腺癌早期诊断、转移和耐药中的作用

The Egyptian Journal of Chemistry Pub Date : 2021-06-06 DOI: 10.21608/EJCHEM.2021.77940.3833

Afnan N. Abdrabou, Sara M. Radwan, Reham El shimy, H. E. Mesallamy

{"title":"Role of CNK1, Ephrin B1, GPR19 and SMURF1 in breast cancer early diagnosis, metastasis and drug resistance","authors":"Afnan N. Abdrabou, Sara M. Radwan, Reham El shimy, H. E. Mesallamy","doi":"10.21608/EJCHEM.2021.77940.3833","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.77940.3833","url":null,"abstract":"Background: The extracellular signal-regulated kinase (ERK) pathway is a key signaling pathway involved in the regulation of normal cell proliferation, survival and differentiation. However, aberrant regulations of the ERK pathway contribute to cancer and other human diseases. Objective: This study was designed to investigate the role of some ERK pathway effectors such as the connector enhancer of kinase suppressor of Ras1 (CNK1), Ephrin B1, G protein-coupled receptor 19 (GPR19) and SMAD ubiquitination regulatory factor 1 (SMURF1) in breast cancer (BC) diagnosis and metastasis risk prediction. Methods: The study involved 50 (ERPRHer2=6, ERPRHer2=11, ERPRHER2=8, ERPRHer2=25) newly diagnosed BC patients, 15 chemotherapy resistant BC patients, 15 benign breast tumor patients and 10 controls. All total 65 BC patients (including the chemotherapy resistant group) were subdivided into two groups: metastatic BC (17 patients), and nonmetastatic BC group (48 patients). CNK1, Ephrin B1, GPR19 and SMURF1 serum levels were analyzed using ELISA. Results: The study revealed significantly higher serum levels of CNK1, Ephrin B1, GPR19 and SMURF1 in all malignant groups (ERPRHer2, ERPRHer2, ERPRHER2, ERPRHer2), as well as a significant elevation in the chemotherapy resistant BC group as compared to non-resistant group (P < 0.001). They also revealed excellent value for de novo BC diagnosis and metastasis prediction. Conclusion: CNK1, Ephrin B1, GPR19 and SMURF1 may be considered as novel biomarkers for BC diagnosis and prediction of metastasis risk.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":"1 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83011922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization and Biological Activity Study of Cobalt(II), Nickel(II) and Copper(II) Complexes Derived from Mixed Bi dentate Ligands of Oxime and Phenanthroline11 肟和邻菲罗啉混合双齿配体衍生钴(II)、镍(II)和铜(II)配合物的合成、表征及生物活性研究11

The Egyptian Journal of Chemistry Pub Date : 2021-06-05 DOI: 10.21608/EJCHEM.2021.78216.3827

M. Abid, Fathil R. Hafith, Taghreed M. Musa, B. F. Abbas

{"title":"Synthesis, Characterization and Biological Activity Study of Cobalt(II), Nickel(II) and Copper(II) Complexes Derived from Mixed Bi dentate Ligands of Oxime and Phenanthroline11","authors":"M. Abid, Fathil R. Hafith, Taghreed M. Musa, B. F. Abbas","doi":"10.21608/EJCHEM.2021.78216.3827","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.78216.3827","url":null,"abstract":"The present work involves the synthesis and characterization of cobalt (II), nickel (II) and copper (II) complexes derived from (1:1:1) mole ratios of coumarine-oxime:1,10-phenanthroline:metal ions with respect to the continuous variation method of Job via spectroscopic studies. The isolated metal complexes were characterized with their ligands of 3-acetoxime-coumarine by elemental analyses, FT-IR, EI-MS and NMR spectra. The flame atomic absorption spectroscopy, molar conductivity in DMF and magnetic moment measurements were also employed to determine the supposed molecular weights and their geometry. Furthermore the gravimetric thermal analysis (TG-DTA) was estimated for copper(II) and nickel(II) complexes and the observed data form weight loss percents confirmed the suggested chemical formulas and structures of complexes. The results observed from UV-Visible spectra and elemental analyses together with mass spectra confirmed the octahedral geometry around the cobalt(II) and copper(II) ions whereas the diamagnetic complex of nickel(II) was square-planner in [Ni(Phen)(L)]Cl2 formula. As well as the biological activities of complexes solutions were tested against two types of bacteria and the inhibition zones data proved that all solutions were active compared with standard drugs of 10 ppm concentrations.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":"52 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82175751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Novel Pyrazole Derivatives from 4-Florophenylhydrazine and Study Their Cytotoxicity as Anti-Cancer Agent 11 新型4-Florophenylhydrazine吡唑衍生物的合成、表征及抗癌细胞毒性研究

The Egyptian Journal of Chemistry Pub Date : 2021-06-05 DOI: 10.21608/EJCHEM.2021.78214.3825

Sumaya M. Salih, Hameed M. Alkubaisi, F. L. Faraj

引用次数: 0

Synthesis and Structural Studies of Transition Metals Complexes with Poly dentate Azo dye ligand Derived from Coumarine11 香豆素偶氮染料配体过渡金属配合物的合成与结构研究

The Egyptian Journal of Chemistry Pub Date : 2021-06-05 DOI: 10.21608/EJCHEM.2021.78215.3826

A. Jabbar, M. Al-Jibouri, A. H. Ismail

引用次数: 0

Synthesis, characterization, and anticoagulant activity of new functionalized biscoumarins 新型功能化双香豆素的合成、表征和抗凝血活性

The Egyptian Journal of Chemistry Pub Date : 2021-06-05 DOI: 10.21608/EJCHEM.2021.73699.3641

Yasser Fakri Mustafa, E. Mohammed, R. Khalil

{"title":"Synthesis, characterization, and anticoagulant activity of new functionalized biscoumarins","authors":"Yasser Fakri Mustafa, E. Mohammed, R. Khalil","doi":"10.21608/EJCHEM.2021.73699.3641","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.73699.3641","url":null,"abstract":"Despite their rarity and structural complexity, natural and synthetic biscoumarins have polarized much attention from investigators particularly due to their characteristic activity as anticoagulant agents. In this work, a panel of twelve functionalized biscoumarins was synthesized in two schematic steps; the first one started by condensing various phenol-based derivatives with malonic acid via a Pechmann-type reaction yielding alkyl-substituted 4-hydroxycoumarins herein symbolized as (E1-E12). The latter compounds were undergone a self-coupling under the influence of methylene iodide to afford the target functionalized biscoumarins, which were symbolized as (EY1-EY12). The potential of the synthesized biscoumarins as anticoagulant applicants was investigated in vivo using rabbit as an animal model. The employed assay was the prothrombin time that was monitored after three and five days of the last oral treatment. The results gathered from this test revealed that the synthesized biscoumarins have a promising anticoagulant activity compared with warfarin as a standard anticoagulant drug, with privileged influence contributed to those substituted at position 7 of the coumarin framework. The authors concluded that the substitution of an alkyl group at that position of the coumarin monomer may intensify the anticoagulant activity of the prepared biscoumarins. Also, this intensity was directly proportionated to the increase in the molecular weight of this alkyl group. Accordingly, the synthesized biscoumarins possessing this property would provide an efficient base for synthesizing new compounds, which have a promising anticoagulant effect.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":"1 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76832358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Preparation and Characterization of some new Benzothiazole-Heterocyclic Derivatives 新型苯并噻唑杂环衍生物的制备与表征

The Egyptian Journal of Chemistry Pub Date : 2021-06-01 DOI: 10.21608/EJCHEM.2021.73818.3650

R. Aldujaili, A. Alhasan

引用次数: 2

Prediction of Thermal Isomerization Temperatures of Substituted Benzocyclobutenes to o- Quinodimethanes Using Hardness, Polarizability and energies of σ, σ* and π* orbitals. 利用σ、σ*和π*轨道的硬度、极化率和能预测取代苯并环丁烯到o-喹二甲烷的热异构化温度。

The Egyptian Journal of Chemistry Pub Date : 2021-06-01 DOI: 10.21608/EJCHEM.2021.50081.3057

A. Al-Sabawi, Hyffaa Y. Hussien, Abdulkhalik S. Alkazzaz

引用次数: 0

Bioactive Phytoconstituents of Morus Plants exhibiting Numerous Therapeutic Activities 桑属植物具有多种治疗活性的生物活性成分

The Egyptian Journal of Chemistry Pub Date : 2021-06-01 DOI: 10.21608/EJCHEM.2021.76688.3788

Alaadin E. El-Haddad, E. Deeb, A. Amer, Amr M. Saadeldeen, Fakher M. Ahmed, M. Salem, H. Taha

引用次数: 1

Rate Theory and Relaxation Map Analysis of Iodine-Doped Poly(Ethyl Methacrylate) composite films using Thermally Stimulated Depolarization Current-Thermal Sampling (TSDC-TS) Technique 利用热激退极化电流-热采样(TSDC-TS)技术分析掺碘聚甲基丙烯酸乙酯复合膜的速率理论和弛豫图

The Egyptian Journal of Chemistry Pub Date : 2021-05-31 DOI: 10.21608/EJCHEM.2021.69217.3516

Wafaa B. Elsharkawy

{"title":"Rate Theory and Relaxation Map Analysis of Iodine-Doped Poly(Ethyl Methacrylate) composite films using Thermally Stimulated Depolarization Current-Thermal Sampling (TSDC-TS) Technique","authors":"Wafaa B. Elsharkawy","doi":"10.21608/EJCHEM.2021.69217.3516","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.69217.3516","url":null,"abstract":"Abstract. Iodine-doped Poly (Ethyl Methacrylate) composites have been prepared using casting method. Global TSDC of the composite samples has been investigated using TSDC-TS technique. It is found that, global TSDC spectra of pure PEMA are characterized by two relaxations. The first relaxation which is observed as a shoulder in the temperature range 324-333 K is attributed to the motion of side group and named -relaxation. Whereas, the second relaxation is observed in the glass temperature range of PEMA at Tm= 347 K and named as dipolar relaxation, i.e., -relaxation. On doping with iodine, a new relaxation peak has been obtained at high temperatures ~ 397-409 K, and named as space charge relaxation, i.e., -relaxation. Complex TSDC spectra of PEMA-Iodine composites have been resolved into its elementary peaks using TS technique. These elementary peaks have been used to construct relaxation map (RM) of all samples using Eyring transformation. The existence of compensation phenomenon for all samples is also verified and the coordinates of each compensation point have been estimated. These coordinates are used to calculate the density of disorder (DOD) and thermal expansion coefficient of the samples. The thermodynamic parameters of the samples, such as, enthalpy, entropy and Gibbs free energy have been calculated at different poling temperatures.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":"5 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91091291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Using 9-Chloroacridine as A Chromogenic Reagent for The Detection of Tetracycline 用9-氯吖啶作显色试剂检测四环素

The Egyptian Journal of Chemistry Pub Date : 2021-05-30 DOI: 10.21608/EJCHEM.2021.72434.3601

O. S. Ahmad, Mohammed S. Al-Enizzi, Abdussamed M. A. Saeed

{"title":"Using 9-Chloroacridine as A Chromogenic Reagent for The Detection of Tetracycline","authors":"O. S. Ahmad, Mohammed S. Al-Enizzi, Abdussamed M. A. Saeed","doi":"10.21608/EJCHEM.2021.72434.3601","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.72434.3601","url":null,"abstract":"A simple, sensitive, accurate and cost-effective method has been described for the quantitative determination of Tetracycline hydrochloride (TCs) in bulk drug and its pharmaceutical preparations in an aqueous medium. The proposed method is based on the nucleophilic substitution reaction of 9-chloroacridine (9-CA) as a chromogenic reagent with TCs in an aqueous solution forming a colored complex. The spectrum of the product shows maximum absorption at 385 nm against the blank. The linearity range of the calibration graph was (1-28) μg.mL-1 with a limited detection value (LOD) 0.138 μg.mL-1. The results show the absence of interferences from the excipients compounds on the determination of the drug. The suggested method exhibited high reproducibility (RSD) 2.3 % with mean percentage recovery (R%) 99.95. Furthermore, the stability constant has been calculated to be 9.843×105 L.mol-1 and the reaction mechanism is proposed. A ratio of 1: 1 was found between the above drug and the reagent using Job and molar ratio methods. The accuracy and validity of the proposed method were further determined by performing a recovery experiment by the use of the standard addition method. It is found that the method does not require extraction process and it agree well standard addition method. Appli","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":"33 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84807439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1